检索结果-南通市图书馆

Combined effects of gallic acid and propolis on beryllium-induced hepatorenal toxicity

Integrative Zoology 2008年第3期3卷 194-207页

作者： Satendra K.NIRALA Peiqiang LI monika bhadauria Guangqin GUO Institute of Cell Biology School of Life SciencesLanzhou UniversityLanzhouChina Institute of Genetics School of Basic Medical SciencesLanzhou UniversityLanzhouChina National Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhouChina

The combined effect of gallic acid (3,4,5-trihydroxy benzoic acid;GA;50 mg kg^(-1) i.p.) and propolis (200 mg kg^(-1)p.o.)was evaluated against beryllium-induced biochemical and morphological alterations in the liver and kidney. Femalealbino rats were exposed to beryllium nitrate (1 mg kg^(-1)i.p.) daily for 28 days followed by treatment with the abovementioned therapeutic agents either individually or in combination for five consecutive days. Exposure to berylliumincreased its concentration in the serum, liver and kidney and caused significant alterations in cytochrome P450enzymes, microsomal lipid peroxidation and protein contents. Beryllium administration significantly altered theaspartate aminotransaminase, alanine aminotransaminase, lactate dehydrogenase, -glutamyl transpeptidase,bilirubin, creatinine and urea in serum, and the activity of acid phosphatase, alkaline phosphatase, adenosinetriphosphatase, glucose-6-phophatase and succinic dehydrogenase, triglycerides, cholesterol, protein contents,glycogen contents, lipid peroxidation and glutathione level in the liver and kidney. Beryllium exposure inducedsevere alterations in hepatorenal morphology, revealing its toxic consequences at a cellular level. Individual administrationof GA and propolis reduced the effects on the studied parameters to a degree. Interestingly, GA in conjunctionwith propolis reversed the alterations in all of the variables examined, highlighting the beneficial effects ofcombined therapy over monotherapy in the alleviation of beryllium-induced systemic toxicity.

关键词： beryllium toxicity gallic acid 3,4,5-trihydroxy benzoic acid hepatorenal dysfunction propolis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ameliorative effect of Pergularia daemia(Forssk.) Chiov. leaves extract against anti-tuberculosis drugs induced liver injury in rats

引用

Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 518-525页

作者： Gita Mishra Hemeshwer Kumar Chandra Nisha Sahu Satendra Kumar Nirala monika bhadauria Toxicology and Pharmacology Laboratory Department of ZoologyGuru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social DevelopmentGuru Ghasidas University

Objective:To evaluate therapeutic potential of hydroethanolic extract of Pergularia daemia(***) against anti-tuberculosis drugs(ATDs) induced liver ***:Wistar albino rats were divided into seven groups of six animal in *** ATDs and *** extract(100,200 and 400 mg/kg,p.o.) were conjointly administered for 8 weeks and various biochemical,histoarchitectural,ultrastructural studies were ***:Administration of ATDs significantly increased aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase,triglycerides,cholesterol,bilirubin and decreased glucose and albumin *** lipid peroxidation and reduction in glutathione,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase and glucose-6-phosphate dehydrogenase were found after ATDs *** of *** extract maintained serum biochemical indices as well as antioxidant status similar to control and diminished oxidative stress in dose dependent *** and ultra-structural observations substantiated biochemical ***:*** has therapeutic potential against ATDs induced liver injury and may be of clinical significance after extensive studies.

关键词： Antituberculosis drugs Hepatic injury Pergularia daemia Antioxidant activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury

引用

Asian Pacific Journal of Tropical Medicine 2018年第11期11卷 609-620页

作者： Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala monika bhadauria Toxicology and Pharmacology Laboratory Department of Zoology Guru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social development Guru Ghasidas University

To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury.

关键词： Antituberculosis drugs Propolis Biochemical Hepatic injury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatic endogenous defense potential of propolis after mercury intoxication

引用

Integrative Zoology 2008年第4期3卷 311-321页

作者： monika bhadauria Sangeeta SHUKLA Ramesh MATHUR Om PAGRAWAL Sadhana SHRIVASTAVA Sonia JOHRI Deepmala JOSHI Varsha SINGH Deepak MITTAL Satendra Kumar NIRALA Reproductive Biology and Toxicology Laboratory Insect Physiology and Biochemistry School of Studies in ZoologyJiwaji UniversityGwaliorIndia Boston College for Professional Studies GwaliorIndia

Exposure to mercuric chloride(HgCl2;5 mg kg–1 body weight;i.p.)induced oxidative stress in mice and substantially increased lipid peroxidation(LPO)and oxidized glutathione(GSSG)levels,decreased the level of reduced glu-tathione(GSH)and various antioxidant enzymes in liver and also increased the activities of liver marker enzymes in *** with propolis extract,a resinous wax-like beehive product(200 mg kg–1 orally,after mercury administration),for 3 days inhibited LPO and the formation of GSSG and increased the level of GSH in the *** of serum transaminases,alkaline phosphatase,lactate dehydrogenase and-glutamyl transpeptidase were significantly restored after propolis *** activities of antioxidant enzymes,that is,superoxide dismutase,catalase,glutathione-S-transferase and glucose-6-phosphate dehydrogenase,were also concomitantly restored towards normal levels after propolis *** observations clearly demonstrate that propolis treatment augments antioxidant defense against mercury-induced toxicity and provide evidence that propolis has therapeutic potential as a hepatoprotective agent.

关键词： antioxidant enzymes glutathione hepatoprotection mercuric chloride propolis.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ANTIOXTOATIVE EFFICACY OF PROPOLIS EXTRACT AGAINST OXIDATIVE DAMADE INDUCED BY CARBON TETRACHLORIDE

ANTIOXTOATIVE EFFICACY OF PROPOLIS EXTRACT AGAINST OXIDATIVE...

引用

第十五届国际药理学大会

作者： monika bhadauria Sangeeta Shukla SOS in Zoology Jiwaji UniversityGwalior （M. P.） 474011 INDIA SOS in Zoology Jiwaji UniversityGwalior （M. P.） 474011 INDIA

＜正＞ The purpose of this investigation was to explore whether or not propolis extract could prevent the hepatic damage caused by model toxicant i.e. carbon tetrachloride（CCl4）. Antioxidative efficacy of propolis extract was evaluated against acute （1.5 ml/kg, ip. once only） and subchronic （0.15 ml/kg, ip. 21 days） exposure to CCl4. Toxicant exposure provoked marked elevation in the activities of serum transaminases. alkaline phosphatase and lactate dehydrogenase. Significant increased lipid peroxidation was observed after toxicant exposure. Drastic alterations were observed in enzymatic and non - enzymatic antioxidant defense system, which were estimated by reduced and oxidised glutathione. glutathione peroxidaseand glutathione reductase in liver. Initial screening of Propolis extract at different doses （50. 100. 200 and 400 mg/kg. once only, po） revealed recoupment in acute study and found to be very effective in restoring all the parameters. Treatment with effective dose of Propolis extract （200 mg/kg. po） for 5 days after subchronic exposure of toxicant caused significant recovery. It was observed that Propolis exerts its beneficial hepatoprotective effect as a natural antioxidant due to the presence of polyphenols and flavonoids.

关键词： Propolis GSH cycle CCl4

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

基于县域尺度的黑龙江省乡村人地系统耦合测度及其时空演化分析

引用

水土保持研究 2025年第1期32卷 347-357页

作者：左文洁李玉恒杜国明 monika Stanny 姜博东北农业大学公共管理与法学院中国科学院地理科学与资源研究所中国科学院大学资源与环境学院波兰科学院农村与农业发展研究所

[目的]探究乡村人地系统耦合协调，为乡村可持续发展，协调乡村人地关系，推进实施乡村振兴战略提供决策参考。[方法]利用空间热点分析、耦合协调度模型等方法研究了黑龙江省2000—2020年乡村人地时空演化热点及耦合特征。[结果](1) 200... 详细信息

[目的]探究乡村人地系统耦合协调，为乡村可持续发展，协调乡村人地关系，推进实施乡村振兴战略提供决策参考。[方法]利用空间热点分析、耦合协调度模型等方法研究了黑龙江省2000—2020年乡村人地时空演化热点及耦合特征。[结果](1) 2000—2020年黑龙江省乡村人口呈持续下降的趋势，与此同时，耕地和以农村居民点用地为主的建设用地呈现出小幅度增加的趋势，以工业、交通用地为主的建设用地快速扩张。(2)研究期内，黑龙江省耕地变化的热点区呈现由西向东转变的趋势，建设用地变化的热点区呈现出逐渐向东、西部扩散的趋势，乡村人口变化的热点区呈现由南部向北部转变的趋势。(3)黑龙江省乡村人地耦合协调水平整体呈小幅度上升趋势，但大多区县仍处于严重失衡和濒临失调状态。“人口—耕地”协调度由0.34上升至0.38,“人口—建设用地”协调度由0.44上升至0.50。[结论]2000年以来，黑龙江省乡村人地关系不协调的趋势凸显，制约了乡村可持续发展。调控措施包括科学引导人才回流，因地制宜发挥高耦合协调地区的辐射和带动作用，提高中低耦合协调地区的产业多元化程度和政策支持力度等。

关键词：人地耦合乡村振兴可持续发展

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Analysis of mobility data-A focus on Mobile Mapping Systems

引用

Geo-Spatial Information Science 2020年第1期23卷 68-74页

作者： monika Sester Institute of Cartography and Geoinformatics Leibniz Universitat HannoverHannoverGermany

The increasing availability of devices to capture the position of moving objects(and other environmental information)leads to a very large amount and variety of mobility *** order to obtain important information about the objects,their behavior or the environment of the objects,an automatic analysis is *** article highlights current research questions in the context of the analysis of mobility data and presents them on the basis of work carried out at the Institute of Cartography and Geoinformatics(ikg)at Leibniz University of Hannover,Germany.A focus is put on the analysis and exploitation of information from Mobile Mapping vehicles.

关键词： Trajectories Lidar data automatic analysis traffic applications

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermal Analysis and Kinetics of Coal during Oxy-Fuel Combustion

引用

Journal of Thermal Science 2017年第4期26卷 355-361页

作者： monika Kosowska-Golachowska Czestochowa University of Technology Institute of Thermal MachineryArmii Krajowej 2142-201 CzestochowaPoland

The pyrolysis and oxy-fuel combustion characteristics of Polish bituminous coal were studied us/ng non- isothermal thermogravimetric analysis. Pyrolysis tests showed that the mass loss profiles were almost similar up to 870℃ ha both N2 and CO2 atmospheres, while further mass loss occurred ha CO2 atmosphere at higher temper- atures due to char-CO2 gasification. Replacement of N2 ha the combustion environment by CO2 delayed the com- bustion of bituminous coal. At elevated oxygen levels, TG/DTG profiles shifted through lower temperature zone, ignition and burnout temperatures decreased and mass loss rate significantly increased and complete combustion was achieved at lower temperatures and shorter times. Kinetic analysis for the tested coal was performed using Kissinger-Akahira-Sunose （KAS） method. The activation energies of bituminous coal combustion at the similar oxygen content in oxy-fuel with that of air were higher than that in air atmosphere. The results indicated that, with O2 concentration increasing, the activation energies decreased.

关键词： oxy-fuel combustion pyrolysis bituminous coal TGA DTA kinetics analysis KAS method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Culturomics and metagenomics: In understanding of environmental resistome

引用

Frontiers of Environmental Science & Engineering 2019年第3期13卷 29-40页

作者： monika Nowrotek Lukasz Jalowiecki monika Harnisz Grazyna Anna Plaza Microbiology Unit Institute for Ecology of Industrial Areas Kossutha 6 Str. 40-844 Katowice Poland Department of Environmental Microbiology Faculty of Environmental Sciences University of Warmia and Mazuiy Prawochenskiego 1 Str. 10-720 Olsztyn Poland Silesian University of Technology Faculty of Organization and Management Institute of Engineering Production Roosevelta 26 Str. 41-800 Zabrze Poland

Pharmaceutical residues, mainly antibiotics, have been called "emerging contaminants" in the environment because of their increasing frequency of detection in aquatic and terrestrial systems and their sublethal ecological effects. Most of them are undiscovered. Both human and veterinary pharmaceuticals, including antibiotics, are introduced into the environment via many different routes, including discharges from municipal wastewater treatment plants and land application of animal manure and biosolids to fertilize croplands. To gain a comprehensive understanding of the widespread problem of antibiotic resistance, modem and scientific approaches have been developed to gain knowledge of the entire antibiotic-resistant microbiota of various ecosystems, which is called the resistome. In this review, two omics methods, i.e. culturomics, a new approach, and metagenomics, used to study antibiotic resistance in environmental samples, are described. Moreover, we discuss how both omics methods have become core scientific tools to characterize microbiomes or resistomes, study natural communities and discover new microbes and new antibiotic resistance genes from environments. The combination of the method for get better outcome of both culturomics and metagenomics will significantly advance our understanding of the role of microbes and their specific properties in the environment.

关键词： Culturomics Metagenomics Antibiotic resistance Resistome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermal Analysis of Underground Power Cable System

引用

Journal of Thermal Science 2017年第5期26卷 465-471页

作者： monika Rerak Pawel Oclon Cracow University of Technology Institute of Thermal Power Engineering al. Jana Pawta Ⅱ 37 31-864 Krakow Polan

The paper presents the application of Finite Element Method in thermal analysis of underground power cable system. The computations were performed for power cables buried in-line in the ground at a depth of 2 meters. The developed mathematical model allows determining the two-dimensional temperature distribution in the soil, thermal backfill and power cables. The simulations studied the effect of soil and cable backfill thermal conductivity on the maximum temperature of the cable conductor. Also, the effect of cable diameter on the temperature of cable core was studied. Numerical analyses were performed based on a program written in MATLAB.

关键词： thermal analysis power cable soft backfill

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：