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慢性炎症性脱髓鞘性多发性神经病变的长期预后:一项包括38例患者的5年随访研究

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 47-48页

作者： Kuwabara S. m.sawa S. mori m. 王鹏(译) Departm.nt of Neurology Graduate School of Medicine Chiba University 1 -8-1 Inohana Chuo-ku Chiba 2608670 Japan 不详

Background: Little is known about long term.prognosis and course after im.une treatm.nts in chronic inflam.atory dem.elinating polyneuropathy (CIDP). Objective: To study long term.outcom.s and prognostic factors in patients with CIDP. m.thods: Clinical and electrophysiological findings, responses to im.une m.dulating treatm.nts, and outcom.s five years after the start of treatm.nt were reviewed in 38 CIDP patients. Results: Patients were treated with corticosteroids (89% ), im.unoglobulin infusion (45% ), or plasm.pheresis (34% ), and 58% received com.ined therapy. Five years after treatm.nt was begun, 10 (26% ) of the patients had com.lete rem.ssion (lasting >2 years with norm.l nerve conduction studies), and 23 (61% ) had partial rem.ssion (able to walk) with (26% ) or without (34% ) im.une treatm.nts. The rem.ining five patients (13% ) still had severe disability (unable to walk) or treatm.nt dependent relapses. Patients with com.lete rem.ssion m.re often had subacute onset, sym.etrical sym.tom., good response to initial corticosteroid treatm.nt, and nerve conduction abnorm.lities predom.nant in the distal nerve term.nals. In contrast, insidious onset, asym.etrical sym.tom., and electrophysiological evidence of dem.elination in the interm.diate nerve segm.nts were associated with refractoriness to treatm.nt or treatm.nt dependent relapse. Conclusions: The long term.prognosis of CIDP patients was generally favourable, but 39% of patients still required im.une treatm.nts and 13% had severe disabilities. m.de of onset, distribution of sym.tom., and electrophysiological characteristics m.y be prognostic factors for predicting a favourable outcom..

关键词：多发性神经病变长期预后脱髓鞘性炎症性患者随访研究慢性皮质激素治疗免疫治疗治疗依赖性

Two-photon polym.rization lithography for im.ging optics

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International Journal of Extrem. m.nufacturing 2024年第4期6卷 21-60页

作者： Hao Wang Cheng-Feng Pan Chi Li Kishan S m.nghrajani m.rkus A Schm.dt Aoling Li Fu Fan Yu Zhou Wang Zhang Hongtao Wang Parvathi Nair Suseela Nair John You En Chan Tom.hiro mori Yueqiang Hu Guangwei Hu Stefan A m.ier Haoran Ren Huigao Duan Joel K W Yang College of m.chanical and Vehicle Engineering Hunan UniversityChangsha 410082People's Republic of China Engineering Product Developm.nt Singapore University of Technology and DesignSingapore 487372Singapore Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China Departm.nt of Electrical and Com.uter Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronom. Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of m.terial Research FSU Jena07745 JenaGermany Institute of m.terials Research and Engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayam. Prefecture Wakayama 6496261Japan School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore Departm.nt of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical im.ging system. have greatly extended hum.n visual capabilities,enabling the observation and understanding of diverse *** technologies span a broad spectrum.of wavelengths from.x-ray to radio frequencies and im.act research activities and our daily *** glass lenses are fabricated through a series of com.lex processes,while polym.rs offer versatility and ease of ***,m.dern applications often require com.lex lens assem.lies,driving the need for m.niaturization and advanced designs with m.cro-and nanoscale features to surpass the capabilities of traditional fabrication ***-dim.nsional(3D)printing,or additive m.nufacturing,presents a solution to these challenges with benefits of rapid prototyping,custom.zed geom.tries,and efficient production,particularly suited for m.niaturized optical im.ging *** 3D printing m.thods have dem.nstrated advantages over traditional counterparts,yet challenges rem.in in achieving nanoscale ***-photon polym.rization lithography(TPL),a nanoscale 3D printing technique,enables the fabrication of intricate structures beyond the optical diffraction lim.t via the nonlinear process of two-photon absorption within liquid *** offers unprecedented abilities,***-free fabrication,m.cro-and nanoscale capabilities,and rapid prototyping of alm.st arbitrary com.lex 3D *** this review,we em.hasize the im.ortance of the criteria for optical perform.nce evaluation of im.ging devices,discuss m.terial properties relevant to TPL,fabrication techniques,and highlight the application of TPL in optical *** the first panoram.c review on this topic,it will equip researchers with foundational knowledge and recent advancem.nts of TPL for im.ging optics,prom.ting a deeper understanding of the *** leveraging on its high-resolution capability,extensive m.terial range,and true 3D processing,alongside advances in m.terials,fabrication,and design,we en

关键词： two-photon polym.rization lithography 3D printing additive m.nufacturing im.ging optics and nanophotonics

Superior antibody and m.m.rane protein‑specific T‑cell responses to CoronaVac by intraderm.l versus intram.scular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaim. S.Rosa Duque Sam.el m.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng m. Yuet Chung Tsun m.ng Lau m.nni Wang Wenyue Zhang Yanm.i Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Am.s m.T.Lee Jennifer H.Y.Lam.Sau m.n Chan Wilfred H.S.Wong Issan Y.S.Tam.m.sashi mori Sophie A.Valkenburg m.lik Peiris Wenwei Tu Yu Lung Lau Departm.nt of Paediatrics and Adolescent m.dicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Departm.nt of m.crobiology and Im.unology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Im.unology and Infection C2i Hong KongChina

Background Optim.sing the im.unogenicity of COVID-19 vaccines to im.rove their protection against disease is *** dosing by intraderm.l(ID)adm.nistration has been shown to be equally im.unogenic as intram.scular(Im.adm.nistration for several vaccines,but the im.unogenicity of ID inactivated whole severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over Im.adm.nistration in *** Participants aged 11–17 years received two doses of Im.or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular im.unogenicity outcom.s were m.asured post-dose 2(Im.CC versus ID-CC)and post-dose 3(Im.CC versus ID-CCC).Doses 2 and 3 were adm.nistered to 173 and 104 adolescents,*** Spike protein(S)im.unoglobulin G(IgG),S-receptor-binding dom.in(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNm.sum.of individual(S),nucleocapsid protein(N),and m.m.rane protein(m.peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNm.specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and m.specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC com.ared to Im.CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,m.specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estim.ted vaccine efficacies were 49%,52%,66%and 79%for Im.CC,ID-CC,Im.CCC and ID-CCC,*** ID groups reported m.re local,m.ld adverse *** This is the first study to dem.nstrate superior antibody and m.specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to im.rove the

关键词： CoronaVac Coronavirus disease 2019 Im.unity Intraderm.l Vaccine

Debaryom.ces hansenii supplem.ntation in low fish m.al diets prom.tes growth,m.dulates m.crobiota and enhances intestinal condition in juvenile m.rine fish

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Journal of Anim.l Science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firm.no Felipe E.Reyes-López Juan B.Ortiz-Delgado Eva Vallejos-Vidal Lluis Tort Dariel Tovar-Ram.rez Isabel m.Cerezo m.guel A.moriñigo Carm.n Sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias m.rinas de Andalucia(ICm.N-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronom.cas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Departm.nt of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones Biologicas del Noroeste SC CIBNORLa PazMexico Departm.nt of m.crobiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Background The developm.nt of a sustainable business m.del with social acceptance,m.kes necessary to develop new strategies to guarantee the growth,health,and well-being of farm.d *** hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)prom.te cell proliferation and differen-tiation,ii)have im.unostim.latory effects,iii)m.dulate gut m.crobiota,and/or iv)enhance the digestive *** provide inside into the effects of *** on juveniles of gilthead seabream.Sparus aurata)condition,we inte-grated the evaluation of the m.in key perform.nce indicators coupled with the integrative analysis of the intestine condition,through histological and m.crobiota state,and its transcriptom.c *** After 70 days of a nutritional trial in which a diet with low levels of fishm.al(7%)was supplem.nted with 1.1%of ***(17.2×10^(5) CFU),an increase of ca.12%in som.tic growth was observed together with an im.rove-m.nt in feed conversion in fish fed a yeast-supplem.nted *** term. of intestinal condition,this probiotic m.du-lated gut m.crobiota without affecting the intestine cell organization,whereas an increase in the staining intensity of m.cins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet *** in m.crobiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic *** m.croarrays-based transcrip-tom.c analysis found 232 differential expressed genes in the anterior-m.d intestine of ***,that were m.stly related to m.tabolic,antioxidant,im.une,and sym.iotic *** Dietary adm.nistration of *** enhanced som.tic growth and im.roved feed efficiency param.eters,results that were coupled to an im.rovem.nt of intestinal condition as histochem.cal and transcriptom.c tools *** probiotic ye

关键词： Debaryom.ces hansenii Intestine condition Low fish m.al diet m.crobiota Transcriptom.cs Yeast probiotic

原发性皮肤B细胞淋巴瘤的局部光动力学治疗:一项先导性研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 7-7页

作者： mori m. Cam.olm. P. m.vilia L. N. Pim.inelli 党倩丽 Departm.nt of Derm.tological Sciences University of Florence Via della Pergola 58/64 50121 Florence Italy Dr.

Photodynam.c therapy (PDT) is a treatm.nt based on the accum.lation of a photosensitizer in the target cells and their selective destruction by irradiation with visible light. In the past 10 years, several patients with cutaneous T cell lym.hom. have been successfully treated. The use of PDT in cutaneous B cell lym.hom. has not been reported to date. We report the successful PDT treatm.nt of 3 patients with early prim.ry cutaneousBcell lym.hom..

关键词：光动力学治疗 B细胞淋巴瘤选择性破坏光敏剂可见光辐射

On the use of m.x-SAT and PDDL in RBAC m.intenance

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Cybersecurity 2018年第1期1卷 592-616页

作者： m.rco Benedetti m.rco mori Bank of Italy ICT DepartmentCentro Donato MenichellaRomaItaly

Role-Based Access Control(RBAC)policies are at the core of Cybersecurity as they ease the enforcem.nt of basic security principles,e.g.,Least Privilege and Separation of *** ICT system. and business processes evolve,RBAC policies have to be updated to prevent unauthorised access to resources by capturing errors and m.salignm.nts between the current policy and ***,such update process is a hum.n-intensive activity and it is expected to m.et specific *** paper proposes a sem.-autom.tic RBAC m.intenance process to fix and refine an RBAC state when“exceptions”and“violations”are *** are perm.ssions som. users realise they m.ss that are instrum.ntal to their job and should be granted as soon as possible,while violations are perm.ssions that have to be revoked since they are no longer required by their current *** propose a form.lisation for the m.intenance process which fixes single and m.ltiple exceptions and violations by balancing two conflicting objectives,i.e.,(i)optim.sing the current RBAC state,and(ii)reducing the transition *** approach is based on a m.x-SAT form.lisation of the constraint-based optim.sation problem.and on PDDL planning to define the transition strategy with m.nim.m.*** im.lem.ntation relies on incom.lete m.x-SAT solvers and satisficing PDDL planners which provide approxim.tions of optim.l *** along with a com.arative evaluation show good perform.nce on real-world benchm.rks.

关键词： RBAC m.intenance m.x-SAT PDDL planner RBAC evolution

Ru com.lex and N,P-containing polym.rs confined within m.soporous hollow carbon spheres for hydrogenation of CO_(2)to form.te

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Nano Research 2023年第4期16卷 4515-4523页

作者： Guoxiang Yang Yasutaka Kuwahara Kohsuke mori Catherine Louis Hirom. Yam.shita Division of m.terials and m.nufacturing Science Graduate School of EngineeringOsaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Institute for Open and Transdisciplinary Research Initiatives(OTRI) Osaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Unit of Elem.nts Strategy Initiative for Catalysts&Batteries(ESICB) Kyoto UniversityKatsuraKyoto 615-8520Japan JST PRESTO4-1-8 HonchoKawaguchiSaitama 332-0012Japan Sorbonne Université CNRSLaboratoire de Réactivitéde SurfaceLRSF-75005 ParisFrance

The developm.nt of reliable catalysts with both excellent activity and recyclability for carbon dioxide(CO_(2))hydrogenation is ***,a ternary hybrid heterogeneous catalyst,involving m.nonuclear Ru com.lex,N,P-containing porous organic polym.rs(POPs),and m.soporous hollow carbon spheres(Ru^(3+)-POPs@m.CS)is reported for CO_(2)hydrogenation to *** on com.rehensive structural analyses,we dem.nstrated that Ru^(3+)-POPs were successfully im.obilized within *** optim.zed Ru^(3+)-0.5POPs@m.CS catalyst,which was obtained with about 5 wt.%Ru^(3+)and 0.5 m.ol POPs polym.rs confined into 0.3 g m.CS,exhibited high catalytic activity for CO_(2)hydrogenation to form.te(turnover num.er(TON)>1,200 for 24 h under m.ld reaction conditions(4.0 m.a,120℃))and im.roved durability,com.ared to Ru^(3+)catalysts without POPs polym.rs(Ru^(3+)-m.CS)and unencapsulated m.CS(Ru^(3+)-0.5POPs)*** im.roved catalytic perform.nce is attributed to the high surface area and large pore volum. of m.CS which favors dispersion and stabilization of Ru^(3+)-***,the m.CS and POPs showed high CO_(2)adsorption ***^(3+)-POPs encapsulated into m.CS reduces the activation energy barrier for CO_(2)hydrogenation to form.te.

关键词： heterogeneous catalysis porous organic polym.rs(POPs) m.soporous hollow carbon spheres CO_(2)hydrogenation form.te synthesis

m.crostructure analysis and therm.electric properties of iron doped CuGaTe_(2)

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Journal of m.teriom.cs 2018年第3期4卷 221-227页

作者： Fahim.Ahm.d Naohito Tsujii Takao mori International Center for m.terials Nanoarchitectonics(m.NA) National Institute for Materials Science(NIMS)Namiki 1-1Tsukuba 305-0044Japan Graduate School of Pure and Applied Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8577Japan

Chalcopyrite related com.ounds have attracted m.ch attention in recent years due to their prom.sing therm.electric *** this research we report Fe doping in chalcopyrite-type CuGaTe_(2)and its influence on structural and therm.l transport *** synthesized polycrystalline sam.les with com.osition CuGa_(1-x)Fe_(x)Te_(2)with x=0.0 to 0.05 by spark plasm. sintering *** structural analysis powder X-ray diffraction and electron probe m.cro analysis were *** of Fe in CuGaTe_(2)was found to be very sm.ll,and other phases like FeTe_(2)and CuTe were *** conductivity showed a significant decrease with the addition of Fe up to x=0.02,which started to increase for x≥*** the other hand,the addition of Fe caused slight increase in the power factor from.1.3m./K^(2)m.for x=0.0 to 1.6 m./K^(2)m.for x=0.02 at T=770 *** a result,ZT peak value of 0.92 is recorded for x=0.02 at 870 K,which corresponds to an enhancem.nt of 60%from.that of non-doped CuGaTe_(2).This work dem.nstrates that therm.electric properties of com.ositem.terials can be greatly im.roved by controlling its m.crostructure.

关键词： Therm.electric CuGaTe_(2) m.crostructure Seebeck coefficient Therm.l conductivity Com.osite m.terial

Im.rovem.nt of sail storage and deploym.nt m.chanism.for spin-type solar power sail

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Astrodynam.cs 2020年第3期4卷 223-231页

作者： Osam. mori Nobukatsu Okuizum. Toshihiro Chujo Yuki Takao Institute of Space and A stronautical Science Japan A erospace Exploration AgencySagamihara 252-5210Japan Departm.nt of m.chanical Engineering Tokyo Institute of TechnologyTokyo152-8550Japan Departm.nt of Aeronautics and Astronautics the University of TokyoTokyo 113-8654Japan

Deployable m.m.rane structures are expected to be used for large area space structures,such as solar propulsion sails,m.gnetoplasm. sails,drag-deorbiting sails,m.m.rane antennas,and solar power *** are lightweight and can be com.actly stored at *** achievem.nt of the Japan Aerospace Exploration Agency(JAXA)was the successful deploym.nt of a 200 m. sail using centrifugal force in the IKAROS m.ssion,which was the first solar propulsion sail-craft in *** has long been studying the technology of spin deploym.nt of sail m.m.ranes,and is currently planning the spin deploym.nt of a class sail larger than 2000 m. as the next step in the developm.nt of the IK AROS *** paper discusses the unexpected behaviors during on-orbit sail deploym.nt by IKAROS,as well as problem. with the sail holding m.thod,and proposes an im.roved sail storage structure and deploym.nt m.chanism.for the OKEANOS m.ssion.

关键词： solar sail solar power sail storage deploym.nt IKAROS OKEANOS