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Infarction Patterns in Posterior Cerebral Circulation: Etiology and Prognosis

Neuroscience & Medicine 2019年第3期10卷 175-193页

作者： t. Alloush r. r. moustafa M. M. Fouad H. Ahmed M. Hamdy Department of Neurology and Psychiatry Faculty of Medicine Ain Shams University Cairo Egypt

Study Objectives: About a quarter of strokes and transient ischemic attacks occur in the vertebrobasilar distribution. Vertebrobasilar stroke is particularly prone to devastating consequences especially brain stem infarctions due to damage of the regional brain tissues that contain vital centers, and is associated with high rates of death and disability. Study Design: this was across sectional observational prospective hospital-based study conducted on 60 patients with first-ever acute posterior circulation ischemic stroke. the aim of the current study was to determine the relationship between different risk factors and different infarction patterns in posterior circulation;single small lacunar lesion, single large lesion, or multiple scattered lesions. Diagnosis of ischemic stroke and stroke subtypes were defined using the trial of OrG 10,172 in Acute Stroke treatment (tOASt) criteria as well as clinical and brain imaging features. Stroke severity using National Institutes of Health Stroke Scale (NIHSS) score was done on admission, after 24 hours from admission, and at 7 days from onset of symptoms. the patients functional status was assessed by modified rankin scale (mrS) done on admission and on discharge from hospital and at 7-day follow up from onset of symptoms. Patients were classified according to infarction patterns into a single small lacunar lesion (group I), a single large lesion (group II), and multiple scattered lesions (group III) 20 patients in each group. results: there was no significant difference between the three groups as regard the presence of vascular risk factors and the only significant difference as regard vascular risk factors was atrial fibrillation (AF). there was significant difference between the three groups as regard the occurrence of previous transient ischemic attacks (tIA). there was significant difference between the three groups as regard NIHSS score on admission, after 24 hours, and at 7 days from admission. there were signifi

关键词： Posterior Circulation Stroke risk Factors for Stroke National Institutes of Health Stroke Scale (NIHSS) Modified rankin Scale (mrS) Echocardiography Brain Magnetic resonance Imaging and Angiography Carotid Duplex

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Impact of human sequences in variable domains of therapeutic antibodies on the location of CD4 t-cell epitopes

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Cellular & Molecular Immunology 2020年第6期17卷 656-658页

作者： Sylvain Meunier moustafa Hamze Anette Karle Marie de Bourayne Abdelaziz Gdoura Sebastian Spindeldreher Bernard Maillère CEA-Saclay Institut Frederic JoliotSIMOPROUniversitéParis-Saclay91191 Gif sur YvetteFrance Novartis Pharma AG BaselSwitzerland Present address:Integrated Biologix GmbH BaselSwitzerland

the clinical efficacy of therapeutic antibodies is recognized in many indications,explaining their rapid rise in the worldwide drug ***,therapeutic antibodies can be immunogenic by inducing a specific immune response characterized by the production of anti-drug antibodies(ADAs).ADAs can potentially increase the clearance of therapeutic antibodies,decrease their therapeutic effects1 and induce hypersensitivity *** humans are thought to be tolerant to their own proteins,sequences of the therapeutic antibodies have been humanized or human antibodies have been directly generated by technologies using human ***,human(ized)antibodies exhibit highly variable levels of immunogenicity,1,2 illustrating the poor understanding of the role of sequence humanization in mitigating the immunogenicity of therapeutic *** lines of evidence highlight the role of CD4 t lymphocytes during the initiation of an ADA response,3 but few t-cell epitopes of marketed therapeutic antibodies have been described to date.

关键词： therapeutic antibodies clinical

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Mineralogy,Chemical Characteristics and Upgrading of Beach Ilmenite of the top Meter of Black Sand Deposits of the Kafr Al-Sheikh Governorate,Northern Egypt

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Acta Geologica Sinica(English Edition) 2017年第4期91卷 1326-1338页

作者： Abdel-Aal M. ABDEL-KArIM Mohamed I. moustafa Adel H. EI-AFANDY Mohamed G. BArAKAt Faculty of Science Zagazig University Egypt Engineering Colleges Northern Border University Saudi Arabia Nuclear Materials Authority P. O. Box 530 Maadi Cairo Egypt

Egyptian beach ilmenite occurs in a relatively high content in the naturally highly concentrated superficial black sand deposits at specific beach zones in the northern parts of the Nile Delta at rosetta. Microscopic study shows that the ilmenite occurs as fresh homogeneous black or heterogeneous multicoloured altered grains and exhibits three types （homogeneous, exsolved and altered） of ilmenite varieties. XrD data of ilmenite indicates their association with minor hematite and quartz, whereas leucoxene shows its association with Nb-rutUe, pseudorutile and hematite. Grain size distribution suggests a very fine sand size of 〉89% and 80% and a fine sand size of 10.5% and 18.3% for fresh and altered ilmenites, respectively. the density of fresh, altered ilmenite and leucoxene concentrates varies from 2.70, 2.50 to 2.40 ton/m^3, suggesting a gradual decrease from high grade fresh to leucoxene and consistent with variation in magnetic susceptibility as a consequence of the leaching of iron. Mass magnetic susceptibility reveals 97.6% of ilmenite and 92% of the altered form are obtained at 0.20 and 0.48 ampere. Fresh iimenite exhibits variable tiO2 （47.18%） and Fe2O3^t （46.10%） with minor MnO, MgO and Cr2O3 （1.22, 1.10 and 0.51%）. the altered ilmenite is higher in tiO2 （76.16%） and SiO2 （4.68%） and lower in Fe2O3^t （14.45%）, MnO, MgO and Cr2O3 （0.39, 0.52 and 0.11%） compared with the fresh form. three concentrates of ilmenites （G1, G2 and G3） were prepared from crude ore using a reading cross belt magnetic separator under different conditions, revealing a gradual increase of tiO2, SiO2, Al2O3 and CaO accompanied by a decrease of Fe2O3^t, MgO and Cr2O3 with repetition of the separation processes. Several ore dressing techniques were carried out to upgrade the iimenite concentrate.

关键词： Beach ilmenite mineralogy chemistry upgrading Northern Egypt

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Effect of metal-fingers/doped-ZnO transparent electrode on performance of gaN/IngaN solar cell

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Journal of Semiconductors 2017年第9期38卷 1-7页

作者： S.r.routray t.r.Lenka Microelectronics and VLSI Design Group Department of Electronics and Communication EngineeringNational Institute of Technology SilcharAssam788010India

the effect of doped-ZnO transparent conductive oxide （tCO） with metal （Ag）-fingers contact on gaN/IngaN solar cell is investigated through numerical simulations. An optical and electrical analysis of different dopant elements （such as B, A1, ga, In and Sn） with ZnO as a top tCO layer is studied. A comparative analysis of metal square pad electrode, metal grid pattern electrode and metal-finger/ZnO type electrodes are taken into consideration to ensure the effect of anti-reflectivity by ZnO. the effect of thickness of ZnO and i-IngaN layer on performance of solar cell is also studied in detail. the proposed solar cell structure with Ag-fingers/ZnO：Al as top contact electrode shows interesting device characteristics compared to other dopants and metal top electrodes. the device achieves open circuit voltage -2.525 V, short circuit current -4.256 mA/cm^2, fill factor -87.86% and efficiency -9.22% under 1 Sun, air mass 1.5 global illumination.

关键词： Ag-finger/doped-ZnO tCO resistivity dopants gaN/IngaN solar cell

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Optimal placement of wind turbines within a wind farm considering multi-directional wind speed using two-stage genetic algorithm

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Frontiers in Energy 2021年第1期15卷 240-255页

作者： A.S.O.OGUNJUYIGBE t.r.AYODELE O.D.BAMGBOJE Power Energy Machines and Drives(PEMD)research Group Department of Electrical and Electronic EngineeringUniversity of IbadanNigeria

Most wind turbines within wind farms are set up to face a pre-determined wind ***,wind directions are intermittent in nature,leading to less electricity production *** paper proposes an algorithm to solve the wind farm layout optimization problem considering multi-angular(MA)wind direction with the aim of maximizing the total power generated on wind farms and minimizing the cost of installation.A twostage genetic algorithm(ga)equipped with complementary sampling and uniform crossover is used to evolve a MA layout that will yield optimal output regardless of the wind *** the first stage,the optimal wind turbine layouts for 8 different major wind directions were determined while the second stage allows each of the previously determined layouts to compete and inter-breed so as to evolve an optimal MA wind farm *** proposed MA wind farm layout is thereafter compared to other layouts whose turbines have focused site specific wind turbine *** results reveal that the proposed wind farm layout improves wind power production capacity with minimum cost of installation compared to the layouts with site specific wind turbine *** paper will find application at the planning stage of wind farm.

关键词： optimal placement wind turbines wind direction genetic algorithm wake effect

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Optimization of cellulase production using trichoderma reesei by rSM and comparison with genetic algorithm

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Frontiers of Chemical Science and Engineering 2012年第4期6卷 443-452页

作者： Saravanan P Muthuvelayudham r rajesh Kannan r Viruthagiri t Department of Chemical Engineering Annamalai UniversityAnnamalainagar-608002TamilnaduIndia

Abstract the potential of trichoderma reesei for cellulase production using pineapple waste as substrate has been investigated. A maximum cellulase activity of 9.23 U/mL is obtained under the optimum experimental conditions： pH （5.5）, temperature （37.5℃）, initial substrate concentration （3%）, inoculum concentration （6.6 X 108 CFU/mL）, and culture time （6 days）. Box-Behnken design （BBD） statistical tool and genetic algorithm （ga） are used to optimize the process parameters. the BBD study of linear and quadratic interactive effects of experimental variables on the desired response of cellulase activity showed that the second order polynomial is significant （r2 = 0.9414）. the experimental cellulase activity under the optimal conditions identified by the BBD is 9.23 U/mL and that by ga is 6.98 U/mL. this result indicates that the BBD model gives better result than ga in the present case.

关键词： cellulase pineapple waste trichoderma ree-sei Box-Behnken design genetic algorithm

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Anisotropic Dzyaloshinskii-Moriya interaction protected by D_(2d) crystal symmetry in two-dimensional ternary compounds

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npj Computational Materials 2022年第1期8卷 1209-1215页

作者： Yonglong ga Qirui Cui Yingmei Zhu Dongxing Yu Liming Wang Jinghua Liang Hongxin Yang Ningbo Institute of Materials technology and Engineering Chinese Academy of SciencesNingbo315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China

Magnetic skyrmions,topologically protected chiral spin swirling quasiparticles,have attracted great attention in fundamental physics and ***,the discovery of two-dimensional(2D)van der Waals(vdW)magnets have aroused great interest due to their appealing physical ***,both experimental and theoretical works have revealed that isotropic Dzyaloshinskii–Moriya interaction(DMI)can be achieved in 2D magnets or ferromagnet-based ***,2D magnets with anisotropic DMI haven’t been reported ***,via using first-principles calculations,we unveil that anisotropic DMI protected by D_(2d)crystal symmetry can exist in 2D ternary compounds MCuX_(2)(M:3d transition metal(tM),X:group VIA).Interestingly,by using micromagnetic simulations,we demonstrate that ferromagnetic(FM)antiskyrmions,FM bimerons,antiferromagnetic(AFM)antiskyrmions,and AFM bimerons can be realized in the MCuX_(2)*** discovery opens up an avenue to creating antiskyrmions and bimerons with anisotropic DMI protected by D_(2d)crystal symmetry in 2D magnets.

关键词： DMI symmetry magnets

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the first record of a Konservat-Lagerstätten in which early post-settlement stages of fossil archaeobalanids(Cirripedia:Balanomorpha)are preserved

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Integrative Zoology 2024年第2期19卷 200-223页

作者： tomáš KOCÍ rok gaŠPArIC John BUCKErIDGE Martina KOCOVÁ VESELSKÁ Aleš ŠOStEr Ivancická581 PragueCzech Republic Palaeontological Department Natural History MuseumNational MuseumPragueCzech Republic Oertijdmuseum Bosscheweg 80Boxtel5293 WBThe Netherlands Institute for Palaeobiology and Evolution Novi TrgKamnikSlovenia Earth and Oceanic Systems Group RMIT UniversityMelbourneAustralia Museums Victoria CarltonVictoriaAustralia Department of Paleobiology and Paleoecology Institute of Geology of the Czech Academy of SciencesPragueCzech Republic Institute of Geology and Palaeontology Charles UniversityPragueCzech Republic Faculty of Natural Sciences and Engineering University of LjubljanaLjubljanaSlovenia

A diverse sessile barnacle fauna from a Miocene shallow-water deposit at Dolnja Stara vas in Slovenia is *** includes the first descriptions of early post settlement juveniles of Actinobalanus sloveniensis attached to mangrove *** represent three distinct growth phases,the earliest being interpreted as being less than 24 h post settlement,the others being 1 to 2 days post *** assessment of their taphonomy is *** adult balanomorphs are attached to a variety of organic substrates,including mangrove leaves and branches,fragments of the conifers?taxodioxylon,Carapoxylon,pine cones,molluscs,and cetacean *** barnacles include ***,Amphibalanus venustus,and Perforatus perforatus—many with opercula retained within the *** retains some of the original shell *** is the second record of barnacle–plant associations from the Central Paratethys from Kamnik and *** paleoecology and paleogeography of the site are discussed.

关键词： acorn barnacles barnacle metamorphosis epibiont paleoecology taxonomy

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A bibliometric analysis and visualization of research on heart failure complicated with malnutrition

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Frontiers of Nursing 2023年第4期10卷 413-426页

作者： Wu-ga Jishi Jin-Bo Fang Jie Li West China School of Nursing/Department of West China Hospital Sichuan UniversityChengduSichuan 610065China

Objective:this study aimed to have a good knowledge of heart failure complicated with malnutrition research status,hotspots,and forecast research trends using bibliometric analysis and visualization of studies of hear t failure complicated with malnutrition in the past 10 ***:Ar ticles related to malnutrition-induced hear t failure were obtained from the Web of Science Core Collection(Wo SCC)series from January 2012 to January *** software(Java Cite Space 5.8r3 and Microsoft Excel 2019)were used to perform bibliometric and knowledge-map analysis,including analyzing the annual publication and trend of ar ticles,authors and co-cited authors,institutions/countries,co-cited journals,co-occurrence,clusters,and burst of keywords,co-cited references,and reference ***:A total of 672 articles appeared in 180 scientific journals by 4249 authors from 1453 institutions in 71 *** the past 10 years,the number of related studies released has shown an upward trend,and the range of increases has been larger over the past 5 *** Kasai released the most papers,while Anker S D had the most ***,active cooperation existed in complicated hear t failure with researchers on ***,Journal of the American College of Cardiology,and Clinical Nutrition were the top 3 co-cited *** USA,Japan,and China were the most productive countries,while Johns Hopkins University was the most active *** addition,the reference published by Ponikowski P had the most co-citations,relating to as a knowledge *** latest hotspots of hear t failure complicated with malnutrition mainly included research on:(1)assessment of nutrition status,the impact/risk factor of nutrition,and the prevalence and outcome of the patients;(2)hear t failure complicated with malnutrition when complicated with other diseases,for example,chronic kidney disease and diabetes mellitus;(3)the nutrition of child patients with heart fail

关键词： bibliometric CiteSpace heart failure malnutrition visualization

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Unsupervised neural network model optimized with evolutionary computations for solving variants of nonlinear MHD Jeffery-Hamel problem

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Applied Mathematics and Mechanics(English Edition) 2015年第12期36卷 1611-1638页

作者： M.A.Z.rAJA r.SAMAr t.HArOON S.M.SHAH Department of Electrical Engineering COMSATS Institute of Information Technology Department of Electrical Engineering Mohammad Ali Jinnah University Department of Mathematics COMSATS Institute of Information Technology

A heuristic technique is developed for a nonlinear magnetohydrodynamics （MHD） Jeffery-Hamel problem with the help of the feed-forward artificial neural net- work （ANN） optimized with the genetic algorithm （ga） and the sequential quadratic programming （SQP） method. the twodimensional （2D） MHD Jeffery-Hamel problem is transformed into a higher order boundary value problem （BVP） of ordinary differential equations （ODEs）. the mathematical model of the transformed BVP is formulated with the ANN in an unsupervised manner. the training of the weights of the ANN is carried out with the evolutionary calculation based on the ga hybridized with the SQP method for the rapid local convergence. the proposed scheme is evaluated on the variants of the Jeffery-Hamel flow by varying the reynold number, the Hartmann number, and the an- gles of the walls. A large number of simulations are performed with an extensive analysis to validate the accuracy, convergence, and effectiveness of the scheme. the comparison of the standard numerical solution and the analytic solution establishes the correctness of the proposed designed methodologies.

关键词： Jeffery-Hamel problem neural network genetic algorithm (ga) nonlinear ordinary differential equation (ODE) hybrid technique sequential quadratic programming

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