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Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness:Lessons from a contemporary single institution radical prostatectomy series

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Asian Journal of Urology 2015年第1期2卷 53-58页

作者： Zachary b.Koloff Daniel A.Hamstra John T.Wei Jeffrey S.Montgomery Scott A.Tomlins Angela J.Wu Todd M.morgan Javed Siddiqui Kellie Paich Arul M.Chinnaiyan Felix Y.Feng Alon Z.Weizer Lakshmi P.Kunju brent K.Hollenbeck David C.Miller Ganesh S.Palapattu Rohit Mehra Department of Urology University of Michigan Medical SchoolAnn ArborMIUSA Department of Radiation Oncology University of Michigan Medical SchoolAnn ArborMIUSA Department of Pathology University of Michigan Medical SchoolAnn ArborMIUSA

Objective:To better evaluate tertiary Gleason pattern reporting and to evaluate the impact of tertiary Gleason pattern 5(TP5)on prostate cancer pathological features and biochemical recurrence at our large single ***:We retrospectively reviewed 1962 patients who underwent radical prostatectomy(RP)for prostate cancer;TP5 was reported in 159 cases(8.1%).Men with Gleason score(GS)7 and GS 8 disease were divided into subgroups with and without TP5,and histopathological features were *** analyses were conducted to assess the impact on TP5 on biochemical-free survival(bFS).Results:Tumors possessing GS 3+4 with TP5 were more likely to exhibit extraprostatic extension(EPE)and had a larger tumor diameter(TD)than GS 3+4 *** 3+4 with TP5 was also associated with positive surgical margins(SM),seminal vesicle involvement(SVI),and higher pre-operative prostate-specific antigen(PSA)values,but without statistical *** 4+3 with TP5 more commonly presented with EPE,positive SM,SVI,and greater TD and pre-operative PSA level than GS 4+3 *** multivariate analysis,Gleason score,EPE,and TP5 were overall independent risk factors for PSA recurrence in this ***,GS 4+3 with TP5 was associated with shorter time to recurrence versus GS 4+3 ***:Our results emphasize the importance of TP5 and suggest that criteria for tertiary pattern reporting in prostate cancer should be *** studies are needed to evaluate the role of tertiary patterns in prognostic models.

关键词： Tertiary Gleason pattern Prostate cancer Prostatic neoplasm Gleason score Radical prostatectomy Disease-free survival

Tay-Sachs carrier screening in the genomics age: Gene sequencing versus enzyme analysis in non-Jewish individuals

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Open Journal of Genetics 2013年第1期3卷 61-66页

作者： Charles M. Strom Noh Jin Park Craig morgan Raynah Lobo beryl Crossley Rajesh Sharma Reuben bonilla-Guerrero Denise Salazar Department of Genetics Quest Diagnsotics Nichols Institute San Juan Capistrano USA

Purpose: To compare the sensitivity of Hexosaminidase A (HexA) enzyme-based testing to gene sequencing for carrier detection in non-Jewish individuals. Methods: blood samples were obtained from parents and relatives of affected patients at an annual Tay-Sachs and Allied Diseases Foundation meeting. A family history was taken for each individual. Samples were analyzed for leukocyte HexA activity, serum HexA activity and subjected to extensive gene sequencing. The results from these analyses were combined with our previously published data describing 34 obligate Tay-Sachs disease (TSD) carriers. Results: Twelve additional TSD carriers were detected in this study. Gene sequencing successfully identified all 12 carriers whereas enzyme analysis identified 11 of 12 carriers. This individual is a carrier of the b1 variant that is known to cause false negative results with enzyme testing. Combined data from 46 non-Jewish TSD carriers revealed that gene sequencing had a higher sensitivity rate than HexA enzyme-based testing (94% versus 87%) in non-Jewish TSD carriers. In our series, approximately 4% of non-Jewish TSD carriers have this mutation. Conclusions: HexA gene sequencing provides a higher sensitivity for TSD carrier detection than HexA based enzyme analysis in non-Jewish patients primarily due to the presence of individuals with the b1 variant.

关键词： Tay-Sachs Screening Gene Sequencing Hexosaminidase A

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Now decision theory

Probability, Uncertainty and Quantitative Risk 2023年第3期8卷 391-416页

作者： Dilip b.Madan Wim Schoutens King Wang Robert H.Smith School of business University of MarylandCollege ParkMD.20742USA Department of Mathematics K.U.LeuvenLeuven3000 LeuvenBelgium Derivative Product Strats Morgan Stanley1585 Broadway5th floorNew YorkNY 10036USA

The spirit of now in nowcasting suggests expanding the current to include the near *** theory is then developed by incorporating the consequences of actions into the *** the future falling into the present discounting it is no longer *** functions are then observed to be determinate only up to scale and shift that are then locked down by fixing values arbitrarily in two selected states,much like declaring water to freeze and boil at zero and a hundred degrees *** locked down value functions associated policy functions are seen to exist in decision contexts in where the only time is *** are studied in univariate and multivariate dimensions for the decision state space and the dimension of shocks delivering state *** policy functions are expanded from realisitic training sets to the full state space using Gaussian Process *** are implemented on real data with reported performances.

关键词： State dependent discounting bilateral gamma process Probability distortion Measure distortion Gamma discounted averaging Multivariate bilateral gamma model

A phase 1b randomized clinical trial of CT1812 to measure Aβoligomer displacement in Alzheimer’s disease using an indwelling CSF catheter

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Translational Neurodegeneration 2023年第1期12卷 568-571页

作者： Kelsie M.Labarbera Yvette I.Sheline Nicholas J.Izzo Carla M.Yuede Lora Waybright Raymond Yurko Hannah M.Edwards Woodrow D.Gardiner Kaj blennow Henrik Zetterberg Anne börjesson-Hanson Roger morgan Charles S.Davis Robert J.Guttendorf Lon S.Schneider Steven DeKosky Harry LeVine III Michael Grundman Anthony O.Caggiano John R.Cirrito Susan M.Catalano Mary E.Hamby Cognition Therapeutics Inc. PittsburghPAUSA University of Pennsylvania PhiladelphiaUSA Washington University St.LouisUSA University of Gothenburg MölndalSweden Department of Psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Neurochemistry Laboratory Sahlgrenska University HospitalMölndalSweden Department of Neurodegenerative Disease UCL Institute of NeurologyQueen SquareLondonUK UK Dementia Research Institute at UCL LondonUK Hong Kong Center for Neurodegenerative Diseases Clear Water BayHong KongChina Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA Karolinska University Hospital StockholmSweden MedSurgPI LLCRaleighNCUSA CSD biostatistics Inc.Oro ValleyAZUSA Aclairo Pharmaceutical Development Group IncViennaVAUSA Keck School of Medicine of USC Los AngelesCAUSA McKnight brain Institute University of FloridaGainesvilleFLUSA Sanders-brown Center on Aging University of KentuckyLexingtonKYUSA Global R&D Partners LLCSan DiegoCAUSA Department of Neurosciences University of CaliforniaSan DiegoUSA

Trial Registration:May 11th,2018 *** Identifier:NCT03522129 https://clini caltr ***/ct2/show/*** therapies for Alzheimer’s disease(AD)target a wide range of mechanisms,yet promising dis-ease-modifying therapies remain a huge unmet *** evidence indicates that the oligomeric form of amyloid-beta(Aβ)is a toxic species contributing to AD through synaptic damage and neuronal toxicity[1].

关键词： Alzheimer Aβ damage

Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms

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bioactive Materials 2023年第8期26卷 52-63页

作者： Nisakorn Yodsanit Takuro Shirasu Yitao Huang Li Yin Zain Husain Islam Alexander Christopher Gregg Alessandra Marie Riccio Runze Tang Eric William Kent Yuyuan Wang Ruosen Xie Yi Zhao Mingzhou Ye Jingcheng Zhu Yi Huang Nicholas Hoyt Mengxue Zhang John A.Hossack morgan Salmon K.Craig Kent Lian-Wang Guo Shaoqin Gong bowen Wang Department of biomedical Engineering Wisconsin Institute for DiscoveryUniversity of Wisconsin-MadisonMadisonWI53715USA Department of Ophthalmology and Visual Sciences University of Wisconsin-MadisonMadisonWI53715USA Department of Surgery School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA The biomedical Sciences Graduate Program(bIMS) School of MedicineUniversity of VirginiaCharlottesvilleVA22908USA Department of biomedical Engineering School of EngineeringUniversity of VirginiaCharlottesvilleVA22908USA School of Medicine and Health Sciences George Washington UniversityWashingtonDC20052USA Department of Cardiac Surgery Michigan MedicineUniversity of MichiganAnn ArborMI48109USA

Abdominal aortic aneurysm(AAA)is a progressive aortic dilatation,causing~80%mortality upon ***,there is no approved drug therapy for *** repairs are invasive and risky and thus not recommended to patients with small AAAs which,however,account for~90%of the newly diagnosed *** is therefore a compelling unmet clinical need to discover effective non-invasive strategies to prevent or slow down AAA *** contend that the first AAA drug therapy will only arise through discoveries of both effective drug targets and innovative delivery *** is substantial evidence that degenerative smooth muscle cells(SMCs)orchestrate AAA pathogenesis and *** this study,we made an exciting finding that PERK,the endoplasmic reticulum(ER)stress Protein Kinase R-like ER Kinase,is a potent driver of SMC degeneration and hence a potential therapeutic ***,local knockdown of PERK in elastase-challenged aorta significantly attenuated AAA lesions in *** parallel,we also conceived a biomimetic nanocluster(NC)design uniquely tailored to AAA-targeting drug *** NC demonstrated excellent AAA homing via a platelet-derived biomembrane coating;and when loaded with a selective PERK inhibitor(PERKi,GSK2656157),the NC therapy conferred remarkable benefits in both preventing aneurysm development and halting the progression of pre-existing aneurysmal lesions in two distinct rodent models of *** summary,our current study not only establishes a new intervention target for mitigating SMC degeneration and aneurysmal pathogenesis,but also provides a powerful tool to facilitate the development of effective drug therapy of AAA.

关键词： Abdominal aortic aneurysm ER stress PERK biomimetic nanomedicine Targeted delivery

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试论特定生境农业所需信息及限度

水土保持应用技术 2001年第3期 33-35,40页

作者： b.C.Atherton M.T.morgan S.A.Shearer T.S.Stombaugh A.D.Ward 姚阳美国俄亥俄州大学研究协会教授辽宁省农业职业技术学院

特定生境农业依赖于大量的可信赖的资料。信息的获得与其在制定农业管理决策中的有效利用之间存在着很大的差异。重要的是收集能够有效地运用于管理决策方面的资料。制定特定生境管理决策所需要的资料主要有土壤条件、地貌特征、栽培技... 详细信息

特定生境农业依赖于大量的可信赖的资料。信息的获得与其在制定农业管理决策中的有效利用之间存在着很大的差异。重要的是收集能够有效地运用于管理决策方面的资料。制定特定生境管理决策所需要的资料主要有土壤条件、地貌特征、栽培技术、有害生物及气候等因素对作物产量的影响。资料收集主要采用传统的人工收集及现代的传感器、遥感技术测定。应用收集到的信息资料进行数理分析 ,制定生境农业管理决策 ,为今后特定生境农业发展提供科学依据。

关键词：特定生境农业精细农业变量施用有害生物防治养分管理遥感美国

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新型家禽疫苗佐剂研究

中国家禽 2011年第6期33卷 41-41页

作者： M.J.morgan G.Tellez b.M.Hargis 美国阿肯色州立大学

佐剂是许多疫苗的必要成分,对疫苗发挥最佳的免疫反应至关重要。目前,美国家禽疫苗生产中主要使用两种佐剂体系,一种是氢氧化铝凝胶即通常所说的"明胶",另一种是矿物油乳剂。每种佐剂体系在实际应用中各有优缺点。近年来,一种新物质—... 详细信息

佐剂是许多疫苗的必要成分,对疫苗发挥最佳的免疫反应至关重要。目前,美国家禽疫苗生产中主要使用两种佐剂体系,一种是氢氧化铝凝胶即通常所说的"明胶",另一种是矿物油乳剂。每种佐剂体系在实际应用中各有优缺点。近年来,一种新物质——壳聚糖,作为疫苗佐剂的有效成分逐渐引起了人们的关注。壳聚糖是壳多糖的衍生物,已有研究证实其可作为哺乳动物疫苗的有效佐剂。

关键词：疫苗佐剂家禽禽类壳聚糖组

在某些热水矿物中稀土元素的分配结晶的控制证据

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地球科学与环境学报 1981年第1期 82-90页

作者： J.W.morgan ,G.A.WANDLESS ,何胤周

稀土元素丰度在硬石膏（CaSo4）、重晶石（baSo4）、菱铁矿（FeCo3）和方铅矿（Pbs）中用中子活化分析测定了。一种简单的结晶化学模式定性的描述了在硬石膏、重晶石和菱铁矿中稀土元素代替的相对亲合力。当地壳的丰度正常化时（近似热... 详细信息

稀土元素丰度在硬石膏（CaSo4）、重晶石（baSo4）、菱铁矿（FeCo3）和方铅矿（Pbs）中用中子活化分析测定了。一种简单的结晶化学模式定性的描述了在硬石膏、重晶石和菱铁矿中稀土元素代替的相对亲合力。当地壳的丰度正常化时（近似热液稀土元素模式）,三个热水矿物个别的和集体的对数稀土元素丰度是一种惊人地线形函数。（大阳离子离子半径——稀土元素的离子半径）。然而,重要的例外是Eu,相对于稀土元素的邻近原子序数和三价离子的半径,Eu在重晶石中异常富集而在菱铁矿中缺失。原则上,共生热水矿物的成对稀土元素分析,结合适当的实验资料,能得到稀土元素含量和原始热液的温度。稀土元素仅有微弱的亲铜倾向,反映在方铅矿上有很低的丰度——La 0.6P Pb,Sm 0.06P Pb;其余的稀土元素含量低于侦查极限。

关键词：稀土元素重晶石硬石膏 Ⅲb族元素硫酸盐矿物无水石膏非金属矿物矿物元素丰度

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