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Profile of Female Hyperandrogenism at the Medical Clinic II: About 19 Cases

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Open Journal of Endocrine and Metabolic Diseases 2023年第5期13卷 63-74页

作者： Michel Assane Ndour Demba Diédhiou Djiby Sow Ibrahima Mané Diallo Mouhamed Dieng Fatou Gueye Astou Mbodj Julie Borges Preira Fatou Kiné Gadji Muriel Diembou Fama Ndiaye El Hadj mouhamadou moustapha Thioye Charles Halim Anna Sarr Maïmouna Ndour Mbaye Internal Medicine Department Abass Ndao Hospital Cheikh Anta Diop University of Dakar Dakar Senegal

Introduction: Female hyperandrogenism is essentially manifested by hirsutism. It is present in Senegal but not yet elucidated for lack of data. This is why we proposed to study the profile of hyperandrogenism in our context. Patients and Methods: This was an observational, cross-sectional cohort study of 19 patients of reproductive age followed for hyperandrogenism at the Medical Clinic II of Abass Ndao Hospital, from November 1st, 2019 to August 31st, 2021. Results: Our cohort consisted of women with an average age of 25.3 years, single (73.7%), with a low socioeconomic level (42.1%). A family history of hirsutism was found in 31.6% of cases. The main reasons for consultation were a menstrual cycle disorder in 94.7% of cases, and hirsutism in 78.9% of cases. The latter was post-pubertal (66.7%), with a slow or progressive evolution. The physical examination revealed: hirsutism (100%) with an average modified Ferriman Gallwey score (mFG) of 8.9 ± 5.8, acne (36.8%), hyperseborrhea (57.9%), major signs of virilization (10.5%), acanthosis nigricans (47.4%) and galactorrhea (5.3%). Hormonal explorations revealed an elevation of: testosterone (31.6%), 17-hydroxyprogesterone (5.3%), dihydrotestosterone (31.6%), and prolactin (10.5%). The ovarian morphology was micropolycystic (84.2%). The etiological profile corresponded to polycystic ovarian syndrome or PCOS (68.4%), ovarian hyperthecosis (10.5%), hyperprolactinemia (10.5%), congenital adrenal hyperplasia or CAH (5.3%). Idiopathic hirsutism was found in 5.3% of cases. Conclusion: Female hyperandrogenism is a less frequent reason for consultation in endocrinology. It deserves to be further evaluated in a large-scale study focused on epidemiological, clinico-biological and etiological investigation, in order to assess its prevalence and better define its profile in our context.

关键词： Female Hyperandrogenism Hirsutism Senegal

Efficiency of Nanofiltration Membrane TFC-SR3 and SelRo MPF-34 for Partial Elimination of Fluoride and Salinity from Drinking Water

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Journal of Water Resource and Protection 2015年第7期7卷 547-552页

作者： mouhamadou A. Diallo Saidou N. diop Mohamad M. Diémé Courfia K. Diawara Ecole Doctorale Eau Qualité et Usage de l’Eau Université Cheikh Anta DIOP de Dakar Dakar Senegal UFR Sciences et Technologies Université Assane Seck de Ziguinchor Ziguinchor Senegal

Consumption of safe drinking water is essential to human health. The excess of certain elements in drinking water causes health problem for people consuming these waters. In Senegal, the excessive levels of fluoride and salts found in the groundnut basin cause public health problem such as dental and/or skeletal fluorosis. Thus, the treatment of such waters is essential before consumption to prevent health problems. For a partial removal of fluoride and salinity, we tested the performance of two commercial nanofiltration membranes namely TFC-SR3 and SelRO MPF-34 at laboratory scale. The results showed that TFC-SR3 membrane was very efficient with rejection rates of 83% - 96% for fluoride ions and 89% - 96% for salinity. For SelRo MPF-34 membrane, retention rates of 25% - 52% were obtained for fluoride ions and 24% - 60% for the salinity.

关键词： Fluoride Nanofiltration Rejection Salinity

Study of the Duration of Treatment in Drug Prescriptions Received in Pharmacies in Dakar

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Open Journal of Preventive Medicine 2021年第3期11卷 80-89页

作者： Mbathio diop Serigne Dame Dieng Aida Kanouté Bineta Faye Mansoum Ndiaye Cheikh mouhamadou Mbacké Lô Daouda Faye Department of Odontology Faculty of Medicine Pharmacy and Odontostomatology Cheikh Anta Diop University Dakar Senegal Health Department of the African Center for Advanced Studies in Management Dakar Senegal

The prescription must include the name of the drugs or products prescribed, dosage form, dosage, directions for use and duration of treatment. However, sometimes errors can occur that can have consequences for the health of patients. Our study concerns the use of medical prescriptions received in pharmacies in the Dakar department. The survey was conducted in 90 pharmacies in these communes, which represent one third of the 270 pharmacies in the department of Dakar. This allowed us to study 2700 prescriptions. The study took place from 1 December 2016 to 30 June 2017, i.e. over a period of 7 months. Our results show that neurologists and urologists have a longer average treatment time than other specialists, with an average of 120 days and 90 days of treatment respectively. Then, the specialists who take a long time the drug represent more than 27%, and require renewal of the drug. In 63.90% of the cases, no notification on the duration of treatment was given by the prescriber. Only 5.39% were only given the mention “to be renewed”. At the end of our analysis, we can say that the prescription must be perfectly legible to avoid confusion by the patient or the pharmacist. The pharmacist then participates in the therapeutic education of the patient and thus helps him/her to live better with his/her disease. Therefore, socio-professional health associations and organisations must provide more continuous training on prescribing to ensure good compliance and above all avoid people buying medicines in the parallel circuit in order to better control health expenditure.

关键词： Duration of Treatment Prescription Drugs

Complementarity of Sentinel-1 and Sentinel-2 Data for Mapping Agricultural Areas in Senegal

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Advances in Remote Sensing 2020年第3期9卷 101-115页

作者： Gayane Faye Fama Mbengue Lacina Coulibaly Mamadou Adama Sarr Modou Mbaye Amath Tall Dome Tine Omar Marigo mouhamadou moustapha Mbacke Ndour Laboratoire de Télédétection Appliquée Institut des Sciences de la Terre Cheikh Anta DIOP University of Dakar (LTA/IST/UCAD) Dakar Senegal Laboratoire de Géomatique Environnementale école de Foresterie Université de Moncton Nouveau-Brunswick Canada Centre de Suivi Ecologique (CSE) of Dakar Dakar Senegal Laboratoire d’études et de Recherche en Statistique et Développement UFR de Sciences Appliquées et de Technologie Département de Mathématiques Appliquées Université Gaston BERGER of Saint-Louis Dakar Senegal Ecole Nationale Supérieure d’Agriculture (ENSA) Thies University Thies Senegal UFR Science de l’Ingenieur Thies University Thies Senegal

The small size of agricultural plots is the main difficulty for crops mapping with remote sensing data in the Sahelian region of Africa. The study aims to combine Sentinel-1 (radar) and Sentinel-2 (Optic) data to discriminate millet, maize and peanut crops. Training plots were used in order to analyse temporal variation of the three crops’ signals. The NDVI (Normalized Difference Vegetation Index) was able to differentiate crops only at the end of the rainy season (October). The optical data as well as the radar ones could not easily discriminate the three crops during the growing season, because in that period vegetation cover is low, and soil contribution to the signals (due to roughness and moisture) was more important than that of real vegetation. However, the ratio of VH/VV (VH: incident signal in vertical polarization and reflected signal in horizontal polarization;VV: incident signal in vertical polarization and reflected signal in horizontal polarization) gave a difference between millet and the two other crops at the beginning cultural season (July 11). Difference appears from the second third of September when the harvest of cereals crops (millet and maize) began. From middle of October, the peanut signal dropped sharply thus facilitating the differentiation of peanut from the two other crops. This analysis led to the identification of data that have could be used to discriminate these crops (useful data). Classification of the combined useful data gave an overall high accuracy of 82%, with 96%, 61% and 65% for peanut, maize and millet, respectively. The non-agricultural areas (water, natural vegetation, habit, bare soil) were well classified with an accuracy greater than 90%.

关键词： Agricultural Areas Remote Sensing Sentinel-1 Sentinel-2 Senegal

Severity and Magnitude of Caries among Rural Populations in Ferlo in Senegal

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Open Journal of Epidemiology 2016年第1期6卷 10-15页

作者： Diouf Massamba Boetsch Gilles Cisse Daouda Lo Cheikh mouhamadou Mbacké Kanouté Aida diop Mbatio Barro Ibrahima Faye Daouda Public Health Service Department of Dentistry Cheikh Anta Diop University Dakar Senegal CNRS-UMI “Environment Health Society” Marseille France

Oral diseases belong to non-communicable diseases. They are characterized by their importance especially in disadvantaged areas. The objective of this study was to measure the extent and severity of caries among rural populations of Widou, an area located in central Ferlo. It was a descriptive and cross-sectional study which involved 300 individuals selected using simple random sampling. The socio-demographic characteristics collected were sex, age, educational level and occupation. The dental status was rated by the prevalence of dental caries and DMF and its components. The data were analyzed with the software Epi info 3.4.5 with 5% of threshold statistical significance. The prevalence of dental caries was 89%. The mean DMF was 5.4 ± 5.6 with a maximum of 26. The mean of component “D” was 3.8 with a maximum of 24. Variables significantly associated with dental caries were sex (p = 0.012) and occupation (p = 0.03). The extent and severity of caries in rural areas of the Ferlo evoke a relatively low support or management and require efforts in prevention, directed on oral hygiene and dietary habits.

关键词： Dental Status Rural Population Ferlo Senegal

Relationship between Circulating Plasma Galectin-3 Levels and T-Cell Activation during Cervical Cancer Chemotherapy

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Open Journal of Immunology 2023年第1期13卷 14-31页

作者： Folly M. Gaba Maïmouna diop Doudou G. M. Niang Sidy Ka Doudou Diouf Moussa Ndour Comlan J. G. Montcho moustapha Mbow Babacar Faye Rokhaya N. Diallo Maguette S. Niang Ahmadou Dem Babacar Mbengue Alioune Dieye Immunology Department Faculty of Medicine Pharmacy and Odontology University of Cheikh Anta Diop Dakar Senegal Immunology Laboratory Aristide Ledantec Hospital (HALD) Dakar Senegal Oncology Department Juliot Curie Institute Aristide Ledantec Hospital (HALD) Dakar Senegal Human Genetic Department Faculty of Medicine Pharmacy and Odontology University of Cheikh Anta Diop Dakar Senegal

Objective: Despite the existence of several therapeutic strategies, the management of cervical cancer remains challenging. Our region has very little data on the interaction between the immune system and the clinical response to chemotherapy. This work examines plasma levels of galectin-3 (Gal-3) and percentages of activated T cells in patients with cervical cancer treated with chemotherapy and investigates if there is a relationship between the rates of these two elements. Methods: We compared data from 37 patients with cervical cancer undergoing chemotherapy and 42 controls with normal cervical cytology. Plasma Gal-3 concentrations were assessed by ELISA and expression of activation markers by T cells (CD69 and HLA-DR) was assessed by flow cytometry at three different time points during chemotherapy. Results: Our results showed that patients had a significantly higher concentration of Gal-3 compared to controls (4.025 vs. 1.340, p 0.001), similarly, they had a significantly high percentage of activated lymphocytes (2.610 vs. 0.731;p 0.0001). According to the response to treatment, patients with no response to treatment had a lower concentration of circulating Gal-3 but had approximately the same percentage of activated CD4 and CD8 lymphocytes as patients with a partial or total response. In addition, we found a positive correlation between the Gal-3 level and CD4 T cells expressing the activation marker CD69 (p 0.05;rho = 0.44). Conclusion: In conclusion, our results show that there would be a relationship between circulating galectin-3 and the percentage of peripheral CD4+CD69+ cells in cervical cancer.

关键词： Uterine Cervical Neoplasm Chemotherapy Galectin 3 T-Lymphocytes Activation

Evaluation of Kidney Function in Patients with COVID-19 at the Epidemiological Treatment Centre in CHNU Fann

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Advances in Biological Chemistry 2023年第1期13卷 17-24页

作者： Thioune Ndeye Mareme Kandji Pape Matar Djite moustapha Barry Nene Oumou Kesso Zaamoumi Bassma Kane Mame Coumba Diagne Bineta Mbacke Mame Ndoumbé Sagne René Ngor Ndour El Hadji Malick Gueye-Tall Fatou Lopez-Sall Philomene Cisse Aynina diop Pape Amadou Gueye Papa Madieye Laboratory of Biochemistry-Hematology National University Hospital of Fann Dakar Senegal Laboratory of Pharmaceutical Biochemistry Faculty of Medicine Pharmacy Cheikh Anta Diop University Dakar Senegal

Alteration of renal function during SARS-CoV-2 infection is frequent and is associated with excess mortality. It is multifactorial, involving mechanisms more specific to COVID-19: viral invasion, endothelitis and thrombosis, activation of the renin-angiotensin-aldosterone system, and elevation of pro-inflammatory cytokines. Thus, the objective of this work was to assess renal function in patients with moderate and severe forms of COVID-19. This was a prospective cross-sectional study of patients with COVID-19. The parameters studied were age, sex, uremia, creatinine and glomerular filtration rate (GFR). All biological parameters were measured with the A15 Biosystems automated system (Barcelona, Spain) and the GFR was calculated according to the MDRD formula. Data processing was carried out with the SPSS (Statistical Package for Social Sciences) software version 23. Our study population consisted of 192 subjects with COVID-19, of which 111 were moderate and 81 were severe. The mean age of our subjects was 60 years and a sex ratio of 1.02. GFR assessment showed that 28% of the population had a lowered GFR (2). Analysis of the results according to the clinical forms showed frequencies of 19% of disturbance of renal function for the moderate forms against 40% for the severe forms. Impaired renal function appears to be frequent in patients with severe SARS-CoV-2 infection and is associated with a bad prognosis. Any patient hospitalized with SARS-CoV-2 should benefit from an initial nephrological assessment which could be used as a marker to dictate the prognosis of the severity of COVID-19.

关键词： COVID-19 CTE GFR Renal Function SARS-CoV-2

Epidemiology of Fetal Death and Analysis of Causes According to CODAC Classification at Amath Dansokho Regional Hospital of Kedougou, Senegal

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Open Journal of Obstetrics and Gynecology 2023年第12期13卷 1909-1918页

作者： mouhamadou Wade Mamour Gueye Abdoul Aziz Diouf Mouhamet Sene Khadim Faye Adjie Betty Faye Heyssam Ghais Amath Dansokho Regional Hospital of Kedougou Kedougou Senegal Gynecology and Obstetrics Department Cheikh Anta DIOP University Dakar Senegal

Objectives: This paper aims to study the epidemiology and causes of fetal deaths in utero at Regional Hospital Amath Dansokho of Kedougou (RHADK). Methodology: This was a retrospective epidemiological study conducted at the Maternity Ward of the Regional Hospital Amath Dansokho of Kedougou from June 01, 2022 to June 30, 2023, including all patients seen for delivery care. Data were analyzed using Statistical Package for Social Science (SPSS 22, Windows version). The parameters studied were the frequency of in-utero fetal death, sociodemographic characteristics, pregnancy and delivery data, neonatal data and cause-of-death classification according to the Cause of Death and Associated Conditions (CODAC) classification. Results: We recorded 1628 deliveries, with 231 cases of in-utero fetal death, a frequency of 14.2%. Fetal death occurred most frequently in multiparous women (64.5%). The majority of patients (72.3%) were transferred. 51.9% of patients with fetal death had at least 3 antenatal visits. On admission, fetal heart rate was absent in 73.2% of patients. The etiology of in-utero fetal death was dominated by maternal factors (high blood pressure, anaemia and diabetes), which accounted for 36.9% of deaths, followed by placental pathologies (retroplacental haematoma) and intrapartum pathologies (uterine rupture, abnormal presentation). Conclusion: In-utero fetal death can be prevented, and is mainly due to direct obstetric complications. The focus should be on the prevention and management of hypertensive disorders and their complications during pregnancy, the fight against anaemia and, above all, the rapid and correct management of dystocia.

关键词： Obstetrical Complications Fetal Death CODAC Classification

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老年人在非洲社会中的地位

科学与社会 1990年第1期 85-89页

作者： Amadou moustapha diop 李鹰巴黎东方语言文化学院

与公认的信念相反,在整个黑非洲,对老年人的看法和老年人受到的待遇因地而异。有些社会,老年人受到尊敬,被视为力量和知识的源泉,而另一些社会,老年人的合法地位引起争议。在受年长原则控制的社会,由于一些民族国家引进新的技术、新的... 详细信息

与公认的信念相反,在整个黑非洲,对老年人的看法和老年人受到的待遇因地而异。有些社会,老年人受到尊敬,被视为力量和知识的源泉,而另一些社会,老年人的合法地位引起争议。在受年长原则控制的社会,由于一些民族国家引进新的技术、新的管理和新的经济结构,老年人的地位正日益受到挑战。

关键词：老人统治族长人中非洲老年人地位