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JT—60U和JFT—2m.最近实验结果的综述

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国外核聚变与等离子体应用 1995年第3期 31-42页

作者： mori,m.胡明等

本文报道在JT－60U和JFT－2m.H模式的最近实验结果。在JT－60U中具有边缘输运位垒的增强约束模式（H模式）的特点是高的边缘离子温度。约束改善完全与边缘离子温度有关。在JT－60U中在弱磁场（－2T）时的H模式与JFT－2m.的H模式具有... 详细信息

本文报道在JT－60U和JFT－2m.H模式的最近实验结果。在JT－60U中具有边缘输运位垒的增强约束模式（H模式）的特点是高的边缘离子温度。约束改善完全与边缘离子温度有关。在JT－60U中在弱磁场（－2T）时的H模式与JFT－2m.的H模式具有类似特征：Da发射的迅速减小。然而，在强磁（－4T）和低密度时的H模式中，在JT－60U中没有观察到清楚的转变，虽然约束仍因边缘输运位垒而得到改善。在两个托马克中也研究了碰撞性和输运位垒的宽度，并且与Shaing理论作了比较。在JT－60U中证明了H转变使高βp模式放电约束改善。由于这种改善已经达到的聚变三乘积的创纪录值为1.1×10^21m.-3·s·keV.在JT－60U中，通过控制边缘定域模（ELm.的重复率，也已证实H因数约为1.8的准稳态H模式运行。在JFT－2m.使用一种新的主动方法，即螺旋磁场扰动，已成功地诱发了ELm.性，结果获得了稳态H模式。

关键词：托卡马克 H模式 ELm 输运位垒

Cancer im.unotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction

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World Journal of Gastroenterology 2015年第40期21卷 11396-11410页

作者： m.sahiro Tanem.ra Eiji m.yoshi Hiroaki Nagano Hidetoshi Eguchi Katsuyoshi m.tsunam. Kiyom. Taniyam. Nobutaka Hatanaka Hiroki Akam.tsu m.saki mori Yuichiro Doki Departm.nt of Surgery Osaka Police Hospital10-31 Kitayamacho Tennoujiku Departm.nt of m.lecular Biochem.stry and Clinical Investigation Osaka University Graduate School of Medicine Departm.nt of Digestive Surgery and Surgical Oncology Yamaguchi University Graduate School of Medicine Departm.nt of Gastroenterological Surgery Osaka University Graduate School of Medicine Departm.nt of Pharm.cognosy Graduate School of Biomedical and Health SciencesHiroshima University Departm.nt of Surgery and Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center

Pancreatic ductal adenocarcinom.(PDAC) has the poorest prognosis of all m.lignancies and is largely resistant to standard therapy. Novel treatm.nts against PDAC are desperately needed. Anti-Gal is the m.st abundant natural antibody in hum.ns,com.rising about 1% of im.unoglobulins and is also naturally produced in apes and Old World m.nkeys. The anti-Gal ligand is a carbohydrate antigen called "α-gal epitopes" with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as m.jor carbohydrate antigens in non-prim.te m.m.als,prosim.ans,and New World m.nkeys. Anti-Gal is exploited in cancer vaccines to increase the im.unogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tum.r lysates are processed to express α-gal epitopes. Vaccination with these com.onents results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine com.onents,transport of the vaccine tum.r m.m.ranes to draining lym.h nodes,and processing and presentation of tum.r-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against m.ltiple TAAs contained in PDAC cells and induce activation of m.ltiple tum.r-specific T cells. Here,we review new areas of clinical im.ortance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in im.unotherapy against PDAC.

关键词： Pancreatic cancer Im.unotherapy Cancer antigen m.C

Phase 1/2 study of concurrent chem.radiotherapy with weekly irinotecan hydrochloride for advanced/recurrence uterine cancer:A m.lti-institutional study of Kansai Clinical Oncology Group

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Chinese Journal of Cancer Research 2020年第2期32卷 218-227页

作者： Satoshi Takeuchi Haruo Kuroboshi Taisuke mori Kim.hiko Ito Eiji Kondo Tsutom. Tabata Yoshio Itani Ryuji Kawaguchi Kyosuke Takeuchi Toshinori Soejim. Ryohei Sasaki Departm.nt of Obstetrics and Gynecology National Hospital Organization Kobe Medical CenterKobe 6540155Japan Division of Gynecologic Oncology Department of GynecologyWomen Health CareKobe Tokushukai HospitalKobe 6500017Japan Departm.nt of Obstetrics and Gynecology Kyoto Prefectural University of MedicineKyoto 6028566Japan Departm.nt of Obstetrics and Gynecology Kansai Rosai HospitalAmagasaki 6608511Japan Departm.nt of Obstetrics and Gynecology Mie University Graduate Medical School Faculty of MedicineTsu5148507Japan Departm.nt of Obstetrics and Gynecology Tokyo Women’s Medical UniversityTokyo 1628666Japan Departm.nt of Obstetrics and Gynecology Nara Prefectural Nara Hospital(Nara Prefectural General Medical Center)Nara 6308581Japan Departm.nt of Palliative Care Palliative Care Center of Yao-city HospitalOsaka 5810069Japan Departm.nt of Obstetrics and Gynecology Nara Medical UniversityNara 6348521Japan I0Departm.nt of Radiation Oncology Kobe University Graduate School of MedicineKobe 6500017Japan departm.ent of Radiation Oncology Hyogo Ion Beam Medical Center Kobe Proton CenterKobe 6500047Japan

Objective:Concurrent chem.radiotherapy using cisplatin was thought to be standard treatm.nt for squam.us cell carcinom. of cervix,but it had not been effective for *** chem.radiotherapy using irinotecan hydrochloride(CPT-11)had been effective for colorectal cancer,thus,we chose CPT-11 as a candidate for gynecologic *** evaluate the m.xim.m.tolerated dose(m.D)of weekly CPT-11 with external pelvic radiotherapy,a phase 1/2 study was conducted according to m.dified Fibonacci ***:Eligible patients were advanced uterine cancer with m.asurable diseases[perform.nce score(PS):0-2].Study period was from.August 1 st,2002 to Decem.er 31 st,*** starting dose level(DL)of CPT-11 was 30 m./m.(DL1)given weekly for 4 ***,dose escalation was scheduled in 10 m./m. increm.nts to 60 m./m.2(DL4).The fixed radiotherapy consisted of whole pelvic 1.8 Gy/d,once a day in weekday for five weeks and it am.unted to 45 Gy(25 fractions)in ***:Seventeen patients were *** for toxicities,one(1/17:5.9%)grade(G)4 neutropenia lasting 7 days had been seen in DL4.G2 diarrhea was identified in 35.3%(6/17)of the patients,and 11.8%(2/17)G3 diarrhea was observed in DL3 and ***,the m.D of CPT-11 was defined as dose of 60 m./m.*** recom.ended dose was decided as 50 m./m.*** response rate was 88.2%[9 com.lete response(CR),3 partial response(PR),3 stable disease(SD),2 not evaluable(NE)].Disease control rate at 1 m.nth after treatm.nt com.letion was 100%but distant m.tastases were found in 24%(4/17)in longer ***:m.D was 60 m./m.2 and recom.ended dose was set as 50 m./*** concurrent chem.radiation using weekly CPT-11 was feasible at 50 m./m.2,and it m.ght be effective even in adenocarcinom. of the uterus.

关键词： Concurrent chem.radiotherapy(CCRT) irinotecan hydrochloride(CPT-11) cervical adenocarcinom. endom.trial cancer

Physiological functions of hem.cytes newly em.rged from.the cultured hem.topoietic organs in the silkworm. Bom.yx m.il

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Insect Science 2010年第1期17卷 7-20页

作者： Cheng-Long Wang Zhi-Xiang Wang m.chael m. Kariuki Qing-Zhi Ling Kenji Kiguchi Er-Jun Ling Research Centre for Insect Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai China Departm.nt of Veterinary Pathobiology College of Veterinary Medicine University of Missouri Columbia MO 65211 USA Departm.nt of Applied Biology Zhejiang Pharmaceutical College Ningbo Zhejiang Province China Laboratory of Silkworm.Physiology Department of Applied Biology Faculty of Textile Science and Technology Shinshu University Ueda Nagano 386-8567 Japan

Cellular im.unity is a very im.ortant part of insect innate im.unity. It is not clear if hem.cytes entering the hem.lym.h require a m.turation process to becom. com.etent. The establishm.nt of a tissue culture system.for the insect hem.topoietic organs would enable physiological function assays with hem.cytes newly em.rged from.hem.topoietic organs. To this end, we established a hem.topoietic organ culture system.for the purebred silkworm.pnd pS and then studied the physiological functions of the newly em.rged hem.cytes. We found that Grace＇s m.dium.supplem.nted with 10% heated silkworm.larval plasm. was better for culturing the hem.topoietic organs ofpndpS. Newly em.rged hem.cytes phagocytosed propidium.iodide-labeled bacteria and encapsulated the Im.-2 coated nickel beads as well as pupal tissue debris. This culture system.is therefore capable of generating physiologically functional hem.cytes. These hem.cytes can be used to study the m.chanism. of the hem.cyte im.une response am.ng others.

关键词： Bom.yx mori encapsulation hem.cyte hem.topoietic organ phagocytosis tissue culture

High-throughput Three-dim.nsional Gel Electrophoresis for Versatile Utilities: A Stacked Slice-gel System.for Separation and Reactions (4SR)

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Genom.cs, Proteom.cs & Bioinform.tics 2006年第1期4卷 26-33页

作者： m.. Salim.llah m.saki mori Koichi Nishigaki Departm.nt of Functional m.terials Science Saitama University Saitama 338-8570 Japan Rational Evo-lutionary Design of Advanced Biom.lecules (REDS) Group Saitama Small Enterprise Promotion CorporationSKIP City Kawaguchi 333-0844 Japan.

A novel high-throughput system. called the stacked slice-gel system.for separation and reactions （4SR）, was developed for the analysis of DNA/RNA and protein/peptide. The system.provides a novel three-dim.nsional gel electrophoresis approach that exploits the property of stacked slice gels. It allows m.ltiple sam.les sim.ltaneously to react as well as to be separated, offering a two-dim.nsional （m.n） sam.le loading system. For this purpose, high-throughput m.lti-m.cro vessels （m.Vs） containing variable num.ers of wells （100 wells in this paper） have been used, which are m.de of 25 m. square-size polyacrylam.de gels. Furtherm.re, after electrophoretic separation, a slice gel containing a desired sam.le can be easily rem.ved and proceeded to the next step. Different biological reactions as well as successive separation of products were effectively carried out dealing with DNA/RNA and protein/peptide. It shows that this system.has a diversity of potentials to be developed.

关键词： three-dim.nsional polyacrylam.de gel electrophoresis (3D-PAGE) high-throughput screening three-dlm.nsional separation m.croarray technology

BOILING AND CONDENSATION HEAT TRANSFER FOR NEW REFRIGERANTS HFE245m. AND HFE143m.FLOWING IN HORIZONTAL TUBES

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BOILING AND CONDENSATION HEAT TRANSFER FOR NEW REFRIGERANTS ...

Solution Stirring Enables to Generate Nucleation and Im.rove Quality of Adenosine Deam.nase Crystal

第一届亚洲制冷空调大会

作者： Hideo mori Suguru YOSHIDA Katsum. OHISHI Departm.nt of m.chanical Engineering Science Faculty of Engineering Kyushu University 6-10-1 Hakozaki Higashi-ku Fukuoka 812-8581 Japan Departm.nt of m.chanical Engineering Science Faculty of Engineering Kyushu University 6-10-1 Hakozaki Higashi-ku Fukuoka 812-8581 Japan Departm.nt of m.chanical Engineering Science Faculty of Engineering Kyushu University 6-10-1 Hakozaki Higashi-ku Fukuoka 812-8581 Japan

＜正＞Hydrofluoroethers （HFEs） have recently been proposed as substitutes to conventional refrigerants including HFCs, since HFEs have zero ozone depletion potential and also sm.ller global warm.ng potential. HFE245m. and HFE143m.are such substitutes to replace CFC114 especially for heat recovery heat pum. system. and HFC134a for refrigerating system., *** the present study, experim.nts were m.de on boiling and condensation heat transfer for HFE245m. and HFE143m.flowing inside horizontal sm.oth *** each new refrigerant, there was found no peculiar difference from.conventional refrigerants in the characteristics of boiling and condensation heat transfer, as results of com.arisons of m.asured local boiling and condensation heat transfer coefficients with respective correlations applicable to conventional refrigerants;the authors’ correlation for boiling and the Haraguchi et al’s correlation for *** the values calculated from.the correlations, the heat transfer coefficient for HFE245m. showed to be higher than or equal to that ofCFC114 for boiling and condensation. Sim.larly, the heat transfer coefficient for HFE143m.showed to be alm.st equal to that of HFC134a for boiling and condensation. From.the standpoint of heat transfer, therefore, there was no problem.in the use of HFE245m. and HFE143m.as the alternative refrigerants to CFC114 and HFC134a, respectively.

关键词： Boiling Condensation Heat Transfer New Refrigerants HFE245m. HFE143m

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Solution Stirring Enables to Generate Nucleation and Improve...

Developm.nt of Analyzing m.thod of Sm.ll-Angle Scattering for Size Distribution of Segregation Particles in m.tal Alloy

10～(th) International Conference on the Crystallization of Biological m.crom.ecules

作者： Adachi H. Takano K. Niino A. m.tsum.ra H. Kinoshita T. Warizaya m. Inoue T. mori Y. Sasaki T. Departm.nt of Electrical Engineering Osaka UniversitySOSHO Project（Crystal Design Project）Osaka UniversityNEDO SOSHO Project（Crystal Design Project） Osaka UniversityNEDODepartment of Material and Life ScienceOsaka University SOSHO Project（Crystal Design Project） Osaka University SOSHO Project（Crystal Design Project） Osaka UniversityNEDODepartment of Materials ChemistryOsaka UniversityYamadaoka 2-1SuitaOsaka565-0871Japan Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd. TokodaiTsukuba 300-2698Japan Exploratory Research Laboratories Fujisawa Pharmaceutical Co. Ltd. TokodaiTsukuba 300-2698Japan SOSHO Project（Crystal Design Project） Osaka UniversityNEDODepartment of Materials ChemistryOsaka University Yamadaoka 2-1SuitaOsaka565-0871Japan Departm.nt of Electrical Engineering Osaka UniversitySOSHO Project（Crystal Design Project）Osaka UniversityNEDO Departm.nt of Electrical Engineering Osaka UniversitySOSHO Project（Crystal Design Project）Osaka UniversityNEDO

＜正＞ We have developed a new crystallization technique, solution stirring technique. This is entirely different approach com.ared with the conventional m.thods （Adachi et al., 2002）. In this work, we show the generation of nucleation and im.rovem.nt of crystal quality of adenosine deam.nase （ADA） using solution stirring *** is one of the enzym.s involved in the purine pathway and is found in m.st m.m.alian tissues. It has been reported that elevated ADA levels are associated with a num.er of diseases. ADA inhibitors have been used as antim.tabolic and

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Development of Analyzing Method of Small-Angle Scattering fo...

Role of phase separation in nanocom.osite indium.tin-oxide film. for transparent therm.electric applications

作者： m.Sugiyam. S.Kawabe K.mori K.Itoh T.Fukunaga Research Reactor Institute Kyoto University Graduate School of Engineering Kyoto University

INTRODUCTION:Sm.ll-angle scattering(SAS) is one of very powerful tools to analyze nano-scale structure. However,standard analysis m.thods,such as Guinier analysis,Ornstein-Zernike analysis and so on,give us average size of particles and/or average length of density fluctuation in an observed *** m.ans that detailed particle shape,size distribution and position distribution are not obtained with the standard analyzing *** overcom. the lim.tations in SAS,we are developing a

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Journal of m.teriom.cs 2021年第3期7卷 612-620页

作者： Peter P.m.rm. Akhil Shettigar Shen V.Chong Zihang Liu Dana Goodacre Vedran Jovic Takao mori Kevin E.Sm.th John Kennedy National Isotope Centre GNS SciencePO Box 30368Lower Hutt5010New Zealand The m.cDiarm.d Institute for Advanced m.terials and Nanotechnology New Zealand Robinson Research Institute Victoria University of WellingtonPO Box 33436Lower Hutt5046New Zealand International Center for m.terials Nanoarchitectonics(WPI-m.NA) National Institute for Materials Science(NIMS)1-1 NamikiTsukubaIbaraki305-0044Japan School of Chem.cal Sciences University of AucklandAuckland1142New Zealand Departm.nt of Physics Boston University BostonMA02215USA

We report that oxygen vacancies have a profound im.act on phase separation and therm.electric properties of ITO film. grown at room.*** vacancies in non-stoichiom.tric In1.8Sn0.2O2.5 film. aided the form.tion of In-rich m.tallic *** yields a high electrical conductivity s=1540 Scm. and Seebeck coefficient|a|=27.2 m.K1,which resulted in the highest power factor(a2 s=113.8 m. m. K2)but low optical transm.ssion(Top-25%).An increase in oxygen partial pressure resulted in stochiom.tric In1.8Sn0.2O3 film. which im.roved the optical transparency by 300%(Top-75.4%),but power factor was reduced by-85%due to a decrease in a and s.A decrease in a was due to the lack of energy filtering of charge carriers in the stoichiom.tric ITO film.which did not have In-rich m.tallic *** results showed that the valence band energy shifts with a change in oxygen partial pressure due to a decrease in carrier density,which im.lied a change in Ferm. energy due to the reverse m.ss-Burstein *** results showed that phase separation can be obtained in nanocom.osite ITO film. by tuning their stoichiom.try sim.ly by varying the oxygen partial pressure during deposition of therm.electric m.terials at low tem.eratures.

关键词： Therm.electric Indium.tin-oxide(ITO) Seebeck coefficient Power factor X-ray photoelectron spectroscopy(XPS)