检索结果-南通市图书馆

Emerging small-molecule therapeutic approaches for Alzheimer's disease and Parkinson's disease based on targeting microrNAs

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2022年第2期17卷 336-337页

作者： Somaya A.Abdelrahman moustafa t.ga.r Department of Medicinal Chemistry Faculty of PharmacyMansoura UniversityMansouraEgypt Department of radiology Stanford University School of MedicineStanfordCAUSA

the role of micro rNAs in the progression of neurodegenerative diseases: Micro rNAs(mi rNAs) are endogenous, non-coding and short rNA nucleotides that regulate gene expression through base pairing with the targeted me... 详细信息

关键词： endogenous Alzheimer diseases

Multitarget therapeutic strategies for Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural regeneration research 2019年第3期14卷 437-440页

作者： Mostafa M.Ibrahim moustafa t.ga.r Department of Pharmacognosy Faculty of Pharmacy Mansoura University Department of Basic Pharmaceutical and toxicological Sciences College of Pharmacy University of Louisiana at Monroe Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry University of Iowa

Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. the complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. the major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. In this review, we discuss recent advances in profiling single target inhibitors based on these enzymes to multitarget-directed ligands as potential therapeutics for this devastating disease. In addition, therapeutics based on iron chelation strategy are discussed as well.

关键词： multitarget-directed ligands acetylcholinesterase β-secretase Alzheimer's disease hybridization neurodegenerative diseases tacrine brain permeability

Genesis and tectonic Implications of the Kabr El-Bonaya Ultramafic rocks,Sinai Peninsula,Egypt:Constraints from Mineralogical and Geochemical Characteristics

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2021年第2期95卷 393-418页

作者： moustafa Mohammed MOgaHED Geology Department Benha University-EgyptBenhaEgypt

the Kabr El-Bonaya mafic–ultramafic intrusion is exposed along the southeastern border of the Sinai Peninsula and the northernmost segment of the Arabian-Nubian Shield(ANS).It occurs as an elliptical intrusive body that is located along the major NE–SW trending fracture zones that prevail in the Kid metamorphic *** ultramafic rocks in the complex comprise ultramafic cumulates of peridotites(dunite,harzburgite and wehrlite)and *** rocks are generally unmetamorphosed and have intrusive contacts with the country *** chemistry and whole-rock chemical compositions of these ultramafic rocks are mostly consistent with those of residual mantle peridotites from refractory suprasubduction tectonic *** on the variations of the major elements,the studied ultramafic rocks are consistent with those of a supra-subduction zone mantle,as it seems to have melted at 1–2 GPa and 1300–1450℃.Linear variations of Al2O3,Ca O,V and Ni with Mg O,coupled with incompatible and rare-earth-element depletion and mineral compositions,suggest prior events of partial melting in both wehrlites and *** LrEE enrichment in the harzburgite,as well as the development of Cr-rich spinel,is consistent with a history of melt–peridotite *** calculated(Sm/Yb)N variations for the studied peridotites indicate a general increase in the addition of fluids with an increasing degree of melting from the wehrlite(~13–15 wt%of fluid)in the source,after initial spinel peridotite melting to the harzburgite(~20–25 wt%of fluid)in the same source,which is contrary to normal abyssal *** estimated equilibration temperature ranges from 1214 to 1321℃for the studied wehrlites and from 1297 to 1374℃for *** Mg-rich nature of the analysed olivines from the studied ultramafic rocks(Fo=81.41 to 91.77)reflect their primary composition and are similar to olivines in Alaskan-type ultramafic *** Fo content of the analyzed olivines decrease sli

关键词： cumulate ultramafic rocks Alaskan-type rocks partial melting hydrous melting conditions supra-subduction zone Kabr El-Bonaya South Sinai Arabian-Nubian Shield

rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production

在线全文

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2004年第12期25卷 74-80页

作者： Mria GErOV,Jozef trK,Ol’ga PECHV,Jana MAtUKOV Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak republic Institute of Pathophysiology Medical School Comenius University Bratislava Slovak republic Now in Center for Blood research and Department of Pathology Harvard MedicalSchool Boston USA.

AIM: to search tools of high blood pressure in the model of nitric oxide (NO)-defective hypertension, and the study focused on the effect of rilmenidine, agonist of imidazoline receptors, which was suggested to modulate central sympathetic outflow. MEtHODS: three experimental groups, each consisting of 7 rats, were used: (I) rats with inhibition of NO synthase (NOS) by NG-nitro-L-arginine methyl ester (L-NAME) 40 mg·kg-1·d-1 for 4 weeks in drinking water, (II) rats with inhibited NOS as in group I , plus agonist of imidazoline receptors rilmenidine 3 mg·kg-1·d-1 for 4weeks by gavage, and(III) control rats. Systolic blood pressure wasmeasured weekly noninvasively. At the end of experiment aortic ring isometric tension was followed, NOS expression (aorta, left ventricle), and NOS activity (left ventricle and brain) were determined. rESULtS: In the group I systolic blood pressure in- creased significantly, aortic ring relaxation to acetylcholine was significantly attenuated. rilmenidine administered simultaneously with L-NAME (group II) prevented the increase of blood pressure which did not differ significantly from control values; aortic ring relaxation to acetylcholine did not differ from control. No change in NOS expres- sion (aorta and left ventricle) was found in groups I and II. Significant decline in NOS activity (left ventricle and brain) wasfound in groups I and II. CONCLUSION: rilmenidinehas aremarkable role inNO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. the prime cause of hypertension in this experimental model - the compromised production of NO due to inhibition of NOS - was not affected by rilmenidine.

关键词： NO deficiency hypertension imidazoline receptor nitric-oxide synthase sympathetic activity

Synthesis, in vitro antitumor activity and molecular modeling studies of a new series of benzothiazole Schiff bases

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2016年第3期27卷 380-386页

作者： moustafa t.ga.r Nadia S.El-Gohary Eman r.El-Bendary Mohamed M.El-Kerdawy Nanting Ni Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Mansoura 35516 Egypt Department of Chemistry Ceorgia State University Atlanta CA 30303 USA

A new series of benzothiazole Schiff bases 3–29 was synthesized and screened for antitumor activity against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. results indicated that compounds 3, 14, 19, 27 and 28 have promising activity against Hela cell line with IC50 values of 2.41,3.06, 6.46, 2.22 and 6.25 mmol/L, respectively, in comparison to doxorubicin as a reference antitumor agent（IC50 2.05 mmol/L）. In addition, compound 3 displayed excellent activity against COS-7 cell line with IC50 value of 4.31 mmol/L in comparison to doxorubicin（IC50 3.04 mmol/L）. In the present work,structure based pharmacophore mapping, molecular docking, protein-ligand interaction, fingerprints and binding energy calculations were employed in a virtual screening strategy to identify the interaction between the compounds and the active site of the putative target, EGFr tyrosine kinase. Molecular properties, toxicity, drug-likeness, and drug score profiles of compounds 3, 14, 19, 27, 28 and 29 were also assessed.

关键词： Benzothiazole Schiff bases Antitumor activity Molecular modeling In silico studies

Synthesis,antimicrobial, antiquorum-sensing and cytotoxic activities of new series of benzothiazole derivatives

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2015年第12期26卷 1522-1528页

作者： moustafa t.ga.r Nadia S.El-Gohary Eman r.El-Bendary Mohamed M.El-Kerdawy Nanting Ni Mona I.Shaaban Department of Medicinal Chemistry Faculty of Pharmacy Mansoura University Department of Chemistry Georgia State University Department of Microbiology Faculty of Pharmacy Mansoura University Department of Microbiology College of Pharmacy Taibah University

New series of benzothiazole derivatives were designed and synthesized. the newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus cereus. Compounds 6j and 6o showed the highest activity against E. coli and S. aureus. the antifungal activity of these compounds was also tested against Candida albicans and Aspergillus fumigatus293. Compounds 4c, 4g and 6j exhibited the highest activity against C. albicans. In addition, compounds4 a and 6j displayed promising activity against A. fumigatus 293. the same compounds were examined for their antiquorum-sensing activity against Chromobacterium violaceum AtCC 12472, whereas compounds4 a, 6j and 6p showed moderate activity. the in vitro cytotoxicity testing of the synthesized compounds was performed against cervical cancer（Hela） and kidney fibroblast cancer（COS-7） cell lines. results indicated that all tested compounds have IC50 values 〉50 mmol/L against both cell lines. Molecular properties, toxicities, drug-likeness, and drug score profiles of compounds 4a–c, 5a, 6g,h, 6j, 6l, 6o and7 c,d were also assessed.

关键词： antibacterial moiety antifungal antimicrobial cytotoxic screened moderate substituent Candida albicans

High-throughput computational screening for twodimensional magnetic materials based on experimental databases of three-dimensional compounds

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2020年第1期6卷 350-361页

作者： Daniele torelli Hadeel moustafa Karsten W.Jacobsen thomas Olsen Computational Atomic-scale Materials Design(CAMD) Department of PhysicsTechnical University of DenmarkDK-2800 Kgs.LyngbyDenmark

We perform a computational screening for two-dimensional(2D)magnetic materials based on experimental bulk compounds present in the Inorganic Crystal Structure Database and Crystallography Open Database.A recently proposed geometric descriptor is used to extract materials that are exfoliable into 2D derivatives and we find 85 ferromagnetic and 61 antiferromagnetic materials for which we obtain magnetic exchange and anisotropy parameters using density functional *** the easy-axis ferromagnetic insulators we calculate the Curie temperature based on a fit to classical Monte Carlo simulations of anisotropic Heisenberg *** find good agreement with the experimentally reported Curie temperatures of known 2D ferromagnets and identify 10 potentially exfoliable 2D ferromagnets that have not been reported *** addition,we find 18 easy-axis antiferromagnetic insulators with several compounds exhibiting very strong exchange coupling and magnetic anisotropy.

关键词： magnetic compounds ferromagnetic

A Note on Solutions for Asymptotically Linear Elliptic Systems

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2008年第3期24卷 511-522页

作者： Lei-ga Zhao Department of Mathematics Beijing University of Chemical Technology 100029 Beijing China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Mathematics Yunnan Normal University Kunming 650092 China

In this paper, we are concerned with the elliptic system of{ -△u＋V（x）u=g（x,v）, x∈r^N, -△v＋V（x）v=f（x,u）, x∈r^N, where V（x） is a continuous potential well, f, g are continuous and asymptotically linear as t→∞. the existence of a positive solution and ground state solution are established via variational methods.

关键词： Elliptic system ground state solution variational methods concentration-compactness principle

Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel

在线全文

学校读者我要写书评

暂无评论

Nano research 2022年第5期15卷 4302-4309页

作者： Boyang Sun Sanjana Ghosh Xuedan He Wei-Chiao Huang Breandan Quinn Meiling tian Dushyant Jahagirdar moustafa t.Mabrouk Joaquin Ortega Yumiao Zhang Shuai Shao Jonathan F.Lovell translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Biomedical Engineering University at BuffaloState University of New YorkBuffaloNY 14260USA Department of Anatomy and Cell Biology McGill UniversityMontrealQuebec H3A0C7Canada School of Chemical Engineering and technology Tianjin UniversityTianjin 300000China

Photodynamic therapy(PDt)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent ***,we demonstrated that liposomes containing a bilayer-anchored photosensitizer(porphyrin-phospholipid;PoP)can be loaded with drugs in their aqueous core to improve drug delivery and tumor ablation upon target tissue irradiation with *** the present work,we demonstrate that this concept can be extended to drugs loaded within the hydrophobic bilayer of ***(CtX)is a potent second generation taxane anti-cancer drug that was loaded in the bilayer of liposomes also containing 0.1 molar%PoP,generating CtX-loaded PoP liposomes(CtX-PoP-Lip).CtX-PoP-Lip showed unilamellar vesicle morphology,and exhibited integrity in storage and serum,while maintaining drug stability under laser *** vitro cell killing evaluation showed that red-light laser irradiation induced cytotoxicity in cells incubated with CtX-PoP-Lip,compared to control *** vivo pharmacokinetic analysis revealed that following intravenous administration to mice,CtX and PoP exhibited somewhat altered circulation profiles,suggesting that the CtX may have exchanged with serum factors in ***,when a single treatment of CtX-PoP-Lip with laser irradiation was administered to mice bearing human MIA Paca-2 tumors,tumors were effectively ablated whereas the equivalent chemotherapy and PDt monotherapies were *** results demonstrate the versatility of liposome delivery systems for achieving tumor ablation with chemophototherapy.

关键词： photodynamic therapy cabazitaxel liposome chemotherapy porphyrin-phospholipid