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Gallstones in patients with liver cirrhosis:Incidence,etiology,clinical and therapeutical aspects

World Journal of Gastroenterology 2014年第23期20卷 7277-7285页

作者： monica acalovschi 3~(rd) Medical Clinic University of Medicine and Pharmacy400162 Cluj-NapocaRomania

Gallstones occur in about one third of the patients having liver *** gallstones are the most frequent type,while cholesterol stones represent about15%of all stones in *** secretion of unconjugated bilirubin,increased hydrolysis of conjugated bilirubin in the bile,reduced secretion of bile acids and phospholipds in bile favor pigment lithogenesis in *** hypomotility also contributes to *** most recent data regarding risk factors for gallstones are *** prevalence increases with age,with a ratio male/female higher than in the general *** alcoholism,viral C cirrhosis,and non-alcoholic fatty liver disease are the underlying liver diseases most often associated with *** are often asymptomatic,and discovered *** asymptomatic,expectant management is recommended,as for asymptomatic gallstones in the general ***,a closer follow-up of these patients is necessary in order to earlier treat symptoms or *** symptomatic stones,laparoscopic cholecystectomy has become the therapy of ***-Pugh class and MELD score are the best predictors of outcome after *** with severe liver disease are at highest surgical risk,therefore gallstone complications should be treated using noninvasive or minimally invasive procedures,until stabilization of the patient condition.

关键词： Liver cirrhosis Pigment gallstones Cholesterol gallstones Lithogenesis Risk factors Asymptomatic gallstones Laparoscopic cholecystectomy

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Pancreatic cancer risk variant ABO rs505922 in patients with cholangiocarcinoma

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World Journal of Gastroenterology 2011年第41期17卷 4640-4642页

作者： Marcin Krawczyk Florentina Mihalache Aksana Hblinger monica acalovschi Frank Lammert Vincent Zimmer Department of Medicine Ⅱ Saarland University Medical Center Department of Medicine Ⅲ University Iuliu Hatieganu Department of Internal MedicineⅠ University Hospital Bonn

The aim of this study was to investigate an association between the development of cholangiocarcinoma(CCA)and the ABO variant rs505922(known to increase pan-creatic cancer risk)in a large cohort of European individuals with *** total,180 individuals with CCA and 350 CCA-free controls were *** ABO variant rs505922 was genotyped using a polymerase chain reaction-based *** between this single nucleotide polymorphism(SNP)and CCA was tested in contingency *** allele distributions nor association tests and regression analysis provided evidence for an increased risk of CCA among carriers of the ABO variant(all P > 0.05).Nevertheless,we documented a deviation from Hardy-Weinberg equilibrium in the entire CCA cohort(P = 0.028)and for patients with intrahe-patic(P = 0.037)but not extrahepatic tumor localization(P > 0.05).The association tests did not provide evidence for a prominent role of the investigated SNP in the genetic risk of ***,Hardy-Weinberg disequilibrium in the entire cohort and the intrahepatic CCA subgroup warrants future studies investigating a potential CCA risk modulation by individual blood groups.

关键词： ABO Biliary tract cancer Blood groups Genetic risk Single nucleoUde polymorphism

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A common variant in the precursor miR-146a sequence does not predispose to cholangiocarcinoma in a large European cohort

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 412-417页

作者： Florentina Mihalache Aksana Hblinger monica acalovschi Tilman Sauerbruch Frank Lammert Vincent Zimmer Department of Medicine Ⅱ Saarland University Hospital66421 HomburgGermany Department of Medicine Ⅲ University Iuliu Hatieganu Department of Internal Medicine Ⅰ University Hospital Bonn

BACKGROUND:Micro-RNAs(miRNAs) are small,non-coding RNA species considered to fine-tune basic cellular functions by modulating target gene translation and/or mRNA stability.A common G/C polymorphism(rs2910164) in the precursor(pre-) miR-146a gene engaged in NF-κB signaling and apoptosis pathways has been reported to modulate the genetic risk of hepatocellular carcinoma by increased G-allelic production of mature *** investigated rs2910164 in a large Europeanbased cholangiocarcinoma(CCA) ***:We recruited 182 CCA patients and 350 controls in three academic medical *** for rs2910164 was performed by PCR-based assays with 5’-nuclease and fluorescence *** frequencies were tested for consistency with the Hardy-Weinberg equilibrium using an exact test;allelic and genotypic differences between the patients and controls were assessed by the Chi-square test and Armitage’s trend *** subgroup analyses included gender,tumor localization(extra-versus intrahepatic CCA) and early-onset ***:Genotype distributions were consistent with the Hardy-Weinberg *** significant differences in either allele or genotype distributions were detected between the CCA and control groups or the respective subgroups ***,there was a trend for a protective effect of the heterozygous single-nucleotide polymorphism state GC,as indicated by an underrepresentation in the CCA group in general(29% vs 35%;P=0.18) and,in particular,for extrahepatic tumor sites(26% vs 35%;OR=0.67;95% CI,0.43-1.02;P=0.065).CONCLUSIONS:Our data do not support a prominent contribution of the pre-miR-146a sequence variant in the genetic predisposition to ***,current studies functionally characterizing rs2910164 have proposed that distinct repertoires of target genes are addressed by genotype-specific mature miR146a *** the detected trend towards a potentially protective role of GC heterozygosity,a subtle modulation of g

关键词： miR-146a miR-SNP biliary tract cancer cholangiocarcinoma genetic risk

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