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BIOCELL 2022年第12期46卷 2525-2530页

作者： monica SAVIO VALENTINA MINOIA PAOLA FULGHIErI LUCIA ANNA STIVALA VIrGINIE SOTTILE Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene

recovery of free volume in PIM-1 membranes through alcohol vapor treatment

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 872-881页

作者： Faiz Almansour monica Alberto rupesh S.Bhavsar Xiaolei Fan Peter M.Budd Patricia Gorgojo Department of Chemical Engineering and Analytical Science School of EngineeringThe University of ManchesterManchester M139PLUK Department of Chemistry School of Natural SciencesThe University of ManchesterManchester M139PLUK

Physical aging is currently a major obstacle for the commercialization of PIM-1 membranes for gas separation applications.A well-known approach to reversing physical aging effects of PIM-1 membranes at laboratory scale is soaking them in lower alcohols,such as methanol and ***,this procedure does not seem applicable at industrial level,and other strategies must be *** this work,a regeneration method with alcohol vapors(ethanol or methanol)was developed to recover permeability of aged PIM-1 membranes,in comparison with the conventional soaking-in-liquid *** gas permeability and separation performance,before and post the regeneration methods,were assessed using a binary mixture of CO_(2) and CH_(4)(1:1,v:v).Our results show that an 8-hour methanol vapor treatment was sufficient to recover the original gas permeability,reaching a CO_(2) permeability>7000 barrer.

关键词： polymer of intrinsic microporosity(PIM) PIM-1 physical aging gas separation vapor-phase regeneration

Does offering only the spherical contact lens trial to the low astigmats mislead the practitioners?

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1281-1284页

作者： monica Chaudhry Surendra Prasad Sah Indra Prasad Sharma Soujanya Mondal Department of Optometry and Vision Science Amity UniversityHaryana 122003India School of Health Sciences Ansal UniversityGurugramHaryana 122003India Himalaya Eye Hospital GharinpatanPokhara 00977Nepal Gyalyum Kesang Choeden Wangchuck National Eye Center JDW National Referral HospitalThimphu 11001Bhutan Optsight Eye Care HCB RoadAmulapattiNear MFCSivasagarAssam 785640India

AIM:To compare the visual acuity(VA),comfort,and patient preference in a soft toric contact lens(TCL)versus soft spherical contact lens(SCL)in low astigmatic subjects during the contact lens(CL)***:This subject-masked,block randomized,2×2 crossover study recruited 40 neophyte subjects(80 eyes)aged 18 to 33 y with astigmatism in the range of 0.75-1.25 D with or without spherical power from-6.00 D to+6.00 *** participants were scheduled for two days CL trial and were fitted with the best-fit SCL and *** 4 h of wear,they were assessed objectively for high contrast VA and subjective vision,comfort,and ***:The responses of 36 subjects(response rate 90%)with a mean age of 23.02±2.97 y(range 18 to 33 y)were ***-line improvement of monocular VA in the logMAr chart was reported to TCL as compared to SCL(-0.044±0.06 vs 0.04±0.03 logMAr,P=0.01)but the binocular vision remained similar(-0.12±0.07 vs-0.14±0.04 logMAr,P=0.38).Subjects felt a noticeable difference in clarity when shifted to TCL as compared to the *** satisfaction with vision(vision quality)was significantly better with TCL(P=0.03).The fatigue with TCL was graded less at 2.5±0.6,compared to SCL at 4.6±1.3(P=0.04).Thirty-three participants(91.6%)preferred to use contact lens of which 26 participants(79%)preferred ***:The findings suggest that VA and comfort are better with TCL as compared to SCL which is only observed if the patient was offered both offering SCL with spherical equivalent power alone as the first option can mislead the practitioner;TCL trial should be the first choice of the lens in low-to-moderate astigmatism.

关键词： astigmatism comfort spherical contact lens toric contact lens visual acuity

Different kinds of stem cells in the development of SArS-CoV-2 treatments

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World Journal of Stem Cells 2021年第5期13卷 439-451页

作者： monica Maribel Mata-Miranda Miguel Sanchez-Brito Gustavo Jesus Vazquez-Zapien Cell and Tissue Biology Laboratory Escuela Militar de MedicinaMexico 11200Mexico Computational Sciences TecNM/Technological Institute of AguascalientesAguascalientes 20256Mexico Embryology Laboratory Escuela Militar de MedicinaMexico 11200Mexico

On February 11,2020,the World Health Organization officially announced the coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2(SArS-CoV-2),as an emerging recent pandemic illness,which currently has approximately taken the life of two million persons in more than 200 ***,clinical,and scientific efforts have focused on searching for new prevention and treatment *** medicine and tissue engineering focused on using stem cells(SCs)have become a promising tool,and the regenerative and immunoregulatory capabilities of mesenchymal SCs(MSCs)and their exosomes have been ***,it has been essential to establishing models to reproduce the viral life cycle and mimic the pathology of COVID-19 to understand the virus's *** fields of pluripotent SCs(PSCs),induced PSCs(iPSCs),and artificial iPSCs have been used for this purpose in the development of infection models or ***,some inconveniences have been declared in SC use;for example,it has been reported that SArS-CoV-2 enters human cells through the angiotensin-converting enzyme 2 receptor,which is highly expressed in MSCs,so it is important to continue investigating the employment of SCs in COVID-19,taking into consideration their advantages and *** this review,we expose the use of different kinds of SCs and their derivatives for studying the SArS-CoV-2 behavior and develop treatments to counter COVID-19.

关键词： COVID-19 SArS-CoV-2 Stem cells Exosomes Pluripotent stem cells Mesenchymal stem cells Artificial stem cells

Ectopic expression of the osteogenic master gene rUNX2 in melanoma

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World Journal of Stem Cells 2018年第7期10卷 78-81页

作者： Maria Teresa Valenti Luca Dalle Carbonare monica Mottes Department of Medicine University of Verona Department of Neurosciences Biomedicine and Movement Sciences University of Verona

The transcription factor rUNX2 is the osteogenic master gene expressed in mesenchymal stem cells during osteogenic commitment as well as in pre-osteoblasts and early ***,rUNX2 is also ectopically expressed in melanoma and other *** melanoma(MM)is a highly metastatic skin *** incidence of MM has increased considerably in the past *** expression levels and mutation rates of genes such as BrAF,KIT,NrAS,PTEN,P53,TErT and MITF are higher in melanoma than in other solid ***,transcription factors can affect cellular processes and induce cellular transformation since they control gene ***,several studies have identified alterations in rUNX2 *** particular,the regulation of KIT by rUNX2 and the increased expression of rUNX2 in melanoma specimens have been ***,whose transformation results in melanoma,arise from the neural crest and therefore show"stemness"***2 plays an important role in the re-activation of the MAPK and PI-3K/AKT pathways,thus endowing melanoma cells with a high metastatic *** melanoma,the most frequent metastatic sites are the lung,liver,brain and lymph *** addition,bone metastatic melanoma has been ***,studies focusing on rUNX2may contribute to the identification of an appropriate oncotarget in melanoma.

关键词： rUNX2 Mesenchymal stem cells Epitelial mesenchymal transition Bone Melanoma

Characterization and electrochemical performance of CeO2 and Eu-doped CeO2 films as a manganese redox flow battery component

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Journal of rare Earths 2018年第10期36卷 1074-1083页

作者： monica A.rodrigues Ariadne C.Catto Elson Longo Edson Nossol renata C.Lima Institute of Chemistry.Federal University of Uberlandia 38400-902UberlandiaMGBrazil Institute of Chemistry Sao Paulo State UniversityP.O.Box 35514801-907Araraquara.SPBrazil LIEC Department of ChemistryFederal University of Sao Carlos13565-905Sao CarlosSPBrazil

Hexagonal CeO2 and Eu-doped CeO2 nanoparticles were obtained using a facile microwave-hydro thermal method under mild conditions and their application towards manganese redox flow battery component were studied. The structural properties were studied by X-ray diffraction and indicate that samples present a fluorite structure. raman spectroscopy shows Eu3＋ ions substitute Ce4＋ and generate oxygen vacancies. Electrochemical properties of pure and Eu-doped CeO2 films deposited at graphite substrates investigated by cyclic voltammetry and galvanostatic charge-discharge indicate that dopant concentration affects the electrochemical properties of CeO2. The increase in the reversibility redox of electrochemical systems observed is attributed to coexistence of Ce4＋/Ce3＋ redox couple confirmed by ***-discharge tests display coulombic and voltage efficiency values of above 80% and 90%, respectively. The obtained specific capacity for Ce（0.99）Eu（0.01）O2（372.49 mAh/g） and pure oxide（334.84 mAh/g）indicates that both samples are promising for application in Mn-batteries.

关键词： Cerium oxide Europium Nanoparticles Electrochemical properties Batteries rare earths

role of live microbial feed supplements with reference to anaerobic fungi in ruminant productivity: A review

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Journal of Integrative Agriculture 2015年第3期14卷 550-560页

作者： Anil K Puniya Abdelfattah Z M Salem Sanjay Kumar Sumit S Dagar Gareth W Griffith monica Puniya Sreenivas r ravella Nikhil Kumar Tejpal Dhewa ravinder Kumar Dairy Microbiology Division National Dairy Research Institute Faculy of Veterinary Medicine and Animal Science Autonomous University of the State of Mexico Department of Clinical Studies School of Veterinary Medicine University of Pennsylvania Microbial Science Division Agharkar Research Institute Institute of Biological Environmental and Rural Sciences Aberystwyth University Department of Microbiology Bhaskarcharya College of Applied Sciences University of Delhi

To keep the concept of a safe food supply to the consumers, animal feed industries world over are showing an increasing interest in the direct-fed microbials（DFM） for improved animal performance in terms of growth or productivity. This becomes all the more essential in a situation, where a number of the residues of antibiotics and/or other growth stimulants reach in milk and meat with a number of associated potential risks for the consumers. Hence, in the absence of growth stimulants, a positive manipulation of the rumen microbial ecosystem to enhance the feedstuff utilization for improved production efficiency by ruminants has become of much interest to the researchers and entrepreneurs. A few genera of live microbes（i.e., bacteria, fungi and yeasts in different types of formulations from paste to powder） are infrequently used as DFM for the domestic ruminants. These DFM products are live microbial feed supplements containing naturally occurring microbes in the rumen. Among different DFM possibilities, anaerobic rumen fungi（ArF） based additives have been found to improve ruminant productivity consistently during feeding trials. Administration of ArF during the few trials conducted, led to the increased weight gain, milk production, and total tract digestibility of feed components in ruminants. Anaerobic fungi in the rumen display very strong cell-wall degrading cellulolytic and xylanolytic activities through rhizoid development, resulting in the physical disruption of feed structure paving the way for bacterial action. Significant improvements in the fiber digestibility were found to coincide with increases in ArF in the rumen indicating their role. Most of the researches based on DFM have indicated a positive response in nutrient digestion and methane reducing potential during in vivo and/or in vitro supplementation of ArF as DFM. Therefore, DFM especially ArF will gain popularity but it is necessary that all the strains are thoroughly studied for their beneficial

关键词： anaerobic rumen fungi bacterial DFM direct-fed microbials probiotics rumen

role of autophagy in bone and muscle biology

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World Journal of Stem Cells 2016年第12期8卷 396-398页

作者： Maria Teresa Valenti Luca Dalle Carbonare monica Mottes Department of Medicine Section of Internal Medicine D University of Verona Department of Neurological Biomedical and Movement Sciences Section of Biology and Genetics University of Verona

Autophagy in eukaryotic cells is a constitutive process and functions as a homeostatic mechanism; it is up-regulated in response to specific stress stimuli such as starvation, hypoxia and as oxidative stress. In addition to playing a crucial role in adaptive responses to different stimuli, autophagy is also required for intracellular quality control. This second aspect is important to prevent the activation of pathological processes. Autophagy also plays a central role in cellular development and differentiation because it is involved in the regulation of energetic balance. This final aspect is critical for maintaining proper bone and muscle function as well as to prevent any pathological changes. Therefore, identifying new molecular targets involved in autophagy is critical to assure a good quality of life.

关键词： Autophagy Bone Muscle

LiYF_(4):Yb/LiYF_(4) and LiYF_(4):Yb,Er/LiYF_(4) core/shell nanocrystals with luminescence decay times similar to YLF laser crystals and the upconversion quantum yield of the Yb,Er doped nanocrystals

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Nano research 2021年第3期14卷 797-806页

作者： Frederike Carl Leonie Birk Bettina Grauel monica Pons Christian Würth Ute resch-Genger Markus Haase Institute of Chemistry of New Materials Department Biology/ChemistryUniversity OsnabrueckBarbarastr.749076OsnabrueckGermany Division 1.2 Biophotonics Federal Institute for Materials Research and Testing(BAM)Richard-Willstaetter-Str.1112489BerlinGermany

We developed a procedure to prepare luminescent LiYF_(4):Yb/LiYF_(4) and LiYF_(4):Yb,Er/LiYF_(4) core/shell nanocrystals with a size of approximately 40 nm revealing luminescence decay times of the dopant ions that approach those of high-quality laser crystals of LiYF_(4):Yb(Yb:YLF)and LiYF_(4):Yb,Er(Yb,Er:YLF)with identical doping *** the luminescence decay times of Yb^(3+)and Er^(3+)are known to be very sensitive to the presence of quenchers,the long decay times of the core/shell nanocrystals indicate a very low number of defects in the core particles and at the core/shell *** improvement in the performance was achieved by introducing two important modifications in the commonly used oleic acid based ***,the shell was prepared via a newly developed method characterized by a very low nucleation rate for particles of pure LiYF_(4) shell ***,anhydrous acetates were used as precursors and additional drying steps were applied to reduce the incorporation of OH−in the crystal lattice,known to quench the emission of Yb^(3+)*** power density(P)-dependent absolute measurements of the upconversion luminescence quantum yield(ΦUC)of LiYF_(4):Yb,Er/LiYF_(4) core/shell particles reveal a maximum value of 1.25%at P of 180 W·cm^(−2).Although lower than the values reported for NaYF4:18%Yb,2%Er core/shell nanocrystals with comparable sizes,theseΦUC values are the highest reported so far for LiYF_(4):18%Yb,2%Er/LiYF_(4) nanocrystals without additional *** improvements may nevertheless be possible by optimizing the dopant concentrations in the LiYF_(4) nanocrystals.

关键词： nanocrystal decay time luminescence LiYF_(4) quantum yield upconversion