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Dietary Intervention with Yoghurt, Synbiotic Yogurt or Traditional Fermented Sobya: Bio-Potency among Male Adolescents Using Five Bio-Markers of Relevance to Colonic Metabolic Activities

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Food and Nutrition Sciences 2014年第12期5卷 1131-1144页

作者： Laila Hussein moustafa gouda Mohamed Fouad Eid Labib Ranya Bassyouni Mahmoud Mohammad Children’s Nutrition Research Center Baylor College of Medicine Houston USA Dairy Science National Research Center Giza-Dokki Egypt Departments of Nutrition National Research center Giza-Dokki Egypt

The objective of the present work is to test the effectiveness of probiotic potency of regular yoghurt, synbiotic yoghurt and traditional fermented Egyptian sobya containing endogenous probiotic strains compared to unfermented rice milk porridge. Methods: The study consisted of 28 male subjects with mean age of 13.9 ± 0.1 years. The subjects were divided into four groups, three groups consumed one of three fermented supplements, while the fourth group served as a control group. Stool and urinary samples were carried out prefeeding and after 3-week nutritional intervention for assessing five indicators of revelance to colonic metabolic activities. The fermented supplements used for evaluation were regular yoghurt, synbiotic yoghurt and traditional fermented sobya;while the fourth group was given unfermented rice milk and served as control. Intestinal permeability was assessed by the urinary lactulose mannitol ratio. Results: The mean fecal total lactobacilli counts increased (P 0.05). Mean fecal short chain fatty acids concentrations (acetic;propionic and butyric) tended to increase following the intervention with synbiotic yogurt or sobya compared to respective pre-intervention values;but the difference didn’t attain significance (0.1>P> 0.05). The 3-week nutritiona

关键词： Probiotics Egyptian Male Adolescents Intestinal Microbiota Fecal Short Chain Fatty Acids

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Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 109-118页

作者： Ibrahim H.Borai Yehia Shaker Maha moustafa Kamal Wafaa M.Ezzat Esmat Ashour Mie Afify Weaam gouda Maha M.Elbrashy Biochemistry Department Faculty of Science Ain Shams University Cairo Egypt Biochemistry Department National Research Centre Giza Egypt Department of Internal Medicine National Research Center Giza Egypt

Background and Aims:Nonalcoholic fatty liver disease (NAFLD) is a silent disease;its spectrum includes simple steatosis,nonalcoholic steatohepatitis and ***-and anti-inflammatory cytokines play roles in the pathogenesis of NAFLD and insulin resistance (IR).Moreover,plasma cell antigen-1 (PC-1) is related to IR and associated with NAFLD ***,we aimed to detect biomarkers,ultrasonographic and anthropometric findings capable of differentiating NAFLD grades,since most previous investigators were concerned more with NAFLD patients without classifying them into ***:A total of 87 NAFLD patients (31 with grade 1 (mild NAFLD),26 with grade 2 (moderate NAFLD) and 30 with grade 3 (severe NAFLD) were included in the study,in addition to 47 controls (grade 0).All subjects underwent ultrasonographic examination for NAFLD *** interleukin-10 (IL-10),plasma interleukin-18 (IL-18) and plasma PC-1 levels were determined using enzyme-linked immunosorbent ***:Homoeostasis model assessment (HOMA)-IR was higher in different NAFLD grades than in *** and anthropometric findings and lipid profile indices (except for high-density lipoprotein cholesterol,which was decreased) were increased with NAFLD *** 3 patients showed significant increase in levels of IL-18 and significant decrease in IL-10 and PC-1 levels when compared to grade 1 ***:Anthropometric and ultrasonographic findings were valuable in differentiating NAFLD *** is very important in NAFLD ***-18,HOMA-index and PC-1 levels could be used to differentiate between NAFLD grades,together with other measurements.

关键词： NAFLD Interleukin-18(IL-18) Interleukin-10(IL-10) Plasma cell antigen-1(PC-1)

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