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Production and characterization of bioaerosols for model validation in spacecraft environment

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Journal of Environmental Sciences 2018年第7期30卷 227-238页

作者： Anniina Salmela Eero Kokkonen Ilpo Kulmala Anna-Maria Veijalainen Rob van Houdt Natalie leys Audrey Berthier Ilyin Viacheslav Sergey Kharin Julia Morozova Alexander Tikhomirov Pertti Pasanen Department of Environmental and Biological Sciences University of Eastern Finland PO Box 1627 FI-70211 Kuopio Finland VTT Ltd PO Box 1300 FI-33100 Tampere Finland Microbiology Unit Belgian Nuclear Research Centre B-2400 Mol Belgium Institut de Medecine et de Physiologie Spatiales BP 74404 F-31405 Toulouse Cedex France Institute of Bio-Medical Problems 76-A Khorosheu Skoye shosse RU-123007 Moscow Russia Institute of Biophysics SB RAS Akademgorodok Krasnoyarsk RU-660036 Russia

This study aimed to evaluate the suitability of two bioaerosol generation systems（dry and wet generation） for the aerosolization of microorganisms isolated from the International Space Station, and to calibrate the produced bioaerosols to fulfill the requirements of computational fluid dynamics model（CFD） validation. Concentration, stability, size distribution, agglomeration of generated bioaerosol and deposition of bioaerosols were analyzed. In addition, the dispersion of non-viable particles in the air was *** proved that wet generation from microbial suspensions could be used for the production of well-calibrated and stabile bioaerosols for model validation. For the simulation of the natural release of fungal spores, a dry generation method should be used. This study showed that the used CFD model simulated the spread of non-viable particles fairly well. The mathematical deposition model by Lai and Nazaroff could be used to estimate the deposition velocities of bioaerosols on surfaces, although it somewhat underestimated the measured deposition velocities.

关键词： Bioaerosol Modeling CFD Spacecraft Fungi Bacteria

Six-year outcomes in neovascular age-related macular degeneration with ranibizumab

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 81-90页

作者： Julie Jacob Heidi Brié Anita leys Laurent Levecq Filip Mevgaerts Kris Denhaerynck Stefaan Vancayzeele Eline Van Craeyveld Ivo Abraham Karen MacDonald Leuven University Eye Hospital Kapucijnenvoer 33Leuven B-3000Belgium Novartis Pharma Medialaan 40Vilvoorde B-1800Belgium Catholic University of Louvain CHU UCL NamurYvoirB-5530Belgium Medisch Centrum Aarschot Langdorpsesteenweg 129Aarschot B-3200Belgium Matrix45 6159 W Sunset RdTucsonAZ 85743USA Center for Health Outcomes and Pharmacoeconomic Research University of ArizonaTucsonAZ 85721USA

AIM： To evaluate the outcomes of （6y ranibizumab therapy in neovascular age-related macular degeneration （AMD）.METHODS： HELIX was a retrospective, observational effectiveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab （0.5 mg） between November 1, 2007 and October 31, 2008, had （6y of data available, and were treated on an ongoing, as-needed basis. Outcomes included best-corrected visual acuity （BCVA） and central retinal thickness （CRT）.RESULTS： The sample consisted of 88 eyes from 69 patients. Mean age was 76.4±6.5y, most patients were female （62.3%）. Most eyes （62.5%） were treatment-naive, 33 previously treated eyes had received predominantly other anti-vascular endothelial growth factor agents and verteporfin. Mean baseline BCVA was 57.4±12.7 ETDRS letters and CRT was 291.5±86.1 （m. On average, patients received 20.6±11.9 ranibizumab injections over the （6y. Intervals between injections were on average 12.7±16.1wk. Mean change in BCVA from baseline to last observation for the sample was less than one letter （-0.9±17.3 letters）, with an average loss of -3.2±15.6 letters in previously treated eyes versus a gain of 0.6±18.4 letters in treatment-na？ve eyes. When considering a loss of 〈15 letters over 6y as stabilization of disease, 75.9% of all eyes showed a positive （improvement or stabilization） outcome. Mean change in CRT from baseline to last observation for the sample was -26.9±148.4 （m with the greatest reduction observed in treatment-naive ***： This retrospective study of 69 neovascular AMD patients treated for （6y with ranibizumab demonstrates long-term visual stabilization. In light of the natural evolution of the disease, these data confirm that ranibizumab is effective long-term under real-world conditions of heterogeneity of patients, clinicians, and centers.

关键词： ranibizumab age-related macular degeneration visual acuity central retinal thickness optical coherence tomography visual function, long-term outcome

Physical Process of Wind Erosion and Its Relation to Ground Surface Conditions in East Asia

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Physical Process of Wind Erosion and Its Relation to Ground ...

第三届中日韩气象学术会议

作者： M.Mikami M.Ishizuka J.leys Y.Yamada S.Heidenreich Meteorological Research Institute JMAJapan Kagawa University Japan NSW government Australia RIKEN Japan NSW government Australia

＜正＞As the first intensive observation on Japan Australia Dust Experiment（JADE）, which was launched from April 2005 as a three years project,we conducted a filed experiment at a fallow-wheat-field in the Lower Murray Darling Catchments in *** experiment aims to monitor the whole processes of wind erosion from anthropogenic source *** was made for monitoring multi-size saltation process using sand particle counter（SPC）,which monitors saltation particle ranging from 40 micron meters to 600 micron meters for every second.

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房颤患者的卒中前痴呆:发病率和相关因素

世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 30-31页

作者： Lefebvre C Deplanque D Touzé E. D. leys 刘凯 Dept. of Neurology University of Lille Roger Salengro Hospital 59037 Lille FranceDr.

Background and purpose: Prestroke dementia is frequent but usually not identified. Non-valvular atrial fibrillation (NVAF)is independently associated with an increased risk for dementia. However, the frequency and determinants of prestroke dementia in patients with NVAF have never been evaluated. Objective: The aim of this study was to determine the frequency of prestroke dementia and associated factors in patients with a previously known NVAF. Methods: This is an ancillary study of Stroke in Atrial Fibrillation Ensemble II (SAFE II), an observational study conducted in patients with a previously known NVAF, consecutively admitted for an acute stroke in French and Italian centers. Prestroke dementia was evaluated by the IQCODE in patients with a reliable informant. Patients were considered as demented before stroke when their IQCODE score was ≥ 104. Results: of 204 patients, 39 (19.1 % ; 95 % confidence interval [CI]: 13.7 % - 24.5 % ) patients met criteria for prestroke dementia. The only variable independently associated with prestroke dementia was increasing age (adjusted odds ratio for 1 year increase in age: 1.10; 95 % CI: 1.04- 1.17), and there was a non-significant tendency for previous ischemic stroke or TIA and arterial hypertension. Conclusion: One fifth of stroke patients with a previously known NVAF were already demented before stroke. The main determinant of prestroke dementia is increasing age. A large cohort is necessary to identify other determinants.

关键词：急性卒中房颤患者痴呆发病率 NVAF 非瓣膜性房颤观察性研究缺血性卒中发生风险住院患者

岛叶梗死和入院心电图改变:大脑岛叶梗死预后研究(PRINCESS)的结果

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世界核心医学期刊文摘(神经病学分册) 2006年第10期 24-25页

作者： Pasquini M. Laurent Ch. Kroumova M. D. leys 牛亚利 Department of Neurology University of Lille Roger Salengro Hospital 59037 LilleFrance Prof.

Background and purpose: Previous studies showed that insular strokes are associated with electrocardiographic (ECG)- ***, they did not take into account the 1st ECG recorded at admission, but continuous ECG recorded up to 72 hours after onset. Whether these changes are the consequence of the infarct, or are associated with a cardiac source of cerebral ischemia, remains unsettled. If ECG changes are the consequence of insular infarcts, they should not have developed by the time of admission. The aim of this study was to test the hypothesis that ECG changes in patients with insular infarcts are not present at admission. Methods: We recruited consecutive patients admitted within 48 hours (median 3 hours) after the onset of symptoms of acute hemispheric cerebral ischemia. We compared ECG variables between patients with and without insular infarcts, and with left and right insular infarcts. Results: The study population consisted of 208 patients (94 men; median age: 69 years). Seventy patients had a recent insular infarct (right in 33). ECG variables did not significantly differ between patients with and without insular infarcts, and with left and right insular infarcts. These results were not explained by a lack of statistical power (1- β ≥ 0.90). Conclusion: The lack of statistical link between insular infarcts and ECG changes at admission, suggests that ECG changes are not associated with the cause of insular infarcts, but are their consequence.

关键词：岛叶 ECG 梗死 PRINCESS 心电图电诊断图

无机械性肠梗阻的婴儿和儿童接受择期肠道手术:试点研究

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 44-45页

作者： leys C.M. Austin M.T. Pietsch J.B. 王经纬 Department of Pediatric Surgery Vanderbilt Children's Hospital Vanderbilt University Medical Center Nashville TN 37203 United States

Background/Purpose: Preoperative mechanical bowel preparation (MBP) for elective intestinal operations has been a long accepted practice. However, MBP is often unpleasant and time-consuming for patients, and clinical trials in adults have not shown improved outcomes. We conducted this pilot study to test whether omitting MBP before elective intestinal operations in infants and children would increase the risk of infectious or anastomotic complications. Methods: Retrospective review was performed of 143 patients who had an elective colon or distal small bowel procedure performed at our children’s hospital between 1990 and 2003. Results: Thirty-three patients (No PREP) were managed by a single surgeon who routinely omitted MBP, whereas another 110 patients (PREP) were prepared with enemas, laxatives, or both. Both groups received 24 hours of preoperative dietary restriction to clear liquids and perioperative parenteral antibiotics. The No PREP group had one anastomotic leak and no wound infections, whereas the PREP group had 2 anastomotic leaks and 1 wound infection (P =. 58). These results occurred despite greater duration of antibiotic therapy and incidence of delayed wound closures in the PREP group. Conclusion: The results of this pilot study suggest that omitting MBP before elective intestinal operations in infants and children carries no increased risk of infectious or anastomotic complications. Eliminating MBP may reduce health care costs and inconvenience to patients. These findings warrant a large, prospective, randomized clinical trial to validate our findings and to investigate further the necessity of MBP in the pediatric population.

关键词：机械性肠梗阻肠道手术试点研究肠道准备外科手术儿童医院导泻吻合口临床试验伤口感染

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缺血性卒中后的次级预防及病情的进展评估

世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 33-34页

作者： Girot M. Mackowiak- Cordoliani M.- A. Deplanque D. D. leys 胡慧敏 Department of Neurology University of Lille Roger Salengro Hospital 59037 Lille France Prof.

Background and Abstract:Objective: An optimal management of vascular risk factors, associated with antithrombotic drugs and carotid surgery when appropriate, reduces the risk of a new vascular event after stroke. Although secondary prevention is not optimal in many patients in practice, the question of whether there is an improvement over time remains unanswered. The aim of our study was to test the hypothesis that secondary prevention measures after cerebral ischemia improve over time. Method: We included 123 consecutive patients in 1994, and 125 consecutive patients in 2002, who were admitted to a neurological department for any reason and had had an episode of cerebral ischemia less than 6 years earlier. We compared the groups for the management of arterial hypertension, hypercholesterolemia, diabetes mellitus and smoking. We recorded the values of blood pressure, biological parameters, and presence of antithrombotic therapy, lipid- lowering and anti- hypertensive drugs. Whether patients were properly treated or not, was determined by a comparison between their current treatment and guidelines available when recruited. Results: Prevention was not optimal in 96 of 123 (78% ) patients in 1994, and in 77 of 125 (62% ) in 2002. Vascular risk factors were better identified and managed in 2002 than in 1994, especially for hypercholesterolemia. Antithrombotic therapies, statins and anti- hypertensive drugs, except calcium channel blockers, were more often used in 2002. The proportion of patients in whom arterial hypertension and hypercholesterolemia were identified was higher in 2002, but the proportion of patients identified as diabetics remained stable. However, the proportion of patients with blood pressure > 140/90 mmHg, glycemia ≥ 126 mg/dl, total cholesterol level ≥ 240 mg/dl, or being current smokers, were significantly lower in 2002 than in 1994. Conclusion: Although most of patients with previous cerebral ischemia did not receive an optimal management of their

关键词：次级预防缺血性卒中脑缺血血管危险因素抗血栓药物高胆固醇血症动脉高血压降压药物外科手术发病风险

非心电门控多层CT在卵圆孔未闭中的应用价值

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国际医学放射学杂志 2008年第A6期31卷 506-507页

作者： M.P.Revel J.B.Faivre T.Letourneau H.Henon D.leys V.Delannoy-Deken 郑丽丽 Department of Radiology Calmette Hospital Centre Hospitalier Regional Universitaire de Lille University of Lille-2 Boule-vard Jules Leclercq 59037 Lille France.

目的与经食管超声(TEE)对照,探讨非心电门控多层螺旋CT对卵圆孔未闭(PFO)及房间隔动脉瘤(ASA)的诊断价值。材料与方法本研究经伦理委员会审议通过。

关键词：卵圆孔未闭心电门控房间隔伦理委员会脑卒中病史卵圆窝时间-密度曲线放射剂量诊断医师分