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BIOCELL 2022年第12期46卷 2525-2530页

作者： monica SAVIO VALENTINA MINOIA PAOLA FULGHIERI LUCIA ANNA STIVALA VIRGINIE SOTTILE Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： Resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene

Thermo-electro-mechanical microstructural interdependences in conductive thermoplastics

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npj Computational Materials 2023年第1期9卷 955-965页

作者： Javier Crespo-Miguel Sergio Lucarini Angel Arias Daniel garcia-Gonzalez Department of Continuum Mechanics and Structural Analysis Universidad Carlos III de MadridAvda.de la Universidad 3028911 LeganésMadridSpain Department of Civil and Environmental Engineering Imperial College of LondonSouth Kensington CampusLondon SW72AZUK

Additive manufacturing has enabled the design of thermoplastic components that provide structural support,electrical conductivity and heat generation modulated by mechanical *** mechanisms and interplays that govern the material response at the microstructural level remain,however,***,we develop an experimental method to characterise conductive filaments from a combined mechanical,electrical and thermal *** approach is used to unravel exciting material interplays of conductive polylactic *** overcome experimental limitations that prevent a complete microstructural analysis of the problem,we develop a full-field homogenisation framework and implement it for finite *** framework accounts for viscoplasticity,electrical and thermal conduction,convection and heat generation via Joule effect,as well as for the interdependences between *** experimental validation,the framework is applied to virtually optimise fabrication requirements to obtain desired properties in final products,i.e.,stiffer products,filaments with higher conductivities or with better sensing capabilities.

关键词： conductive electrical overcome

Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

Resilience, the 6th Vital Sign: Conceptualizing, Contextualizing, and Operationalizing All Six Vital Signs

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Health 2024年第7期16卷 657-673页

作者： Rose E. Constantino Betty J. Braxter Chi Ching Vivian Hui Larissa C. Allen Lillian J. Wolfe Katherine H. Endres Jezyl Cempron Cutamora Laurence L. garcia Daisy R. Palompon Kathleen Thimsen Brayden N. Kameg Margarete L. Zalon Department of Health and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hong Kong Polytechnic University Hong Kong China School of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School of Nursing University of Pittsburgh Pittsburgh PA USA Department of Health Promotion and Development School of Nursing University of Pittsburgh Pittsburgh PA USA College of Nursing Cebu Normal University Cebu City Philippines School of Nursing University of Nevada Las Vegas USA Department of Health and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital signs that healthcare providers assess: temperature, pulse, respiration, blood pressure, and pain. Normal levels for the five vital signs are published by the American Heart Association, and other specialty organizations, however, the sixth vital sign (resilience) which adopts the measure of immune resilience is suggested in this paper. Resilience is the ability of the immune system to respond to attacks and defend effectively against infections and inflammatory stressors, and psychological resilience is the capacity to resist, adapt, recover, thrive, and grow from a challenge or a stressor. Individuals with better optimal immune resilience had better health outcomes than those with minimal immune resilience. The purpose of this paper is to conceptualize, contextualize, and operationalize all six vital signs. We suggest measuring resilience subjectively and objectively. Subjectively, use a 5-item guided interview revised from the Connor-Davidson Resilience Scale (CDRC), a scale of 10 items. The revised CDRC scale is a 5-item scale. The scale is rated on a 5-point Likert scale from 0 (not true) to 4 (true all the time). The total score ranges from 0 to 20, with higher total scores indicating greater resilience. The scale demonstrated good construct validity and internal consistency (α = 0.85) during the development of the scale. The CD-RISC had a good Cronbach’s alpha level of 0.85. The Revised CD-RISC can be completed in 2 - 4 minutes. To measure resilience objectively, we suggest using Immune Resilience (IR) levels, the level of resilience to preserve and/or rapidly restore immune resilience functions that promote disease resistance and control inflammation and other inflammatory stress. IR levels are gauged with two peripheral blood metrics that quantify the balance between CD8 and CD4 T-cell levels and gene expression signatures tracking longevity-associated immunocompetence and mortality- or entropy-associated inflammation. IR deregulation i

关键词： Conceptualization Contextualization Operationalization Body Temperature Pulse Respiration Blood Pressure Pain Resilience

Vascular complications of pancreatitis

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World Journal of Clinical Cases 2022年第22期10卷 7665-7673页

作者： M Ammar Kalas monica Leon Luis Omar Chavez Eduardo Canalizo Salim Surani Department of Medicine Texas Tech University Health CenterEl PasoTX 79905United States Department of General Surgery Centro Medico ABCCiudad de Mexico 01120Mexico Department of Medicine Texas A&M UniversityBryanTX 77807United States

More than 200000 hospital admissions happen per year for acute pancreatitis and more than 50000 for chronic pancreatitis in the United States of *** pancreatitis accounts for 20%-30%of the ***-quarter of the patients with pancreatitis develop vascular complications,which carries a high *** mini-review will address these complications that can help primary care physicians and hospitalists in managing their patients effectively.

关键词： Acute pancreatitis Vascular complications Gastrointestinal bleeding Pseudoaneurysm Hemosuccus pancreaticus Pancreas

Classification of osteogenesis imperfecta:Importance for prophylaxis and genetic counseling

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World Journal of Clinical Cases 2023年第12期11卷 2604-2620页

作者： monica-Cristina Panzaru Andreea Florea Lavinia Caba Eusebiu Vlad Gorduza Department of Medical Genetics Faculty of Medicine“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Department of Medical Genetics-Medical Genetics resident “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania

Osteogenesis imperfecta(OI)is a genetically heterogeneous monogenic disease characterized by decreased bone mass,bone fragility,and recurrent *** phenotypic spectrum varies considerably ranging from prenatal fractures with lethal outcomes to mild forms with few fractures and normal *** basic mechanism is a collagen-related defect,not only in synthesis but also in folding,processing,bone mineralization,or osteoblast *** recent years,great progress has been made in identifying new genes and molecular mechanisms underlying *** this context,the classification of OI has been revised several times and different types are *** Sillence classification,based on clinical and radiological characteristics,is currently used as a grading of clinical *** on the metabolic pathway,the functional classification allows identifying regulatory elements and targeting specific therapeutic *** classification has the advantage of identifying the inheritance pattern,an essential element for genetic counseling and *** genotype-phenotype correlations may sometimes be challenging,genetic diagnosis allows a personalized management strategy,accurate family planning,and pregnancy management decisions including options for mode of delivery,or early antenatal OI *** research on molecular pathways and pathogenic variants involved could lead to the development of genotype-based therapeutic *** narrative review summarizes our current understanding of genes,molecular mechanisms involved in OI,classifications,and their utility in prophylaxis.

关键词： Osteogenesis imperfecta Heterogeneity Classification Molecular mechanism Genetic counseling Prophylaxis

Comparison of intraocular pressure readings with Perkins,Tonopen,iCare 200,and iCare Home to manometry in cadaveric eyes

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2022-2027页

作者： monica K Ertel Leonard K Seibold Jennifer L Patnaik Malik Y Kahook Department of Ophthalmology University of ColoradoUC Health Sue Anschutz-Rodgers Eye CenterAuroraColorado 80045USA

AIM:To compare intraocular pressure(IOP)readings obtained with Perkins tonometry,i Care Home,i Care 200,and Tonopen to IOP readings obtained with the manometer of a perfusion system to assess the accuracy and reproducibility of each method of tonometry at set ***:The IOP of human cadaveric eyes(n=2)was measured using a manometer inserted into the eye through the optic *** measurements were obtained using a Perkins tonometer,i Care Home,i Care 200,and *** measurements were compared to set point IOP measurements of a manometer to determine accuracy and reproducibility of each ***:Mean IOP readings obtained with the Perkins tonometer compared to manometer readings demonstrated a difference of-1.0±5.0 mm Hg(P=0.45),indicating a lower reading on average than manometery although not *** IOP difference between iCare 200 and manometer was 5.3±2.2 mm Hg(P<0.0001).Mean difference in IOP between iCare Home and manometer was 3.5±2.4 mm Hg(P=0.0004).Mean IOP difference compared to manometer was 4.6±4.0 mm Hg for the Tonopen(P<0.0001).IOP measurements obtained with the Perkins tonometer demonstrated a standard deviation of 5.0 mm Hg while the Tonopen measurements demonstrated a 4.0 mm Hg standard *** comparison,iCare 200 and iCare Home demonstrated 2.2 and 2.4 mm Hg standard deviation,***:Applanation tonometry produces more accurate IOP readings than rebound tonometry or Tonopen,however it demonstrates greater variability than the other forms of *** tonometry is more reproducible but tends to over-estimate IOP.

关键词： intraocular pressure ocular tonometry manometry

Maneuvering Angle Rigid Formations With Global Convergence Guarantees

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IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1464-1475页

作者： Liangming Chen Zhiyun Lin Hector garcia de Marina Zhiyong Sun Mir Feroskhan School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Computer Architecture and Technology and also with CITICUniversity of Granada18014 GranadaSpain Department of Electrical Engineering Eindhoven University of Technology5600 MB Eindhoventhe Netherlands

Angle rigid multi-agent formations can simultaneously undergo translational,rotational,and scaling maneuvering,therefore combining the maneuvering capabilities of both distance and bearing rigid ***,maneuvering angle rigid formations in 2D or 3D with global convergence guarantees is shown to be a challenging problem in the existing literature even when relative position measurements are *** by angle-induced linear equations in 2D triangles and 3D tetrahedra,this paper aims to solve this challenging problem in both 2D and3D under a leader-follower *** the 2D case where the leaders have constant velocities,by using local relative position and velocity measurements,a formation maneuvering law is designed for the followers governed by double-integrator *** the leaders have time-varying velocities,a sliding mode formation maneuvering law is proposed by using the same *** the 3D case,to establish an angle-induced linear equation for each tetrahedron,we assume that all the followers'coordinate frames share a common Z ***,a formation maneuvering law is proposed for the followers to globally maneuver Z-weakly angle rigid formations in *** extension to Lagrangian agent dynamics and the construction of the desired rigid formations by using the minimum number of angle constraints are also *** examples are provided to validate the effectiveness of the proposed algorithms.

关键词： Index Terms—Angle rigid formations formation control formation maneuvering global convergence multi-agent systems

Bronchiectasis and COVID-19 infection:a two-way street

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Chinese Medical Journal 2022年第20期135卷 2398-2404页

作者： Grace Oscullo Jose DanieGómez-Olivas Thais Beauperthuy AminaBekki Alberto garcia-Ortega Maria Gabriella Matera Mario Cazzola Miguel Angel Martinez-garcia Department of Pneumology Hospital Universitario y Politécnico la Fe de ValenciaValencia 46012Spain Department of Experimental Medicine University of Campania“Luigi Vanvitelli”Naples 80121Italy Department of Experimental Medicine University of Rome Tor VergataRome 00185Italy CIBERES de enfermedades respiratorias Instituto de Salud Carlos IIIMadrid 41263Spain

Bronchiectasis(BE)has been linked to past viral infections such as influenza,measles,or *** years ago,a new pandemic viral infection severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)broke out and it still persists today,and a significant proportion of surviving patients have radiological and clinical sequelae,including *** aim was to thoroughly review the information available in the literature on the bidirectional relationship between SARS-CoV-2 infection and the development of BE,as well as the impact of this infection on patients already suffering from *** information indicates that only a small percentage of patients in the acute phase of coronavirus disease 2019(COVID-19)pneumonia develop BE,although the latter is recognized as one of the radiological sequelae of COVID-19 pneumonia,especially when it is caused by *** severity of the initial pneumonia is the main risk factor for the development of future BE,but during the COVID-19 pandemic,exacerbations in BE patients were reduced by approximately 50%.Finally,the impact of BE on the prognosis of patients with COVID-19 pneumonia is not yet known.

关键词： Bronchiectasis Coronavirus COVID-19 SARS-CoV-2