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“培育制造名城建设幸福株洲”背景下株洲城市IP形象设计研究

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绿色包装 2024年第9期 164-168页

作者：张弘韬牟亚菲湖南工业大学包装设计艺术学院湖南株洲412007

打造IP形象是塑造城市品牌、传播城市理念的有效途径。近年来,“培育制造名城、建设幸福株洲”已成为株洲城市发展的新定位,在此背景下,本研究阐释了城市IP形象的内涵,剖析了株洲城市IP形象的设计主题,并围绕“培育制造名城、建设幸福... 详细信息

打造IP形象是塑造城市品牌、传播城市理念的有效途径。近年来,“培育制造名城、建设幸福株洲”已成为株洲城市发展的新定位,在此背景下,本研究阐释了城市IP形象的内涵,剖析了株洲城市IP形象的设计主题,并围绕“培育制造名城、建设幸福株洲”理念提出了株洲城市IP形象的设计原则,总结归纳了设计策略。最后,本研究对株洲城市IP形象及其周边衍生产品进行了设计创作,以期为相关理论研究和行业实践提供参考依据。

关键词：制造名城幸福感株洲市城市形象 IP设计

Studies on Antibacterial Effect of Berberis julianae Schneid and Cinnamomum camphora( L.) Presl. to Avian Escherichia coli and Salmonella

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Animal Husbandry and Feed Science 2013年第3期5卷 105-107页

作者： XI Ge-ji mou ya CHEN Chao-xi College of Life Science and Technology Southwest University for Nationalities Animal Husbandry and Veterinary Bureau of Heishui County

[Objective]This study aimed to observe the antibacterial activity of Berberis julianae Schneid and Cinnamomum camphora（ L.） Presl. aqueous extracts and their antibiotical effect when being used with commonly used antibiotics in- vitro. [Method] Broth microdilution method and checkerboard dilution method were used and the reference strain E. coli ATCC25922 and clinical sample separation strains of E. coli and Salmonella were selected to determine the minimum inhibitory concentration（ MIC） and fractional inhibitory concentration（ FIC）. [Result] The MICs of Berberis julianae Schneid and Cinnamomum camphora（ L.） Presl. for E. coli and Salmonella were both 1 mg /mL,and that of other antibiotics for the two strains were in the quality control range provided by NCCLS. [Conclusion] The synergistic effect or additive effect were observed when they were applied with the commonly used antibiotics.

关键词： Berberis julianae Schneid Cinnamomum camphora(L.) Presl. Minimum inhibitory concentration(MIC) Fractional inhibitory concentration(FIC).

Evaluation of the efficacy and safety of endoscopic band ligation in the treatment of bleeding from mild to moderate gastric varices type 1

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World Journal of Gastroenterology 2024年第5期30卷 440-449页

作者： Yue Deng ya Jiang Tong Jiang Ling Chen Hai-Jun mou Bi-Guang Tuo Guo-Qing Shi Department of Gastroenterology Digestive Disease HospitalThe Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Guizhou Hospital of the First Affiliated HospitalSun Yat-sen UniversityGuiyang 550000Guizhou ProvinceChina Department of Gastroenterology Yinjiang Autonomous County People’s HospitalTongren 554300Guizhou ProvinceChina

BACKGROUND According to practice guidelines,endoscopic band ligation(EBL)and endoscopic tissue adhesive injection(TAI)are recommended for treating bleeding from esophagogastric ***,EBL and TAI are known to cause serious complications,such as hemorrhage from dislodged ligature rings caused by EBL and hemorrhage from operation-related ulcers resulting from ***,the optimal therapy for mild to moderate type 1 gastric variceal hemorrhage(GOV1)has not been ***,the aim of this study was to discover an individualized treatment for mild to moderate *** To compare the efficacy,safety and costs of EBL and TAI for the treatment of mild and moderate *** A clinical analysis of the data retrieved from patients with mild or moderate GOV1 gastric varices who were treated under endoscopy was also *** were allocated to an EBL group or an endoscopic TAI *** differences in the incidence of varicose relief,operative time,operation success rate,mortality rate within 6 wk,rebleeding rate,6-wk operation-related ulcer healing rate,complication rate and average operation cost were compared between the two groups of *** The total effective rate of the two treatments was similar,but the efficacy of EBL(66.7%)was markedly better than that of TAI(39.2%)(P<0.05).The operation success rate in both groups was 100%,and the 6-wk mortality rate in both groups was 0%.The average operative time(26 min)in the EBL group was significantly shorter than that in the TAI group(46 min)(P<0.01).The rate of delayed postoperative rebleeding in the EBL group was significantly lower than that in the TAI group(11.8%vs 45.1%)(P<0.01).At 6 wk after the operation,the healing rate of operation-related ulcers in the EBL group was 80.4%,which was significantly greater than that in the TAI group(35.3%)(P<0.01).The incidence of postoperative complications in the two groups was *** average cost and other related economic factors were g

关键词： Gastric varices Type 1 gastric variceal hemorrhage Endoscopic band ligation Tissue adhesive injection

Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone

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Chinese Medical Journal 2010年第24期123卷 3684-3688页

作者： LIAO Lin yaNG Ming QIU Lu-lu mou ya-ru ZHAO Jia-jun DONG Jian-jun Division of Endocrinology Department of Medicine Provincial Hospital affiliated to Shandong University Jinan Shandong 250021 China Department of Internal Medicine Peking University People's Hospital Beijing 100044 China Division of Endocrinology Department of Medicine Qilu Hospital of Shandong University Jinan Shandong 250012 China

Background Few studies have given suggestions on appropriate initiation insulin dosage when combined with oral antidiabetic drugs （OADs）. This research was to investigate appropriate initiation insulin doses for insulin-naive type 2diabetes patients with different combinations and the relationship between insulin dosage and relevant *** This was a randomized, open-label, treat to target study. The target was 20% decrease of both fasting plasma glucose （FPG） and 2 hours post-breakfast blood glucose （P2hBG）. One hundred and forty-seven insulin-naive Chinese patients recruited were randomiy assigned to 3 groups： group A, patients received insulin monotherapy; group B, received insulin plus metformin （0.5 g, tid） and group C, received insulin plus metformin （0.5 g, tid） and pioglitazone （15 mg, qd）.Results Both the time of getting 20% reduction of FPG and P2hBG showed significant differences among the three groups. The time was shortest in Group C. The insulin doses needed to achieve glucose reduction of 20% in three treatment groups were （0.40±0.04） U·kg-1·d-1 for Group A, （0.37±0.04） U·kg-1·d-1 for Group B, and （0.35±0.03） U·kg-1·d-1 for Group C, respectively. Multiple linear stepwise regression analysis showed that insulin doses correlated with body weight, FPG, diabetes duration, age and history of sulfonylurea treatment. The standardized regression coefficients were 0.871, 0.322, 0.089, 0.067 and 0.063 （with all P ＜0.05）.Conclusions To achieve blood glucose＇s reduction of 20% within safety context, initial insulin doses were recommended as the following： 0.40 U·kg-1·d-1 for insulin mono-therapy, 0.37 U·kg-1·d-1 for insulin plus metformin treatment, and 0.35 U·kg-1.d-1 for insulin plus metformin and pioglitazone treatment in Chinese type 2 diabetes outpatients. Body weight is found the most closely related factor to the insulin dosage.

关键词： initiation dosage insulin metformin pioglitazone type 2 diabetes

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航空发动机进口整流支板防冰槽裂纹故障分析

航空发动机 2020年第4期46卷 47-51页

作者：张弛王雅谋中国航发沈阳发动机研究所沈阳110015

为了排除某型发动机进口整流支板裂纹故障,利用故障树的排查方法分析了故障原因,并对试验件进行了断口分析、尺寸测量、动应力及残余应力测试、防冰槽结构形式及表面状态疲劳对比试验。结果表明:支板防冰槽裂纹产生的主要原因是进气机... 详细信息

为了排除某型发动机进口整流支板裂纹故障,利用故障树的排查方法分析了故障原因,并对试验件进行了断口分析、尺寸测量、动应力及残余应力测试、防冰槽结构形式及表面状态疲劳对比试验。结果表明:支板防冰槽裂纹产生的主要原因是进气机匣焊接后残余应力较大,且防冰槽边缘存在应力集中,在试车过程中,防冰槽应力集中处在转子叶片激振的作用下萌生裂纹并扩展。针对故障原因开展了结构改进设计与试验,提出了修改防冰槽宽度、倾角尺寸及增加重熔层控制等措施,使得该故障得以排除。

关键词：整流支板防冰槽进气机匣裂纹振动风扇航空发动机

Transmission Tower Stress Analysis and Online Monitoring Scheme

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Transmission Tower Stress Analysis and Online Monitoring Sch...

Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin

作者： Tuan-jie GAN Xin yaN Xi yaNG Yi-nan GENG Xin TANG ya mou Zhan-qing YU Jiangmen Power Supply Bureau of Guangdong Power Grid Co China Southern Power Grid Corporation Key Lab of Power Systems Department of Electrical EngineeringTsinghua University

So far,the theoretical study of the transmission tower line is not enough for the research and analysis of the transmission line under the wire icing and strong wind *** understanding of the disaster load mechanism,structural analysis method and vibration control is still insufficient,resulting in the accidents of broken towers caused by ice coating,wind load and geological disasters still occur frequently,which is one of the main hazards of safe operation of power *** of this paper,the failure mechanism of transmission towers in various environments is studied in ***,the mechanical characteristics of towers under environmental load are analyzed by finite element simulation ***,an online monitoring method which is based on the mechanical characteristics of transmission tower,is proposed to detect the stress state and determine if there is a fault will occur or has *** these circumstances,the force of transmission towers will be known in real time,and power grid disaster can be prevented in advance.

关键词： Transmission tower Failure mechanism Mechanical properties Online monitoring

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Traditional Medicine Research 2024年第7期9卷 25-34页

作者： Xiao-Jie Wang Ming-Jun Zhang Li-Mei Cui Zhe-Ying Song ya-Qi Wang Yu-Teng yang Xiang-Kun Zhao ya-Kui mou Yu-Mei Li Xi-Cheng Song School of Clinical Medicine Weifang Medical UniversityWeifang 261042China. Department of Otorhinolaryngology Head and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantai 264000China. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai 264000China. yantai Key Laboratory of Otorhinolaryngologic Diseases Yantai Yuhuangding HospitalYantai 264000China. The 2nd Medical College of Binzhou Medical University Yantai 264000China.

Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer ***,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear ***:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were *** analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene *** the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration ***,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by *** s:Four active ingredients of saffron and 184 of their target genes were ***,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC *** docking experiments indicated that ESR1 and CCND1 were the target genes of *** results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu ***:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating ***,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.

关键词： saffron hub genes crocetin network pharmacology analysis HNSCC ESR1 CCND1

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Morbihan病

临床皮肤科杂志 2023年第4期52卷 226-229页

作者：牟娅周小勇武汉市中西医结合医院皮肤科湖北武汉430022

报告1例Morbihan病。患者男,51岁。面部反复水肿性红斑4年余,加重4个月。皮肤科检查:额部(眉间)、上眼睑、鼻部、颧部可见水肿性红斑,其上散在分布约粟米大红色丘疹;胸部及背部可见片状境界不清的红斑。皮损组织病理检查:表皮萎缩,基底... 详细信息

报告1例Morbihan病。患者男,51岁。面部反复水肿性红斑4年余,加重4个月。皮肤科检查:额部(眉间)、上眼睑、鼻部、颧部可见水肿性红斑,其上散在分布约粟米大红色丘疹;胸部及背部可见片状境界不清的红斑。皮损组织病理检查:表皮萎缩,基底细胞空泡变性;真皮浅层可见扩张的管腔,胶原间明显水肿,血管周围可见淋巴组织细胞浸润。诊断:Morbihan病。予口服羟氯喹及异维A酸治疗,未见明显疗效。

关键词： Morbihan病酒渣鼻异维A酸

HPLC/MS/MS法分离鉴定罗通定在大鼠胆汁中的代谢产物

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中国天然药物 2006年第6期4卷 448-451页

作者：牟昀雅余伯阳中国药科大学中药复方研究室南京210038

目的:研究罗通定在大鼠胆汁中的主要代谢产物。方法:灌胃给药后,收集大鼠胆汁,液液萃取,采用HPLC/MS/MS法分析鉴定罗通定的代谢产物。色谱柱Lichrospher-C18(5μm,4.6mm×250mm),流动相:甲醇-水-三乙胺(37630.063,V/V/V),冰醋酸调pH至6... 详细信息

目的:研究罗通定在大鼠胆汁中的主要代谢产物。方法:灌胃给药后,收集大鼠胆汁,液液萃取,采用HPLC/MS/MS法分析鉴定罗通定的代谢产物。色谱柱Lichrospher-C18(5μm,4.6mm×250mm),流动相:甲醇-水-三乙胺(37630.063,V/V/V),冰醋酸调pH至6.3,检测波长281nm。结果:在大鼠胆汁中发现2个罗通定代谢产物,初步推测其结构为罗通定单羟基化后再与葡萄糖醛酸结合的产物。结论:罗通定在大鼠胆汁中主要以羟基化后的葡萄糖醛酸结合物形式排泄。

关键词：罗通定左旋四氢巴马汀胆汁代谢产物 LC/MS/MS