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Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis

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Cancer Communications 2024年第7期44卷 718-738页

作者： Wei mu Pengfei Gu Huating Li Jinjin Zhou Yulun Jian Weiping Jia Yang Ge School of Public Health Center for Single-cell OmicsShanghai Jiao Tong University School of MedicineShanghaiP.R.China Shanghai Key Laboratory of Diabetes Mellitus Department of Endocrinology and MetabolismShanghai Diabetes InstituteShanghai Clinical Center for DiabetesShanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China

Background:Benzo[a]pyrene(B[a]P),a carcinogen pollutant produced by combustion processes,is present in the western diet with grilled *** exposure of B[a]P in hepatocellular carcinoma(HCC)cells promotes metastasis rather than primary proliferation,implying an unknown mechanism of B[a]P-induced *** that exosomes carry bioactive molecules to distant sites,we investigated whether and how exosomes mediate cancer-stroma communications for a toxicologically associated ***:Exosomes were isolated from B[a]P stimulated BEL7404 HCC cells(7404-100Bap Exo)at an environmental relevant dose(100 nmol/L).Lung preeducation animal model was prepared via injection of exosomes and *** inflammatory genes of educated lungs were evaluated using quantitative reverse transcription PCR *** LM3.cells transfected with firefly luciferase were next injected to monitor tumor burdens and organotropic *** of B[a]P-exposed exosomes were determined by ceRNA *** between circular RNA(circRNA)and microRNAs(miRNAs)were detected using RNA pull-down in target lung *** in situ hybridization and RNA immunoprecipitation assay was used to evaluate the“on-off”interaction of circRNA-miRNA *** further developed an adenoassociated virus inhalation model to examine mRNA expression specific in lung,thereby exploring the mRNA targets of B[a]P induced circRNA-miRNA ***:Lung fibroblasts exert activation phenotypes,including focal adhesion and motility were altered by 7404-100Bap *** the exosome-educated in vivo model,fibrosis factors and pro-inflammatory molecules of are up-regulated when injected with *** to non-exposed 7404 cells,circ_0011496 was up-regulated following B[a]P treatment and wasmainly packaged into 7404-100Bap *** circ_0011496 were delivered and competitively bound to miR-486-5p in recipient *** down-regulation of miR-486-5p converted fi

关键词： benzo(a)pyrene cancer associate fibroblast circular RNA exosome organotropic metastasis

Facilitating prelithiation of silicon carbon anode by localized high-concentration electrolyte for high-rate and long-cycle lithium storage

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Carbon Energy 2024年第6期6卷 216-233页

作者： Yuanxing Zhang Borong Wu Jiaying Bi Xinyu Zhang Daobin mu Xin-Yu Zhang Ling Zhang Yao Xiao Feng Wu School of Materials Science and Engineering Beijing Institute of TechnologyBeijingChina Chongqing Innovation Center Beijing Institute of TechnologyChongqingChina College of New Energy Xi′an Shiyou UniversityXi′anChina Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjinChina

The commercialization of silicon-based anodes is affected by their low initial Coulombic efficiency(ICE)and capacity decay,which are attributed to the formation of an unstable solid electrolyte interface(SEI)***,a feasible and cost-effective prelithiation method under a localized highconcentration electrolyte system(LHCE)for the silicon-silica/graphite(Si-SiO_(2)/C@G)anode is designed for stabilizing the SEI layer and enhancing the *** thin SiO_(2)/C layers with-NH_(2) groups covered on nano-Si surfaces are demonstrated to be beneficial to the prelithiation process by density functional theory calculations and electrochemical *** SEI formed under LHCE is proven to be rich in ionic conductivity,inorganic substances,and flexible organic ***,faster Li+transportation across the SEI further enhances the prelithiation effect and the rate performance of Si-SiO_(2)/C@G *** also leads to uniform decomposition and high stability of the SEI with abundant organic *** a result,the prepared anode shows a high reversible specific capacity of 93..5 mAh g^(-1)after 400 cycles at a current density of 1 *** 811‖Li-SSGLHCE full cell achieves a high-capacity retention of 126.15 mAh g^(-1)at 1 C over 750 cycles with 84.82%ICE,indicating the great value of this strategy for Si-based anodes in large-scale applications.

关键词： localized high-concentration electrolytes prelithiation SEI layer silicon anode

Self-powered stimuli responsive material for dual stimulation of heat and guest molecules

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Chinese Chemical Letters 2024年第2期35卷 590-593页

作者： Jintao Men Ke Xu Taiting Sha Lei He Yan Xu Jie mu Tijian Yin Qiong Ye Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China

Stimuli-responsive smart materials exhibit reverse chemical/physical changes in response to external stimuli and research on stimuli-responsive smart materials with self-powered properties is still uncultivated ***,we report perovskite crystalline self-powered multiple stimuli-responsive materials triggered by chemical and thermal stimuli.[HMEP]PbI_(3.·(H_(2)O)(1;HMEP is a hydroxytris(1-methylethyl)phosphorus cation)crystallizes in a chiral space group P 21 at 293.K and has the piezoelectric reaction(d_(3.)=10 pC/N and output voltage=1 V)of self-powered modes,this value is larger than the value of 3.pC/N for the classical piezoelectric material *** materials can generate energy due to mechanical deformation,and using thermal heating to lose water,[HMEP]PbI_(3.(2)can be obtained.2 crystallizes in the non-centrosymmetric space group,undergoes two reversible phase transitions at 243.255 K and 3.5/3.8 K,and shows second harmonic generation ***,2 can return to the hydrated form 1 after absorbing *** work will lay the foundation for self-powered stimuli-responsive compounds and contribute to the construction of novel organic-inorganic hybrid materials with second harmonic generation switching.

关键词： Self-powered Dual stimulation reactive Phase transition SHG switch Organic-inorganic hybrid perovskite

Miniature tunable Airy beam optical meta-device

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Opto-Electronic Advances 2024年第2期7卷 5-12页

作者： Jing Cheng Zhang mu Ku Chen Yubin Fan Qinmiao Chen Shufan Chen Jin Yao Xiaoyuan Liu Shumin Xiao Din Ping Tsai Department of Electrical Engineering City University of Hong KongKowloonHong Kong SAR 999077China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongKowloonHong Kong SAR 999077China Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong Kong SAR 999077China Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China

Tunable Airy beams with controllable propagation trajectories have sparked interest in various fields,such as optical manipulation and laser *** research approaches encounter challenges related to insufficient compactness and integration feasibility,or they require enhanced tunability to enable real-time dynamic manipulation of the propagation *** this work,we present a novel method that utilizes a dual metasurface system to surpass these limitations,significantly enhancing the practical potential of the Airy *** approach involves encoding a cubic phase profile and two off-axis Fresnel lens phase profiles across the two *** validity of the proposed strategy has been confirmed through simulation and experimental *** proposed meta-device addresses the existing limitations and lays the foundation for broadening the applicability of Airy beams across diverse domains,encompassing light-sheet microscopy,laser fabrication,optical tweezers,etc.

关键词： metasurface miniature device tunable Airy beam tunable meta-device

Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis

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Nano Research 2024年第4期17卷 2919-2928页

作者： Guanghao Wu Changwen mu Qianru Zhao Yao Lei Ran Cheng Weidong Nie Jiamin Qu Yuping Dong Ruili Yang Haiyan Xie State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesChemical Biology CenterPeking UniversityBeijing 100191China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China School of Life Science Beijing Institute of TechnologyBeijing 100081China School of Stomatology Peking UniversityBeijing 100081China

Atherosclerosis is the most common cause of cardiovascular diseases that contribute to the major morbidity worldwide,but still lacking of effective treatment ***,a hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis by fusing M2 macrophages with thylakoid(TK)*** systemic administration,the obtained TK-M2 actively accumulates in the early atherosclerotic plaques,wherein M2 macrophages relieve the cholesterol accumulation and the inflammation in the foam ***,the TK membranes decorated on the M2 macrophages exhibit both type I and type II sonodynamic effects under ultrasound(US)activation,inducing the direct apoptosis of foam *** cooperation of M2 and TK leads to significant outcome in eliminating atherosclerotic plaques without obvious side-effects,providing a new avenue for atherosclerosis treatment.

关键词： atherosclerosis thylakoid ultrasound M2 macrophage

Characteristics and sources of peroxyacetyl nitrate(PAN)in the rural North China Plain:Results from1-year continuous observations

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Journal of Environmental Sciences 2024年第4期138卷 719-731页

作者： Xin Liu Xiaowei He Chenglong Zhang Yifei Song Shuyang Xie Chengtang Liu Pengfei Liu Yuanyuan Zhang Yujing mu Junfeng Liu Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Peroxyacetyl nitrate(PAN)is an important photochemical pollutant in the troposphere,whereas long-term measurements are scarce in rural areas in North China Plain(NCP),resulting in unclear seasonal variations and sources of PAN in rural *** this study,we conducted a 1-year observation of PAN during 2021-2022 at the rural NCP *** average concentrations of PAN were 1.10,0.75,0.65,and 0.88 ppbv in spring,summer,autumn,and winter,respectively,with a 1-year average of 0.81±0.60 *** indicate that the loss of PAN through thermal decomposition in summer accounts for 43.2% of the total formed PAN,which is an important reason for the low concentration of PAN in *** speculate that since the correlation between PAN and O_(3. in winter is significantly lower than that in other seasons,the observed regional transport of PAN cannot be ignored in *** budget analysis,regional transport accounted for 12.8% and 55.9% of the observed PAN on the spring and winter pollution days,respectively,which showed that regional transport played key roles during the photochemical pollution of the rural NCP in *** potential source contribution function revealed that the transported PAN mainly comes from southern Hebei in *** winter,the transported PAN was mainly from Langfang,Hengshui,and southern *** findings may aid in understanding PAN variations in different seasons in rural areas and highlight the impact of regional transport on the PAN budget.

关键词： Photochemical pollution Peroxyacetyl nitrate(PAN) Seasonal variations Regional transport Rural area

Ultra-broadband microwave absorber and high-performance pressure sensor based on aramid nanofiber,polypyrrole and nickel porous aerogel

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1912-1921页

作者： Leyi Zhang Hongyu Jin Hanxin Liao Rao Zhang Bochong Wang Jianyong Xiang Congpu mu Kun Zhai Tianyu Xue Fusheng Wen State Key Laboratory of Metastable Materials Science&Technology Yanshan UniversityQinhuangdao 066004China Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

Electronic devices have become ubiquitous in our daily lives,leading to a surge in the use of microwave absorbers and wearable sensor devices across various sectors.A prime example of this trend is the aramid nanofibers/polypyrrole/nickel(APN)aerogels,which serve dual roles as both microwave absorbers and pressure *** this work,we focused on the preparation of aramid nanofibers/polypyrrole(AP15)aerogels,where the mass ratio of aramid nanofibers to pyrrole was 1:*** employed the oxidative polymerization method for the preparation *** this,nickel was thermally evaporated onto the surface of the AP15 aerogels,resulting in the creation of an ultralight(9.3. mg·cm^(-3.).This aerogel exhibited a porous *** introduction of nickel into the aerogel aimed to enhance magnetic loss and adjust impedance matching,thereby improving electromagnetic wave absorption *** minimum reflection loss value achieved was-48.7 dB,and the maximum effective absorption bandwidth spanned 8.42 GHz with a thickness of 2.9 *** impressive metrics can be attributed to the three-dimensional network porous structure of the aerogel and perfect impedance ***,the use of aramid nanofibers and a three-dimensional hole structure endowed the APN aerogels with good insulation,flame-retardant properties,and compression *** under a compression strain of 50%,the aerogel maintained its resilience over 500 *** incorporation of polypyrrole and nickel particles further enhanced the conductivity of the ***,the final APN aerogel sensor demonstrated high sensitivity(10.78 kPa-1)and thermal *** conclusion,the APN aerogels hold significant promise as ultra-broadband microwave absorbers and pressure sensors.

关键词： porous aerogel aramid nanofibers microwave absorbers pressure sensor porous structure

Untargeted metabolomics combined with 16S rRNA sequencing reveals the characteristics of intestinal metabolism and gut microbiota in hazelnut Cor a 14-allergic BALB/c mice

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Food Science and Human Wellness 2024年

作者： Chen Chen Kaiyu mu Qiang Xie Wentong Xue College of Food Science and Nutritional Engineering， China Agricultural University

Cor a 14 is one of the most vital allergens in hazelnuts. However， the features of intestinal metabolites and microbiota associated with Cor a 14-induced allergy remain unclear. In this study， we established a hazelnut Cor a 14-allergic BALB/c mice model， which was distinguished by the dropped temperature and enhanced allergic inflammatory factor levels in serum. Faeces were collected to detect characteristics of the intestinal metabolites by untargeted metabolomics and the gut microbiota by 16S rRNA sequencing. The α- and β-diversity of gut microbiota in Cor a 14-allergic mice differed from the controls with elevated relative abundance of Lactobacillus and reduced relative abundances of Odoribacter， Chloroplast， Alistipes and Lachnospiraceae＿NK4A13.＿group. Untargeted metabolomics results revealed that 23. significantly differential metabolites (111 up-regulated， 127 down-regulated) were identified， of which， L-tryptophan， histamine and N-acetylhistamine were remarkably accumulated and primarily enriched in the enhanced L-tryptophan and histidine metabolism pathways. Spearman correlation analysis suggested that L-tryptophan was positively correlated with allergic indicators and screened as the potential biomarker for Cor a 14 allergy. Collectively， our findings uncovered the characteristics of intestinal metabolites and gut microbiota during Cor a 14 anaphylaxis and provided new potential insights for diagnosis of hazelnut allergy.

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Polar codes based OFDM-PLC systems in the presence of impulsive noise

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High Technology Letters 2024年第2期30卷 188-198页

作者：周玉 LI Yue ZHAO Shuangshuang GAO Fan ZHOU Chao mu Zhuowen CHEN Rui Marketing Service Center of State Grid Jiangsu Electric Power Co. LtdNanjing 210000P.R.China College of Information and Communication Engineering Nanjing Institute of TechnologyNanjing 211167P.R.China

Power line communication(PLC)has the potential to become the preferred technique for providing broadband communication to homes and offices with advantage of eliminating the need for new wiring infrastructure and reducing the *** it suffers from the impulsive noise because it introduces significant time variance into the power line *** this paper,a polar codes based orthogonal frequency division multiplexing(OFDM)PLC system is proposed to deal with the impulsive noise and thereby improve the transmission ***,the impulsive noise is modelled with a multi-damped sine function by analyzing the time behavior of impulse *** the polar codes are used to combat the impulsive noise of PLC channel,and a low complexity bit-flipping decoding method based on CRC-aided successive cancellation list(CA-SCL)decoding algorithm is *** evaluate the proposed decoding algorithm and the results validate the suggested polar codes based OFDM-PLC scheme which can improve the BER performance of PLC with impulsive interference.

关键词： orthogonal frequency division multiplexing(OFDM) polar code impulsivenoise power line communication(PLC) bit-flipping