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Sleep disturbances as an adverse effect of propranolol use in children with infantile hemangioma

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World Journal of Pediatrics 2020年第5期16卷 537-538页

作者： Ellen M.S.Xerfan monica l.andersen Anamaria S.Facina Sergio Tufik Jane Tomimori Programa de Pós-Gradua(c)(a)o em Medicina Translacional Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Dermatologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil Departamento de Psicobiologia Universidade Federal de S(a)o Paulo(UNIFESP)S(a)o PauloBrazil

Infantile hemangiomas(IHs)are the most prevalent benign vascular tumor in children,with an estimated rate of 5-10%.Most IHs resolve spontaneously after the proliferation stage,but about 12-24%develop with sequelae and complications which require pharmacological interventions[1].The beta blocker propranolol is considered as the first-line treatment for complicated cases of IHs[2].

关键词： propranolol children effect

Challenges facing the USA in matching Germany on advanced manufacturing for green growth

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International Journal of Innovation Studies 2024年第1期8卷 13-24页

作者： Mikael Skou andersen Aarhus University Dept.of Environmental ScienceKatrinebjergvej 89G8200Aarhus N.Denmark

This study explores the relative strength of public policies promoting advanced manufacturing by comparing the government programs and capacities of two world leaders in science and technology:the USA and *** on insights from’varieties-of-capitalism’literature and using process tracing methodology,this study identifies significant differences in today’s pursuit of advanced *** German model of Rhine capitalism has strength due to its long tradition of diversified quality work,built on a long-term commitment to government-industry collaboration,with significant indirect public support provided by vocational training and research *** American model of Manchester capitalism has been challenged by the loss of millions of low-skilled manufacturing jobs due to outsourcing and competition from *** study finds that the“Manufacturing USA”policy initiative of the Obama era,although directly inspired by Germany’s Fraunhofer institutes,is hampered by the contextual and institutional circumstances *** biobased carbon fibers offering the potential of a novel,low-cost material,pursued with research and development(R&D)efforts in both countries,it provides a measure for evaluating policy outcomes,and the study confirms Germany’s technological *** addition,the study’s process-tracing methodology reveals that significant legacies from German knowledge creation in the past have spilled over to American science and technology,and may continue to do so,lured by government *** studies on advanced manufacturing should test the robustness of these findings.

关键词： Research policy Industry 4.0 Bioeconomy low-carbon innovation Varieties of capitalism Process tracing

Functions of lysosomes in Mammalian Female Reproductive System

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Reproductive and Developmental Medicine 2020年第2期4卷 109-122页

作者： Yuehuan li Zidao Wang Christian l.andersen Xiaoqin Ye Department of Physiology and Pharmacology College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Toxicology Program University of GeorgiaAthensGA 30602USA

The lysosome is the most acidic membrane-bound intracellular *** acidity is primarily maintained by vacuolar H+-ATPase(V-ATPase)and counter ion *** are>60 hydrolytic enzymes in the lysosome for its fundamental digestive *** also play important roles in endocytosis,exocytosis,autophagy,and cell *** that have implicated roles of lysosomes in the female reproductive system are reviewed *** the ovary,lysosomes are implicated in the preparation of free cholesterol for steroidogenesis and degradation of regulators of steroidogenesis,regulation of follicular atresia,follicle rupture during ovulation,luteal cell survival,and luteal *** the oviduct,lysosomes are involved in endocytosis of both serum and oviductal luminal *** the uterus during the menstrual/estrous cycle,lysosomes are associated with endometrial secretion,apoptosis,and *** the uterus during early pregnancy,lysosomes are involved in the temporal and directional changes of endocytosis,uterine epithelial acidification upon embryo implantation initiation,and embryo-maternal mutual communications via extracellular *** the placenta,lysosomes are implicated in nutrient transport and placental separation from the uterus for *** the mammary gland,lysosomes are important for mammary gland development and *** findings suggest/demonstrate functions of lysosomes in multiple processes of female reproduction,from ovulation to ovarian steroidogenesis for pregnancy maintenance,and from essential in utero nurturing of developing embryos/fetuses via embryo/fetal-maternal communications,to optional postpartum nurturing of newborns via *** studies using genetically or modified animal models and pharmacological approaches will provide novel insights into the functions and mechanisms of lysosomes in the mammalian female reproductive system.

关键词： Autophagy Endocytosis lysosome Ovary Steroidogenesis Uterus

Investigation of Hexavalent Chromium Reduction in Strong Saline and Acidic Nitro-Phosphate Solutions

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Journal of Analytical Sciences, Methods and Instrumentation 2024年第1期14卷 1-13页

作者： Deniz Avsar Niels Højmark andersen Dag Øistein Eriksen Jon Petter Omtvedt Department of Chemistry University of Oslo Oslo Norway

Phosphorus fertilizers from less pure sedimentary sources become increasingly important, due to depletion of phosphorus from igneous rock of high quality. Consequently, robust methods with potential to remove various types of hazardous elements are required. Among such impurities, hexavalent chromium (Cr(VI)) is very likely to become a future challenge. Different industrial ways to treat phosphate rock are currently being practised, and we have here studied how chromium behaves when using the nitro-phosphate process. The reduction mechanism of Cr (VI) in nitric acid and phosphoric acid solutions was investigated by measuring redox potential and UV-VIS spectra. The results show that Cr (VI) is not stable in strong nitric acid solutions. Reduction of Cr (VI) species decreased with decreasing temperature, NO2 concentration, ionic strength and absence of light. These findings support the proposed reduction reaction:The reduction rate was observed proportional to the nitric acid decomposition: .

关键词： Nitro-Phosphate Fertilizers Chromium (VI) Reduction Chromium Speciation Ultraviolet-Visible Spectroscopy

Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek lichota Preben Bruun-Nyzell Mads Christian andersen Nanna Marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

Cellular stress responses regulated by two ubiquitin-conjugating enzyme variants

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Cellular stress responses regulated by two ubiquitin-conjuga...

Extracellular Vesicles from Mesenchymal Stromal Cells (imEVs) Improve Cold Preservation of Isolated Mitochondria

中国细胞生物学学会2005年学术大会、青年学术研讨会

作者： Parker l.andersen Department of Microbiology and Immunology University of Saskatchewan Saskatoon SK Canada

When cells face environmental stresses such as bacterial and viral infections, they activate pro-survival and anti-apoptotic pathways to enhance proliferation of defending cells. On the other hand, stresses that cause DNA damage activate cell-cycle checkpoints and induce apoptosis when the damage cannot be repaired. A central question is how cells detect different types of environmental stresses and make correct response.

关键词： Cellular stress responses regulated by two ubiquitin-conjugating enzyme variants

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Journal of Biosciences and Medicines 2024年第1期12卷 52-63页

作者： Xianpeng Jiang Sergey Rodin Ken Braesch-andersen Catherine C. Baucom Karl-Henrik Grinnemo Brent Segal Elliott Mitochondrial Center Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Department of Surgical Sciences Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitochondrial organelle transplantation (MOT) is an innovative strategy for the treatment of mitochondrial dysfunction such as cardiac ischemic reperfusion injuries, Parkinson’s diseases, brain and spinal cord injuries, and amyotrophic lateral sclerosis (AlS). However, one of the major challenges for widespread usage is a methodology for preservation of isolated mitochondria. Extracellular vesicles (EVs) are phospholipid bilayer-enclosed vesicles released from cells. EVs carry a cargo of proteins, nucleic acids, lipids, metabolites, and even organelles such as mitochondria. Purpose: To test if EVs enhance the stability of isolated mitochondria. Methods: We mixed isolated mitochondria of fibroblasts with EVs of mesenchymal stromal cells (imEVs) (9:1 in volume) and stored the mixture at 2°C - 6°C for different time periods. We measured morphology, mitochondrial membrane potential (MMP) and mitochondrial ATP content at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-chondria without imEVs lost approximate 70% MMP (RFU: 1822 ± 68), compared to the fresh mitochondria (RFU: 5458 ± 52) (p 0.05). In agreement with MMP, mitochondria without imEVs lost significant mitochondrial ATP content (p 0.05), after 2 days of cold storage, compared to fresh mitochondria. Microscopy showed that imEVs promoted aggregation of isolated mitochondria. Summary: The preliminary data showed that imEVs enhanced the stability of isolated mitochondria in cold storage.

关键词： Mitochondria Extracellular Vesicles Mitochondrial Preservation MOT imEVs

Mindfulness interventions during pregnancy:A narrative review

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Journal of Integrative Medicine 2020年第6期18卷 470-477页

作者： leandro lucena Cristina Frange Ana Claudia Amorim Pinto monica levy andersen Sergio Tufik Helena Hachul Department of Psychobiology Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04023062Brazil Department of Neurology and Neurosurgery Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04039002Brazil Department of Gynecology Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo 04024002Brazil

Pregnancy is a period of major transformations in a woman’s life;increased stress,and mood and sleep disorders are *** review evaluates mindfulness interventions during pregnancy and their ability to help manage stress,anxiety,depression,emotional regulation,level of mindfulness and sleep quality.A search of English language scientific literature relevant to mindfulness interventions for pregnant women was conducted using PubMed,Scopus and Web of Science,without restriction on publication *** criteria were randomized clinical trials with pregnant women,using mindfulness as an intervention for at least three weeks,in one of our main areas of interest,and using only validated scales to measure *** hundred and thirty studies were identified in our searches of research databases,and thirteen were included in our *** found a large diversity of mindfulness programs,heterogeneity among the instruments used to evaluate outcomes,and inconsistency in the gestational periods used in the *** interventions were beneficial for stress,anxiety and *** was also effective when applied in pregnant women with a history of depression or experiencing *** emotional regulation and the level of mindfulness,there were signs of improvement,but more studies are *** of the studies evaluated sleep *** review provides information about current mindfulness programs,an overview of the effects of mindfulness interventions,a description of the measurements used so far,and recommendations for developing highquality mindfulness protocols for pregnant women.

关键词： Mindfulness Pregnancy Anxiety Stress Depression Sleep

Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： Therese Hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper l.andersen lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained ***: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 ml/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 ml/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and ***: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p l treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p ll-being subscale "energy"(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women.

关键词： Bone mineral density (BMD) Intensity Intermittent Motivation Muscle mass Physical performance Recreational handball Well-being