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Effects of a Community-Based Intervention on the lifestyle and Health of People at Risk of Type 2 Diabetes in Benin

Food and Nutrition Sciences 2022年第10期13卷 842-860页

作者： Clemence Germaine Metonnou Colette Sylvie Azandjeme Charles Jerome sossa Bio Nigan Issiako moussiliou noël paraïso Victoire Agueh Health Promotion Department Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin laboratory Sports Performance Health And Evaluation National Institute of Youth Physical Education And Sport (Injeps) University of Abomey-Calavi (Uac) Porto-Novo Benin

Introduction: Worldwide, the prevalence of type 2 diabetes (T2D) is increasing at an epidemic rate. The objective of this study was to measure the effects on lifestyle intervention in subjects at risk of T2D in a West African country. Methods: This study involved Beninese adults at risk of T2D randomly selected from 2 groups of villages: control villages and villages exposed to nutrition education, cooking demonstrations and physical activity sessions. Anthropometric, clinical, and biological measurements were taken in both groups at the beginning and end of the intervention, which lasted 12 months. The paired sample t-test was used to assess the effect of the intervention on the lifestyle of people at risk of T2D. Results: After 12 months of exposure to nutrition education, cooking demonstrations and physical activity sessions in the intervention villages, the mean body mass index, waist circumference, body fat percentage, blood glucose, triglycerides, total cholesterol and amount of alcohol consumed per week had significantly decreased. Conversely, the mean intensity of physical activity and food consumption score had significantly increased. In the control group, 5.6% of the people at risk developed to diabetes. The relative risk was RR = 0.20 [0.14 - 0.56]. Conclusion: The intervention significantly improved metabolic indicators, intensity of leisure activity and dietary score. We suggest larger studies to better assess the effect of community-based interventions on the lifestyle and health of people at risk of T2D in Africa.

关键词： Effects Primary Prevention People at Risk of Type 2 Diabetes Benin

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Disability to Admit as a Change of life after a Road Crash: Estimates and Related Factors in Benin for Prevention

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Open Journal of Epidemiology 2023年第1期13卷 83-96页

作者： Yolaine Glèlè-Ahanhanzo Alphonse Kpozèhouen Donatien Daddah Bella Hounkpè-Dos Santos lamidhi Salami moussiliou noël paraïso Multidisciplinary Research Unity for Road Crashes Prevention (ReMPARt) Department of Epidemiology and Bio-Statistics Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin Regional Direction of Health Mono Lokossa Benin Regional Direction of Health Atlantic Abomey-Calavi Benin Policies and Health Systems Department Regional Institute of Public Health Ouidah Benin Department of Health Promotion Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin

Background: Disability is an underestimated issue in public health, with road crashes as leading cause. In Africa, motorcyclists disproportionately bear the burden of road crash injuries, including disability. To contribute to decision-making for disability prevention, this study aims to determine the prevalence and factors associated with disability at 12 months among motorcyclists involved in road crashes in Benin. Methods: This is a prospective, cross-sectional, analytical study based on 12-month follow-up data from a cohort of road crash victims set up in five hospitals in Benin. Data were collected from November 2020 to January 2021. Sample used for this analysis size was 297 motorcyclists. Disability was assessed using the Washington Group on Disabilities Statistics question set. logistic regression analysis was used to identify risk factors for disability in victims 12 months after the crash. Results: The prevalence of disability was 12.5% 95% CI (9.2 - 16.7). Disability occurrence was associated with being over 45 years old (OR = 3.1;95% CI = 1.5 - 6.6), severity of initial injury (OR = 3.3;95% CI = 1.5 - 7.3) and hospitalisation of the victim (OR = 6.9;95% CI = 2.0 - 24). Conclusion: Age over 45 years, severity of initial injuries and hospitalisation of the victim were risk factors for the occurrence of disability among motorcyclists who were victims of road crashes in Benin. User awareness, law enforcement, holistic and early management of road crash victims could contribute to reducing the prevalence of disability among victims in Benin.

关键词： Disability Motorcyclists Road Traffic Accident

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Performance Evaluation of a Communication Plan Implementation for Behaviour Change in People at Risk of Type 2 Diabetes in the Commune of Tchaourou in Benin

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Journal of Diabetes Mellitus 2022年第4期12卷 224-242页

作者： Clémence Germaine Metonnou Colette Sylvie Azandjeme Charles Jérôme sossa moussiliou noël paraïso Bio Nigan Victoire Damienne Agueh Department of Promotion Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin laboratory Sports Performance Health and Evaluation National Institute of Youth Physical Education and Sport (INJEPS) University of Abomey-Calavi (UAC) Porto-Novo Benin

Introduction: There are very few programmes to delay or prevent diabetes in Africa. This study aims to evaluate the communication plan implementation to reduce risk factors for Type 2 diabetes in people at risk. Methods: The cross-sectional evaluative study focuses on the resources used for the implementation of the programme, the activities carried out and the beneficiaries of the programme. The non-probabilistic method was used to select. All target populations under study with appropriate sampling techniques. The performance of the communication plan implementation for behaviour change was assessed through the three sub-variables of evaluation of Donabedian health programmes: structure, process and results. The components assessment was based on the Varkevisser scale. The performance of the communication plan implementation for behaviour change was obtained by the sum of the scores of the three sub-variables. Results: The performance of the communication plan implementation for behaviour change was satisfactory in all programme villages at 89%. The establishment of the research team, the management team and the technical team, the availability of financial resources on a timely basis, the follow-up of nutritionists, sports teachers and peer educators, the implementation of the programme package and the home coaching of the targets were effective in all the programme villages of the study. The scores for structure performance, process performance, and results performance were 100%, 95%, and 83.8%, respectively. The involvement of the entire research team, the commitment of local authorities and the motivation of the targets were also important in the obtained result. Conclusion: This study shows that effective T2D preventive communication is possible at community level in Benin and probably in Sub-Saharan Africa.

关键词： Implementation People at Risk Type 2 Diabetes Benin

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Knowledge, Attitudes, and Practices Relating to Food and Nutrition among Pregnant Women Attending Antenatal Clinics at Menontin Hospital (Benin)

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Health 2023年第11期15卷 1202-1217页

作者： Charles Jérôme sossa lamidhi Salami Clémence Germaine Metonnou Eloïse Tozoukan Colette Azandjeme Virginie Mongbo moussiliou noël paraïso Health Promotion Department Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin Department of Health Policy and System Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin Department of Food Technology Engineering Ecole Polytechnique d’Abomey-Calavi University of Abomey-Calavi Abomey-Calavi Benin

Introduction: Pregnancy is a critical period during which environmental factors such as nutrition can affect the optimal development of the fetus. This study aims to evaluate the knowledge, attitudes, and practices in food and nutrition among pregnant women in antenatal consultation at Menontin Hospital in 2021. Methods: This was a cross-sectional, descriptive study including 96 pregnant women at Menontin Hospital in Cotonou. Variables including socio-anthropological data, level of knowledge of nutritional requirements and their consequences on malnutrition, and description of physical activity practices were collected using a questionnaire and data on pregnant women’s dietary practices, macronutrient consumption, and fruit and vegetable consumption were documented using a food frequency questionnaire. Results: The majority of pregnant women (88%) were unaware of their nutrient needs during pregnancy. Only 49.6% of them took at least three meals and two snacks a day, and 45% practiced less than 30 minutes of physical activity per day. The consumption of carbohydrates, proteins, and lipids were respectively in the proportions of 36.5%, 50%, and 38.5%. It was also found that 48% of pregnant women did not consume fruits and vegetables daily. Conclusion: The pregnant women followed in the Mènontin area hospital had a low level of knowledge in terms of food and nutrition during pregnancy. Consequently, their attitudes and practices were unfavorable to good nutrition for both the mother and the child.

关键词： Knowledge Attitudes Practices Nutrition Pregnancy Bénin

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Modifiable Behavioral Risk Factors Associated with Biological Risk Factors in Subjects at Risk of Type 2 Diabetes in Benin: PREDIBE Study

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Open Journal of Epidemiology 2020年第4期10卷 432-445页

作者： Clemence Germaine Metonnou Colette Sylvie Azandjeme Bio Nigan Issiako Charles Jerome sossa Ghislain Emmanuel sopoh moussiliou noël paraïso Victoire Agueh Health Promotion Department Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin laboratory Sports Performance Health and Evaluation National Institute of Youth Physical Education and Sport (INJEPS) University of Abomey-Calavi (UAC) Porto-Novo Benin Environment and Health Department Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin

Introduction: Type 2 diabetes is a major public health problem worldwide. This study aimed at identifying modifiable behavioral risk factors associated with biological factors in people at risk of type 2 diabetes which could be targeted in the design and implementation of appropriate interventions to prevent the disease. Methods: 180 subjects at risk of type 2 diabetes (aged 15 - 60 years) were identified and selected at random during a preliminary survey conducted in two groups of villages in northeastern Benin. The study took part on August 2017. Questionnaires were administered to consenting subjects;anthropometric measurements taken and blood samples withdrawn. Blood samples were subjected to biochemical testing according to standard protocols. Results: Data was obtained from 180 subjects at risk of type 2 diabetes. The average age of the subjects was 42.76 ± 11.30 years. Multivariate analysis showed inadequate dietary intake score, low physical activity and tobacco use as behavioral factors significantly associated with high waist circumference, high blood sugar, low HDl cholesterol, high triglyceride levels and high body fat percentage. Conclusion: There is a possible association between biological and behavioral risk factors.

关键词： Modifiable Risk Factors Type 2 Diabetes Benin

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Extension of Chemoprevention of Seasonal Malaria to Five Cycles and to Children from the Age of 6 to 9 Years in Africa: Analysis of Its Acceptability, Feasibility, Cost and Impact A Systematic Review

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Advances in Infectious Diseases 2024年第1期14卷 74-86页

作者： N’Kpingou Théodore Nadakou moussiliou Noel paraïso Ounoussa Tapha Mahamane Moustapha lamine Jean Blaise Yobo Salifou Ibrahim Alkassoum Fidel Tossou Hamidou Ramatoulaye lazoumar Eric Omar Adehossi Regional Instutte of Public Health University of Abomey-Calavi (UAC) Ouidah Benin Pratical Institute of Public Health (IPSP) Niamey Niger Andre Salifou University of Zinder (UAS) Zinder Niger ABDOU Moumouni University of Niamey (UAM) Niamey Niger Medical and Health Researche Center (CERMES) Niamey Niger

Introduction: Seasonal Malaria Chemoprevention (SMC) aims at preventing malaria in children during the high transmission season. It has been recommended by the WHO since 2013 for children from the age of 3-59 months. However, despite the impact of this intervention, a peak in the prevalence and incidence of malaria is observed in children from the age of 5-9 years. The aim of this study is to determine from the current literature the feasibility, impact and cost-effectiveness of extending SMC to five cycles and to older children. Methods: A litterature search of PubMed/Medline, NCBI and Google scholar identified 1333 articles. After reading the titles and abstracts by two authors, 24 articles were selected and submitted for full reading. Random control studies on the extension of SMC, malaria, feasibility of SMC, impact of SMC and cost-effectiveness of SMC were selected. A total of 16 articles were included for the qualitative synthesis after excluding 8 studies. Results: Following the summary of the evidence, we conclude that the extension is feasible but will be confronted with the unavailability of older children. The intervention period coincides with field work. SMC is effective in reducing the prevalence and incidence of malaria and the parasite density in children. The financial cost of administering SMC is lower than that of treating a child suffering from malaria. Conclusion: After analysing the information, it was found that the majority of the African population supports the extension of the SMC to the number of cycles and the age group in order to alleviate the high mortality and morbidity rates among children due to malaria.

关键词： SMC Feasibility Impact Profitability and Africa

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Unraveling the role of METTl14 in metabolic dysfunction-associated fatty liver disease:insights and therapeutic implications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1781-1783页

作者： so Jung Kim Jeongeun Hyun Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PlUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center College of DentistryDankook UniversityCheonanRepublic of Korea

The recent article published in Signal Transduction and Targeted Therapy sheds light on the significance of N6-methyladenosine(m6A)methyltransferase-like protein METTl14 in mitigating the progression of metabolic dysfunction-associated fatty liver disease(MAFlD).1 In this study,Wang et *** the downregulation of METTl14 in hepatocytes from both MAFlD patients and high-fat diet(HFD)-induced MAFlD mouse models,underscoring its pivotal role in maintaining hepatic lipid and redox homeostasis in normal livers.

关键词： liver homeostasis al.

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A core scientific problem in the treatment of central nervous system diseases:newborn neurons

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Neural Regeneration Research 2024年第12期19卷 2588-2601页

作者： Peng Hao Zhaoyang Yang Kwok-Fai so Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland laboratory(Guangzhou Regenerative Medicine and Health Guangdong laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

It has long been asserted that failure to recover from central nervous system diseases is due to the system's intricate structure and the regenerative incapacity of adult *** over recent decades,numerous studies have established that endogenous neurogenesis occurs in the adult central nervous system,including humans'.This has challenged the long-held scientific consensus that the number of adult neurons remains constant,and that new central nervous system neurons cannot be created or ***,we present a comprehensive overview of the alterations and regulatory mechanisms of endogenous neurogenesis following central nervous system injury,and describe novel treatment strategies that to rget endogenous neurogenesis and newborn neurons in the treatment of central nervous system *** nervous system injury frequently results in alterations of endogenous neurogenesis,encompassing the activation,proliferation,ectopic migration,diffe rentiation,and functional integration of endogenous neural stem *** of the unfavorable local microenvironment,most activated neural stem cells diffe rentiate into glial cells rather than ***,the injury-induced endogenous neurogenesis response is inadequate for repairing impaired neural *** have attempted to enhance endogenous neurogenesis using various strategies,including using neurotrophic factors,bioactive materials,and cell reprogramming *** alone or in combination,these therapeutic strategies can promote targeted migration of neural stem cells to an injured area,ensure their survival and diffe rentiation into mature functional neurons,and facilitate their integration into the neural *** can integration re plenish lost neurons after central nervous system injury,by improving the local *** regulating each phase of endogenous neurogenesis,endogenous neural stem cells can be harnessed to promote effective regeneration of newborn ***

关键词： bioactive materials brain trauma endogenous neurogenesis hippocampal dentate gyrus neural stem cells neurotrophic factors newborn neurons spinal cord injury stroke subventricular zone

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Exploring the Factors Associated with 12-Month Non-Return to Work among Motorcyclists Involved in Road Accidents

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Open Journal of Preventive Medicine 2024年第1期14卷 1-16页

作者： Yolaine Glèlè-Ahanhanzo Donatien Daddah Alphonse Kpozehouen Bella Hounkpè Dos Santos moussiliou N. paraiso Multidisciplinary Research Unity for Road Crashes Prevention (ReMPARt) Department of Epidemiology and Bio-Statistics Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin Regional Direction of Health Lokossa Benin Regional Direction of Health Abomey-Calavi Benin Health Promotion Department Regional Institute of Public Health Ouidah Benin

Introduction: Motorcyclists bear a disproportionate burden of morbidity and mortality from road accidents. In addition, the consequences of these accidents affect the ability of victims to return to work. This study aimed to determine the prevalence and factors associated with non-return to work among surviving motorcyclists involved in road accidents 12 months after the event. Materials and Methods: It was a cross-sectional study conducted using data from a cohort of motorcyclists involved in accidents and recruited in five hospitals in Benin from July 2019 to January 2020. The dependent variable was non-return to work 12 months after the accident (yes vs no). The independent variables were categorized into two groups: baseline and 12-month follow-up variables. logistic regression was used to determine the factors associated with non-return to work at 12 months among the participants. Results: Among the 362 participants, 55 (15.19%, 95% CI = 11.84 - 19.29) had not returned to work 12 months after the accident. Risk factors for non-return to work identified were: smoking (aOR = 4.41, 95% CI = 1.44 - 13.56, p = 0.010), hospitalization (aOR = 2.87, 95% CI = 1.14 - 7.24, p Conclusion: The prevalence of non-return to work at 12 months was high among surviving motorcyclists involved in road accidents in Benin. Integrated support for patients based on identified risk factors should effectively improve their return to work.

关键词： Road Accident Return to Work Motorcyclists Hospital Mental Health Cohort Benin

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无绝缘REBCO饼型线圈变形引起的特性电阻变化

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Acta Mechanica Sinica 2024年第4期40卷 21-26页

作者： so Noguchi Hokkaido University Kita 14 Nishi 9Kita-kuSapporo060-0814Japan

近年来稀土钡铜氧化物(REBCO)饼型线圈在高磁场产生中的变形引起了人们的关注.一些考虑线圈变形的电流模拟显示了线圈变形可能影响屏蔽电流分布的可能性.屏蔽电流会产生强大的电磁力,对REBCO饼型线圈造成机械损伤.然而,线圈变形也可能... 详细信息

近年来稀土钡铜氧化物(REBCO)饼型线圈在高磁场产生中的变形引起了人们的关注.一些考虑线圈变形的电流模拟显示了线圈变形可能影响屏蔽电流分布的可能性.屏蔽电流会产生强大的电磁力,对REBCO饼型线圈造成机械损伤.然而,线圈变形也可能影响无绝缘(NI)REBCO饼型线圈的接触电阻,通常称为“特性电阻”.NI特性电阻是NI REBCO饼型线圈稳定性的一个重要因素.因此,有必要研究随着线圈形状变形的NI接触电阻.本文展示了外部场充电和NI线圈充电期间NI特性电阻的变化.

关键词：屏蔽电流接触电阻线圈变形铜氧化物 REBCO 电阻变化机械损伤电磁力

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