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CA19-9 antigen levels can distinguish between benign and malignant pancreaticobiliary disease

Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 620-626页

作者： Gareth morris-Stiff Mary Teli Nicky Jardine Malcolm CA Puntis Department of Surgery University Hospital of Wales

BACKGROUND:CA19-9 is a carbohydrate tumor-associated antigen which is frequently upregulated in pancreatobiliary ***,it may also be elevated in patients with jaundice in the absence of a tumor due to biliary obstruction,and in other non-hepato-pancreatico-biliary *** study aimed to evaluate whether CA19-9 levels could accurately differentiate between benign and malignant pancreatobiliary ***:All patients referred to a single surgeon for investigation of pancreaticobiliary disease in 2003 in whom a firm diagnosis had been established were *** malignant disease,a histological diagnosis was required but for benign disease a firm radiological diagnosis was deemed *** patients were divided into 4 categories:pancreatic adenocarcinoma(PCa);cholangiocarcinoma(CCa);chronic pancreatitis(CP)and biliary calculous disease(Calc).Bilirubin and alkaline phosphatase levels corresponding to the point of assessment of CA19-9 were also ***:Final diagnoses were made of pancreatic adenocarcinoma(PCa,n=73),cholangiocarcinoma(CCa,n=19),ampullary carcinoma(Amp,n=7),neuroendocrine carcinoma(Neu,n=4),duodenal carcinoma(Duo,n=3),chronic pancreatitis(CP,n=115),and biliary calculous disease(Calc,n=27).Median CA19-9 levels(U/ml)were:PCa,653;CCa,408;Duo,403;Calc,27;CP,19;Neu,10.5;Amp,8(reference range:0-37).The CA19-9 levels were significantly greater for malignant than for benign disease,could differentiate PCa from CCa/Duo,and were significantly higher in unresectable than in resectable *** sensitivity,specificity,positive predictive value(PPV)and negative predictive value(NPV)for CA19-9 were 84.9%,69.7%,67.7%and 86.1%,respectively.A ROC analysis provided an area under the curve for CA19-9 of 0.871(0.820-0.922),giving an optimal CA19-9 of 70.5 U/ml for differentiating benign from malignant *** this cut-off,the sensitivity was 82.1%,while specificity,PPV and NPV improved to 85.9%,81.3%and 86.5%,*** sta

关键词： CA19-9 antigen pancreatic disease biliary tract disease malignant benign

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作者： Jan morris.

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Mechanism and catalytic performance for direct dimethyl ether synthesis by CO2 hydrogenation over CuZnZr/ferrierite hybrid catalyst

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Journal of Environmental Sciences 2020年第6期32卷 106-117页

作者： Qingtao Sheng Run-Ping Ye Weibo Gong Xiufeng Shi Bang Xu morris Argyle Hertanto Adidharma Maohong Fan College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Engineering and Applied Science University of WyomingLaramieWY 82071USA Key Laboratory of Coal to Ethylene Glycol and Its Related Technology Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFujian 350002China University of Chinese Academy of Sciences Beijing 100049China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China Department of Chemical Engineering Brigham Young UniversityUT 84602USA Department of Petroleum Engineering University of WyomingLaramieWY 82071USA School of Energy Resources University of WyomingLaramieWY 82071USA School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Direct synthesis of dimethyl ether(DME)by CO2 hydrogenation has been investigated over three hybrid catalysts prepared by different methods:co-precipitation,sol-gel,and solid grinding to produce mixed Cu,ZnO,ZrO2 catalysts that were physically mixed with a commercial ferrierite(FER)*** catalysts were characterized by N2 physisorption,X-ray diffraction(XRD),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),temperature programmed desorption of CO2(CO2-TPD),temperature programmed desorption of NH3(NH3-TPD),and temperature programmed H2 reduction(H2-TPR).The results demonstrate that smaller CuO and Cu crystallite sizes resulting in better dispersion of the active phases,higher surface area,and lower reduction temperature are all favorable for catalytic *** reaction mechanism has been studied using in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS).Methanol appears to be formed via the bidentate-formate(b-HCOO)species undergoing stepwise hydrogenation,while DME formation occurs from methanol dehydration and reaction of two surface methoxy groups.

关键词： CO2 hydrogenation Ether Dimethyl ether(DME)synthesis Mechanism

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Dominant species of mid-elevation grasslands of the uKhahlamba-Drakensberg Park are predicted to be largely immune to climate change

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山地科学学报(英文) 2023年第9期20卷 2468-2486页

作者： Debbie JEWITT Craig D.morris Tim G.O’CONNOR Michelle J.TEDDER Ezemvelo KZN Wildlife Scientific ServicesPO Box 13053Cascades 3202South Africa School of Animal Plant and Environmental SciencesUniversity of the WitwatersrandJohannesburgPrivate Bag X3WITS 2050South Africa Agricultural Research Council-Animal Production(ARC-AP) ℅School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa

Anticipating global change impact on natural vegetation,especially in poorly researched systems,requires an understanding of the environmental factors that most strongly influence the organisation of plant communities at different *** environmental relations of plant communities in the Drakensberg mountains of South Africa remain poorly *** study investigated the influence of selected environmental determinants on the dominant species of plant community organisation in this *** order to provide an overview of the influence of the environment on botanical composition and plant diversity,this study,conducted as four discrete exercises,investigated the interplay of altitude,aspect and slope on the abundance of selected species,and to examine the influence of latitude,geological substrate and local topography on species *** diversity showed no pattern of response to investigated environmental *** composition was related to temperature and solarradiation *** altitude sites facing east were distinct for non-graminoid *** and latitude exerted a pronounced effect on species composition,confounded by longitude and precipitation *** substrate,in concert with slope steepness and orientation,influenced composition,restricting the abundance but not distribution of some *** individualistic responses were found for C_3,C_4,and non-graminoid species in relation to altitude,slope and *** and aspect mediate the effects of altitude and hence temperature for some *** study has demonstrated the complexity of drivers influencing species and compositional distribution in the Drakensberg and permits a preliminary consideration of potential changes in the composition and dominance structure of mid-elevation grasslands in response to climate *** dominant grass species were widespread across environmental gradients,occupying currently warm,cool,moist and dry habitats

关键词： Drakensberg Environmental gradients Grasslands Mountain biodiversity Vegetation

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Pancreaticopleuralfistula:etiology,treatmentandlong-termfollow-up

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 215-219页

作者： Keith J Roberts Maria Sheridan Gareth morris-Stiff Andrew M Smith Department of Pancreatic Surgery St James University HospitalLeedsUK

BACKGROUND:Pancreaticopleural fistula(PPF) are *** multidisciplinary treatment is required due to nutritional compromise and *** is the first description of long-term follow-up of patients with ***:Eleven patients with PPF treated at a specialist unit were ***,investigation,treatment and outcomes were ***:Pancreatitis was the etiology of the PPF in 9 patients,and in the remaining 2 the PPF developed following distal ***-sectional imaging demonstrated the site of duct disruption in 10 cases,with endoscopic retrograde cholangiopancreatography identifying the final *** of pancreatic exocrine secretion and percutaneous drainage formed the mainstay of *** cases resolved following pancreatic duct stent insertion and three patients required surgical treatment for established *** were no *** all cases that resolved there has been no recurrence of PPF over a median follow-up of 50 months(range 15-62).CONCLUSIONS:PPF is an uncommon event complicating pancreatitis or pancreatectomy;pancreatic duct disruption is the common link.A step-up approach consisting of minimally invasive techniques treats the majority with surgery needed for refractory sepsis.

关键词： pancreatic disease pancreatitis pancreatic pseudocyst

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Fishing for Atlantic cod (Gadus morhua) with pots and gillnets: A catch comparison study along the southeast coast of Labrador

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Aquaculture and Fisheries 2022年第4期7卷 433-440页

作者： Khanh Q.Nguyen Corey J.morris Fisheries and Oceans Canada Northwest Atlantic Fisheries CentreSt.John’sNewfoundlandA1C5X1Canada

Gillnets are the primary fishing gear used to catch Atlantic cod(Gadus morhua)in coastal areas of Newfoundland and Labrador but are known to catch non-target species and produce lower quality fish than live-catch *** purpose of this study was to compare the catch efficiency of collapsible cod pots against gillnets near the Gilbert Bay Marine Protected Area(MPA),Labrador,where a reduction in by-catch is *** showed that one cod pot caught half as much Atlantic cod as a gillnet,and pots had a relatively stable catch rate throughout the sampling period,whereas gillnets caught relatively few fish later in the sampling ***,nearly all fish sampled with pots were caught alive undamaged,whereas most gillnet-caught fish experienced damage or *** a conservation measure pot-fishing would enable fishing within close proximity to the Gilbert Bay MPA and the live-release of visually distinguishable Gilbert Bay cod,thereby mitigating against the negative effects of commercial fishing on this protected Atlantic cod population.

关键词： Catch rates Cod pots Bycatch reduction Gillnets Conservation Atlantic cod fishery

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Traditional Medicine Diagnostic Codes in ICD-11 and Alternative Diagnostic Classifications in the Mainstream Healthcare

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Chinese Medicine and Culture 2021年第2期4卷 86-92页

作者： Ioannis Solos William morris Jian-Ping Zhu Mei Hong Foundation for PIHMA Research and Education Phoenix 85012ArizonaUSA A0MA Graduate School of Integrative Medicine Austin 78745TexasUSA Institute for History of Medicine and Medical Literature China Academy of Chinese Medical SciencesBeijing 100700China

In 2018,the 11^(th) Edition of the International Classification of Diseases(ICD-11)defined a diagnostic code list for standard traditional medicine(TM)*** codes improve patient safety by providing more comprehensive and accurate medical records for hospitals in the Western Pacific *** these facilities,TM is often a standard of care for those *** several mainstream media sources,writers are circumventing evidence-based peer-reviewed medical literature by unduly influencing public opinion and,in this case,against the new ICD-11 *** dangers imposed by the transgression of popular writing onto the discipline of peer-reviewed works are present since best practices in medical record-keeping will fail without the inclusion of TM in the ICD-11 *** failures directly affect the health of the patients and policymakers in regions where TM and conventional medicine are *** article investigates the boundaries between substantial evidence and popular *** this era where media is used to manipulate evidence,the reader’s use of sound judgment and critical thought are *** article also challenges three controversial themes in pop literature,including the threat to endangered species,increased patient risk,and contaminants in the *** themes are made without evidence and are,in fact,of flawed *** is no reason to assume that improved medical record-keeping and knowledge of patient cases increase risks.

关键词： Endangered species 11^(th)Edition of the International Classification of Diseases(ICD-11) medical error pattern differentiation terminology study traditional medicine

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Ecological connectivity in fragmented agricultural landscapes and the importance of scattered trees and small patches

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Ecological Processes 2021年第1期10卷 274-289页

作者： Darrel Chin Fung Tiang Andrew morris Mathew Bell Christopher NGibbins Badrul Azhar Alex MLechner School of Environmental and Geographical Sciences University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangorMalaysia MidCoast Council 2 Biripi WayTareeNSW 2430Australia Faculty of Forestry&Environment Universiti Putra Malaysia43400 SerdangSelangorMalaysia Lincoln Centre for Water and Planetary Health School of GeographyUniversity of LincolnLincoln LN67TSUK

Background:Fragmentation and habitat loss can restrict species movement and reduce connectivity,negatively impacting *** the overall connectivity of an area can inform better management of human modified *** connectivity modelling methods seldom incorporate fine-scale movement patterns associated with movement between fine-scaled structural connectivity elements such as scattered trees,roadside corridors and small patches of *** study aims to characterise connectivity within the Karuah-Myall catchments,a typical woodland ecosystem that is fragmented by agriculture,using least-cost path analysis and a graph-theoretic approach;it focuses on how fine-scaled vegetation such as scattered trees support *** mapped scattered(and paddock)trees within this agricultural landscape where the main human modified land use was *** modelled connectivity for a general representative woodland species using an interpatch dispersal distance and gap crossing threshold,and resistance from different land cover *** gap crossing distance threshold was used to model movement between fine-scaled vegetation *** compared the least-cost paths modelled with and without scattered ***:Our results show that by excluding scattered trees,least-cost paths across the cleared pasture landscape did not reflect the types of movement patterns typically observed from field studies,such as those associated with a foray-search strategy used by small and medium mammals and *** modelling also shows that the KaruahMyall catchments are well connected and provide value to biodiversity beyond the catchment borders,by connecting coastal vegetation to the Great Eastern Ranges national wildlife corridor ***:Connectivity models that exclude fine-scale landscape features such as scattered trees and small,linear patches risk misrepresenting connectivity *** of regional-scale connectivity can b

关键词： Scattered trees Landscape connectivity Gap crossing Fragmentation Agricultural landscape

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Responses to oral glucose challenge differ by physical activity volume and intensity: A pilot study

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Journal of Sport and Health Science 2020年第6期9卷 645-650页

作者： Trevor N.Simper Cecile morris Anthony Lynn Ciara O’Hagan Karen Kilner Food Group Sheffield Business School Sheffield Hallam UniversitySheffield S11WBUK Academy of Sport and Physical Activity Sheffield Hallam UniversitySheffield S102BPUK Department for Health and Social Care Research Sheffield Hallam UniversitySheffield S102BPUK

Background:One-hour postprandial hyperglycemia is associated with increased risk of type 2 diabetes and cardiovascular *** activity(PA)has short-term beneficial effects on post-meal glucose *** study compared the oral glucose tolerance test results of 3 groups of people with habitually different levels of ***:Thirty-one adults without diabetes(age 25.9±6.6 years;body mass index 23.8±3.8 kg/m^2;mean±SD)were recruited and divided into 3 groups based on self-reported PA volume and intensity:low activity0.05).The groups were significantly different in terms of baseline glucose level(p=0.003)and,marginally,for gender(p=0.053)and BMI(p=0.050).There was a statistically significant effect of PA on the 1-h postprandial glucose results(p=0.029),with differences between very active and low activity groups(p=0.008)but not between the moderately active and low activity groups(p=0.360),even when baseline glucose level and gender differences were accounted *** incremental area under the curve there was no significant effect of activity group once gender and body fat percentage had been accounted for(p=0.401).Those in the low activity group took 15 min longer to reach peak glucose level than those in the very active group(p=0.012).Conclusion:The results suggest that high levels of PA have a beneficial effect on postprandial blood glucose profiles when compared to low and moderate levels of activity.

关键词： Blood glucose response Incremental area under the curve Oral glucose tolerance test Physical activity Time to peak Type 2 diabetes

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Mechanical Behaviour and Structure Instability of Al_3Ti Alloy

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Journal of Materials Science & Technology 1994年第1期10卷 1-14页

作者： D.G.morris(Institute of Structural Metallurgy, University of Neuchatel, Avenue de Bellevaux 51, Neuchatel, Switzerland) Univ of Neuchatel Neuchatel Switzerland

Trialuminide alloys of elements such as Ti. Nb or Zr are of particular interest as materials for high temperature usage because their density is very low and specific strength and elastic rnoduli are then very high. This report concentrates on recent work on Al3Ti alloys which have been alloyed with ternary elements such that the higher symmetry ordered cubic structure is obtained, leading to somewhat easier operation of deformation mechan isms and hence improved ductility and *** details of the crystal structure of cubic trialuminides are considered here and it is shown that the materials generally possess some remnant tetragonal chemical ordering which can affect their me chanical behaviour. In addition the compositional range over which a stable single phase is retained is shown to be extremely small, such that in most cases the materials examined show some form of microstructural instability. These instabilities affect the mechanical behaviour of the materials, for exarnple producing general strengthening. leading to precipitation hardening du ring hig h temperature testing, and causing age hardening instabilities during high temperature static or dynamic *** structural instabifity feads to significant modifications at superdislocations, affecting both the dislocation cores and their associated APB's. Failure for these cubic materials still occurs at very small plastic strains and seems to be determined by difficulties of superdislocation creation near a propagating crack rather than by problems of suitable dislocation configuration and mobility. Possible ways to enhance ductility and toughness by alloying and microstructural modification will be discussed.

关键词： Ti Figure Mechanical Behaviour and Structure Instability of Al3Ti Alloy Al

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