检索结果-南通市图书馆

抗血管紧张素Ⅱ1型受体抗体对移植肾功能影响及其免疫机制研究进展

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

实用器官移植电子杂志 2022年第6期10卷 572-576页

作者： mounia lalouly 王祥慧周佩军邵琨安会敏周全上海交通大学医学院附属瑞金医院肾移植中心上海200025

供体和受体之间的人类白细胞抗原(human leukocyte antigen,HLA)差异与抗体介导的排斥反应(antibody-mediated rejection,ABMR)风险增加相关,并阻碍移植肾长期存活[1]。然而,并非所有活检证实ABMR相关的移植物功能障碍患者均具有供体HL... 详细信息

供体和受体之间的人类白细胞抗原(human leukocyte antigen,HLA)差异与抗体介导的排斥反应(antibody-mediated rejection,ABMR)风险增加相关,并阻碍移植肾长期存活[1]。然而,并非所有活检证实ABMR相关的移植物功能障碍患者均具有供体HLA特异性抗体(donor specific antigen,HLA-DSA)[2]。文献报道了已鉴定出的各种组织来源的非HLA抗原,对这些靶标的致敏与移植物功能延迟恢复(delayed graft function,DGF)、同种异体移植物损伤和排斥反应有关[3-5]。非HLA抗体包括次要组织相容性抗原抗体和抗自身组织抗原抗体[5]。移植物受体的非HLA抗体的效应功能取决于内在特征,如抗体滴度、亲和力和基因型,以及外在因素,如不同的同种异体组织内非HLA靶抗原的表达密度[6]。然而,了解非HLA抗体何时以及如何导致同种异体移植物损伤至关重要。

关键词： HLA抗原效应功能移植肾功能人类白细胞抗原移植物靶抗原抗体滴度抗原抗体

维普期刊数据库

Optimizing wind farm layout for enhanced electricity extraction using a new hybrid PSO-ANN method

在线全文

学校读者我要写书评

暂无评论

Global Energy Interconnection 2024年第3期7卷 254-269页

作者： Mariam El Jaadi Touria Haidi Abdelaziz Belfqih mounia Farah Atar Dialmy LAGES Laboratory Hassania School of Public Works(EHTP)Casablanca 20230Morocco LESE Laboratory National School of Electricity and Mechanics(ENSEM)Casablanca 20100Morocco LAGCET Laboratory Hassania School of Public Works(EHTP)Casablanca 20230Morocco

With the growing need for renewable energy,wind farms are playing an important role in generating clean power from wind *** best wind turbine architecture in a wind farm has a major influence on the energy extraction *** paper describes a unique strategy for optimizing wind turbine locations on a wind farm that combines the capabilities of particle swarm optimization(PSO)and artificial neural networks(ANNs).The PSO method was used to explore the solution space and develop preliminary turbine layouts,and the ANN model was used to fine-tune the placements based on the predicted energy *** proposed hybrid technique seeks to increase energy output while considering site-specific wind patterns and topographical *** efficacy and superiority of the hybrid PSO-ANN methodology are proved through comprehensive simulations and comparisons with existing approaches,giving exciting prospects for developing more efficient and sustainable wind *** integration of ANNs and PSO in our methodology is of paramount importance because it leverages the complementary strengths of both ***,this novel methodology harnesses historical data through ANNs to identify optimal turbine positions that align with the wind speed and direction and enhance energy extraction efficiency.A notable increase in power generation is observed across various *** percentage increase in the power generation ranged from approximately 7.7%to 11.1%.Owing to its versatility and adaptability to site-specific conditions,the hybrid model offers promising prospects for advancing the field of wind farm layout optimization and contributing to a greener and more sustainable energy future.

关键词： Layout optimization Turbine placement Wind energy Hybrid optimization Particle swarm optimization Artificial neural networks Renewable energy Energy efficiency

维普期刊数据库

肾移植受者T细胞亚群绝对计数动态监测对感染的预警作用

在线全文

学校读者我要写书评

暂无评论

中华移植杂志（电子版） 2022年第4期16卷 210-215页

作者： mounia lalouly 王祥慧周佩军邵琨安会敏周全上海交通大学医学院附属瑞金医院肾移植中心 200025

目的探讨长期监测T细胞亚群绝对计数水平对肾移植受者术后感染的预警作用。方法回顾性分析2017年1月至2021年5月在上海交通大学医学院附属瑞金医院26例行肾移植术后新发感染受者临床资料(感染组,感染发生在移植后1~240个月)。选择129例... 详细信息

目的探讨长期监测T细胞亚群绝对计数水平对肾移植受者术后感染的预警作用。方法回顾性分析2017年1月至2021年5月在上海交通大学医学院附属瑞金医院26例行肾移植术后新发感染受者临床资料(感染组,感染发生在移植后1~240个月)。选择129例同期肾移植术后无感染、健康受者作为对照组。感染组连续或定期测量外周血T细胞亚群CD3^(+)、CD4^(+)和CD8^(+)绝对计数,并与对照组检测数据进行比较。根据移植后采样时间将感染组和对照组各分为6个亚组,分析感染亚组与其相应对照亚组之间T细胞亚群绝对计数的差异。正态分布计量资料采用两独立样本t检验和单因素方差分析比较,非正态分布计量资料采用Mann-Whitney U检验比较,计数资料采用χ^(2)检验比较。使用受试者工作特征(ROC)曲线分析T细胞亚群绝对计数在肾移植术后预警感染性疾病的最优值。P0.05)。感染组受者CD3^(+)、CD4^(+)和CD8^(+)T细胞绝对计数[(367±212)、(189±117)和(161±92)个/μL]均低于对照组[(1374±663)、(695±334)和(626±377)个/μL],差异均有统计学意义(t=14.036、13.541和12.311,P均0.05)。对照亚组1受者CD3^(+)、CD4^(+)和CD8^(+)T细胞绝对计数均低于对照亚组5,差异均有统计学意义(P均<0.05)。CD4^(+)、CD8^(+)和CD3^(+)绝对计数预测肾移植术后感染性疾病最优截断值分别为712、362和255个/μL,敏感度分别为94.6%、92.2%和96.1%,特异度分别为92.3%、96.2%和88.5%。结论肾移植受者低T细胞亚群绝对计数水平具有预示及预警感染风险的作用。

关键词： T细胞亚群绝对计数肾移植机会性感染移植后监测

Kostmann’s Neutropenia: A Case Report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2024年第5期14卷 869-872页

作者： Khaoula Achir Ilham Tadmori mounia Lakhdar Idrissi Fatima Zahra Souilmi Mohamed Hbibi Moustapha Hida Pediatric Department of CHU Hassan II in Fez Fez Morocco

Kostmann syndrome, or severe congenital neutropenia, is a rare condition in children marked by a neutrophil count of less than 500/mm3. This congenital agranulocytosis, an autosomal recessive genetic disorder, is often first identified by a neonatal infectious syndrome. The deficiency in neutrophils increases susceptibility to bacterial and fungal infections. Prior to the availability of hematopoietic growth factors, the disease was associated with significant morbidity and early mortality. We present the case of a 17-month-old boy who was admitted to the pediatric emergency department at Hassan II University Hospital in Fes with skin abscesses.

关键词： Kostmann Syndrome Severe Congenital Neutropenia Skin Abscesses

Unraveling the Impact of Direct-Acting Antivirals on Hepatitis-Linked Cirrhosis: A Comprehensive Analysis of Fibrosis, Child Score, and Disease Progression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2024年第6期14卷 203-212页

作者： Hajar Cherkaoui Maryam Elkhayari Maria Lahlali Asmae Lamine Nada Lahmidani Amine Mekkaoui mounia Elyousfi Dafr Allah Benajah Mohammed El Abkari Adil Ibrahimi Hakima Abid Department of Hepato-Gastroenterology Hassan II University Hospital Fez Morocco Faculty of Medicine and Pharmacy of Fez USMBA Fez Morocco

The treatment of hepatitis C has undergone a significant boom since the advent of direct acting antivirals (DAA). Indeed, the interferon-ribavirin combination that has been used to treat hepatitis C has a virological response in only 45% of cases with significant side effects. The advent of direct-acting antivirals has changed the prognosis of cirrhotic patients with hepatitis C. DAAs have ensured a sustained viral response in the majority of patients. Our work aims to see the evolution of hepatitis C patients at the cirrhosis stage under DAA. We conducted a retrospective study over 15 years (January 2009, January 2024) including all patients with post-viral cirrhosis C, whom we divided into two groups: group A, cirrhotic patients who received ribavirin and interferon, and group B, patients on DAA. From January 2009 to January 2024, we conducted a study of 182 patients with viral hepatitis C, including 102 cirrhotic patients. The mean age was 55 years. 66% of patients were initially treated with the ribavirin interferon combination, while 34% received direct-acting antivirals (DAAs). Since the introduction of DAAs, the most commonly used regimens have been sofosbuvir/daclatasvir with or without ribavirin and sofosbuvir/ledipasvir with or without ribavirin. Group A achieved sustained virological response (SVR) in 60% of cases, with notable side effects. In Group B, SVR was 98.18%, with improved tolerability and fewer side effects than previous treatments. Fifteen patients developed hepatocellular carcinoma (HCC), with a significantly lower mortality rate in those treated with DAAs compared with pegylated dual therapy (p: 0.001).

关键词： Post-Viral Cirrhosis C Pegylated Interferon Direct Acting Antivirals Sustained Viral Response Child Score Fibrosis

Dunbar Syndrome and Hypoxic Hepatitis: An Unusual Presentation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Gastroenterology 2024年第6期14卷 226-232页

作者： Hajar Cherkaoui Ismail Chaouech Yousra El Abidi Haroun Robleh Asmae Lamine Maria Lahlali Nada Lahmidani Amine Mekkaoui mounia Elyousfi Dafr Allah Benajah Adil Ibrahimi Mohammed El Abkari Nizar Bouardi Mohammed Maaroufi Hakima Abid Department of Gastroenterology University Hospital Hassan II Fez Morocco Faculty of Medicine and Pharmacy Fez Morocco Department of Radiology University Hospital Hassan II Fez Morocco

Hypoxic hepatitis, also known as ischemic hepatitis, is characterized by acute hepatocellular injury due to inadequate oxygen delivery to the liver. Celiac trunk stenosis can lead to hepatic ischemia and subsequent liver damage. We present the case of an 81-year-old patient with a history of hypertension, ischemic heart disease, hypothyroidism, and biliary lithiasis, who developed hypoxic hepatitis secondary to Dunbar syndrome and a stenosis of the superior mesenteric artery. The patient improved symptoms and liver function tests with conservative management, including intravenous fluids and supportive care. Long-term management involved continued antiplatelet therapy and statins, with consideration of further interventions for celiac trunk stenosis. This case underscores the importance of recognizing Dunbar syndrome as well as superior mesentery trunk stenosis as a potential cause of hypoxic hepatitis. It highlights the need for multidisciplinary management in such cases.

关键词： Dunbar Syndrome Hypoxic Hepatitis Stenosis of Mesentery Artery

Characterisation of sediments polluted by acid mine drainage in the northeast of Algeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2012年第3期27卷 402-407页

作者： Chahrazed BOUKHALFA mounia CHAGUER Laboratory of pollution and water treatment Chemistry DepartmentUniversity Mentouri Constantine

The present study investigates the composition and the mineralogy of sediments in the Essouk River, located in the Northeast of Algeria in Sidi Kamber mining zone at approximately 2km upstream Guenitra *** mine is abandoned since 1976,but acidic drainage water is still a source of river *** X-Ray diffraction(XRD),scanning electron microscopy(SEM) with energy dispersive analyses(EDX),X -Fluorescence analyses and infrared spectroscopy analyses were used to characterize surface sediments sampled at various sites in the area near the mining effluents. The obtained results show that the composition of the sediments is mainly dominated by iron and *** the vicinity of the mine,jarosite and schwertmannite are the essential precipitates. Downstream,sediments are formed by various phases of iron oxyhydroxydes with the presence of adsorbed sulphate.

关键词： Acid mine drainage Sediments pollution Sediments analyses Iron oxyhydroxydes

Chemically modified carbon-based electrodes for the determination of paracetamol in drugs and biological samples

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2021年第2期11卷 138-154页

作者： Wafaa Boumya Nawal Taoufik mounia Achak Noureddine Barka Sultan Moulay Slimane University of Beni Mellal Research Group in Environmental Sciences and Applied Materials(SEMA)FP KhouribgaB.P.14525000KhouribgaMorocco Chouaib Doukkali University Ecole Nationale des Sciences AppliqueesLaboratoire des Sciences de l’Ingenieur pour l’EnergieEl JadidaMorocco Chemical&Biochemical Sciences Green Process EngineeringCBSMohammed VI Polytechnic UniversityBen GuerirMorocco

Paracetamol is a non-steroidal, anti-inflammatory drug widely used in pharmaceutical applications for its sturdy, antipyretic and analgesic action. However, an overdose of paracetamol can cause fulminant hepatic necrosis and other toxic effects. Thus, the development of advantageous analytical tools to detect and determine paracetamol is required. Due to simplicity, higher sensitivity and selectivity as well as costefficiency, electrochemical sensors were fully investigated in last decades. This review describes the advancements made in the development of electrochemical sensors for the paracetamol detection and quantification in pharmaceutical and biological samples. The progress made in electrochemical sensors for the selective detection of paracetamol in the last 10 years was examined, with a special focus on highly innovative features introduced by nanotechnology. As the literature is rather extensive, we tried to simplify this work by summarizing and grouping electrochemical sensors according to the by which manner their substrates were chemically modified and the analytical performances obtained.

关键词： Paracetamol Electrochemical sensors Modified electrodes Pharmaceutical samples

维普期刊数据库

In vivo exploration of the functional activity of the non-coding 8q24 prostate cancer risk locus

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第6期12卷 787-789页

作者： Dolores J. Lamb mounia Tannour-Louet Scott Department of Urology Baylor College of Medicine Houston TX 77030 USA Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 USA

Genome-wide association studies （GWAS） have successfully identified a substantial number of risk variants for prostate cancer [1-10]. In total, more than 20 single nucleotide polymorphisms （SNPs） that predispose to prostate malignancy have been found scattered throughout the genome in coding and non-coding regions. The 8q24 chromosomal region is an intriguing locus as it harbors five independent susceptibility variants （rs10086908; rs16901979; rs620861; rs6983267; rs1447295） that span a 440-kb genomic interval devoid of genes or protein-coding transcripts.

关键词： Genomes Cancer (genus) Neoplasms Variants Prostate Genes Andean region