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Inhibitory effect of Thymus vulgaris extract on memory impairment induced by scopolamine in rat

Asian Pacific Journal of Tropical Biomedicine 2015年第10期5卷 845-851页

作者： Zahra Rabiei Shiva Mokhtari Samira Asgharzade mostafa gholami Samira Rahnama Mahmoud Rafieian-kopaei Medical Plants Research Center Shahrekord University of Medical Sciences Department of Molecular Medicine Faculty of Advanced Medical TechnologiesTehran University of Medical Sciences Clinical Biochemistry Research Center Shahrekord University of Medical Sciences

Objective: To investigate the effect of Thymus vulgaris(T. vulgaris) on learning and memory functions in scopolamine-induced memory deficit in rats. Memory enhancing activity in scopolamine-induced amnesic rats was investigated by assessing the Morris water maze and passive avoidance ***: A total of 42 male Wistar rats were divided into 6 equal groups as follow:control group: received water, scopolamine treated group: received scopolamine 1 mg/kg for 15 days, two scopolamine + T. vulgaris treated groups: received scopolamine and T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days, two intact groups:received T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 ***: Administration of T. vulgaris extract significantly restored memory and learning impairments induced by scopolamine in the passive avoidance test and Morris water maze ***: T. vulgaris extract has repairing effects on memory and behavioral disorders produced by scopolamine and may have beneficial effects in the treatment of Alzheimer’s disease.

关键词： vulgaris Thymus impairment deficit avoidance resto

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Evaluation of plant growth and spacing effects on bioengineered slopes subjected to rainfall

Biogeotechnics

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Biogeotechnics 2024年第2期2卷 19-27页

作者： Farshad Yazdani Hamed Sadeghi Pouya AliPanahi mostafa gholami Anthony Kwan Leung Department of Civil Engineering Sharif University of TechnologyAzadi Ave.TehranIran Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Shallow landslides can be mitigated through the hydro-mechanical reinforcement provided by vegetation. Several critical parameters, such as plant spacing and plant age, play a significant role in influencing bioengineered slope stability facilitated by vegetation. However, the coupling of these effects on the stability of vegetated slope has been ignored. The objective of this study is to investigate the hydro-mechanical impact of vegetation growth and spacing on the stability of bioengineered slopes based on the predictions of a calibrated numerical model against field measurements. The impact of vegetation is investigated, with specific attention given to different plant spacing and growth stages, utilizing Schefflera arboricola. In the context of rainfall, it was observed that younger vegetation demonstrated more effective matric suction retention and recovery up to 25 kPa compared to the aged vegetation. Vegetation was revealed to substantially enhance the factor of safety up to 0.3 compared to the bare slope. Plant growth and reducing plant spacing increased the impact of root systems on both hydraulic and mechanical stability, primarily attributable to the influence of root cohesion rather than transpiration rates. The results revealed that the mechanical contribution to the factor of safety enhancement was raised from one-third to two-thirds because of the vegetation-induced cohesion within the growing rooted zone.

关键词： Bioengineered slopes Shallow landslide Plant age Plant spacing Slope stability

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Oncolytic viruses:A novel treatment strategy for breast cancer

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Genes & Diseases 2023年第2期10卷 430-446页

作者： Mohammad Javanbakht Sanaz Tahmasebzadeh Luca Cegolon Nasrin gholami Mandana Kashaki Hassan Nikoueinejad Mohamad Mozafari Mahsa Mozaffari Shi Zhao mostafa Khafaei Morteza Izadi Saeid Fathi Reza Akhavan-Sigari Nephrology and Urology Research Center Baqiyatallah University of Medical SciencesTehran ***Iran Mehrestan Health Network Iranshahr University of Medical SciencesIranshahr ***Iran University of Trieste Department of MedicalSurgical & Health SciencesTrieste 34128Italy University Health Agency Giuliano-Isontina (ASUGI) Public Health DepartmentTriesteItaly Hematology and Oncology Research Center Tabriz University of Medical SciencesTabriz ***Iran Shahid Akbarabadi Clinical Research Development Unit (ShACRDU) Iran University of Medical Sciences (IUMS)Tehran ***Iran Department of General Surgery Urmia University of Medical ScienceUrmia 57147Iran Department of Pediatrics Iran University of Medical SciencesTehran ***Iran JC School of Public Health and Primary Care Chinese University of Hong KongHong Kong Special Administrative Region 999077China Human Genetics Research Center Baqiyatallah University of Medical SciencesTehran 169875931Iran Health Research Center Baqiyatallah University of Medical SciencesTehran ***Iran Razi Vaccine and Serum Research Institute Agriculture ResearchEducation and Extension Organization (AREEO)Karaj 11365-1558Iran Department of Neurosurgery University Medical CenterTuebingen 72076Germany

Breast cancer,an unceasingly occurring neoplasm,is one of the major determinants of mortality in *** ineffective attempts have been pursued using with conventional therapies against breast *** to existing therapies and their respective debilitating adverse effects have led research toward a new era of cancer treatment using *** constitutes a developing treatment modality with multiple mechanisms of therapeutic activity in which the viruses can be directly oncolyticand can express transgenes or induce host immune response against tumor *** different DNA-and RNA-containing viruses have been considered for virotherapy of breast cancer including adenovirus,herpes virus,vaccinia,reovirus,Newcastle Disease virus,measles virus and vesicular stomatitis *** review aims to summarize the viro-therapeutical agents against breast *** Scientific Concepts of Review:In this review paper,we proposed a new strategy to virus's combinatorial treatments using several kinds of transgenes and *** recombinant viruses have provided evidence of treatment efficacy against human breast cancer.

关键词： Adenovirus Breast cancer Herpes virus Measles virus Newcastle disease virus Reovirus Vaccinia Vesicular stomatitis virus Virotherapy

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Survey of epidemiology and bacteriology features of cholera in Iran

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 45-47页

作者： Mohammad Rahbar Mohsen Zahraei Aboulgasm Omidvarnia Mohammad Taqi Afshani mostafa Glami Rogaeieh Sabourian Shahla Farsi Hosein gholami Saeid Mahdavi Parisa Islami Mona Mohammad Zadeh Massoud Hajia Azar Valipour Rana Amini Department of Microbiology Iranian Reference Health LaboratoryHafez StreetZartoshteian AveKeikhosrow Shahrookh AlleyNo 48TehranIran Department of Food Borne Disease Control Center for Disease Control and Prevention of IranHefez StreetTehranIran Department of Microbiology Central LaboratoryMilad HospitalHemmat High Way TehranIran

Objective:To determine epidemiology and antimicrobial susceptibility patterns of Vibrio(V.) cholerae O1 biotype EL Tor in summer outbreak of 2008 in ***:Stool samples were collected from patients suspected to have cholera admitted to hospitals and *** examined by conventional bacteriological *** isolates were sent to cholera reference laboratory for further confirmation,stereotyping and susceptibility ***:A total of 220 patients were diagnosed as *** cases confirmed by Iranian reference health *** hundred ninety nine of 220 *** serotypes were Inaba and 21 serotypes were *** cases were reported from thirteen *** majorities of cases were from Tehran,Qum and Zahedan provinces with 56,26 and 25 cases respectively.24(11%) of patients were under 15 years old and 196(89%) of patients were older than 15 years.149(68%) of patients were male and 71(32 %) were female.129(59%) of patients had Iranian nationality,79(36.5%) were from Afghanistan and,12(5%) were from *** isolates were resistant to co-trimoxazole,nalidixic acid,furazolidone,and intermediate to chloramphenicol and were susceptible to tetracycline, ciprofloxacin,and ***:Our study reveals that in recent outbreak caused by *** EL Tor serotype Inaba is the predominant *** isolates are resistant to cotrimoxazole. nalidix acid and furazolidon.

关键词： Cholera Epidemiology Drug resistance

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