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Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats:oxidative/inflammatory/apoptotic pathways

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Asian Journal of Andrology 2024年第4期26卷 396-401页

作者： Ramadan S Hussein moustafa m eyada Rashad m mostafa Samah m Elaidy Shereen H Elsayed Hany m Saad Department of Dermatology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Department of Dermatology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Department of Dermatology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Department of Andrology and Sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Clinical Pharmacology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Department of Rehabilitation Sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones play essential roles in spermatogenesis,but their effects on infertile males remain poorly *** study aimed to evaluate the impact of combining carbimazole(CBZ)with vitamin E(VE)on testicular injury induced by experimental hyperthyroidism in adult albino rats,focusing on oxidative,inflammatory,and apoptotic *** this experimental study,64 adult male albino Wistar rats were divided into eight groups:Group I(control-untreated),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced testicular injury),Group VI(levothyroxine+CBZ-treated),Group VII(levothyroxine+VE-treated),and Group VIII(levothyroxine+CBZ+VE-treated).The study was conducted in the Faculty of medicine,Suez Canal University(Ismailia,Egypt).After cervical decapitation,both testes and epididymis were examined histopathologically and *** differences were observed among groups concerning malondialdehyde(mDA),glutathione(GSH),superoxide dismutase(SOD),and catalase(CAT;all Pmerase chain reaction analysis showed significant differences in tumor necrosis factor-α(TNF-α),interleukin-10(IL-10),Bcl-2-associated X protein(BAX),B-cell lymphoma 2 protein(Bcl2),p53,Caspase-3,Caspase-8,Caspase-9,and nuclear factor-kappa B(NF-κB)mRNA levels(all Pminiferous tubules and ***,the Group VIII showed improved spermatogenesis and a decrease in testicular side *** addition of VE to the treatment of hyperthyroid rats with CBZ reduced testicular side effects and seminiferous tubular affection when potentially improving *** research is needed to elucidate the underlying mechanisms fully.

关键词： antithyroid drugs testicular injury thyroid gland vitamin E

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Solute transport and geochemical modeling of the coastal quaternary aquifer, Delta Dahab Basin, South Sinai, Egypt

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Acta Geochimica 2024年第1期43卷 16-39页

作者： Amira Samy mustafa Eissa Seham Shahen moustafa m.Said Rabab m.Abou-shahaba Division of Water Resources and Arid Land Department of HydrogeochemistryDesert Research CenterCairoEgypt Egypt Desalination Research Center of Excellence Desert Research CenterCairoEgypt Center for Water Supply Studies S&E-Physical&Environmental SciencesTexas A&M University Corpus ChristiCorpus ChristiUSA Department of Chemistry Faculty of Science(Girls)Al-Azhar UniversityYousef Abbas StrNasr CityP.O.Box:11754CairoEgypt

The wadi dahab delta is in a dry, arid coastal zone within Egypt’s south Sinai Peninsula’s eastern portion. The primary water source is the Quaternary coastal alluvial aquifer. The groundwater salinity varies from 890to 8213 mg/L, with a mean value of 3417 mg/L. The dissolved major ions have been used to calculate the seawater mixing index(SWmI) using a linear equation that discriminates the groundwater mostly affected by water–rock interaction(SWmI 1>) and other samples mixed with Seawater(SWmI mposition of groundwater for specifically chosen groundwater samples ranges from-0.645‰ to +5.212‰ for δ^(18)O and from-9.582‰ to + 22.778‰ for δ^(2)H, where the seawater represented by a Red Sea water sample(δ^(18)O + 1.64‰-δ^(2)H + 9.80‰) and reject brine water are considerably enriched the isotopic groundwater values. The geochemical NETPATH model constrained by the dissolved significant ions, isotopes, and the rock aquifer forming minerals as phases indicate the mixing percent with the seawater ranges from 9% to 97% of seawater from 91% to 3% of original recharge water. According to the SEAWAT 3-D flow models, seawater has penetrated the Northeastern Dahab delta aquifer, with the intrusion zone extending1500 m inland. The salt dissolution, upwelling of saline water, recharge from the upstream mountain block, and seawater encroachment are the primary aspects contributing to the deterioration of groundwater quality. These findings may have significance for effective groundwater withdrawal management in arid locations worldwide with similar hydrogeological systems.

关键词： Groundwater geochemistry Seawater intrusion Solute transport SEAWAT

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Planning Target Volume margin in Linac-Based Stereotactic Radiosurgery for Brain metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany S. Attallah Radwa m. Hamed Khaled m. EL-Shahat Aliaa mahmoud mahmoud Abdallah Ibraheem Haggag Emad moustafa Adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of medical Physics Al Azhar University Cairo Egypt Department of medical Physics International Medical Center (IMC) Cairo Egypt Department of medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. material and methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： SRS Brain metastases PTV

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Ibuprofen-Induced Toxic Epidermal Necrolysis:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 108-110页

作者： Nevin Kannappilly mohamed Z.Peediyakkal mohamad Y.Khatib Dore C.Ananthegowda moustafa S.Elshafei Hani El Zeer Karimulla S.Shaik moayad m.AlFayoumi Dyaneshwar P.mutkule Ahmed A.Soliman Abdulqadir J.Nashwan Critical Care Department Hamad Medical Corporation(HMC)Doha 3050Qatar

Introduction:Toxic epidermal necrolysis(TEN)is a medical emergency that most commonly occurs as an adverse effect of certain ***,we describe a case of a 41-year-old man with no comorbid illness who developed *** presentation:The patient had been prescribed ibuprofen for myalgia and developed skin lesions after the single *** lesions were erythematous papules and macules distributed all over the body after ibuprofen *** was diagnosed based on the patient’s clinical presentation and laboratory *** was treated with intravenous dexamethasone,intravenous immunoglobulin,and *** dressing changes and skin care was done with saline,chlorhexidine,and liquid *** patient was intubated and tracheostomized,and he gradually improved and ***,he developed septicemia in the intensive care unit and was treated ***:The management of TEN includes cessation of the causative cause,multidisciplinary intensive care unit(ICU)care,prevention and early detection of sepsis,fluid and electrolyte balance,adequate analgesia and temperature control,proper organ support,aggressive nutritional management,and good psychological *** pharmacological therapy for TEN includes corticosteroids,intravenous immunoglobulin,and *** key elements of management are aseptic care and proper dressing of the ***:TEN is associated with high mortality if not managed in a systemic and protocolized way.

关键词： ibuprofen toxic epidermal necrolysis erythema drug-induced erythema

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Framework for COVID-19 Segmentation and Classification Based on Deep Learning of Computed Tomography Lung Images

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Journal of Electronic Science and Technology 2022年第3期20卷 246-256页

作者： Wessam m.Salama moustafa H.Aly the Department of Basic Science Faculty of EngineeringPharos UniversityAlexandria12455Egypt the Department of Electronics and Communications Engineering College of Engineering and TechnologyArab Academy for ScienceTechnology and Maritime TransportAlexandria1029Egypt

Corona Virus Disease 2019(COVID-19) has affected millions of people worldwide and caused more than6.3 million deaths(World Health Organization, June 2022). Increased attempts have been made to develop deep learning methods to diagnose COVID-19 based on computed tomography(CT) lung images. It is a challenge to reproduce and obtain the CT lung data, because it is not publicly available. This paper introduces a new generalized framework to segment and classify CT images and determine whether a patient is tested positive or negative for COVID-19 based on lung CT images. In this work, many different strategies are explored for the classification ***50 and VGG16 models are applied to classify CT lung images into COVID-19 positive or negative. Also,VGG16 and ReNet50 combined with U-Net, which is one of the most used architectures in deep learning for image segmentation, are employed to segment CT lung images before the classifying process to increase system performance. moreover, the image size dependent normalization technique(ISDNT) and Wiener filter are utilized as the preprocessing techniques to enhance images and noise suppression. Additionally, transfer learning and data augmentation techniques are performed to solve the problem of COVID-19 CT lung images deficiency, therefore the over-fitting of deep models can be avoided. The proposed frameworks, which comprised of end-to-end, VGG16,ResNet50, and U-Net with VGG16 or ResNet50, are applied on the dataset that is sourced from COVID-19 lung CT images in Kaggle. The classification results show that using the preprocessed CT lung images as the input for U-Net hybrid with ResNet50 achieves the best performance. The proposed classification model achieves the 98.98%accuracy(ACC), 98.87% area under the ROC curve(AUC), 98.89% sensitivity(Se), 97.99 % precision(Pr), 97.88%F-score, and 1.8974-seconds computational time.

关键词： Augmentation classification computed tomography(CT) Corona Virus Disease 2019(COVID-19) deep learning ResNet50 segmentation U-Net VGG16

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Deterministic and Stochastic Fractional Order model for Lesser Date moth

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Computer Systems Science & Engineering 2022年第2期40卷 749-764页

作者： moustafa El-shahed Asmaa m.Al-Dububan Department of mathematics Unaizah College of Sciences and ArtsQassim UniversityP.O.Box 3771Unaizah51911Saudi Arabia Department of mathematics Buraydah College of Sciences and ArtsQassim UniversityP.O.Box 1162Buraydah51431Saudi Arabia

In this paper,a deterministic and stochastic fractional order model for lesser date moth(LDm)using mating disruption and natural enemies is proposed and *** interaction between LDm larvae,fertilized LDm female,unfertilized LDm female,LDm male and the natural enemy is *** order to clarify the characteristics of the proposed deterministic fractional order model,the analysis of existence,uniqueness,non-negativity and boundedness of the solutions of the proposed fractional-order model are *** addition,some sufficient conditions are obtained to ensure the local and global stability of equilibrium *** occurrence of local bifurcation near the equilibrium points is investigated with the help of Sotomayor’s *** simulations are conducted to illustrate the properties of the proposed fractional order model with respect to the intrinsic growth rate of the LDm larvae,natural enemy’s mortality rate,predation rate,sex pheromone trap parameter,fractional order and environmental *** impact of mating disruption on lesser date moth is ***,a numerical approximation method is developed for the proposed stochastic fractional-order model.

关键词： Lesser date moth stochastic stability natural enemies Sotomayor’s theorem mating disruption

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Deterministic and Stochastic Fractional-Order Hastings-Powell Food Chain model

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Computers, materials & Continua 2022年第2期70卷 2277-2296页

作者： moustafa El-Shahed Asmaa m.Al-Dububan Department of mathematics Unaizah College of Sciences and ArtsQassim UniversityUnaizah51911Saudi Arabia Department of mathematics Buraydah College of Sciences and ArtsQassim UniversityBuraydah51431Saudi Arabia

In this paper,a deterministic and stochastic fractional-order model of the tri-trophic food chain model incorporating harvesting is proposed and *** interaction between prey,middle predator and top predator population is *** order to clarify the characteristics of the proposed model,the analysis of existence,uniqueness,non-negativity and boundedness of the solutions of the proposed model are *** sufficient conditions that ensure the local and global stability of equilibrium points are *** using stability analysis of the fractional-order system,it is proved that if the basic reproduction number R_(0)m point E_(1) is globally asymptotically *** occurrence of local bifurcation near the equilibrium points is investigated with the help of Sotomayor’s *** numerical examples are given to illustrate the theoretical *** impact of harvesting on prey and themiddle predator is *** conclude that harvesting parameters can control the dynamics of the middle predator.A numerical approximation method is developed for the proposed stochastic fractional-order model.

关键词： Food chain model global dynamics stability stochastic Hastings-Powell model harvesting

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Emerging small-molecule therapeutic approaches for Alzheimer's disease and Parkinson's disease based on targeting microRNAs

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Neural Regeneration Research 2022年第2期17卷 336-337页

作者： Somaya A.Abdelrahman moustafa T.Gabr Department of medicinal Chemistry Faculty of PharmacyMansoura UniversityMansouraEgypt Department of Radiology Stanford University School of MedicineStanfordCAUSA

The role of micro RNAs in the progression of neurodegenerative diseases: micro RNAs(mi RNAs) are endogenous, non-coding and short RNA nucleotides that regulate gene expression through base pairing with the targeted me... 详细信息

关键词： endogenous Alzheimer diseases

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Nanotechnology for Water Treatment: Is It the Best Solution Now?

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Journal of Earth Science 2023年第5期34卷 1616-1620页

作者： moustafa Gamal Snousy Hassan mohamed Helmy Jianhua Wu m.F.Zawrah A.Abouelmagd Egyptian Petroleum Sector Petrotrade Co.1 Anwar Al Moftty St.-Abbas El Akkad St.-Nasr CityCairoEgypt Geology Department Faculty of ScienceMinia UniversityEl-Minia 61519Egypt School of Water and Environment Chang'an UniversityNo.126 Yanta RoadXi'an 710054China Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of the ministry of Education Chang'an UniversityNo.126 Yanta RoadXi'an 710054China Key Laboratory of Eco-Hydrology and Water Security in Arid and Semi-Arid Regions of the ministry of Water Resources Chang'an UniversityNo.126 Yanta RoadXi'an 710054China Refractory Ceramics and Building Materials DepartmentCenter of Excellence for Advanced SciencesAdvanced Materials and Nano GroupNational Research CentreCairo 12622-DokkiEgypt Egyptian Petroleum Sector 85 Nasr Road1st DistrictNasr CityCairoEgypt

INTRODUCTION Preservation of the freshwater resources is a big challenge for a healthy civilized *** water consumption increased more than twice the population increase rate,drinking water pollution and freshwater shortage increased dramatically during the last decades(Kar et al.,2012;mueller and Nowack,2010).Only 0.01%of freshwater resources are suitable for human needs(Rashid et al.,2019),even in the areas of abundant freshwater(Yeston et al.,2006).By 2050,over 5 billion of the world population will be under severe fresh water supply conditions due to climate change and urbanization exacerbate(Sealy,2019;Oves et al.,2015;Kar et al.,2012).Currently,one billion people drink unhygienic water,especially in developing countries which leads to severe waterborne diseases which might cause death(Aminiyan et al.,2018).Twelve million people die every year due to this problem(Zhao et al.,2019;Oves et al.,2015).

关键词： abundant freshwater pollution

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PAN-DeSpeck:A Lightweight Pyramid and Attention-Based Network for SAR Image Despeckling

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Computers, materials & Continua 2023年第9期76卷 3671-3689页

作者： Saima Yasmeen muhammad Usman Yaseen Syed Sohaib Ali moustafa m.Nasralla Sohaib Bin Altaf Khattak Department of Computer Sciences Comsats UniversityIslamabadPakistan Department of Research and Development Shearwater GeoservicesCrawleyWest SussexUK Department of Communications&Networks Engineering Prince Sultan UniversityRiyadhSaudi Arabia

SAR images commonly suffer fromspeckle noise,posing a significant challenge in their analysis and *** convolutional neural network(CNN)based despeckling methods have shown great performance in removing speckle ***,these CNN-basedmethods have a *** do not decouple complex background information in ***,they have deep network structures thatmay result in many parameters,limiting their applicability tomobile ***,extracting key speckle information in the presence of complex background is also a major problem with *** proposed study addresses these limitations by introducing a lightweight pyramid and attention-based despeckling(PAN-Despeck)*** primary objective is to enhance image quality and enable improved information interpretation,particularly on mobile devices and scenarios involving complex *** PAN-Despeck network leverages domainspecific knowledge and integrates Gaussian Laplacian image pyramid decomposition for multi-resolution image *** utilizing this approach,complex background information can be effectively decoupled,leading to enhanced despeckling ***,the attention mechanism selectively focuses on key speckle features and facilitates complex background *** network incorporates recursive and residual blocks to ensure computational efficiency and accelerate training speed,making it lightweight while maintaining high *** comprehensive evaluations,it is demonstrated that PAN-Despeck outperforms existing image restoration *** an impressive average peak signal-to-noise ratio(PSNR)of 28.355114 and a remarkable structural similarity index(SSIm)of 0.905467,it demonstrates exceptional performance in effectively reducing speckle noise in SAR *** source code for the PAN-DeSpeck network is available on GitHub.

关键词： Synthetic Aperture Radar(SAR) SAR image despeckling speckle noise deep learning pyramid networks multiscale image despeckling

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