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Cancer Drug Resistance 2021年第4期4卷 984-995页

作者： montserrat estruch Camilla Vittori Teresa Muñoz Montesinos Kristian Reckzeh Kim Theilgaard-Mönch The Finsen Laboratory Rigshospitalet/National University HospitalFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Biotech Research and Innovation Centre Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Novo Nordisk Foundation Centre for Stem Cell Biology DanStemFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen DK-2200Denmark Department of Hematology Rigshospitalet/National University HospitalUniversity of CopenhagenCopenhagen DK-2200Denmark

Resistance of cancer patients to DNA damaging radiation therapy and chemotherapy remains a major problem in the *** current review discusses the molecular mechanisms of therapy resistance in acute myeloid leukemia(AML)conferred by cooperative chemotherapy-induced DNA damage response(DDR)and mutational activation of PI3K/AKT *** addition,strategies to overcome resistance are discussed,with particular focus on studies underpinning the vast potential of therapies combining standard chemotherapy AML regimens with small molecule inhibitors targeting key regulatory hubs at the interface of DDR and oncogenic signaling pathways.

关键词： DNA damage response PI3K/AKT chemotherapy resistance AML

Microbial phenolic metabolites are associated with better frontal lobe cognition

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Food Science and Human Wellness 2024年

作者： Inés Domínguez-López Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Casta?er Ramon estruch Emili Ros Rosa M.Lamuela-Raventós Lipid Clinic， Endocrinology and Nutrition Service， Institut d'Investigacions Biomèdiques August Pi i Sunyer， Hospital Clínic 08036 Barcelona， Spain Unit of Cardiovascular Risk and Nutrition， Institut Hospital del Mar de Investigaciones Médicas (IMIM) Department of Preventive Medicine and Public Health， University of Navarra Departament de Nutrició， Ciències de l'Alimentació i Gastronomía， Facultat de Farmacia， Universitat de Barcelon (UB)， Av.de Joan XXII Department of Endocrinology， Hospital Clinic IDIBAPS， Barcelona， Spain Department of Internal Medicine， Hospital Clinic， Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS)， University of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)， Instituto de Salud Carlos III Institut de Nutrició i Seguretat Alimentària (INSA)， Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the Mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDIMED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM， and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.

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Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food Science and Human Wellness 2024年

作者： Emily P.Laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón estruch Patricia Bodega Mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute， Icahn School of Medicine at Mount Sinai Department de Nutrició， Ciències de l'Alimentació I Gastronomia， XIA， Facultat de Farmàcia i Ciències de l'alimentació， Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB)， Universitat de Barcelona Department of Internal Medicine， Hospital Clínic， Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)， University of Barcelona Consorcio CIBER， M.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn)， Instituto de Salud Carlos III (ISCIII) Mediterranean Diet Foundation 5. Foundation for Science， Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend <0.001)， and the highest quintile of stilbene intake with lower BG (β=-1.83， 95%CI= -3.103;-0.64， P-for trend <0.001) and TG (β=-3.22， 95%CI= -4.95;-1.49， P-for trend=0.034)， and with higher HDL-c (β=2.328， 95%CI= 1.40;3.17， P-for trend=0.466) compared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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高超声速下表面凸起干扰气动热实验研究

航空学报 2012年第9期33卷 1578-1586页

作者： estruch-SAMPER David 卜雪琴 Department of Aeronautics Imperial College London 北京航空航天大学航空科学与工程学院北京100191 北京航空航天大学人机工效与环境控制重点学科实验室北京100191

对高超声速飞行器表面凸起附近的气流流动和气动加热开展了实验研究和分析。实验在高超声速炮风洞中进行,来流马赫数为8.2、单位雷诺数为9.35×106 m-1。利用薄膜传热测量方法进行了凸起几何形状和边界层状态对干扰流动加热的影响评估... 详细信息

对高超声速飞行器表面凸起附近的气流流动和气动加热开展了实验研究和分析。实验在高超声速炮风洞中进行,来流马赫数为8.2、单位雷诺数为9.35×106 m-1。利用薄膜传热测量方法进行了凸起几何形状和边界层状态对干扰流动加热的影响评估。利用流油图谱和纹影摄像法得到了凸起周围的流动特征:若凸起上游边界层未分离,最大峰值热流发生在凸起侧方附近处;若凸起上游边界层完全分离,最大峰值热流通常发生在凸起的上游表面。实验发现最大峰值热流和来流边界层状态关系不大,原因是流动干扰区表现出较强的三维扰动特性,使得来流层流边界层在干扰区内会转变成过渡甚至完全湍流状态。

关键词：高超声速表面凸起干扰加热实验最大峰值热流

Circulating immune cell activation and diet: A review on human trials

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World Journal of Immunology 2014年第1期4卷 12-19页

作者： Gemma Chiva-Blanch Ramon estruch Department of Internal Medicine Hospital Clinic 08036 Barcelona Spain Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) University of Barcelona 08041 Barcelona Spain

Protein energy malnutrition is the main cause of immunodeficiency and, secondarily, of several infections. However, immune cell activation is involved in several pathophysiological processes that play a crucial role in the appearance of cardiovascular disease(CVD) or cancer. The aim of this review is to update the knowledge of the modulation of immune cell activation by different dietary patterns and its components focusing on CVD or cancer. While a westernized high-saturated fat highcarbohydrate diet is positively associated with lowgrade inflammation, vegetable- and fruit-based diets rich in monounsaturated fatty acids, polyunsaturated fatty acids and polyphenols, key nutrients of Mediterranean diet, decrease the levels of cellular and circulating inflammatory biomarkers thereby reducing the risk of related chronic diseases.

关键词： Mediterranean diet Immune cell activa tion Leukocyte adhesion Inflammation Fatty acids Fruits Vegetables Polyphenols Cardiovascular disease Cancer

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固定化乙酰化酶催化制备头孢菌素

中国医药工业杂志 2008年第5期39卷 365-365页

作者： estruch I 张伟（译）胡又佳（校）

来源于大肠杆菌的青霉素G乙酰化酶（PGA）在催化头孢尼西的合成过程中，通过145位的精氨酸和底物β-内酰胺中的磺酸根离子之间的相互作用，有效提高了PGA活性位点吸附头孢菌素母核（7-SACA）的效率。将PGA固定化于乙醛酰基活化的琼脂糖... 详细信息

来源于大肠杆菌的青霉素G乙酰化酶（PGA）在催化头孢尼西的合成过程中，通过145位的精氨酸和底物β-内酰胺中的磺酸根离子之间的相互作用，有效提高了PGA活性位点吸附头孢菌素母核（7-SACA）的效率。将PGA固定化于乙醛酰基活化的琼脂糖上，通过对不同的β-内酰胺类抗生素进行动力学控制N-酰化，显示其良好的催化效率。较环氧氯丙烷法活化的疏水载体大大提高了合成率与分解率之比。

关键词：头孢菌素催化制备乙酰化酶固定化 β-内酰胺类抗生素动力学控制合成过程青霉素G

地中海饮食对心血管疾病危险因素的影响:一项随机试验

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 7-8页

作者： estruch R. Martínez-González M.A. Corella D. 罗亮 Department of Internal Medicine Hospital Clinic Villarroel 170 08036 Barcelona Spain Dr.

背景:地中海饮食被认为对心血管疾病危险因素具有保护作用。目的:对比2种地中海饮食与1种低脂饮食对心血管风险中间标记物的短期影响。设计:PRED-IMED研究(一项关于心血管疾病的多中心、随机。

关键词：地中海饮食低脂饮食橄榄油心血管疾病危险因素营养教育

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酒精性心肌病在男女性之间的比较

西藏医药 1998年第2期19卷 64-64页

作者：益西巴珍李小清 Fernandez-solaJ estruch.R NicolasJ.M. 成都市第三人民医院

地中海膳食可降低24h动态血压、空腹血糖及血脂:1年随机临床试验

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中华高血压杂志 2014年第7期22卷 699-699页

作者： Doménech M Roman P Lapetra J García de la Corte FJ Sala-Vila A de la Torre R Corella D Salas-Salvadó J Ruiz-Gutiérrez V Lamuela-Raventós RM Toledo E estruch R Coca A Ros E 赵狄

地中海膳食（MedDiets）添加橄榄油或坚果，较对照组低脂膳食可减少心血管事件，特别是脑卒中，但其心血管保护机制尚不清楚。研究人员进行随机、平行设计、对照试验研究，评估长达1年添加橄榄油或坚果的地中海膳食对24h动态血压、血糖... 详细信息

地中海膳食（MedDiets）添加橄榄油或坚果，较对照组低脂膳食可减少心血管事件，特别是脑卒中，但其心血管保护机制尚不清楚。研究人员进行随机、平行设计、对照试验研究，评估长达1年添加橄榄油或坚果的地中海膳食对24h动态血压、血糖和血脂的影响。膳食时间随意，

关键词： 24h动态血压随机临床试验低脂膳食空腹血糖地中海血脂心血管事件保护机制

地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系

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中华高血压杂志 2017年第12期25卷 1108-1108页

作者：黄洁叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J

血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。

关键词：心血管病膳食干预代谢物地中海胆碱风险血浆通路