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Current approaches of managing microbial diseases:focus on nanosciences technique

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Journal of Coastal Life Medicine 2015年第8期 658-662页

作者： mostafa sayed mostafa el-ansary Plant Biotechnology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)University of Sadat CitySadat City22857 Egypt

Nanoscience is a fast growing research area that focuses on producing and utilizing nano-sized particles,which are measured in ***,nanoparticles are used in various ***,studies on the effect of nanoparticles on microorganisms are worthy of ***,using many antimicrobial agents has been avoided because of their methodical harmful ***,this review paper focuses on the use of some nanomaterials to manage microbial *** discussed nanomaterials as antimicrobial agents include sliver nanoparticles,gold nanoparticles and copper *** review also explains the mechanisms of action of some nanotechnological products to inhibit *** are many problems in the development of an evaluation for the effect of nanomaterials on ***,the defect of the approaches used to analyze nanomaterials toxicity gives no ground for hampering the development of nanotechnologies for safety *** order to overcome this problem,ecotoxicological studies should be extended to include the analysis of the biological safety of nanomaterials in environment and accumulate experimental data.

关键词： Nanoparticles Antimicrobial agent Mechanisms Toxicity Environment

FIRST-ORDER METHODS FOR SOLVING THE OPTIMAL STATIC H∞-SYNTHESIS PROBLEM

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Journal of Computational Mathematics 2007年第6期25卷 672-689页

作者： el-sayed M.E. mostafa Department of Mathematics Faculty of Science Alexandria University Alexandria Egypt

In this paper, we consider the static output feedback （SOF） H∞-synthesis problem posed as a nonlinear semi-definite programming （NSDP） problem. Two numerical algorithms are developed to tackle the NSDP problem by solving the corresponding Karush- Kuhn-Tucker first-order necessary optimality conditions iteratively. Numerical results for various benchmark problems illustrating the performance of the proposed methods are given.

关键词： Static output feedback H∞-synthesis Semi-definite programming Nonlinear programming.

Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani el-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu Reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa mostafa el-sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

Toxoplasma gondii infection can induce retinal DNA damage: an experimental study

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 431-436页

作者： Nagwa mostafa el-sayed Eman Mohamed Aly Department of Medical Parasitology Research Institute of Ophthalmology Department of Basic Science Biophysics and Laser Science Unit Research Institute of Ophthalmology

AIM:To detect whether Toxoplasma gondii(***)infection of mice can induce retinal DNA ***:A total of 20 laboratory-bred male Swiss albino mice were used and divided into four groups:control group(non-infected animals);*** infected group;immunosuppressed infected group;and infected group treated with sulfadiazine and *** eyes were collected 6wk post infection and retinas were *** retina was immediately processed for comet assay and the frequency of tailed nuclei(DNA damage)was *** addition,retinal DNA damage was revealed by various comet assay parameters that were provided by the image analysis software including tail length,percentage of DNA in the tail,percentage of tailed cells and tail ***:The obtained results showed that *** infection induced a statistically significant increase in the frequency of tailed nuclei,tail length,percentage of DNA in the tail,and tail moment in mice retinal cells compared to the control group(which showed some degree of DNA damage).In immunosuppressed infected group,retinal DNA damage was severing and there was significant increase in various comet assay parameters compared to both control and infected *** treatment with sulfadiazine and pyrimethamine,retinal DNA damage decreased and all comet assay parameters showed a statistical significant decrease compared to infected ***:*** infection can induce DNA damage in mice retinal cells.

关键词： Toxoplasma gondii retinochoroiditis DNA damage comet assay

Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?

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World Journal of Gastroenterology 2016年第16期22卷 4238-4249页

作者： Behairy el-sayed Behairy mostafa Mohamed Sira Khaled Refat Zalata el-sayed Ebrahem Salama Mohamed Ahmed Abd-Allah Department of Pediatric Hepatology National Liver Institute Menofiya University Department of Pathology Faculty of Medicine Mansura University

AIM: To evaluate transient elastography (TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver ***: A total of 90 children [50 with chronic hepatitis C virus (HCV), 20 with autoimmune hepatitis (AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement (LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction (FAF) using digital image analysis (morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was also performed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiver-operating characteristic curve. Cut-off values with optimal clinical performance (optimal sensitivity and specificity simultaneously) were ***: The majority of HCV group had minimal activity (80%) and no/mild fibrosis (72%). On the other hand, the majority of AIH group had mild to moderate activity (70%) and moderate to severe fibrosis (95%) and all Wilson disease group had mild to moderate activity (100%) and moderate to severe fibrosis (100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter (r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH (16.15 ± 7.23 kPa) compared to Wilson disease (8.30 ± 0.84 kPa) and HCV groups (7.43 ± 1.73 kPa). Multiple regression analysis revealed that Ishak fibrosis stage was the only ind

关键词： Autoimmune hepatitis Chronic hepatitis C Liver fibrosis Liver stiffness Morphometry Pediatrics Transient elastography Wilson disease

Dipper Throated Optimization for Detecting Black-Hole Attacks inMANETs

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Computers, Materials & Continua 2023年第1期74卷 1905-1921页

作者： Reem Alkanhel el-sayed M.el-kenawy Abdelaziz A.Abdelhamid Abdelhameed Ibrahim mostafa Abotaleb Doaa Sami Khafaga Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Communications and electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Department of Computer Science Faculty of Computer and Information SciencesAin Shams UniversityCairo11566Egypt Department of Computer Science College of Computing and Information TechnologyShaqra University11961Saudi Arabia Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt Department of System Programming South Ural State UniversityChelyabinsk454080Russia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

In terms of security and privacy,mobile ad-hoc network(MANET)continues to be in demand for additional debate and *** more MANET applications become data-oriented,implementing a secure and reliable data transfer protocol becomes a major concern in the ***,MANET’s lack of infrastructure,unpredictable topology,and restricted resources,as well as the lack of a previously permitted trust relationship among connected nodes,contribute to the attack detection burden.A novel detection approach is presented in this paper to classify passive and active black-hole *** proposed approach is based on the dipper throated optimization(DTO)algorithm,which presents a plausible path out of multiple paths for statistics transmission to boost MANETs’quality of service.A group of selected packet features will then be weighed by the DTO-based multi-layer perceptron(DTO-MLP),and these features are collected from nodes using the Low Energy Adaptive Clustering Hierarchical(LEACH)clustering *** is a powerful classifier and the DTO weight optimization method has a significant impact on improving the classification process by strengthening the weights of key features while suppressing the weights ofminor *** hybridmethod is primarily designed to combat active black-hole *** the LEACH clustering phase,however,can also detect passive black-hole *** effect of mobility variation on detection error and routing overhead is explored and evaluated using the suggested *** diverse mobility situations,the results demonstrate up to 97%detection accuracy and faster execution ***,the suggested approach uses an adjustable threshold value to make a correct conclusion regarding whether a node is malicious or benign.

关键词： Black-hole attack mobile ad-hoc network optimization dipper throated optimization

Al-Biruni Based Optimization of Rainfall Forecasting in Ethiopia

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Computer Systems Science & Engineering 2023年第6期45卷 2885-2899页

作者： el-sayed M.el-kenawy Abdelaziz A.Abdelhamid Fadwa Alrowais mostafa Abotaleb Abdelhameed Ibrahim Doaa Sami Khafaga Department of Communications and elecronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Department of Computer Science F aculty of Computer and Infomation SciencesAin Shams UniversityCairo11566Egypt Department of Computer Science College of Computing and Information TechnologyShaqra University11961Saudi Arabia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of System Progamming South Ual State UniversityChelyabinsk454080Russia Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt

Rainfall plays a significant role in managing the water level in the *** unpredictable amount of rainfall due to the climate change can cause either overflow or dry in the *** individuals,especially those in the agricultural sector,rely on rain *** rainfall is challenging because of the changing nature of the *** area of Jimma in southwest Oromia,Ethiopia is the subject of this research,which aims to develop a rainfall forecasting *** estimate Jimma's daily rainfall,we propose a novel approach based on optimizing the parameters of long short-term memory(LSTM)using Al-Biruni earth radius(BER)optimization algorithm for boosting the fore-casting accuracy.N ash-Sutcliffe model eficiency(NSE),mean square error(MSE),root MSE(RMSE),mean absolute error(MAE),and R2 were all used in the conducted experiments to assess the proposed approach,with final scores of(0.61),(430.81),(19.12),and(11.09),***,we compared the proposed model to current machine-learning regression models;such as non-optimized LSTM,bidirectional LSTM(BiLSTM),gated recurrent unit(GRU),and convolutional LSTM(ConvLSTM).It was found that the proposed approach achieved the lowest RMSE of(19.12).In addition,the experimental results show that the proposed model has R-with a value outperforming the other models,which confirms the superiority of the proposed *** the other hand,a statistical analysis is performed to measure the significance and stability of the proposed approach and the recorded results proved the expected perfomance.

关键词： Rainfall prediction long short-term memory Al-Biruni earth radius algorithm meta-heuristic optimization

Network Intrusion Detection Based on Feature Selection and Hybrid Metaheuristic Optimization

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Computers, Materials & Continua 2023年第2期74卷 2677-2693页

作者： Reem Alkanhel el-sayed M.el-kenawy Abdelaziz A.Abdelhamid Abdelhameed Ibrahim Manal Abdullah Alohali mostafa Abotaleb Doaa Sami Khafaga Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Communications and electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Department of Computer Science Faculty of Computer and Information SciencesAin Shams UniversityCairo11566Egypt Department of Computer Science College of Computing and Information TechnologyShaqra University11961Saudi Arabia Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt Information Systems Department College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of System Programming South Ural State UniversityChelyabinsk454080Russia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Applications of internet-of-things(IoT)are increasingly being used in many facets of our daily life,which results in an enormous volume of *** computing and fog computing,two of the most common technologies used in IoT applications,have led to major security *** are on the rise as a result of the usage of these technologies since present security measures are *** artificial intelligence(AI)based security solutions,such as intrusion detection systems(IDS),have been proposed in recent *** technologies that require data preprocessing and machine learning algorithm-performance augmentation require the use of feature selection(FS)techniques to increase classification accuracy by minimizing the number of features *** the other hand,metaheuristic optimization algorithms have been widely used in feature selection in recent *** this paper,we proposed a hybrid optimization algorithm for feature selection in *** proposed algorithm is based on grey wolf(GW),and dipper throated optimization(DTO)algorithms and is referred to as *** proposed algorithm has a better balance between the exploration and exploitation steps of the optimization process and thus could achieve better *** the employed IoT-IDS dataset,the performance of the proposed GWDTO algorithm was assessed using a set of evaluation metrics and compared to other optimization approaches in 2678 CMC,2023,vol.74,no.2 the literature to validate its *** addition,a statistical analysis is performed to assess the stability and effectiveness of the proposed *** results confirmed the superiority of the proposed approach in boosting the classification accuracy of the intrusion in IoT-based networks.

关键词： Feature selection grey wolf optimization dipper throated optimization intrusion detection internet-of-things(IoT)

Availability,sustainability and accessibility of agro crop residue production and solar radiation in Egypt for producing highly chemical products through pyrolysis processes

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Clean Energy 2023年第3期7卷 654-670页

作者： Saad A.el-sayed Mohamed A.Ismail Mohamed E.mostafa Emad H.Noseir Tarek M.Khass Mechanical Power Engineering Department Faculty of EngineeringZagazig UniversityAl-SharkiaEgypt Mechanical Engineering Department College of EngineeringKing Faisal UniversityAl-AhsaSaudi Arabia Environmental Engineering Department Faculty of EngineeringZagazig UniversityAl-SharkiaEgypt

This study examines the large amount of agricultural waste produced in Egypt between 2010 and 2019 by analysing data from various departments within the Agriculture *** also provides a comprehensive database on the biomass available from agricultural waste in Egypt and its potential applications for producing power,heat and chemical *** biomass-pyrolysis systems powered by solar energy are used,research demonstrates the potential to convert agricultural waste into a variety of chemical *** approach utilizes solar energy,a clean and renewable source,and has wide-ranging industrial and power generation *** Egypt’s reliance on agriculture,the country currently utilizes little biomass for energy production and has not previously used it as a source for creating chemical products,which could potentially save on the imported oil used in these *** findings of the study are graphically presented using histograms,pie charts,*** overall production of residues reached the 30-Mt level in *** it contains the most rice-cultivated land,Dakahlia(Lower Egypt region)produces the highest percentage of the total residue(37.17%).Qena governorate(Upper Egypt region)produces 1.14 metric tons of residues,with sugarcane accounting for 20.3%of the total.

关键词： biomass agro-residue solar radiation pyrolysis chemical products sustainability