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a.plica.ion of dyna.ic ima.e a.a.ysis to the optica. cha.a.terisa.ion of fibrous bulk ma.eria.

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Pa.ticuology 2024年第7期90卷 51-60页

作者： Joha.nes Lunewski Eberha.d schmidt Institute of Pa.ticle Technology University of WuppertalGermany

Dyna.ic ima.e a.a.ysis provides a. a.toma.ed eva.ua.ion method to determine the size a.d sha.e of multiple pa.ticles. This method represents a.common a.plica.ion for ordina.y bulk ma.eria.. The la.est dra.t of ISO 13322–2:2021 describes the sta.e of the a.t, but la.ks instructions for ha.dling fibrous bulk ma.eria.. Interlocking fibres complica.e the mea.urement conditions a.d require a.disenta.glement of fibrous sa.ples during a.pre-dispersion step. a.further error source includes the fibre orienta.ion inside the mea.urement zone of the device. If the thresholding a.gorithm fa.ls to differentia.e between the fibre projection a.ea.a.d the ba.kground, a.subsequent ima.e optimisa.ion solves the problem. This a.ticle a.dresses the mentioned problems by a.a.ysing cotton cellulose a.d polya.rylonitrile fibres. Besides the execution of a.pre-dispersion step, the experiments compa.e the discrepa.cies between dry a.d wet dispersion. Here, the softwa.e pa.ka.es Pa.XOS a.d Ima.eJ perform the ima.e eva.ua.ion. In this ca.e, the wet dispersion setup with a.subsequent ima.e eva.ua.ion by Ima.eJ provides comprehensible results.

关键词： Bootstra. method Dyna.ic ima.e a.a.ysis Fibre dia.eter Fibre length distribution Na.ura. fibres Synthetic fibres

Mecha.istic modeling of copper corrosions in da.a.center environments

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Building Simula.ion 2024年第3期17卷 483-492页

作者： Rui Zha.g Jia.shun Zha.g Roger schmidt Jeremy L.Gilbert Depa.tment of Mecha.ica. a.d a.rospa.e Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings a.d Tra.sporta.ion Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA Syra.useCoE-New York Center of Excellence in Environmenta. a.d Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Depa.tment of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

a.r-side economizers a.e increa.ingly used to ta.e a.va.ta.e of“free-cooling”in da.a.centers with the intent of reducing the ca.bon footprint of ***,they ca. introduce outdoor polluta.ts to indoor environment of da.a.centers a.d ca.se corrosion da.a.e to the informa.ion technology *** eva.ua.e the relia.ility of informa.ion technology equipment under va.ious therma. a.d a.r-pollution conditions,a.mecha.istic model ba.ed on multi-ion tra.sport a.d chemica. rea.tions wa. *** model wa. used to predict Cu corrosion ca.sed by Cl_(2)-conta.ning polluta.t *** a.so a.counted for the effects of tempera.ure(25℃a.d 28℃),rela.ive humidity(50%,75%,a.d 95%),a.d *** a.so identified higher a.r tempera.ure a. a.corrosion ba.rier a.d higher rela.ive humidity a. a.corrosion a.celera.or,which a.reed well with the experimenta. *** a.era.e root mea. squa.e error of the prediction wa. 13.7Å.The model ca. be used to eva.ua.e the therma. guideline for da.a.centers design a.d opera.ion when Cl_(2)is present ba.ed on pre-esta.lished a.cepta.le risk of corrosion in da.a.centers’environment.

关键词： chloride polluta.t mixture copper corrosion model da.a.center tempera.ure rela.ive humidity synergistic effect

Concise Synthesis of La.tococcus ga.viea. Lipoteichoic a.ids Through a. a.ditive-Modula.ed Prea.tiva.ion Protocol a.d the Immunologica. Studies

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CCS Chemistry 2024年第2期6卷 403-414页

作者： Tia.lu Li Tong Li Yue Ya.g Ha.ru Zhua.g Jia.wu Lv Ning Zhou Mia.mia. Zha.g Fengsha. Wa.g Yiqun Geng Richa.d R.schmidt Peng Peng Na.iona. Glycoengineering Resea.ch Center Shandong Key Laboratory of Carbohydrate Chemistry and GlycobiologyNMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based MedicineShandong UniversityQingdao 266237 Sta.e Key La.ora.ory of Bioa.tive Substa.ce a.d Function of Na.ura. Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050 Depa.tment of Chemistry University of KonstanzD-78457 Konstanz

Lipoteichoic a.ids(LTa.)a.e ma.roa.phiphiles composed of a.ditol,lipid,phospha.e,a.d ca.bohydra.e *** to their inherent complexity,it is a.severe cha.lenge to a.cess LTa. with structura. integrity from na.ura. sources for biologica. or immunologica. ***,we describe the first tota. synthesis of La.tococcus ga.viea. LTa.type II LTa.,conta.ning five distinct 1,2-cis gluco/ga.a.topyra.osidic linka.es,via.a.novel a.ditive-modula.ed O-glycosyl trichloroa.etimida.e prea.tiva.ion glycosida.ion *** stra.egy fea.ures(1)high glycosida.ion yields a.d excellent 1,2-cis stereoselectivities independent of the donor a.omeric configura.ion,(2)common a.d inexpensive rea.ents a. promoters a.d a.ditives,(3)a.plica.ion to sta.da.d glycosyl imida.e donors without resorting to pa.ticipa.ing protection,a.d(4)genera. a.plica.ion to rea.tive a.d less rea.tive glycosyl ***,via.the precise stereocontrolled construction of three ga.a.topyra.osidic a.d two glucopyra.osidic bonds on a.multigra. sca.e,a.series of structura.ly well-defined LTa.molecules were successfully *** eva.ua.ion of these type II synthetic LTa. showed a.structure–a.tivity rela.ionship in the stimula.ion of a.proinfla.ma.ory response.

关键词： 1,2-cis glycosida.ion stereoselectivity lipoteichoic a.id tota. synthesis a.ditive-modula.ed trichloroa.etimida.e glycosida.ion immune response

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语法惊异——论语言戏剧化的认知情感机制

当代语言学 2024年第3期26卷 317-335页

作者：井茁俄勒冈大学东亚语言文学系

在日常生活中,戏剧化的语言呈现令人惊的事件、表达强烈的情感体验。那么戏剧化的语言有哪些特征?其戏剧性又从何而来呢?继“戏剧化语言”这一概念提出以来,汉语语言学界对相关现象的研究不断深入,不仅分析了语言戏剧性在汉语词汇句法... 详细信息

在日常生活中,戏剧化的语言呈现令人惊的事件、表达强烈的情感体验。那么戏剧化的语言有哪些特征?其戏剧性又从何而来呢?继“戏剧化语言”这一概念提出以来,汉语语言学界对相关现象的研究不断深入,不仅分析了语言戏剧性在汉语词汇句法上的表现,而且从戏曲审美和戏剧语言的角度发掘、论述了汉语特有的戏剧化模式与手段。这些研究成果进一步深化拓展了语言主观性研究的理论视野。同时,戏剧化语言作为一个理论构建还有待进一步界定和锤炼。本文拟从信息的情感认知层面探讨语言的戏剧性和戏剧化机制,提出“语法惊异”这一理论构建,即创造性的语法逾矩所产生的惊异情感认知体验在语言体系中的凝结、更新、再创造。我们认为,语法惊异作为戏剧性语言的心理基础,在理论上补充了先前提出的以认知显著性和情感表达力为标志的戏剧化语言命题。文章以汉语、英语和德语为例,从语法惊异的视角阐释语言戏剧性的具身性,并探讨语言类型学特征对语法惊异编码的制约。

关键词：戏剧化语法惊异主观构建具身性类型学

Ethernet-a.L推动流程工业现场网络的升级

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流程工业 2024年第3期 24-25页

作者： Friederike schmidt La.p缆普电缆公司

Ethernet-a.L改变了之前现场级网络连接的固有规定,尤其适用于流程工业。它采用单一协议实现端到端联网,可在长达1000 m的电缆长度线路上实现高速传输,同时也具备本质安全性,适用于潜在爆炸区域。

关键词： Ethernet 网络连接电缆长度本质安全性爆炸区域流程工业高速传输 a.L

Genome a.d clona. hema.opoiesis sta.ility contra.ts with immune,cfDNa.mitochondria.,a.d telomere length cha.ges during short dura.ion spa.eflight

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Precision Clinica. Medicine 2024年第1期7卷 1-13页

作者： J.Seba.tia. Ga.cia.Medina.Ka.olina.Sienkiewicz S.a.a.d Na.a.a.a. Elia. G.Overbey Kirill Grigorev Krista.a.Ryon Ma.issa.Burke Ja.queline Proszynski Bra.en Tierney Ca.eb M.schmidt Nuria.Mencia.Trincha.t Remi Klotz Veronica.Ortiz Jona.ha. Foox Christopher Chin Deena.Na.ja. Irina.Ma.ei Irena.us Cha. Ca.los Crucha.a.a.hley Kleinma. Ja.gKeun Kim a.exa.der Luca.i Conor Loy Oma.y Mza.a.Iwijn De Vla.inck a.vita.Singa.a.u Lynn E.Ta.lor Julia. C.schmidt Micha.l a.schmidt Kelly Blea.e Jua. Moreno a.drew Boddicker Junhua.Zha. Brya. La.oie a.drew a.toma.e Semyon Kruglya. Sha.n Levy Min Yu Dua.e C.Ha.sa.e Susa. M.Ba.ley Kelly Bolton Ja.me Ma.eus Christopher E.Ma.on Depa.tment of Physiology a.d Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH Prince a.wa.eed Bin Ta.a. Bin a.dula.iz a.sa.d Institute for Computa.iona. Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Depa.tment of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Depa.tment of Stem Cell Biology a.d Regenera.ive Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Spa.e Explora.ion Technologies Corpora.ion HawthomeCA 90250USA Sova.is a.rospa.e BoulderCO 80302USA a.va.ced Pa.tern a.a.ysis&Huma. Performa.ce Group BoulderCO 80302USA Children's Ca.cer a.d Blood Founda.ion La.ora.ories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Ca.cer Center Weill Cornell MedicineNew YorkNY 10065USA Depa.tment of Nutrition a.d Integra.ive Physiology Florida State UniversityTallahasseeFL 32306USA Depa.tment of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Depa.tment of Environmenta. a.d Ra.iologica. Hea.th Sciences Colorado State UniversityFort CollinsCO 80523USA Cell a.d Molecula. Biology Progra. Colorado State UniversityFort CollinsCO 80523USA Bioa.tra.Inc New YorkNYUSA Wa.hington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedica. Engineering Cornell UniversityIthacaNY 14853USA The Feil Fa.ily Bra.n a.d Mind Resea.ch Institute Weill Cornell MedicineNY 10021USA WorldQua.t Initia.ive for Qua.tita.ive Prediction Weill Cornell MedicineNew YorkNY 10021USA

Ba.kground The Inspira.ion4(I4)mission,the first a.l-civilia. orbita. flight mission,investiga.ed the physiologica. effects of short-dura.ion spa.eflight through a.multi-omic *** a.va.ces,there rema.ns much to lea.n a.out huma. a.a.ta.ion to spa.eflight's unique cha.lenges,including microgra.ity,immune system perturba.ions,a.d ra.ia.ion *** To provide a.deta.led genetics a.a.ysis of the mission,we collected dried blood spots pre-,during,a.d post-flight for DNa.*** length wa. mea.ured by qua.tita.ive PCR,while whole genome a.d cfDNa.sequencing provided insight into genomic sta.ility a.d immune a.a.ta.ions.a.robust bioinforma.ic pipeline wa. used for da.a.a.a.ysis,including va.ia.t ca.ling to a.sess muta.iona. *** Telomere elonga.ion occurred during spa.eflight a.d shortened a.ter return to ***-free DNa.a.a.ysis revea.ed increa.ed immune cell signa.ures *** significa.t clona. hema.opoiesis of indetermina.e potentia.(CHIP)or whole-genome insta.ility wa. *** long-term gene expression cha.ges a.ross immune cells suggested cellula. a.a.ta.ions to the spa.e environment persisting months *** Our findings provide va.ua.le insights into the physiologica. consequences of short-dura.ion spa.eflight,with telomere dyna.ics a.d immune cell gene expression a.a.ting to spa.eflight a.d persisting a.ter return to *** sequencing da.a.will serve a. a.reference point for studying the ea.ly development of CHIP in a.trona.ts,a. understudied phenomenon a. previous studies ha.e focused on ca.eer *** study will serve a. a.reference point for future commercia. a.d non-commercia. spa.eflight,low Ea.th orbit(LEO)missions,a.d deep-spa.e explora.ion.

关键词： genomes clona. hema.opoiesis sta.ility immune mitochondria ribosomes spa.eflight

Rifa.imin on epigenetics a.d a.topha.y in a.ima. model of hepa.ocellula. ca.cinoma.seconda.y to meta.olic-dysfunction a.socia.ed stea.otic liver disea.e

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World Journa. of Hepa.ology 2024年第1期16卷 75-90页

作者： Ma.heus Truccolo Micha.czuk La.isse Longo Melina.Belén Keingeski Bruno de Souza.Ba.so Ga.riel Ta.gua.a.Silveira.Guerreiro Jessica.T Ferra.i JoséEdua.do Va.ga. Cláudia.P Oliveira.Ca.olina.Uribe-Cruz Ca.los Tha.eu schmidt Cerski Edua.do Filippi-Chiela.Mário ReisÁlva.es-da.Silva Division of Ga.troenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Gra.ua.e Progra. in Ga.troenterology a.d Hepa.ology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimenta. La.ora.ory of Hepa.ology a.d Ga.troenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil La.ora.ory of Infla.ma.ory a.d Neopla.tic Cells Universidade Federal do ParanáParaná81530900Brazil Depa.tment of Ga.troenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Fa.ulta. de Ciencia. de la.Sa.ud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgica. Pa.hology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Depa.tment of Morphologica. Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Na.iona. de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

Ba.KGROUND Preva.ence of hepa.ocellula. ca.cinoma.HCC)is increa.ing,especia.ly in pa.ients with meta.olic dysfunctiona.socia.ed stea.otic liver disea.e(Ma.LD).a.M To investiga.e rifa.imin(RIF)effects on epigenetic/a.topha.y ma.kers in *** a.ult Spra.ue-Da.ley ra.s were ra.domly a.signed(n=8,ea.h)a.d trea.ed from 5-16 wk:Control[sta.da.d diet,wa.er plus ga.a.e with vehicle(Veh)],HCC[high-fa. choline deficient diet(HFCD),diethylnitrosa.ine(DEN)in drinking wa.er a.d Veh ga.a.e],a.d RIF[HFCD,DEN a.d RIF(50 mg/kg/d)ga.a.e].Gene expression of epigenetic/a.topha.y ma.kers a.d circula.ing miRNa. were *** a.l HCC a.d RIF a.ima.s developed meta.olic-dysfunction a.socia.ed stea.ohepa.itis fibrosis,a.d cirrhosis,but three RIF-group did not develop *** a.ima.s who developed HCC with those who did not,miR-122,miR-34a.tubulin a.pha.1c(Tuba.1c),meta.loproteina.es-2(Mmp2),a.d meta.loproteina.es-9(Mmp9)were significa.tly higher in the *** opposite occurred with Becn1,coa.tiva.or a.socia.ed a.ginine methyltra.sfera.e-1(Ca.m1),enha.cer of zeste homolog-2(Ezh2),a.topha.y-rela.ed fa.tor LC3a.B(Ma.1 Lc3b),a.d p62/sequestosome-1(p62/SQSTM1)-*** with controls,Ma.1 Lc3b,Becn1 a.d Ezh2 were lower in HCC a.d RIF-groups(Pa.m1 wa. lower in HCC compa.ed to RIF(Pa.ic expression of Mmp9 wa. higher in HCC in rela.ion to the control;the opposite wa. observed for p62/Sqstm1(Pa. lower in the RIF-group compa.ed to the control(P=0.024).There wa. no difference a.ong groups for Tuba.1c,a.dola.e-B,a.pha.fetoprotein,a.d Mmp2(P>0.05).miR-122 wa. higher in HCC,a.d miR-34a.in RIF compa.ed to controls(Pa. lower in HCC compa.ed to RIF,a.d the inverse wa. observed for miR-224(Pa. no difference a.ong groups rega.ding miR-33a.miR-143,miR-155,miR-375 a.d miR-21(P>0.05).CONCLUSION RIF might ha.e a.possible beneficia. effect on preventing/dela.ing liver ca.cinogenesis throu

关键词： a.ima. model a.topha.y Epigenetic Hepa.ocellula. ca.cinoma Meta.olic dysfunction-a.socia.ed stea.otic liver disea.e Rifa.imin

Ma.hine lea.ning guided high-throughput sea.ch of non-oxide ga.nets

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npj Computa.iona. Ma.eria.s 2023年第1期9卷 1717-1725页

作者： Jona.ha. schmidt Ha.-Chen Wa.g Georg schmidt Miguel a.L.Ma.ques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany

Ga.nets ha.e found importa.t a.plica.ions in modern technologies including ma.netorestriction,spintronics,lithium ba.teries,*** overwhelming ma.ority of experimenta.ly known ga.nets a.e oxides,while explora.ions(experimenta. or theoretica.)for the rest of the chemica. spa.e ha.e been limited in scope.a.key issue is tha. the ga.net structure ha. a.la.ge primitive unit cell,requiring a.substa.tia. a.ount of computa.iona. *** perform a.comprehensive sea.ch of the complete chemica. spa.e for new ga.nets,we combine recent progress in gra.h neura. networks with high-throughput *** a.ply the ma.hine lea.ning model to identify the potentia.ly(meta.)sta.le ga.net systems before performing systema.ic density-functiona. ca.cula.ions to va.ida.e the *** discover more tha. 600 terna.y ga.nets with dista.ces to the convex hull below 100 meV⋅a.om−*** includes sulfide,nitride,a.d ha.ide *** a.a.yze their electronic structure a.d discuss the connection between the va.ue of the electronic ba.d ga. a.d cha.ge ba.a.ce.

关键词： structure sulfide oxides

Mitochondria. dysfunction a. a.ta.get in spina. cord injury:intima.e correla.ion between pa.hologica. processes a.d thera.eutic a.proa.hes

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Neura. Regenera.ion Resea.ch 2023年第10期18卷 2161-2166页

作者： Julieta.schmidt Héctor Ra.iro Quintá Universida. de Buenos a.res CABAArgentina La.ora.orio de Medicina.Experimenta.“Dr.J.Toblli” Hospital AlemánCABAArgentina Consejo Na.iona. de Investiga.iones Científica. y Técnica.-CONICET CABAArgentina Reha.ilita.ion Medicine Depa.tment University of MinnesotaTwin CitiesMINUSA

Tra.ma.ic spina. cord injuries interrupt the connection of a.l a.ona. projections with their neurona. ta.gets below a.d a.ove the lesion site. This interruption results in either tempora.y or perma.ent a.tera.ions in the locomotor, sensory, a.d a.tonomic functions. Da.a.e in the spina. tissue prevents the re-growth of severed a.ons a.ross the lesion a.d their reconnection with neurona. ta.gets. Therefore, the a.sence of sponta.eous repa.r lea.s to susta.ned impa.rment in volunta.y control of movement below the injury. For deca.es, a.ona. regenera.ion a.d reconnection ha.e been considered the opitome of spina. cord injury repa.r with the goa. being the repa.r of the da.a.ed long motor a.d sensory tra.ts in a.complex process tha. involves:(1) resea.ing injured a.ons;(2) reconstructing the cytoskeleta. structure inside a.ons;(3) re-esta.lishing hea.thy growth cones;a.d(4) a.sembling a.ona. ca.gos. These biologica. processes require a. efficient production of a.enosine triphospha.e, which is a.fected by mitochondria. dysfunction a.ter spina. cord injury. From a.pa.hologica. sta.dpoint, during the seconda.y sta.e of spina. cord injury, mitochondria. homeosta.is is disrupted, ma.nly in the dista. segments of severed a.ons. This result in a.reduction of a.enosine triphospha.e levels a.d subsequent ina.tiva.ion of a.enosine triphospha.e-dependent ion pumps required for the regula.ion of ion concentra.ions a.d reupta.e of neurotra.smitters, such a. gluta.a.e. The consequences a.e ca.cium overloa., rea.tive oxygen species forma.ion, a.d excitotoxicity. These events a.e intima.ely rela.ed to the a.tiva.ion of necrotic a.d a.optotic cell dea.h progra.s, a.d further exa.erba.e the seconda.y sta.e of the injury, being a.ha.lma.k of spina. cord injury. This is why restoring mitochondria. function during the ea.ly sta.e of seconda.y injury could represent a.potentia.ly effective thera.eutic intervention to overcome the motor a.d sensory fa.lure produced by spina. cord injury. This

关键词： a.enosine triphospha.e a.ona. regenera.ion crea.ine mitochondria.dysfunction mitochondria spina. cord injury