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Mechanisms of developmental programming of the metabolic syndrome and related disorders

World Journal of Diabetes 2010年第3期1卷 89-98页

作者： Anne-monique Nuyt Department of Pediatrics CHU Sainte Justine University of Montreal

There is consistent epidemiological evidence linking low birth weight, preterm birth and adverse fetal growth to an elevated risk of the metabolic syndrome (obesity, raised blood pressure, raised serum triglycerides, lowered serum high-density lipoprotein cholesterol and impaired glucose tolerance or insulin resistance) and related disorders. This "fetal or developmental origins/programming of disease" concept is now well accepted but the "programming" mechanisms remain poorly understood. We reviewed the major evidence, implications and limitations of current hypotheses in interpreting developmental programming and discuss future research directions. Major current hypotheses to interpret developmental programming include: (1)thrifty phenotype; (2) postnatal accelerated or catchup growth; (3) glucocorticoid effects; (4) epigenetic changes; (5) oxidative stress; (6) prenatal hypoxia; (7) placental dysfunction; and (8) reduced stem cell number. Some hypothetical mechanisms (2, 4 and 8) could be driven by other upstream "driver" mechanisms. There is a lack of animal studies addressing multiple mechanisms simultaneously and a lack of strong evidence linking clinical outcomes to biomarkers of the proposed programming mechanisms in humans. There are needs for (1) experimental studies addressing multiple hypothetical mechanisms simultaneously; and (2) prospective pregnancy cohort studies linking biomarkers of the proposed mechanisms to clinical outcomes or surrogate biomarker endpoints. A better understanding of the programming mechanisms is a prerequisite for developing early life interventions to arrest the increasing epidemic of the metabolic syndrome, type 2 diabetes and other related disorders.

关键词： Fetal origins Developmental programming mechanisms Metabolic syndrome Insulin resistance Type 2 diabetes

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Monoclonal antibodies to the exon 18 encoded moiety of NCAM

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Journal of Cancer Metastasis and Treatment 2019年第7期4卷 50-55页

作者： Ann Vander Borght Mieke Duysinx monique Ummelen Bernard AMvan der Zeijst Department of Genetics and Cell Biology and GROW School for Oncology and Developmental Biology Maastricht UniversityMaastrichtPO Box 6166200 MDThe Netherlands MUbio Products B.V. Maastricht6200 EVThe Netherlands Catherinn B.V. Manuel de Fallapad 1Rotterdam3069 MRThe Netherlands

Aim: Exon 18 expression of NCAM has been recognized as a biomarker for small cell lung cancer (SCLC). To use this finding for an improved diagnosis of SCLC and personalized treatment of patients, techniques to identify and quantitate E18, the exon 18 encoded protein moiety of NCAM, are needed. We developed three monoclonal antibodies for this purpose. Methods: The his-tagged E18 antigen was expressed in E. coli and, after purification, used to immunize mice. Hybridoma's were isolated by standard procedures and tested for their reaction with E18. Results: Three monoclonal antibodies, MUM-1, MUM-4 and MUM-6 were obtained. They reacted with E18 in western blots, with SCLC cell line NCI-H82, but not with unrelated his-tagged proteins. Only permeabilized NCI-H82 cells stained with the antibodies, confirming the intracellular position of E18. Next an enzyme-linked immunosorbent assay was developed using the earlier isolated monoclonal antibody MUMi-21B2, coated on the surface of microtiter wells as capture antibody and biotinylated MUM-6 as second antibody. Using streptavidin conjugated to horse radish peroxidase a linear dose response curve to his-tagged E18 antigen was obtained between 0 and 5 μg/mL with a sensitivity of at least 0.5 μg/mL or 50 ng/well. Conclusion: Four monoclonal antibodies are available to be used in assays for the identification and quantification of SCLC biomarker E18. This will enable the development of liquid biopsies to follow the tumor load in patients.

关键词： Small cell lung cancer tumor biomarker monoclonal antibodies NCAM exon 18

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Comment to: Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

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Cellular & Molecular Immunology 2021年第5期18卷 1348-1349页

作者： Janine E.Melsen Gertjan Lugthart monique Mvan Ostaijen-ten Dam Marco W.Schilham Laboratory for Pediatric Immunology Willem-Alexander Children’s HospitalLeiden University Medical CenterLeidenThe Netherlands

We have read with interest the article by Crinier et *** a comprehensive single-cell RNA sequencing dataset of human bone marrow natural killer(NK)cells from eight healthy donors.1 Their unbiased analysis resulted in the identification of three NK cell populations in bone marrow:hNK_Bm1,hNK_Bm2 and hNK_*** populations correspond to the NK cell populations that the authors previously described in human spleen:hNK_Spl1,hNK_Sp2 and hNK_Sp3.2 The authors compared the gene signatures of the three bone marrow populations to the conventional CD56bright and CD56dim NK cells in the blood and concluded that hNK_Bm1 cells resemble CD56dim NK cells,hNK_Bm2 cells correspond to CD56bright NK cells,and hNK_Bm3 represent a CD56bright tissue-resident NK cell population that is not present in the blood.

关键词： CD56 killer spleen

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Fractionation of rare earth and other trace elements in crabs,Ucides cordatus,from a subtropical mangrove affected by fertilizer industry

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Journal of Environmental Sciences 2017年第4期29卷 69-76页

作者： Alice Bosco-Santos Wanilson Luiz-Silva Emmanoel Vieira da Silva-Filho monique Dias Corrêa de Souza Elton Luiz Dantas Margareth Sugano Navarro State University of Campinas (UNICAMP) Institute of Geosciences Department of Geology and Natural Resources Campinas Sao Paulo 13083870 Brazil . Fluminense Federal University (UFF) Institute of Chemistry Department of Geochemistry Niteroi Rio de Janeiro 24900970 Brazil University of Brasília(UnB) Institute of Geosciences Department of Geology Brasflia Distrito Federal 70910900 Brazil

Fractionation of rare earth elements（REE） and other trace metal concentrations（Th, U, Cd,Cr, Cu, Ni, Pb, and Zn） between mangrove sediments and claw muscles and shells of male crabs（Ucides cordatus） from a subtropical estuary highly impacted by fertilizer industry activities was investigated. This is the first record of REE distribution in these organisms,and the results showed higher accumulations of these metals, U and Th in shells, probably related to the replacement of Ca during molting. Contents of Cd, Cr and Ni were similar in both tissues, but Cu, Zn and Pb were mostly accumulated in the claw muscle with concentrations above those considered safe for human consumption according to the Brazilian legislation. REE fractionation was different in the analyzed tissues being softer in the shells. The results provided evidences that the water absorbed during molting controls the chemistry of REE in shells. In contrast, the chemistry of REE in the claw muscle, in which was observed preferential absorption of light REE, is controlled by diet. REE fractionation obtained for the claw muscles was closely correlated to the observed in the contaminated substrate and in materials related to the production of phosphate fertilizers（contamination source）, which supports their transference to this Ucides cordatus tissue without fractionation by the ingestion of sediments. Our results showed the potential use of crab tissues for monitoring REE and trace element sources in mangrove areas, with claw muscle exhibiting the contaminant source fingerprint.

关键词： Rare earth elements Trace metals Fertilizer contamination Crabs

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Phylogenetic Analysis of Orgyia pseudotsugata Single-nucleocapsid Nucleopolyhedrovirus

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中国病毒学 2007年第4期22卷 257-265页

作者： Agata Jakubowska monique M. van Oers Imre S. Otvos Just M. Vlak Laboratory of Virology Wageningen UniversityBinnenhaven 11Wageningen6709 PDThe Netherlands Department of Biological Control and Quarantine Institute of Plant ProtectionMiczurina 20 Poznan 60-318 Poland Natural Resources Canada Canadian Forest Service Pacific Forestry Centre 506 West Burnside Road BC V8Z 1M5 Victoria Canada

The Douglas-fir tussock moth Orgyia pseudotsugata (Lepidoptera: Lymantriidae) is a frequent defoliator of Douglas-fir and true firs in western USA and Canada. A single nucleopolyhedrovirus (SNPV) isolated from O. pseudotsugata larvae in Canada (OpSNPV) was previously analyzed via its polyhedrin gene, but is phylogenetic status was ambiguous. Sequences of four conserved baculovirus genes, polyhedrin, lef-8, pif-2 and dpol, were amplified from OpSNPV DNA in polymerase chain reactions using degenerate primer sets and their sequences were analyzed phylogenetically. The analysis revealed that OpSNPV belongs to group II NPVs and is most closely related to SNPVs that infect O. ericae and O. anartoides, respectively. These results show the need for multiple, concatenated gene phylogenies to classify baculoviruses.

关键词：基因分析核型多角体病毒单核壳体生物防治花旗松鳞翅目害虫系统演化

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Boites moléculaires

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法语国家与地区研究 2005年第5期 60-62页

作者： monique Dubois ,Thomas Zemb

Des polyèdres creux se forment spontanément dans un mélange de deux détergents. Shampooings, mousses àraser, cosmétiques, lessives... Tous ces produits contiennent des collodes, c'est-à-dire des substances qui s'asse mblent sous forme de petites particules, nommées micelles, quand elles sont dissoutes dans un solvant. Au Service de chimie moléculaire du Commissariat àl'énergie atomique, nous avons étudié des solutions collodales, dont les molécules s'asse mblent en icosaèdres réguliers, des polyèdres à 20 faces triangulaires agencées autour de 12 sommets, selon une symétrie pentagonale. Dans la nature, les protéines des capsules virales sont agencées de cette facon. En revanche, on n'avait encore jamais observé de tels arrangements avec des composés organiques synthétiques, telles des molécules de détergent.

关键词： Boites mol culaires

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Corrigendum:Edible seaweed-derived constituents:an undisclosed source of neuroprotective compounds

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Neural Regeneration Research 2021年第12期16卷 2564-2568页

作者： Melissa Schepers Nikita Martens Assia Tiane Kenneth Vanbrabant Hong-Bing Liu Dieter Lütjohann monique Mulder Tim Vanmierlo Department of Neuroimmunology Biomedical Research InstituteHasselt UniversityEuropean Graduate School of Neuroscience(EURON)HasseltBelgium Department of Psychiatry&Neuropsychology Division of Translational NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityEuropean Graduate School of Neuroscience(EURON)MaastrichtThe Netherlands Department of Internal Medicine Laboratory of Vascular MedicineErasmus MC University Medical CenterRotterdamthe Netherlands Institue for Clinical Chemistry and Clinical Pharmacology BonnGermany Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong ProvinceChina

Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and *** the last decades,seaweedderived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological ***,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative *** particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory ***,the antiinflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more *** this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

关键词： algae carotenoids neuro-active phenols phytosterols polysaccharides seaweed

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Modeling and Mapping Forest Floor Distributions of Common Bryophytes Using a LiDAR-Derived Depth-to-Water Index

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American Journal of Plant Sciences 2017年第4期8卷 867-890页

作者： monique Goguen Paul A. Arp Forest Watershed Research Centre Faculty of Forestry and Environmental Management University of New Brunswick Fredericton New Brunswick Canada

This article describes how the cartographic depth-to-water (DTW) index in combination with other variables can be used to quantify, model and map the distribution of common forest floor bryophytes, at 1 m resolution. This was done by way of a case study, using 12 terrain and climate representative locations across New Brunswick, Canada. The presence/absence by moss species was determined at each location along upland-to-wetland transects within >10-m spaced 1-m2 forest floor plots. It was found that Bazzania trilobata, Dicranum polysetum, Polytrichum commune, Hylocomium splendens, and Pleurozium schreberi had greater probabilities of occurrence in well-drained forested areas, whereas Sphagnum fuscum and Sphagnum girgensohnii dominated in low-lying wet areas. The presence/absence of each species was quantified by way of logistic regression analyses, using DTW, slope, canopy closure, forest litter depth, ecosite type (8 classes), nutrient regime (4 classes, poor to rich);vegetation type (deciduous, coniferous, mixed, and shrubs), and macro- and micro-topography (upland, wetland;mounds, pits) as predictor variables. Among these, log10DTW and forest litter depth were the most consistent predictor variables, followed by mound versus pit. For the mapping purpose, only log10DTW and already mapped classifications for upland versus wetland and vegetation type were used to predict the probability of occurrences for the most frequent moss species, namely, D. polysetum, P. schreberi and Sphagnum spp. The overall accuracy for doing this ranged from 67% to 83%, with false positives and negatives amounting to 18% to 42%. The overall classification accuracy exceeded the probability by chance alone at 76.8%, with the significance level reached at 75.3%. The average level of probability by chance alone was 60.3%.

关键词： Bryophytes Wet Areas Macro- and Micro-Topography Forest Floor Forest Litter Mound And Pit Canopy Closure Digital Elevation Modeling Logistic Regression

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与出牙有关的9个对与错

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父母必读 2007年第11期 50-51页

作者： monique Fort

出牙,是一件不太舒服的事情。从出现这个迹象开始,你就要十分小心地保护好他的小牙齿了。在妈妈怀孕的第2个月,小胎儿的乳牙胚就已经开始发育。等到宝宝出生时,一部分乳牙已经完成钙化,在宝宝的小牙床下扎下了根,一直到它们准备好拱出来。

关键词：牙釉质幼儿期

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The gardener's companion to medicinal plants

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作者： Simmonds monique S. J. Howes Melanie-Jayne Irving Jason

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