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药学进展 2016年第9期40卷 708-716页

作者： graul ai cruces e dulsat c tracy m 汤森路透

概述并精辟解析2015年全球制药行业发生的重大事件,包括药品定价、孤儿药研发、美国FDA优先审评凭证制度、药品研发管线缩减以及正在持续运作的并购。并展望未来,预测2016年有望上市的新药。

关键词：孤儿药优先审评药品定价产品研发中止

2016年全球新药研发报告--第一部分:新药和生物制品(Ⅰ)

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药学进展 2017年第4期41卷 305-312页

作者： Graul A I Pina P Cruces e Stringer m 科睿唯安

2016年全球首次批准或上市的新药和生物制品接近90种,其中包括重要的延伸性新药。与往年相比,这一数字相对较低。2016年全球首次上市的新药和新生物制品共44种,比前一年减少近10%。新上市药物中,7种药物为首创药物,即具有全新作用机制,... 详细信息

2016年全球首次批准或上市的新药和生物制品接近90种,其中包括重要的延伸性新药。与往年相比,这一数字相对较低。2016年全球首次上市的新药和新生物制品共44种,比前一年减少近10%。新上市药物中,7种药物为首创药物,即具有全新作用机制,并在全球首次通过批准并上市的新药。此外,2016年共批准了23种延伸性新药(即新配方、新联合用药和新适应证)。另有21种产品于2016年首次获批,但截至2016年12月15日尚未上市。在制药和生物技术领域年度报告的第一部分中,将深入报道这些新药的相关信息。

关键词：新上市药物新批准药物延伸性新药首创药物

Recent 28GHz Results with VeNUS

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Chinese Physics C 2007年第S1期31卷 1-7页

作者： D.Leitner D.S.Todd m.L.Galloway C.m.Lyneis Lawrence Berkeley National Laboratory BerkeleyCA 94720-8101USA

The next generation,superconducting eCR ion source VeNUS(Versatile eCR ion source for NUclear Science) has operated with 28GHz since 2004,and has produced world record ion beam intensities. The VeNUS project is focused on two main ***,for the 88-Inch Cyclotron,VeNUS will serve as the third injector source boosting both the energy and intensity of beams available from the ***, VeNUS also serves as the prototype injector source for a high intensity heavy ion beam driver linac for a next generation radioactive ion beam facility,where the goal is to produce intense beams of medium to low charge states ions such as 240eμA of Xe^(20+) or 250eμA of U^(28+to34+).These high intensity ion beam requirements present a challenge for the beam transport system since the total currents extracted from the eCR ion source reach several *** in parallel to ion beam developments,we are also enhancing our ion beam diagnostics devices and are conducting an extensive ion beam simulation effort to improve the understanding of the ion beam transport from the VeNUS eCR ion *** paper will give an overview of recent experiments with the VeNUS eCR ion *** the last eCR ion source workshop in Berkeley in 2004,we have installed a new plasma chamber,which includes X-ray *** enables us to operate the source reliably at high power 28GHz *** this new chamber several high intensity beams(such as 2.4mA of O^(6+),600eμA of O^(7+),1mA of Ar^(9+),etc.)have been *** addition,we have started the development of high intensity uranium *** example,200eμA of U^(33+) and V^(34+) have been produced so *** respect to high charge state ions,leμA of Ar^(18+),133eμA of Ar^(16+),and 4.9eμA of U^(47+) have been *** addition,ion beam profile measurements are presented with,and without the sextupole magnetic field *** experimental results are being compared with simulations using the WARP code.

关键词： VeNUS eCR ion source superconducting eCR uranium beams

3D bioprinting:current status and trends-a guide to the literature and industrial practice

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Bio-Design and manufacturing 2022年第1期5卷 14-42页

作者： Silvia Santoni Simone G.Gugliandolo mattia Sponchioni Davide moscatelli Bianca m.Colosimo Department of mechanical engineering Politecnico di MilanoVia La Masa120156 MilanItaly Department of Chemistry Materials and Chemical Engineering“Giulio Natta”Politecnico di MilanoPiazza Leonardo da Vinci3220133 MilanItaly

The multidisciplinary research field of bioprinting combines additive manufacturing,biology and material sciences to cre-ate bioconstructs with three-dimensional architectures mimicking natural living *** high interest in the possibility of reproducing biological tissues and organs is further boosted by the ever-increasing need for personalized medicine,thus allowing bioprinting to establish itself in the field of biomedical research,and attracting extensive research efforts from companies,universities,and research institutes *** this context,this paper proposes a scientometric analysis and critical review of the current literature and the industrial landscape of bioprinting to provide a clear overview of its fast-changing and complex *** scientific literature and patenting results for 2000-2020 are reviewed and critically analyzed by retrieving 9314 scientific papers and 309 international patents in order to draw a picture of the scientific and industrial landscape in terms of top research countries,institutions,journals,authors and topics,and identifying the technology hubs *** review paper thus offers a guide to researchers interested in this field or to those who simply want to under-stand the emerging trends in additive manufacturing and 3D bioprinting.

关键词： Additive manufacturing 3D bioprinting Biofabrication Organ-on-a-chip Tissue engineering

Formulation and characterization of extruded and spheronized pellets using pectin and crosslinking agents

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Journal of Chinese Pharmaceutical Sciences 2014年第11期23卷 790-798页

作者： Pallavi m.Chaudhari Pravin D.Chaudhari Padmashree Dr.D.Y.Patil College of Pharmacy Akurdi Pune-411044 India P.e.Society's modern College of Pharmacy NigdiPune-411044 India

The aim of this study was to prepare pellets of gliclazide by extrusion spheronization process by use of two methods in situ cross linking method and interfacial complexation method and to study the effect of different cross linking agents on the formed pellets. extrusion/spheronization being an established technique for producing spherical pellets so this technique was used to prepare pellets. The gliclazide pellets prepared by extrusion-spheronization techniques and then the formed pellets were coated with pectin solution by interfacial complexation method. The effect of cross-linkers calcium chloride and aluminium chloride concentration, by in situ cross linking on properties of gliclazide pellets like swelling and drug release were studied. The formed pellets were subjected to swelling, analysis of morphology, in dissolution and vivo studies. most of the pellets were of acceptable shape. From the results calcium chloride when coated with pectin, retarded drug release. As the concentration of calcium chloride increased, it led to slow release of the drug. This may be due to the water solubility of calcium salt, which induced cross linking with pectin. Thus pellets with calcium chloride cross linked with pectin were beneficial, because it retarded the release of the drug. Though the release from interfacial coated pellets was retarded, it was less as compared to the in situ formed pellets. The in vivo studies on alloxan-induced diabetic rats indicated the significant hypoglycemic effect that was observed 24 h after oral administration of optimized pellets. Thus, the developed and optimized pellets were suitable for prolonged systemic absorption of gliclazide to maintain lower blood glucose level and improved patient compliance. The results suggested that the in situ cross linking pellets were able to retard the release of gliclazide greater than the interfacial complexation method. Therefore, this approach has been effectively achieved.

关键词： extrusion-spheronization Gliclazide Pellets Pectin Anti-diabetic activity

三角反对称光滑子多重网格法的Fourier分析(英文)

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应用数学与计算数学学报 2013年第3期27卷 355-362页

作者： mURATOVA G V KRUKIeR L A ANDReeVA e m 南部联邦大学

考虑三角反对称光滑子多重网格法的局部Fourier分析.构造三角反对称迭代法作为多重网格法的光滑子,用于求解由对流占优扩散方程有限差分逼近导出的具有强非对称性矩阵的线性代数方程组.

关键词：多重网格法 Fourier分析光滑子三角迭代法

2015年全球新药研发报告——第二部分:趋势复杂,亮点频现(Ⅶ)

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药学进展 2016年第10期40卷 771-782页

作者： Graul A I Cruces e Dulsat C Tracy m 汤森路透

概述并精辟解析2015年全球制药行业发生的重大事件,包括药品定价、孤儿药研发、美国FDA优先审评凭证制度、药品研发管线缩减以及正在持续运作的并购。展望未来,预测2016年有望上市的新药。

关键词：孤儿药优先审评药品定价产品研发中止

2016年全球新药研发报告——第二部分：难忘的一年，趋势与亮点（Ⅵ）

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药学进展 2017年第11期41卷 872-878页

作者： Graul A I Dulsat C Tracy m Cruces e 科睿唯安

通过敏锐的视角概述了2016年制药行业热点话题，包括传染性疾病爆发推动研发进展、孤儿药开发、管线损耗、药品价格，以及正在进行的并购和收购等。报告还分析了美国和英国最近的政治事件，以及其对新一年制药产业可能产生的影响；此外... 详细信息

通过敏锐的视角概述了2016年制药行业热点话题，包括传染性疾病爆发推动研发进展、孤儿药开发、管线损耗、药品价格，以及正在进行的并购和收购等。报告还分析了美国和英国最近的政治事件，以及其对新一年制药产业可能产生的影响；此外，还预测了2017年将会通过审批的新药。

关键词：药物批准埃博拉寨卡孤儿药药品价格产品管线损耗并购和收购

Does laser surface texturing really have a negative impact on the fatigue lifetime of mechanical components?

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Friction 2021年第6期9卷 1766-1775页

作者： Chia-Jui HSU Andreas STRATmANN Simon meDINA Georg JACOBS Frank mÜCKLICH Carsten GACHOT Institute for engineering Design and Product Development TU WienLehárgasse 6Campus GetreidemarktVienna 1060Austria Chair of Functional materials Saarland UniversityCampus D3.3Saarbrücken 66123Germany AC2T Research GmbH Viktor-Kaplan-Straße 2/CWiener Neustadt 2700Austria Institute for machine elements and Systems engineering RWTH AachenSchinkelstraße 10Aachen 52062Germany

Laser surface texturing(LST)has been proven to improve the tribological performance of machine *** micro-scale patterns manufactured by LST may act as lubricant reservoirs,thus supplying oil when encountering insufficient ***,not many studies have investigated the use of LST in the boundary lubrication regime,likely due to concerns of higher contact stresses that can occur with the increasing surface *** study aims to examine the influence of LST on the fatigue lifetime of thrust rolling bearings under boundary lubrication.A series of periodic patterns were produced on the thrust rolling bearings,using two geometrically different designs,namely cross and dimple *** oil ISO VG 100 mixed with 0.05 wt%P of zinc dialkyldithiophosphate(ZDDP)was *** bearings with cross patterns reduce the wear loss by two orders of *** patterns not only retain lubricant in the textured pockets but also enhance the formation of an anti-wear *** tribofilm generation may be improved by the higher contact stresses that occur when using the textured ***,in contrast to the negative concerns,the ball bearings with cross patterns were instead found to increase the fatigue life by a factor of three.

关键词： thrust rolling bearing laser surface texturing direct laser interference patterning zinc dialkyldithiophosphate(ZDDP) tribofilm

extra-pair paternity and antiparasitic defence

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Avian Research 2020年第4期11卷 391-397页

作者： Anders Pape møller Jørgen Skavdal Søraker Juan JoséSoler ministry of education Key Laboratory for Biodiversity Science and ecological engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China ecologie Systématique et evolution UniversitéParis-SaclayCNRSAgroParisTech91405 OrsayFrance Centre for Biodiversity Dynamics Department of BiologyNorwegian University of Science and TechnologyHøgskoleringen 5No-7491TrondheimNorway Depto.ecología Funcional y evolutiva Estación Experimental de ZonasÁridasCtra.Sacramento S/NLa Cañada de San Urbano04120 AlmeríaSpain

Background:extra-pair paternity(ePP)in birds provides benefits in terms of more offspring,and characteristics for maintenance of this behaviour have been the subject of *** are known to be transmitted during mating,especially when mating with multiple partners,and factors reducing this cost of multiple mating are ***,plumage brightness and colour intensity have been shown to be important traits to benefits from multiple mating as predicted by sexual *** aim of this study was to investigate the relationship between the rate of extra-pair paternity and the relative size of the uropygial gland at the interspecific level,as the uropygial gland is an exocrine gland hypothesized to produce antiparasitic substances and further identified to affect plumage *** of the expected benefits of large uropygial gland in scenarios of sexual selection,we predicted a positive correlation with ***:We collected information from the literature of uropygial gland size and frequency of extra-pair paternity of 60 avian species of different families and explored the predicted positive correlation between *** did so with means of comparative analyses that considered phylogenetic relationship as random factor and included body mass as *** used markov chain monte Carlo generalized linear mixed models that were weighted by number of nests used to estimate extra-pair ***:We detected a positive relationship between level of extra-pair paternity and uropygial gland size at an interspecific *** finding is consistent with the ***:We discuss the importance of this result in scenarios of sexual selection and argue that the detected relationship may have arisen by utilizing antiparasitic secretions through secondary sexual characters indicating parasite resistance.

关键词： Antiparasitic defence Costs of extra-pair paternity microorganisms Uropygial gland Uropygial secretions