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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong Yuan Bo Ma Wenyong Xie na Han department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying du department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang district HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

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Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian Li Wen Yi XiangHui Xue Jie Zeng HaiLun Ye JianYuan Wang JinSong Chen na Li Tingdi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei national Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China national Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment national Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to december *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

Regulating lithium nucleation and growth by zinc modified current collectors

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nano Research 2020年第1期13卷 45-51页

作者： na Zhang Seung-Ho Yu Héctor d.Abruna Baker Laboratory Department of Chemistry and Chemical BiologyCornell UniversityIthacaNew York14853USA department of Chemical and Biological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841Republic of Korea

Lithium metal is commonly regarded as the“Holy Grail”anode material for high energy density rechargeable ***,the uncontrollable growth of Li dendrites has posed safety concerns and thus greatly hindered its large-scale *** we have modified the surface of a commercial anode current collector,Cu foil,with a thin layer of Zn by a facile electroplating method,in order to regulate the Li nucleation and the following growth *** of the formation of a solid solution buffer layer and Li-Zn alloy phases,the Li nucleation overpotential was dramatically reduced,realizing a uniform Li nucleation and a smooth Li plating *** a result,significantly improved long-term cycling performance with a high Coulombic efficiency was achieved by the lithiophilic Zn coated Cu foil as a current *** cells of Li-LiFePO4 and Li-S using the Li deposited on the Zn modified Cu as the anode,showed increased capacity with low voltage hysteresis and greatly enhanced cycling stability,ascribed to the uniform Li deposition and formation of a stable SEI *** work demonstrates the feasibility of employing lithiophilic modified Cu foils as Li metal current collectors for practical applications.

关键词： lithium metal anode lithium dendrite current collector zinc layer

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu na Yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan Yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular Rnas(circRnas) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRnas remain elusive. In this study, we identified a novel circRna,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRna encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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企业数实技术融合与新质生产力发展——来自企业专利信息的经验证据

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华东经济管理 2025年第1期39卷 1-9页

作者：郭娜陈东晖胡丽宁天津财经大学金融学院天津300222

文章以2013—2023年我国上市企业为研究对象,通过手工整理208万条企业专利信息,借助深度学习算法测算专利文本语义以构建企业数实技术融合指数与新质生产力指标。实证检验发现,企业数实技术融合能够有效促进新质生产力发展,且对创新突... 详细信息

文章以2013—2023年我国上市企业为研究对象,通过手工整理208万条企业专利信息,借助深度学习算法测算专利文本语义以构建企业数实技术融合指数与新质生产力指标。实证检验发现,企业数实技术融合能够有效促进新质生产力发展,且对创新突破和绿色转型两类新质生产力均有促进作用,两者存在显著的杠杆效应。机制分析表明,数实技术融合通过降低企业生产成本、提高管理能力、抑制研发操纵以推动企业新质生产力发展。异质性分析发现,在大型国有企业和管理层创新意识、数字化思维较强的企业,数实技术融合的赋能效果更明显。经济后果检验显示,数实技术融合对企业新质生产力的赋能作用是实现经济高质量发展的关键路径。

关键词：企业数实技术融合新质生产力深度学习专利文本语义高质量发展

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ASYMPTOTIC BEHAVIOR OF THE TE ANd TM APPROXIMATIONS TO SECONd HARMONIC GENERATION

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Journal of Computational Mathematics 2007年第1期25卷 49-66页

作者： na■ma A■ssa Faculté de Mathématiques USTHBBP32El AliaBab Ezzouar16111Alger Centre de Mathématiques Appliquées CNRS UMR 7641■Ecole PolytechniquePalaiseau 91128 CedexFrance

We consider a Second Harmonic Generation （SHG） problem of an optical signal wave with an optical pump in a medium represented by a smooth bounded domain Ω→∩ IR^d which is assumed to contain a heterogeneous material： a compactly imbedded subdomain B^r →∩∩ in the shape of a small ball contains a nonlinear material, while Ω／ B^r is filled with a linear material. We begin by proving existence and uniqueness of the solution to the TE approximation of SHG for arbitrary bounded susceptibilities, thus improving the result obtained by Bao and dobson （ Eur. J. Appl. Math. 6 （1995）, 573-590） under small enough susceptibilities assuption. We then establish an existence and uniqueness result of a solution to the TM approximation problem. In both parts we study the asymptotic behavior of the system as the size of the nonlinear material vanishes： error estimates and asymptotic expansion of the solution are derived for both TE and TM approximations.

关键词： Second harmonic generation TE Approximation TM Approximation.

Active control of supersonic/hypersonic aeroelastic flutter for a two-dimensional airfoil with flap

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Science China(Technological Sciences) 2011年第8期54卷 1943-1953页

作者： ZHAO na School of Astronautics Harbin Institute of Technology PO Box 137 Harbin 150001 China

The flutter, post-flutter and active control of a two-dimensional airfoil with control surface operating in supersonic/hypersonic flight speed regions are investigated in this paper. A three-degree-of-freedom dynamic model is established, in which both the cubic nonlinear structural stiffness and the nonlinear aerodynamic load are accounted for. The third order Piston Theory is employed to derive the aerodynamic loads in the supersonic/hypersonic airflow. Nonlinear flutter happens with a phenomenon of limit cycle oscillations (LCOs) when the flight speed is less than or greater than linear critical speed. The LQR approach is employed to design a control law to increase both the linear and nonlinear critical speeds of aerodynamic flutter, and then a combined control law is proposed in order to reduce the amplitude of LCOs by adding a cubic nonlinear feedback control. The dynamic responses of the controlled system are given and used to compare with those of the uncontrolled system. Results of simulation show that the active flutter control method proposed here is effective.

关键词： flutter/post flutter active control supersonic/hypersonic flow 2-d airfoil nonlinearity

Lateral Flight Stability of Two Hovering Model Insects

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Journal of Bionic Engineering 2014年第3期11卷 439-448页

作者： na Xu Mao Sun Ministry-of-Education Key Laboratory of Fluid Mechanics Beihang University Beijing 100191 P. R. China

The longitudinal disturbance motion of different insects at hovering flight has the same modal structure. Here, we consider the case of lateral motion. The lateral dynamic flight stability of two model insects, hoverfly and honeybee, at hovering flight is studied. The method of computational fluid dynamics is applied to compute the stability derivatives. The techniques of eigenvalue and eigenvector analysis are used to solve the equations of motion. Results show that the lateral disturbance motion of the hoverfly has three natural modes of motion： an unstable divergence mode, a stable oscillatory mode and a stable subsidence mode, and the flight is unstable; while the honeybee has a different modal structure （a stable slow subsidence mode, a stable fast subsidence mode, and a nearly neutrally stable oscillatory mode） and the flight is nearly neutrally stable. The change in modal structure between the two insects is due to their roll-moment/side-velocity derivative having different sign, and the sign difference is because that the hoverfly has a relatively small, but the honeybee has a relatively large, distance between the wing roots and the center of mass. Thus, unlike the case of longitudinal motion, for lateral motion, some insects have different modal structures and stability properties from others.

关键词： insect hovering flight dynamic flight stability modal structure