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Correlations between serum kidney injury molecule-1,cystatin C and immunosuppressants:A cross-sectional study of renal transplant patients in Bahrain

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Journal of Biomedical Research 2024年第3期38卷 269-277页

作者： Kannan Sridharan Shamik Shah mona Al Hammad Fatima Ali Mohammed Sindhan Veeramuthu mona a.dulla taher Mustafa Mohamed Hammad Lamees Jawad Eman Farid Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Department of Nephrology Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Internal Medicine College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Salmaniya Medical Complex ManamaKingdom of Bahrain Department of Laboratory Medicine Salmaniya Medical ComplexManamaKingdom of Bahrain Department of Microbiology Immunologyand Infectious DiseasesCollege of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain

Renal transplant patients receive several immunosuppressive drug regimens that are potentially nephrotoxic for *** creatinine is the standard for monitoring kidney function;however,cystatin C(Cys C)and kidney injury molecule-1(KIM-1)have been found to indicate kidney injury earlier than serum creatinine and provide a better reflection of kidney ***,we assessed Cys C and KIM-1 serum levels in renal transplant patients receiving mycophenolate mofetil,tacrolimus,sirolimus,everolimus,or cyclosporine to evaluate kidney *** used both the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)2021 equation,which is based on creatinine and combined creatinine with Cys C,and the CKD-EPI 2012 equation,which is based on Cys C alone,to estimate glomerular filtration rate(GFR).Then,we assessed the association between serum KIM-1 and GFR<90 mL per minute per 1.73 *** observed significantly higher serum Cys C levels in patients with the elevated serum creatinine,compared with those with normal serum *** estimated GFRs based on creatinine were significantly higher than those based on the other equations,while a significant positive correlation was observed among all *** KIM-1 levels were negatively correlated with the estimated GFRs by the CKD-EPI Cys C and the combined creatinine with Cys C equations.A serum KIM-1 level above 0.71 ng/mL is likely to indicate GFR<90 mL per minute per 1.73 *** observed a significant correlation between serum creatinine and Cys C in our renal transplant ***,serum KIM-1 may be used to monitor renal function when using potentially nephrotoxic drugs in renal transplants.

关键词： KIM-1 cystatin C mycophenolate mofetil tacrolimus everolimus sirolimus cyclosporine

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Adaptive Dynamic Dipper Throated Optimization for Feature Selection in Medical Data

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Computers, Materials & Continua 2023年第4期75卷 1883-1900页

作者： Ghada Atteia El-Sayed M.El-kenawy Nagwan Abdel Samee mona M.Jamjoom Abdelhameed Ibrahim Abdelaziz A.Abdelhamid Ahmad taher Azar Nima Khodadadi Reham A.Ghanem Mahmoud Y.Shams Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Communications and Electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt Department of Computer Science Faculty of Computer and Information SciencesAin Shams UniversityCairo11566Egypt Department of Computer Science College of Computing and Information TechnologyShaqra University11961Saudi Arabia Faculty of Computers and Artificial Intelligence Benha UniversityBenha13518Egypt College of Computer and Information Sciences Prince Sultan UniversityRiyadh11586Saudi Arabia Department of Civil Engineering University of Science and TechnologyMiami33101USA Department of Civil and Environmental Engineering Florida International UniversityMiamiUSA Oral Biology Department Faculty of Oral and Dental MedicineDelta University for Science and TechnologyGamasaEgypt Faculty of Artificial Intelligence Kafrelsheikh UniversityKafrelsheikh33511Egypt

The rapid population growth results in a crucial problem in the early detection of diseases inmedical *** all the cancers unveiled,breast cancer is considered the second most severe ***,an exponential rising in death cases incurred by breast cancer is expected due to the rapid population growth and the lack of resources required for performing medical *** recent advances in machine learning could help medical staff in diagnosing diseases as they offer effective,reliable,and rapid responses,which could help in decreasing the death *** this paper,we propose a new algorithm for feature selection based on a hybrid between powerful and recently emerged optimizers,namely,guided whale and dipper throated *** proposed algorithm is evaluated using four publicly available breast cancer *** evaluation results show the effectiveness of the proposed approach from the accuracy and speed *** prove the superiority of the proposed algorithm,a set of competing feature selection algorithms were incorporated into the conducted *** addition,a group of statistical analysis experiments was conducted to emphasize the superiority and stability of the proposed *** best-achieved breast cancer prediction average accuracy based on the proposed algorithm is 99.453%.This result is achieved in an average time of 3.6725 s,the best result among all the competing approaches utilized in the experiments.

关键词： Medical dataset breast cancer guided whale optimizer dipper throated optimizer feature selection meta-heuristics

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