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Portal Vein Thrombosis in Non Cirrhotic Patients: Experience of Gastroenterology and Hepatology Department University Hospital Hassan II

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Open Journal of Gastroenterology 2020年第12期10卷 349-356页

作者： Nada Lahmidani Mariam El Khayari Maria Lahlali Asmae Lamine Hakima Abid mounia El Yousfi Dafr Allah Benajah Sidi Adil Ibrahimi Mohammed El Abkari Department of Gastroenterology and Hepatology School of Medicine and Pharmacy of Fez University Hospital Hassan II University Sidi Mohammed Ben Abdallah Fez Morocco

Portal thrombosis (PT) is a rare condition of heterogeneous etiologies. The aim of our work is to study the epidemiological and etiological profile of portal thrombosis in non cirrhotic patients through the experience of our department. Patients and Methods: This is a retrospective study over a 9-year period (January 2009-July 2018), 54 cases of PT in non cirrhotic patients were collected in the department of Hepato-Gastro-Enterology of the HASSAN II Fez Hospital, 73 cases of PT were excluded among cirrhotic patients. Results: We collected 54 cases of PT cases;the average age was 45 years, with an F/M ratio of 1.42. PT was revealed by abdominal pain in 20 cases, complications of portal hypertension in 24 cases, and ultrasound discovery in 10 asymptomatic cases. Main underlying causes of PT were: A proteine S deficiency in 7 cases, Acute pancreatitis in 5 cases, colonic cancer in 4 cases, pancreatic cancer in 4 cases, Hydatic liver Echinococcoses (3 cases), anti phospholipid syndrom (3 cases), myeloproliferative syndrom (2 cases) and jak mutation 2 in 1 case, non identified etiology was reported in 20 cases (37%). Treatment was based on anticoagulation, treatment of portal hypertension complications, and etiological treatment in cases where etiological diagnosis was certainly posed. Conclusion: PT is a rare but serious condition, according to our study neoplastic causes are predominant followed by protein S deficiency. Etiological investigations have to be wide and early treatment is the best option to avoid extension and complication.

关键词： Portal Thrombosis Etiology Anticoagulant Non Cirrhotic

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抗血管紧张素Ⅱ1型受体抗体对移植肾功能影响及其免疫机制研究进展

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实用器官移植电子杂志 2022年第6期10卷 572-576页

作者： mounia Lalouly 王祥慧周佩军邵琨安会敏周全上海交通大学医学院附属瑞金医院肾移植中心上海200025

供体和受体之间的人类白细胞抗原(human leukocyte antigen,HLA)差异与抗体介导的排斥反应(antibody-mediated rejection,ABMR)风险增加相关,并阻碍移植肾长期存活[1]。然而,并非所有活检证实ABMR相关的移植物功能障碍患者均具有供体HL... 详细信息

供体和受体之间的人类白细胞抗原(human leukocyte antigen,HLA)差异与抗体介导的排斥反应(antibody-mediated rejection,ABMR)风险增加相关,并阻碍移植肾长期存活[1]。然而,并非所有活检证实ABMR相关的移植物功能障碍患者均具有供体HLA特异性抗体(donor specific antigen,HLA-DSA)[2]。文献报道了已鉴定出的各种组织来源的非HLA抗原,对这些靶标的致敏与移植物功能延迟恢复(delayed graft function,DGF)、同种异体移植物损伤和排斥反应有关[3-5]。非HLA抗体包括次要组织相容性抗原抗体和抗自身组织抗原抗体[5]。移植物受体的非HLA抗体的效应功能取决于内在特征,如抗体滴度、亲和力和基因型,以及外在因素,如不同的同种异体组织内非HLA靶抗原的表达密度[6]。然而,了解非HLA抗体何时以及如何导致同种异体移植物损伤至关重要。

关键词： HLA抗原效应功能移植肾功能人类白细胞抗原移植物靶抗原抗体滴度抗原抗体

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Dieulafoy’s Lesion of the Duodenum: The Management of This Unusual Location

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Case Reports in Clinical Medicine 2022年第7期11卷 268-272页

作者： Rajae Bounour Amal Mejait Maria Lahlali Asmae Lamine Hakima Abid Hakima Abid Amine Mekkaoui mounia Elyousfi Dafrallah Benajeh Mohamed El Abkari Sidi Adil Ibrahimi Nada Lahmidani Hepato-Gastroenterology Department CHU Hassan II Fez Morocco

Dieulafoy lesion (DL) is a rare source of gastrointestinal tract bleeding that can affect any site of the gastrointestinal tract, particularly the stomach and less commonly the duodenum. Early endoscopy during a bleeding episode is essential for an accurate diagnosis and sometimes multiple endoscopies are needed to establish the diagnosis. In this report, we describe a case of duodenal DL detected and treated by endoscopy. We report the case of a 65-year-old patient admitted for massive upper gastrointestinal bleeding due to a Dieulafoy lesion of the duodenum. Endoscopic diagnosis and treatment were possible and hemostasis was achieved by injecting adrenaline and placing 3 clips. Various effective endoscopic techniques are available to control bleeding, the combination of injection therapy and mechanical therapy reduces the risk of recurrence.

关键词： Dieulafoy’s Lesion Endoscopy Hemostatic Clips

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The Effect of the Board of Directors and Audit Quality on Disclosure of Internal Control Practices: Evidence from European Companies

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Journal of Modern Accounting and Auditing 2020年第4期16卷 171-189页

作者： Jamel CHOUAIBI mounia BOULHAGA University of Sfax SfaxTunisia

The purpose of this paper is to examine the effect of the board of directors,namely board size,board independence,and CEO duality,as well as audit quality on the disclosure of internal control *** sample consists of 164 European companies listed in the STOXX Europe *** on positive agency theory,the authors posit that board of directors and audit quality influence corporate internal control disclosure *** content analysis and the design of the evaluation criterion were used to calculate the disclosure index of internal ***,multiple regression analysis is utilized to analyze the results of this *** average internal control information disclosure index was 0.285,indicating that most of the companies in our sample do not disclose enough information about the internal *** low level of forward-looking information disclosure makes it very difficult for corporate stakeholders to determine the future performance of the *** results indicate that internal control disclosure is positively and significantly associated with board independence,CEO duality,and audit *** study contributes to the literature on the various governance characteristics and disclosure by showing that the disclosure of internal control information in European countries is positively and significantly associated with board independence,separation of duties,and audit *** study was based on a sample of European companies including countries regulating IC disclosure as well as unregulated *** noted by Bedard and Graham(2014),regulatory differences in countries can contribute insights on the costs and benefits of *** also have policy implications for investors,managers,and regulators.

关键词： board of directors disclosure of internal control audit quality STOXX 600 Board independence CEO duality Introduction

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