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CXCR4表达促进弥漫大B细胞淋巴瘤播散并降低患者生存

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临床与实验病理学杂志 2015年第8期31卷 845-845页

作者： moreno m j Bosch R Dieguez-Gonzalez R 魏建国许春伟邰艳红浙江省绍兴市人民医院病理科绍兴312000 解放军307医院病理科北京100071

moreno m j, Bosch R, Dieguez-Gonzalez R, et al. CXCRg ex- pression enhances diffuse large B cell lymphoma dissemination and decreases patient survival. j Pathol, 2015,235 （3）：445 - 55.在一些血液系统恶性肿瘤中，趋化因子受体CXCR4涉及恶性B细胞的迁移和播散。尽管研究发现CXCR4在血液系统肿瘤过表达，但该受体在弥漫大B细胞淋巴瘤（DL—BCL）中的作用仍未可知。CXCR4在多种肿瘤中是预后不良的标记，与肿瘤转移及患者生存降低相关。

关键词：趋化因子受体CXCR4 弥漫大B细胞淋巴瘤患者血液系统恶性肿瘤 lymphoma 血液系统肿瘤恶性B细胞 cell

RTA和OCT3测量脉络膜新生血管患者黄斑厚度的比较研究

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 38-38页

作者： montero j.A. Ruiz-moreno j.m. 宋虎平 Instituto Oftalmologico de Alicante Avenida de Denia 111 03015 Alicante Spain

Aims. The authors conducted a study to compare retinal thickness in patients with choroidal neovascularization (CNV) using optical coherence tomography (OCT) and retinal thickness analyser (RTA). methods. In all, 11 eyes from 11 patients with subfoveal choroidal neovascularization were examined with OCT and RTA. Results. Three patients could not be explored by RTA due to lack of fixation and high myopia. The mean foveal thickness was 289.9± 92.1 μ m with OCT and 207.7± 60.8 μ m with RTA. The mean perifoveal thickness was 293.8± 46.3 μ m and 200.8± 61.3 μ m, respectively. The maximal perifoveal thickness measured by OCT was 335± 104.0 μ m and 316± 86.8 μ m by RTA. Conclusion. OCT and RTA are able to detect increases in retinal thickness due to the presence of CNV and of fluid extravasation. They can be used in measuring retinal thickness in patients with CNV, although measures are not comparable between both systems.

关键词：脉络膜新生血管 OCT3 RTA 中心凹视网膜厚度高度近视液体渗

microstructural Development and mechanical Properties of Pm Ti-45Al-2Nb-2mn-0.8 vol.%TiB_2 Processed by Field Assisted Hot Pressing

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journal of materials Science & Technology 2014年第11期30卷 1145-1154页

作者： R.munoz-moreno E.m.Ruiz-Navas B.Srinivasarao j.m.Torralba Department of materials Science and Engineering Universidad Carlos Ⅲ de MadridAvda.Universidad 3028911 LeganésMadridSpain ImDEA materials Institute C/Eric Kandel 228906 GetafeMadridSpain

A γ-TiAI intermetallic alloy, Ti-45Al-2Nb-2mn （at.%）-0.8 vol.%TiB2, has been processed from gas atomized praalloyed powder by field assisted hot pressing （FAHP）. An initial analysis of the prealloyed powder helped on the understanding of the intermetallic sintering behavior. Atomized powder consisted of α metastable phase that transformed into α2＋γ equilibrium phases by thermal treating. Different powder particle microstructures were found, which influence the microstructure development of the FAHP T-TiAI material depending on the sintering temperature. Duplex, nearly lamellar and fully lamellar microstructures were obtained at the sintaring temperatures above 1000 ℃. Lower consolidation temperatures, below 1000 ℃, led to the formation of an AI rich phase at powder particle boundaries, which is deleterious to the mechanical properties. High compressive yield strength of 1050 mPa was observed in samples with FAHP duplex microstructures at room temperature. Whereas nearly lamellar and fully lamellar microstructures showed yield strength values of 655 and 626 mPa at room temperature and 440 and 425 mPa at 750 ℃, respectively, which are superior in comparison to similar alloys processed by other techniques. These excellent properties can be explained due to the different volume fractions of the α2 and γ phases and the refinement of the Pm microstructures.

关键词： Titanium aluminides Powder metallurgy microstructure mechanical properties Field assisted sintering

Narrative minireview of the spatial epidemiology of substance use disorder in the United States:Who is at risk and where?

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World journal of Clinical Cases 2023年第11期11卷 2374-2385页

作者： Diego F Cuadros Adam j Branscum Claudia m moreno Neil j macKinnon Digital Futures University of CincinnatiCincinnatiOH 45206United States Department of Biostatistics Oregon State UniversityCorvallisOR 97331United States Department of Physiology and Biophysics University of WashingtonSeattleWA 98195United States Department of Population Health Sciences Augusta UniversityAugustaGA 30912United States

Drug overdose is the leading cause of death by injury in the United *** incidence of substance use disorder(SUD)in the United States has increased steadily over the past two decades,becoming a major public health problem for the *** drivers of the SUD epidemic in the United States have changed over time,characterized by an initial heroin outbreak between 1970 and 1999,followed by a painkiller outbreak,and finally by an ongoing synthetic opioid *** nature and sources of these abused substances reveal striking differences in the socioeconomic and behavioral factors that shape the drug ***,the geospatial distribution of the SUD epidemic is not *** United States has specific locations where vulnerable communities at high risk of SUD are concentrated,reaffirming the multifactorial socioeconomic nature of this epidemic.A better understanding of the SUD epidemic under a spatial epidemiology framework is necessary to determine the factors that have shaped its spread and how these patterns can be used to predict new outbreaks and create effective mitigation *** narrative minireview summarizes the current records of the spatial distribution of the SUD epidemic in the United States across different periods,revealing some spatiotemporal patterns that have preceded the occurrence of *** analyzing the epidemic of SUD-related deaths,we also describe the epidemic behavior in areas with high incidence of ***,we describe public health interventions that can be effective for demographic groups,and we discuss future challenges in the study and control of the SUD epidemic in the country.

关键词： Substance use disorder Spatial epidemiology Risk factors Spatial statistics Disease mapping

DBD-Corona Discharge for Degradation of Toxic Gases

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Plasma Science and Technology 2007年第6期9卷 682-685页

作者： m.PACHECO-PACHECO j.PACHECO-SOTELO H.moreno-SAAVEDRA j.A.DIAZ-GOmEZ A.mERCADO-CABRERA m.YOUSFI National Institute of Nuclear Research OcoyoacacMexico Toluca Institute of Technology TolucaMexico Center of Plasma Physics and their Applications of Toulouse France

The non-thermal plasma technology is a promising technique to treat SO2 and NOx. Chemical radicals produced with this technology can remove several pollutants at atmospheric pressure in a very short period of time simultaneously. Both theoretical and experimental study on SO2 and NOx removal, by a dielectric barrier discharge （DBD） with corona effect, is presented.

关键词： DBD-corona de-NOx process de-SO2 process

Influence of interparticle interactions on the kinetics of self-assembly and mechanical strength of nanoparticulate aggregates

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Particuology 2009年第2期7卷 106-113页

作者： Roberto moreno-Atanasio Simon j.Antony Richard A.Williams Institute of Particle Science and Engineering University of LeedsLeedsLS2 9JTUnited Kingdom

Computer simulations based on Discrete Element method have been performed in order to investigate the influence of interparticle interactions on the kinetics of self-assembly and the mechanical strength of nanoparticle aggregates. Three different systems have been considered. In the first system the interaction between particles has been simulated using the jKR （johnson, Kendall and Roberts） contact theory, while in the second and third systems the interaction between particles has been simulated using van der Waals and electrostatic forces respectively. In order to compare the mechanical behaviour of the three systems, the magnitude of the maximum attractive force between particles has been kept the same in all cases. However, the relationship between force and separation distance differs from case to case and thus, the range of the interparticle force. The results clearly indicate that as the range of the interparticle force increases, the self-assembly process is faster and the work required to produce the mechanical failure of the assemblies increases by more than one order of magnitude.

关键词： Nanoparticles Discrete Element method (DEm) Self-assembly jKR model van der Waals force

Conservation Tillage Influence on Carbon Dynamics Under mediterranean Conditions

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Pedosphere 2014年第1期24卷 65-75页

作者： R.LóPEZ-GARRIDO E.mADEjON F.moreno j.m.mURILLO Instituto de Recursos Naturales y Agrobiologia de Sevilla(IRNAS-CSIC)

Intensity of tillage practices can enhance organic matter decomposition, increasing CO2 emissions from soil to the atmosphere. Conservation tillage （CT） has been proposed as a means of counteracting potential damages to the environment. In this study the effects of two CT systems, reduced tillage in a long-term experiment （RTL） and no-tillage in a short-term experiment （NTs）, were compared to traditional tillage （TT） in the long （TTL） and short-term experiments （TTs）. CO2 fluxes, total soil organic carbon （SOC） and dehydrogenase activity （DHA） were evaluated at 0-5, 5-10 and 10-15 cm depths throughout the three years studied （Oct. 2006 jul. 2009）. Traditional tillage increased C02 emissions compared to CT. The CT treatments （RTL and NTs） accumulated more SOC in the surface layer （0 5 cm） than the TT treatments （TTL and TTs）. SOC accumulation was moderate but DHA consistently increased in CT in the surface soil, especially with a legume crop included in the crop rotation. Values of stratification ratio of all parameters studied were higher in the CT treatments （RTL and NTs）. The agricultural and environmental benefits derived from CT make this system recommendable for semi-arid mediterranean rain-fed agriculture.

关键词： crop rotation dehydrogenase activity rain-fed agriculture soil organic carbon

Patterns of trends in niveograph characteristics across the western United States from snow telemetry data

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Frontiers of Earth Science 2020年第2期14卷 315-325页

作者： S.R.FASSNACHT j.I.LÓPEZ-moreno ESS-Watershed Science Colorado State UniversityFort CollinsCO 80523-1472USA Cooperative Institute for Research in the Atmosphere Colorado State UniversityFort CollinsCO 80523-1375USA Natural Resources Ecology Laboratory Colorado State UniversityFort CollinsCO 80523-1499USA Instituto Pirenaico de Ecología CSICCampus de Aula Dei 50080Spain

The snowpack is changing across the globe,as the climate warms and *** used daily snow water equivalent(SWE)niveograph(time series of SWE)data from 458 snow telemetry(SNOTEL)stations for the period 1982 through *** indices based on amount,timing,time length,and rates were used to describe the annual temporal evolution in SWE accumulation and *** trends in these annual indices were computed over the time period for each station using the Theil-Sen *** trends were then clustered into four groups to determine the spatial pattern of SWE *** and precipitation data were extracted from the PRISm data set,due to the shorter time period of temperature measurement at the SNOTEL *** show that SNOTEL stations can be clustered in four clusters according to the observed trends in snow *** 1 stations are mostly located in the Eastern-and South-eastern most parts of the study area and they exhibit a generalized decrease in the indices related with peak SWE and snow *** stations recorded a negative trend in precipitation and an increase in *** 4 that is mostly restricted to the North and North-west of the study area shows an almost opposite pattern to cluster 1,due to months with positive trends and a more moderate increase of *** grouped in clusters 2 and 3 appear mixed with clusters 1 and 4,in general they show very little trends in the snow indices.

关键词： snow water equivalent cluster analysis SNOTEL

Hydrogen production through glycerol steam reforming using Co catalysts supported on SBA-15 doped with Zr,Ce and La

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journal of Energy Chemistry 2017年第1期26卷 42-48页

作者： Alicia Carrero Arturo j.Vizcaíno joséA.Calles Lourdes García-moreno Department of Chemical and Energy Technology ESCETRey Juan Carlos University28933 MóstolesSpain

The steam reforming of glycerol has been studied at 500 and 600 oC using Co/SBA-15 and Co/m/SBA-15（m: Zr, Ce, or La） promoted catalysts. The prepared materials were characterized by inductively coupled plasma atomic emission spectroscopy（ICP-AES）, X-ray powder diffraction（XRD）, hydrogen temperatureprogramed reduction（H;-TPR）, ammonia temperature-programed desorption（NH;-TPD）, nitrogen physisorption analysis（N;-BET）, transmission electron microscopy（TEm） and thermogravimetric analysis（TGA）. The incorporation of promoters like Zr, Ce and La on SBA-15 support and successive Co impregnation leaded to smaller cobalt crystallites improving metaldispersion. Besides, stronger metal-support interactions between Co species and m/SBA-15 supports were observed. Thanks to the incorporation of Zr, La and mainly Ce, promoted catalysts present higher glycerol conversion than Co/SBA-15 along 5 h of time on stream. Besides, at 600 oC, Co/m/SBA-15（m: Zr, Ce, or La） catalysts produce higher hydrogen amounts than Co/SBA-15.

关键词： Cobalt SBA-15 Cerium Zirconium Lanthanum Steam reforming Hydrogen