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Aqueous extract of lavender(Lavandula angustifolia) improves the spatial performance of a rat model of Alzheimer's disease

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Neuroscience Bulletin 2011年第2期27卷 99-106页

作者： Masoud Soheili Kashani mostafa rezaei Tavirani Sayyed Alireza Talaei Mahmoud Salami Shaheed Beheshti医科大学蛋白质组研究中心卡珊医科大学生理学研究中心

Objective Alzheimer＇s disease（AD） is one of the most important neurodegenerative *** is characterized by dementia including def icits in learning and *** present study aimed to evaluate the effects of aqueous extract of lavender（Lavandula angustifolia） on spatial performance of AD *** Male Wistar rats were f irst divided into control and AD *** model of AD was established by intracerebroventricular injection of 10 ？g A？1-42 20 d prior to administration of the lavender *** in both groups were then introduced to 2 stages of task learning（with an interval of 20 d） in Morris water maze,each followed by one probe *** the f irst stage of spatial learning,control and AD animals received different doses（50,100 and 200 mg/kg） of the lavender *** In the first stage of experiment,the latency to locate the hidden platform in AD group was significantly higher than that in control ***,in the second stage of experiment,control and AD rats that received distilled water（vehicle） showed similar performance,indicating that the maze navigation itself could improve the spatial learning of AD ***,in the second stage of experiment,control and AD rats that received lavender extract administration at different doses（50,100,and 200 mg/kg） spent less time locating the platform（except for the AD rats with 50 mg/kg extract treatment）,as compared with their counterparts with vehicle treatment,*** addition,lavender extract significantly improved the performance of control and AD rats in the probe test,only at the dose of 200 mg/kg,as compared with their counterparts with vehicle *** The lavender extract can effectively reverse spatial learning def icits in AD rats.

关键词： Alzheimer's disease Lavandula angustifolia spatial learning rat water maze

Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

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Neuroscience & Medicine 2012年第4期3卷 362-367页

作者： Masoud Soheili mostafa rezaei Tavirani Mahmoud Salami Physiology Research Center Kashan University of Medical Sciences Kashan Iran. Proteomics Research Center Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran Student Research Committee Faculty of Paramedical Sciences Shaheed Beheshti University of Medical Sciences Tehran Iran

An important marker in neurodegenerative Alzheimer’s disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of Aβ plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of Aβ plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of Aβ 1-42. To confirm formation of Aβ plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the Aβ plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of Aβ aggregates. We concluded that the lavender extract dose dependently underlies elimination of Aβ plaques. The exact mechanism by which the herbal medicine removes the Aβ aggregates needs to be elucidated.

关键词： Alzheimer Amyloid Beta Lavandula angustifolia

Study of Contributing Factors for Cure Response in Patients with Acute Myeloblastic Leukemia （AML）

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Journal of Life Sciences 2012年第5期6卷 570-576页

作者： Sahamaz Ahmadit mostafa rezaei-Tavirani Adeleh Divsalar Soheila Khodakarim and Leila Tahmasebi Department of Biology Science and Research Branch Islamic Azad University Tehran *** lran Clinical Proteomics Research Center Faculty of Paramedical Sciences Shahid Beheshti University (M. C.) Tehran ***Iran Department of Biological Sciences Tarbiat Moallem niversity Tehran *** Iran Department of Biostatistics Faculty of Paramedical Sciences Shahid Beheshti University of Medical Sciences Tehran*** Iran Department of Hematology Faculty of Paramedical Sciences Shahid Beheshti University of Medical Sciences Tehran***. lran

Leukemia comprises a diverse group of malignancies which is accompanied with genetic disorderliness in hematopoietic cells. We evaluated effective risk factors in recovery process of under treatment patients suffering from acute myeloblastic leukemia （AML）. This study conducted a cross-sectional descriptive-analytical study on a population of 76 samples obtained non-randomly from patients in Taleghani Hospital （Tehran, Iran）. 30.3% patients resulted in death. According to logistic regression results, sexes [OR = 6.40, 95% CI = （0.27, 3.45）], ALT [OR = 1.03, 95% CI = （0.01, 0.05）] and HCT [OR = 0.55, 95% CI = （-1.12, -0.06）] were recognized as significant in prognoses. We predicted the probability of death with an error of 20.03% based on a prognoses system using support vector machine （SVM） classifier. Using this theory, we experienced an error of 20.03%. 46.6% patients with a positive and 20.8% patients without positive drug history resulted in death, which shows a significant correlation between patients＇ drug history and their death.

关键词： Acute myeloblastic leukemia risk factors support vector machine.

Thymus vulgaris L.,Glycyrrhiza glabra or Combo^(®)enzyme in corn ***-based broiler diets

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Journal of Coastal Life Medicine 2014年第12期 993-997页

作者： Majid Kalantar mostafa rezaei Jalal Salary Hamid Reza Hemati Matin Scientific Board Member of Agricultural Research Center of Qom Iran Department of Animal Science College of AgricultureSaveh BranchIslamic Azad UniversitySavehIran Department of Animal Science Faculty of AgricultureBu Ali Sina UniversityHamedanIran School of Agriculture Tarbiat Modares UniversityTehranIran

Objective:To test the effect of supplementation of Thymus vulgaris L.(***)or Glycyrrhizaglabra(***)in corn-soybean meal diets as well as the inclusion of an exogenous enzyme ***^(®)in barley-soybean meal diets together with mentioned medicinal plants in broiler ***:A total of 270 unsexed 1-day-old broiler chickens(Ross 308)was randomly assigned to 6 treatments with 3 replications of 15 birds in *** were comprised of the control(T1),the inclusion of ***,***,their mixture(equal amount),Combo^(®)supplementation(T2,T3,T4 and T5,respectively)in diets based on corn-soybean meal diets and enzyme supplementation plus equal amount of tested medicinal plants(T6)based on barley-soybean meal *** plants and enzyme were included in diets at level 0.5%and 0.2%of diets,***:The highest feed intake was obtained by T1 at 1-21 d of age(P<0.05).All diets caused significant increases in weight gain and significant decreases in feed conversion ratio compared to control at this age(P<0.05).Significant reductions were acquired in feed intake by T3 and T6 at 22-42 d of age(P<0.05).All diets significantly decreased total number of aerobic bacteria,coliforms,Gram-negative bacteria and increased lactic acid bacteria compared to control(P<0.05).Conclusions:The results showed that basal diet has vital character to effectiveness of medicinal plants in broiler *** effects on intestinal microflora were brought by use of *** *** *** in corn-based diets or in barley-based diets together with ***,this capability can support growth performance of broiler chickens at lower age.

关键词： Barley Broiler Enzyme Medicinal plant Microflora

Prediction of representative deformation modulus of longwall panel roof rock strata using Mamdani fuzzy system

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International Journal of Mining Science and Technology 2015年第1期25卷 23-30页

作者： Mohammad rezaei mostafa Asadizadeh Abbas Majdi Mohammad Farouq Hossaini School of Mining Engineering College of Engineering University of Tehran

Deformation modulus is the important parameter in stability analysis of tunnels, dams and mining struc- tures. In this paper, two predictive models including Mamdani fuzzy system （MFS） and multivariable regression analysis （MVRA） were developed to predict deformation modulus based on data obtained from dilatometer tests carried out in Bakhtiary dam site and additional data collected from longwall coal mines. Models inputs were considered to be rock quality designation, overburden height, weathering, unconfined compressive strength, bedding inclination to core axis, joint roughness coefficient and fill thickness. To control the models performance, calculating indices such as root mean square error （RMSE）, variance account for （VAF） and determination coefficient （R^2） were used. The MFS results show the significant prediction accuracy along with high performance compared to MVRA results. Finally, the sensitivity analysis of MFS results shows that the most and the least effective parameters on deformation modulus are weatherin~ and overburden height, respectively.

关键词： Deformation modulusDilatometer testMamdani fuzzy systemMultivariable regression analysis