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Science China Earth Sciences 2009年第3期52卷 360-368页

作者： L. R. edwards Department of Geology and Geophysics University of Minnesota Minneapolis

A stalagmite-based isotope record (No. H82) from Nanjing Hulu Cave, spanning from 16.5 to 10.3 ka BP, provided strong evidence for a coherence relation between the East Asian summer monsoon (EASM) and the North Atlant... 详细信息

关键词： Nanjing Hulu Cave stalagmite East Asian summer monsoon event

Beta receptor blocker therapy for the elderly in the COVID-19 era

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World Journal of Clinical Cases 2022年第23期10卷 8088-8096页

作者： Elpidio Santillo monica Migale Geriatric Rehabilitative Department IRCCS-INRCAFermo 63900Italy

When the coronavirus disease 2019(COVID-19)pandemic spread globally from the Hubei region of China in December 2019,the impact on elderly people was particularly *** mortality associated with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection was highest in older individuals,in whom frailty and comorbidities increased susceptibility to severe forms of ***,in older patients,the course of COVID-19 was often characterized by significant cardiovascular complications,such as heart failure decompensation,arrhythmias,pericarditis,and *** that the elderly have adequate therapeutic coverage against known cardiovascular diseases and risk factors is particularly important in the COVID-19 *** blockers are widely used for the treatment and prevention of cardiovascular *** clinical benefits of beta blockers have been confirmed in elderly patients,and in addition to their negative chronotropic effect,sympathetic inhibition and anti-inflammatory activity are theoretically of great benefit for the treatment of COVID-19 *** blockers have not been clearly shown to prevent SARS-CoV-2 infection,but there is evidence from published studies including elderly patients that beta blockers are associated with a more favorable clinical course of COVID-19 and reduced *** this minireview,we summarize the most important evidence available in the literature on the usefulness of beta blocker therapy for older patients in the context of the COVID-19 pandemic.

关键词： Adrenergic beta-antagonist COVID-19 Aged SARS-CoV-2 Cardiovascular diseases

FIXED POINT RESULTS ON METRIC-TYPE SPACES

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Acta Mathematica Scientia 2014年第4期34卷 1237-1253页

作者： monica COSENTINO Peyman SALIMI Pasquale VETRO Dipartimento di Matematica e Informatica Universita degli Studi di PalermoVia Archirafi3490123 PalermoItaly Young Researchers and Elite Club Rasht BranchIslamic Azad UniversityRashtIran

In this paper we obtain fixed point and common fixed point theorems for self- mappings defined on a metric-type space, an ordered metric-type space or a normal cone metric space. Moreover, some examples and an applica... 详细信息

关键词： metric-type space fixed point common fixed point Suzuki type mappings cone metric space integral equation

Effect of caffeine in the intraventricular hemorrhage of the preterm newborn

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Neural Regeneration Research 2023年第9期18卷 1942-1943页

作者： Pilar Alves-Martinez monica Garcia-Alloza Division of Physiology School of MedicineUniversidad de CadizCadizSpain Biomedical Research and Innovation Institute of Cádiz(INiBICA)Research Unit Puerta del Mar University Hospital University of CadizCadizSpain

There are around 15 million preterm newborns(PT) eve ry year(Atienza-Navarro et al., 2020).With these figures in mind,prematurity represents a major health problem worldwide and it is a leading cause of infant mortality,accounting for up to 35%of all deaths among newborns(Atienza-Navarro et al.,2020) and up to 18% of the deaths among children under 5 years of age.

关键词： newborn infant deaths

Optimal dual antiplatelet therapy strategy in elderly patients with acute coronary syndrome

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Journal of Geriatric Cardiology 2021年第3期18卷 210-218页

作者： monica Verdoia Rocco Gioscia Giuseppe De Luca Cardiologia e UnitàCoronarica Ospedale degli InfermiASL BiellaItaly/Division of CardiologyAzienda Ospedaliera-Universitaria“Maggiore della Carità”Universitàdel Piemonte OrientaleNovaraItaly

One out of three hospitalizations for acute coronary syndrome(ACS)involve nowadays elderly patients,carrying together a significant burden of comorbidities and a higher risk of *** particular,both ischemic and haemorrhagic risk are markedly enhanced in advanced age,and strictly interconnected,challenging the management of dual antiplatelet therapy(DAPT)in these *** recent development of several therapeutic options in terms of duration and combination of antiplatelet agents have offered a wider spectrum of opportunities for a more individualized approach in the management of DAPT after an ACS,although the criteria for the selection of the most appropriate strategy in each patient still lack *** particular,dose-adjustment,early aspirin discontinuation,laboratory-driven tailoring and shorter or extended DAPT have been addressed with promising safety and efficacy *** present review provides an updated overview on the emerging evidencefrom randomized clinical trials and subanalyses dedicated to the management of DAPT in elderly patients presenting with ACS.

关键词： patients coronary markedly

Unstructured kinetic models to simulate an arabinose switch that decouples cell growth from metabolite production

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Synthetic and Systems Biotechnology 2020年第3期5卷 222-229页

作者： Harley edwards Peng Xu Department of Chemical Biochemical and Environmental EngineeringUniversity of Maryland Baltimore CountyBaltimoreMD21250USA

Modeling synthetic gene circuits to implement dynamic flux balancing is crucial in teaching and exploring metabolic engineering strategies to repartition metabolic precursors and construct efficient microbial cell *** fitness and production rates are often complex phenotypes that are governed by highly nonlinear,multivariable functions which are intrinsically linked through carbon *** solution of such dynamic system can be difficult for synthetic biologists to visualize or ***,researchers(Santala et al.,***.,2018)have implemented an arabinose based genetic switch to dynamically partition the central carbon flux between cell growth and product *** autonomous switch allowed dynamic shift from arabinose-associated cell growth to acetate-associated product(wax ester)*** system clearly demonstrates the effectiveness of using a genetic switch to decouple cell growth from product formation in a one-pot bioreactor to minimize operational *** with Michaelis-Menten kinetics,and Luedeking-Piret equations,we were able to reconstruct and analyze this metabolic switch in silica and achieved graphical solutions that qualitatively match with the experimental *** assessing physiologically-accessible parameter space,we observed a wide range of dynamic behavior and examined the different limiting *** solutions for this dynamic system can be viewed simultaneously and resolved in real time via buttons on the graphical user interface(GUI).Metabolic bottlenecks in the system can be accurately predicted by varying the respective rate *** GUI serves as a diagnosis toolkit to troubleshoot genetic circuits design constraints and as an interactive workflow of using this arabinose based genetic switch to dynamically control carbon flux,which may provide a valuable computational toolbox for metabolic engineers and synthetic biologists to simulate and understand complex genetic-metabol

关键词： Metabolic switches Biophysical models Dynamic control Metabolic engineering Central carbon flux Intelligent biomanufacturing Green chemistry

The role of the Frontiers of Knowledge Awards in identifying the global leaders in ecological research

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Ecosystem Health and Sustainability 2017年第5期3卷 24-28页

作者： Pablo Jauregui monica Salomone Communications Department BBVA FoundationMadridSpain

Introduction:This paper outlines the origins and rationale of the Frontiers of Knowledge Awards,a new family of international prizes created in 2008 by the BBVA Foundation of *** aim of these awards is to recognize world-class contributions in a range of scientific,technological,and artistic areas which address the central challenges of the twenty-first *** key distinguishing feature is the fact that they have incorporated amongst their categories the two fundamental fields of contemporary environmental research:Ecology and Conservation Biology and Climate ***:By documenting the winners of the Frontiers of Knowledge Awards in these two areas,as well as the reasons for which they received this recognition during their previous nine editions,we show how these prizes have helped to identify some of the leading international figures in environmental science,such as Edward ***,Daniel ***,Jane Lubchenco,and Ilkka ***:In conclusion,we suggest that this initiative contributes to the public salience of the global ecological problems which threaten the future of our *** the same time,the Frontiers of Knowledge Awards serve to highlight the fundamental importance of the pioneering scientists whose research can provide the only reliable basis on which globalpolicy makers must make informed decisions to successfully confront the environmental challenges of our time.

关键词： Ecology conservation biology climate change Awards

Liquid biopsy and blood-based minimal residual disease evaluation in multiple myeloma

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Oncology Research 2023年第3期31卷 271-274页

作者： ALESSANDRO GOZZETTI monica BOCCHIA Division of Hematology University of SienaAzienda Ospedaliera UniversitariaSiena53100Italy

Novel drug availability has increased the depth of response and revolutionised the outcomes of multiple myeloma *** residual disease evaluation is a surrogate for progression-free survival and overall survival and has become widely used not-only in clinical trials but also in daily patient *** marrow aspiration is the gold standard for response evaluation,but due to the patchy nature of myeloma,false negatives are *** biopsy and blood-based minimal residual disease evaluation consider circulating plasma cells,mass spectrometry or circulating tumour *** approach is less invasive,can provide a more comprehensive picture of the disease and could become the future of response evaluation in multiple myeloma patients.

关键词： Myeloma Liquid biopsy Minimal residual disease

Mesoscience: exploring the common principle at mesoscales

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National Science Review 2018年第3期5卷 321-326页

作者： Wenlai Huang Jinghai Li Peter P.edwards State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Department of Chemistry University of Oxford

BACKGROUND OF THE EMERGING MESOSCIENCE In studying a complex system in science,engineering or society,we usually observe its macroscale(system-scale)behavior first,then go deep into mechanisms at the microscale(unit-scale)and finally try to correlate these two scales to reach a complete ***,it is increasingly recognized that correlating these two scales is quite difficult,and some common principles are inevitably missing in between these two extrema[1,2].

关键词： Mesoscience exploring the common principle at mesoscales

Structure-Based Deadlock Checking of Asynchronous Circuits

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Journal of Computer Science & Technology 2011年第6期26卷 1031-1040页

作者：任洪广王志英 Doug edwards School of Computer National University of Defense Technology CCF ACM IEEE School of Computer Science University of Manchester

It is important to verify the absence of deadlocks in asynchronous circuits. Much previous work relies on a reachability analysis of the circuits＇ states, with the use of binary decision diagrams （BDDs） or Petri nets to model the behaviors of circuits. This paper presents an alternative approach focusing on the structural properties of well-formed asynchronous circuits that will never suffer deadlocks. A class of data-driven asynchronous pipelines is targeted in this paper, which can be viewed as a network of basic components connected by handshake channels. The sufficient and necessary conditions for a component network consisting of Steer, Merge, Fork and Join are given. The slack elasticity of the channels is analyzed in order to introduce pipelining. As an application, a deadlock checking method is implemented in a syntax-directed asynchronous design tool Team The proposed method shows a great runtime advantage when compared against previous Petri net based verification tools.

关键词： asynchronous pipeline data-driven deadlock verification