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Expression Profiling of Genes Associated with Cyanogenesis in Three Cassava Cultivars Containing Varying Levels of Toxic Cyanogens

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American Journal of Plant Sciences 2013年第7期4卷 1533-1545页

作者： morgan Echeverry-Solarte Victor Ocasio-Ramirez Annete Figueroa Eduardo González Dimuth Siritunga Department of biology University of Puerto Rico Mayagüez Mayagüez USA.

Cyanogenic glycosides, linamarin and lotaustralin, are presents in all tissues of Cassava (Manihot esculenta Crantz) except seeds and function as a deterrent for herbivores as well as the translocable form of reduced nitrogen. The genes involved in the cyanogenic pathway [CYP79D1/D2 (EC 1.14.13), linamarase (EC 3.***.1.21), α-hydroxynitrile lyase (HNL, acetone-cyanohydrin lyase. EC 4.***.2.37) and b-cyanoalanine synthase (β-CAS. EC 4.***.1.9] have been identified and partially characterized. Our objective was to identify the differential expression pattern of these genes in leaves and roots of three cassava cultivars with varying levels of cyanogenic glucosides. The results show that the differential ex- pression of the genes between leaves and roots is consistent with leaves being the primary site of synthesize of cyano- genic glucosides, which are then translocated to the roots. In addition, the varietal difference for cyanogenic glucoside levels could be explained in part by the combinatorial effort of the synthesis in the leaves and the linamarase catabolic step in the roots. Cluster analysis suggests a coordinated expression between CYP79D1/D2 and β-CAS genes as well as linamarase and HNL genes, which is in agreement with the spatial separation within a cell of the site of linamarin syn- thesis (vacuolar) and its breakdown to cyanide (cell wall). Furthermore, cluster analysis for cultivar classification using its gene expression profile match with the reported cyanide levels comparatively for the three cultivars. This is the first study that evaluates the transcriptional activities of the genes involved in the cyanogenic glycoside metabolism using a systematic approach.

关键词： Cassava Cyanogenic Glucoside Gene Expression Real Time PCR

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大陆裂谷作用研究进展和展望

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地震地质译丛 1982年第5期 1-3页

作者： b.H.baker P.morgan 张文国张崇寿

最近十五年来,对大陆裂谷的研究活动日益增多,新的资料大量涌现,然而,关于裂谷作用的基本机理和成因很少有一致的意见。熟知的地壳断裂运动的特征组合——隆起、断层和火山活动,被广泛认为是软流圈对流和岩石圈变薄引起的。这一概念得... 详细信息

最近十五年来,对大陆裂谷的研究活动日益增多,新的资料大量涌现,然而,关于裂谷作用的基本机理和成因很少有一致的意见。熟知的地壳断裂运动的特征组合——隆起、断层和火山活动,被广泛认为是软流圈对流和岩石圈变薄引起的。这一概念得到长波长的负布格异常和上地幔的近正常Pn波速度的观侧结果

关键词：裂谷系裂谷作用活动裂谷岩石圈板块

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良性苔藓样角化病:对1040例患者的临床及病理学再评价

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 24-25页

作者： morgan M.b. Stevens G.L. Switlyk S. 王琼 16124 Chastain Road Odessa FL 33556 United StatesDr.

benign lichenoid keratosis, otherwise known as lichen planus-like keratosis, is a common, cutaneous entity that is often confused with cutaneous malignancy. Few studies have examined the multiple clinical and pathologic guises of this entity, particularly within the context of clinical pathologic correlation or magnitude of this study. We examined the epidemiologic, clinical, and pathologic attributes of 1040 consecutive cases of benign lichenoid keratosis referred for pathologic examination at a busy laboratory over an entire year. Clinical parameters assessed included the age, anatomic location, gender, and multiplicity of the lesions. Pathologic attributes were assessed yielding discernment of five different subtypes that included a classic type, bullous type, atypical type with cytologically atypical lymphocytes, an early or interface type, and a late regressed or atrophic type. The results yielded an average age at presentation of 59.5 years with an age range of 36 to 87 years. The gender frequency was 76% female, 24% male. The trunk was the most common location (76% ), followed by the extremities (33% ) and head and neck (7% ); 8% of patients presented with two lesions and less than 1% with three lesions prompting consideration of lichen planus. The classic, atypical, and bullous forms of the disease clinically presented with erythematous papule/plaque(s). The early or interface type showed erythematous to hyperpigmented brown macules and the regressed or atrophic type presented as violaceous papules or irregularly distributed macular pigmentation; 81% of the lesions showed the classic histology consisting of epidermal acanthosis with a band-like lichenoid lymphocytic infiltrate. Variable numbers of plasma cells, eosinophils, and neutrophils were identified as well as epidermal parakeratosis distinguishing these lesions from typical lichen planus. The bullous variant showed intraepidermal or subepidermal bullous cavities with a dense associated lymphocytic inf

关键词：苔藓样角化病红色丘疹真皮乳头扁平苔藓皮肤恶性肿瘤非典型淋巴细胞经典型表皮萎缩萎缩型

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Optus b（Aussat b）卫星

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电信快报 1993年第4期 11-12页

作者： morgan,W 秦方

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以赛亚书

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作者：坎伯·摩根(Campbell morgan)

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成长的烦恼

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作者： (英)妮可拉·摩根(Nicola morgan)

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糖尿病增加肝细胞癌发生的危险性:美国一项基于人群的病例对照研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 45-46页

作者： Davila J.A morgan R.O Shaib Y H.b. El-Serag 李翔 Houston Vet. Affairs Medical Center 2002 Holcombe Blvd.(152)Houston TX 77030United States.Dr

background: Diabetes has been associated with an increa- sed risk of hepatocellular carcinoma (HCC) in studies of referred patients. Th is is the first population based case control study in the USA to examine this a ssociation while adjusting for other major risk factors related to HCC. Methods: We used the Surveillance Epidemiology and End-Results Program (SEER)Medicare l inked database to identify patients aged 65 years and older diagnosed with HCC a nd randomly selected non-cancer controls between 1994 and 1999. Only cases and controls with continuous Medicare enrolment for three years prior to the index d ate were examined. Inpatient and outpatient claims files were searched for diagn ostic codes indicative of diabetes,hepatitis C virus (HCV), hepatitis b virus (H bV), alcoholic liver disease, and haemochromatosis. HCC patients without these c onditions were categorised as idiopathic. Unadjusted and adjusted odds ratios we re calculated in logistic regression analyses. Results: We identified 2061 HCC p atients and 6183 non-cancer controls. Compared with non-cancer controls, patie nts with HCC were male (66%v 36%) and non-White (34%v 18%). The proportion of HCC patients with diabetes (43%) was significantly greater than non-cancer controls (19%). In multiple logistic regression analyses that adjusted for demo graphics features and other HCC risk factors (HCV, HbV, alcoholic liver disease, and haemochromatosis),diabetes was associated with a threefold increase in the risk of HCC. In a subset of patients without these major risk factors, the adjus ted odds ratio for diabetes declined but remained significant (adjusted odds rat io 2.87 (95%con-fidence interval 2.49-3.30)). A significant positive interact ion between HCV and diabetes was detected (pbetes recorded between two and three years prior to HCC diagnosis. Conclusions:Diabetes is associated with a 2-3-fold increase in the risk of HCC, regard

关键词：病例对照研究发病风险肝细胞癌血色病酒精性肝脏疾病丙型肝炎酒精性肝病危险比乙型肝炎相关记录

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Correlated squared returns

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Probability, Uncertainty and Quantitative Risk 2021年第2期6卷 139-158页

作者： Dilip b.Madan King Wang Robert H.Smith School of business University of MarylandCollege ParkMD 20742USA Derivative Product Strats Morgan StanleyNew YorkNY 10036USA

Joint densities for a sequential pair of returns with weak autocorrelation and strong correlation in squared returns are *** marginal return densities are either variance gamma or bilateral ***-dimensional matching of empirical characteristic functions to its theoretical counterpart is employed for dependency parameter *** are reported for 3920 daily return sequences of one thousand *** simulation is done using conditional distribution *** paths display levels of squared return correlation and decay rates for the squared return autocorrelation function that are comparable to these magnitudes in daily return *** of log characteristic functions at different time points are used to estimate time scaling *** of these time scaling coefficients on squared return correlations support the view that autocorrelation in squared returns slows the rate of passage of economic *** analysis of financial markets for 2020 in comparison with 2019 displays a post-COVID slowdown in financial markets.

关键词： Correlated gamma processes Joint characteristic functions Digital moment estimation Path simulation

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肿瘤病人在进行多层CT随访时无需常规使用口服阳性对比剂

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国际医学放射学杂志 2009年第2期32卷 182-183页

作者： S.Harieaswar A.Rajesh Y.Griffin R.Tyagi b.morgan 刘靖 Department of Radiology Leicester Royal Infirmary

该回顾性医学分析的目的是评价肿瘤病人进行多层CT随访时停止常规使用口服对比剂对阅片满意度的影响。分析100例病人CT检查经历表明，口服阳性对比剂是他们最不愉快的经历（P〈0．0001）。对447例一般肿瘤病人进行多层CT随访检查时放弃... 详细信息

该回顾性医学分析的目的是评价肿瘤病人进行多层CT随访时停止常规使用口服对比剂对阅片满意度的影响。分析100例病人CT检查经历表明，口服阳性对比剂是他们最不愉快的经历（P〈0．0001）。对447例一般肿瘤病人进行多层CT随访检查时放弃常规口服阳性对比剂，以2．5mm进行多层重组，随访5～13个月。

关键词：口服对比剂阳性对比剂随访检查多层CT 肿瘤病人病人满意度医学分析 CT检查

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Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres

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World Journal of Gastroenterology 2019年第39期25卷 5991-6005页

作者： Melissa Frizziero Xin Wang bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara Department of Medical Oncology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Department of Analytics and Development The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Department of Pathology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Department of Medical Oncology Royal Free London NHS Foundation TrustLondon NW3 2QGUnited Kingdom UCL Cancer Institute University College LondonLondon WC1E 6AGUnited Kingdom Department of Histopathology Royal Free London NHS Foundation TrustLondon NW3 2QGUnited Kingdom Department of Gastroenterology and Medical Oncology Edouard Herriot HospitalHospices Civils de LyonLyon 69003France Department of Gastroenterology Cardiff and Vale University Health BoardUniversity Hospital of WalesCardiff CF14 4XWUnited Kingdom Department of Cellular Pathology Cardiff and Vale University Health BoardUniversity Hospital of WalesCardiff CF14 4XWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B15 2THUnited Kingdom Department of Hepatology University Hospitals Birmingham NHS Foundation TrustBirmingham B15 2THUnited Kingdom Department of Surgical Oncology The Christie NHS Foundation TrustManchester M20 4BXUnited Kingdom Division of Cancer Sciences University of ManchesterManchester M13 9PLUnited Kingdom

bACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic *** is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be *** To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of *** Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European *** data were retrospectively collected from medical *** samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of *** responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours ***-Meier analysis was applied to estimate survival *** between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 ***:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases *** distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine ***-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of *** was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal *** localised cases,median recurre

关键词： Mixed neuroendocrine non-neuroendocrine neoplasm 2017 World Health Organisation classification Mixed adeno-neuroendocrine carcinoma Gastro-enteropancreatic tract Digestive system Neuroendocrine neoplasms Survival outcomes

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