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A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial

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Journal of Otology 2023年第2期18卷 97-100页

作者： Masoud Motesadi Zarandi Zahra Rabbani Mahtab Rabbani Anari Ali Kouhi mona Zeinaloo Department of Cochlear Implant and Otorhinolaryngology Tehran University of Medical SciencesTehranIran Amir Alam Hospital Tehran University of Medical SciencesTehranIran Otorhinolaryngology Research Center Amir Alam HospitalTehran University of Medical SciencesTehranIran Otorhinolaryngology Research Center Tehran University of Medical SciencesTehranIran Department of Otorhinolaryngology and Head and Neck surgery Amir Alam HospitalTehran University of Medical SciencesTehranIran Department of Community Medicine Tehran University of Medical SciencesTehranIran

Purpose:Meniere's disease(MD),first introduced by Prosper Meniere,is characterized mainly by vertigo,tinnitus,aural fullness and sensorineural hearing *** the exact pathophysiology of MD is unknown,immunologic and inflammatory interactions are possible underlying mechanisms involved in *** study is aimed to investigate the immunomodulatory and anti-inflammatory effect of Nigella sativa on MD as a therapeutic ***:We divided 40 patients with definite MD into two groups of 20 *** study group received 1 g of Nigella sativa oil daily for three months and the control group received a *** in hearing,tinnitus and vertigo were estimated by pure tone audiometry,tinnitus handicap inventory questionnaire and dizziness handicap inventory questionnaire,***:At the end of the study we did not observe any significant improvement in study's group hearing threshold,tinnitus and vertigo compared to the control ***:In this study,statistical analysis showed that Nigella sativa failed to improve signs and symptoms of ***,further investigations with a larger study population are needed to ascertain the current conclusion.

关键词： Meniere's disease Nigella sativa Tinnitus Vertigo Hearing loss

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Automated Artificial Intelligence Empowered White Blood Cells Classification Model

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Computers, Materials & Continua 2023年第4期75卷 409-425页

作者： Mohammad Yamin Abdullah M.Basahel mona Abusurrah sulafah M Basahel sachi Nandan Mohanty E.Laxmi Lydia Faculty of Economics and Administration King Abdulaziz UniversityJeddahSaudi Arabia Department of Management Information systems College of Business AdministrationTaibah UniversityAl-MadinahSaudi Arabia E-commerce Department College of Administrative and Financial SciencesSaudi Electronic UniversityJeddahSaudi Arabia school of Computer science&Engineering(sCOPE) VIT-AP UniversityAmaravatiAndhra PradeshIndia Department of Computer science and Engineering Vignan’s Institute of Information Technology(Autonomous)VisakhapatnamAndhra Pradesh530049India

White blood cells (WBC) or leukocytes are a vital component ofthe blood which forms the immune system, which is accountable to fightforeign elements. The WBC images can be exposed to different data analysisapproaches which categorize different kinds of WBC. Conventionally, laboratorytests are carried out to determine the kind of WBC which is erroneousand time consuming. Recently, deep learning (DL) models can be employedfor automated investigation of WBC images in short duration. Therefore,this paper introduces an Aquila Optimizer with Transfer Learning basedAutomated White Blood Cells Classification (AOTL-WBCC) technique. Thepresented AOTL-WBCC model executes data normalization and data augmentationprocess (rotation and zooming) at the initial stage. In addition,the residual network (ResNet) approach was used for feature extraction inwhich the initial hyperparameter values of the ResNet model are tuned by theuse of AO algorithm. Finally, Bayesian neural network (BNN) classificationtechnique has been implied for the identification of WBC images into distinctclasses. The experimental validation of the AOTL-WBCC methodology isperformed with the help of Kaggle dataset. The experimental results foundthat the AOTL-WBCC model has outperformed other techniques which arebased on image processing and manual feature engineering approaches underdifferent dimensions.

关键词： White blood cells cell engineering computational intelligence image classification transfer learning

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Role of cannabinoids and the endocannabinoid system in modulation of diabetic cardiomyopathy

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World Journal of Diabetes 2022年第5期13卷 387-407页

作者： mona F El-Azab Ahmed E Wakiel Yossef K Nafea Mahmoud E Youssef Department of Pharmacology and Toxicology Faculty of PharmacySuez Canal UniversityIsmailia 41522Egypt Program of Biochemistry McMaster UniversityHamilton L8S 4L8OntarioCanada Department of Pharmacology and Biochemistry Delta University for Science and TechnologyMansoura 35511New CairoEgypt

Diabetic complications,chiefly seen in long-term situations,are persistently deleterious to a large extent,requiring multi-factorial risk reduction strategies beyond glycemic *** cardiomyopathy is one of the most common deleterious diabetic complications,being the leading cause of mortality among diabetic *** mechanisms of diabetic cardiomyopathy are multi-factorial,involving increased oxidative stress,accumulation of advanced glycation end products(AGEs),activation of various pro-inflammatory and cell death signaling pathways,and changes in the composition of extracellular matrix with enhanced cardiac *** novel lipid signaling system,the endocannabinoid system,has been implicated in the pathogenesis of diabetes and its complications through its two main receptors:Cannabinoid receptor type 1 and cannabinoid receptor type 2,alongside other ***,the role of the endocannabinoid system in diabetic cardiomyopathy has not been fully *** review aims to elucidate the possible mechanisms through which cannabinoids and the endocannabinoid system could interact with the pathogenesis and the development of diabetic *** mechanisms include oxidative/nitrative stress,inflammation,accumulation of AGEs,cardiac remodeling,and autophagy.A better understanding of the role of cannabinoids and the endocannabinoid system in diabetic cardiomyopathy may provide novel strategies to manipulate such a serious diabetic complication.

关键词： Δ9-tetrahydrocannabinol Autophagy Cannabinoid receptors Diabetic cardiomyopathy Endocannabinoid system Inflammation

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A New Evaluation Criterion for Optimizing the Mechanical Properties of Toughened Polypropylene/silica Nanocomposites

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Chinese Journal of Polymer science 2020年第8期38卷 877-887,I0008页

作者： Hossein Pourrahmani mona Golparvar Mohammad Fasihi Group of Energy Materials (E)cole Polytechnique Fédérale de LausanneSion 1951Switzerland school of Chemical Petroleum and Gas EngineeringIran University of Science and TechnologyTehran 16846-13114Iran school of Mechanical Engineering Braunschweig university of technologyBraunschweig 38106Germany

This study aims to experiment with the mechanical properties of polypropylene(PP)/thermoplastic elastomer/nano-silica/compatibilizer nanocomposite using the melt mixing *** addition of polyolefin elastomers has proved to be an approachable solution for low impact strength of PP,while it would also reduce the Young's modulus and tensile *** is why reinforcement would be applied to this combination to enhance the elastic *** mechanical properties of the prepared composites were devised to train an artificial neural network to predict these properties of the system in 6256 unknown ***,the sensitivity analysis was performed and the share of each input parameter on the respective output values was ***,a novel parameter called nanocomposite evaluation criterion(NEC)is introduced to analyze the suitability of the nanocomposites considering the mechanical ***,the formulation with optimal mechanical properties of toughness,elongation at break,tensile strength,Young's modulus,and impact strength was obtained.

关键词： Nanocomposite Polypropylene(PP) silica Artificial neural networks Nanocomposite evaluation criterion(NEC) sensitivity analysis

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Entropy of Quantum Dynamical systems and sufficient Families in Orthomodular Lattices with Bayessian state

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Communications in Theoretical Physics 2008年第9期50卷 551-556页

作者： mona Khare shraddha Roy Department of Mathematics University of AllahabadAllahabad211 001India Allahabad Mathematical society 10C.S.P.Singh MargAllahabad211 001India

The purpose of the present paper is to study the entropy h_s(Φ) of a quantum dynamical systems Φ=(L,s,φ),where s is a bayessian state on an orthomodular lattice *** introduced the notion of entropy hs(φ,)of partition of a Boolean algebra B with respect to a state s and a state preserving homomorphism φ,we prove afew results on that,define the entropy of a dynamical system h_s(Φ),and show its *** concept of sufficientfamilies is also given and we establish that hs(Φ) comes out to be equal to the supremum of h_s(φ,),where variesover any sufficient *** present theory has then been extended to the quantum dynamical system ( L,s,φ),whichas an effect of the theory of commutators and Bell inequalities can equivalently be replaced by the dynamical system(B,s_o,φ),where B is a Boolean algebra and so is a state on B.

关键词：晶格电子逻辑同构现象平均信息量

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Cardiac stem cells: Current knowledge and future prospects

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World Journal of stem Cells 2022年第1期14卷 1-40页

作者： Radwa A Mehanna Marwa M Essawy mona A Barkat Ashraf K Awaad Eman H Thabet Heba A Hamed Hagar Elkafrawy Nehal A Khalil Abeer sallam Marwa A Kholief samar s Ibrahim Ghada M Mourad Medical Physiology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Oral Pathology Department Faculty of Dentistry/Center of Excellence for Research in Regenerative Medicine and ApplicationsFaculty of MedicineAlexandria UniversityAlexandria 21500Egypt Human Anatomy and Embryology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Histology and Cell Biology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Medical Biochemistry Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt Forensic Medicine and Clinical toxicology Department/Center of Excellence for Research in Regenerative Medicine and Applications Faculty of MedicineAlexandria UniversityAlexandria 21500Egypt

Regenerative medicine is the field concerned with the repair and restoration of the integrity of damaged human tissues as well as whole *** the inception of the field several decades ago,regenerative medicine therapies,namely stem cells,have received significant attention in preclinical studies and clinical *** from their known potential for differentiation into the various body cells,stem cells enhance the organ's intrinsic regenerative capacity by altering its environment,whether by exogenous injection or introducing their products that modulate endogenous stem cell function and fate for the sake of ***,research in cardiology has highlighted the evidence for the existence of cardiac stem and progenitor cells(CsCs/CPCs).The global burden of cardiovascular diseases’morbidity and mortality has demanded an in-depth understanding of the biology of CsCs/CPCs aiming at improving the outcome for an innovative therapeutic *** review will discuss the nature of each of the CsCs/CPCs,their environment,their interplay with other cells,and their *** addition,important issues are tackled concerning the potency of CsCs/CPCs in relation to their secretome for mediating the ability to influence other ***,the review will throw the light on the clinical trials and the preclinical studies using CsCs/CPCs and combined therapy for cardiac ***,the novel role of nanotechnology in cardiac regeneration will be explored.

关键词： Cardiac stem and progenitor cells Cardiac stem cells’secretome Cardiac stem cells’niche and metabolism Nanotechnology Clinical trials Combined therapy

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Assessing decontamination practices at a medical microbiology research laboratory

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Journal of Biosafety and Biosecurity 2022年第2期4卷 124-129页

作者： Merna M.Alfy sherine B.El sayed mona El-shokry Medical Microbiology and Immunology Department Faculty of MedicineAin Shams UniversityCairoEgypt

To our knowledge,this is the first study to conduct an objective assessment of the routine decontamination practices at a medical microbiology research laboratory(MRL)a year after a biosafety training was provided to all laboratory *** March 28th and June 28th,2021,unobtrusive observations were carried out to identify-three high-touch surfaces at the MRL during different working *** was used to evaluate the effectiveness of the disinfectant used in the *** three high-touch surfaces were sampled before and after decontamination with 200 ppm of 5%sodium hypochlorite(household bleach)to quantify the microbial load and identify the types of organisms residing on the laboratory surfaces.A higher concentration(500 ppm)of 5%sodium hypochlorite was employed after refresher training was provided to housekeeping staff,and resampling of the three surfaces was carried out during a 4-week follow-up period using the same *** three high-touch surfaces identified were the two sides of the workbench(22%–24%)and the front surface of one incubator(14%).Anthracoid bacilli and staphylococcus aureus were the most commonly found organisms on laboratory surfaces preintervention(100%and 89%,respectively)and post-intervention(56%and 44%,respectively).Other microorganisms detected included salmonella spp.(27.7%),Proteus spp.(5.6%),Escherichia coli(5.6%),and Klebsiella spp.(33.3%).Employing a higher concentration(500 ppm)of sodium hypochlorite significantly(ps study demonstrated suboptimal decontamination practices at the MRL and the need to apply a higher concentration(500 ppm)of sodium hypochlorite to reduce the overall microbial *** also demonstrated the importance of quantitative assessment to monitor decontamination practices and ensure staff *** studies are needed to identify bacterial communities within the laboratory,which will

关键词： Biosafety Laboratory-acquired infection sodium hypochlorite Environmental decontamination Bacterial contamination Egypt

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Edge Computing Platform with Efficient Migration scheme for 5G/6G Networks

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Computer systems science & Engineering 2023年第5期45卷 1775-1787页

作者： Abdelhamied A.Ateya Amel Ali Alhussan Hanaa A.Abdallah mona A.Al duailij Abdukodir Khakimov Ammar Muthanna Department of Electronics and Communications Engineering Zagazig UniversityZagazigSharqia44519Egypt Department of Computer sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh84428Saudi Arabia Department of Applied Probability and Informatics Peoples’Friendship University of Russia(RUDN University)Moscow117198Russia Center for Telecommunication Research School of Postgraduate Studies&ResearchSri Lanka Technological CampusPadukka10500Sri Lanka

Next-generation cellular networks are expected to provide users with innovative gigabits and terabits per second speeds and achieve ultra-high reliability,availability,and ultra-low *** requirements of such networks are the main challenges that can be handled using a range of recent technologies,including multi-access edge computing(MEC),artificial intelligence(AI),millimeterwave communications(mmWave),and software-defined *** aspects and design challenges associated with the MEC-based 5G/6G networks should be solved to ensure the required quality of service(Qos).This article considers developing a complex MEC structure for fifth and sixth-generation(5G/6G)cellular ***,we propose a seamless migration technique for complex edge computing *** developed migration scheme enables services to adapt to the required load on the radio *** proposed algorithm is analyzed for various use cases,and a test bench has been developed to emulate the operator’s *** obtained results are introduced and discussed.

关键词： 5G 6G mobile edge computing migration offloading quality of service

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Calcitonin and vitamin D3 have high therapeutic potential for improving diabetic mandibular growth

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International Journal of Oral science 2016年第1期8卷 39-44页

作者： mona A Abbassy Ippei Watari Ahmed s Bakry Takashi Ono Ali H Hassan Orthodontic Department Faculty of DentistryKing Abdulaziz UniversityJeddahSaudi Arabia Department of Orofacial Development and Function Division of Oral Health SciencesGraduate SchoolTokyo Medical and Dental UniversityTokyoJapan Alexandria University AlexandriaEgypt Conservative Dentistry Department Faculty of DentistryKing Abdulaziz UniversityJeddahSaudi Arabia Cariology and Operative Dentistry Department Graduate School of Medical and Dental SciencesTokyo Medical&Dental UniversityTokyoJapan Conservative Dentistry Department Faculty of DentistryAlexandria UniversityAlexandriaEgypt

The goal of this study was to assess the effect of the intermittent combination of an antiresorptive agent （calcitonin） and an anabolic agent （vitamin D3） on treating the detrimental effects of Type 1 diabetes mellitus （DM） on mandibular bone formation and growth. Forty 3-week-old male Wistar rats were divided into four groups： the control group （normal rats）, the control C＋D group （normal rats injected with calcitonin and vitamin D3）, the diabetic C＋D group （diabetic rats injected with calcitonin and vitamin D3） and the diabetic group （uncontrolled diabetic rats）. An experimental DM condition was induced in the male Wistar rats in the diabetic and diabetic C＋ D groups using a single dose of 60 ***-1 body weight of streptozotocin. Calcitonin and vitamin D3 were simultaneously injected in the rats of the control C＋D and diabetic C＋D groups. All rats were killed after 4 weeks, and the right mandibles were evaluated by micro-computed tomography and histomorphometric analysis. Diabetic rats showed a significant deterioration in bone quality and bone formation （diabetic group）. By contrast, with the injection of calcitonin and vitamin D3, both bone parameters and bone formation significantly improved （diabetic C＋ D group）（P 〈 0.05）. These findings suggest that these two hormones might potentially improve various bone properties.

关键词： type 1 diabetes mellitus mandibular bone structure mandibular bone formation micro-computed tomography bone histomorphometry

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snapshot multispectral imaging using a diffractive optical network

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Light(science & Applications) 2023年第5期12卷 789-808页

作者： Deniz Mengu Anika Tabassum mona Jarrahi Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA California Nanosystems Institute University of CaliforniaLos AngelesCA 90095USA

Multispectral imaging has been used for numerous applications in e.g.,environmental monitoring,aerospace,defense,and ***,we present a diffractive optical network-based multispectral imaging system trained using deep learning to create a virtual spectral filter array at the output image *** diffractive multispectral imager performs spatially-coherent imaging over a large spectrum,and at the same time,routes a pre-determined set of spectral channels onto an array of pixels at the output plane,converting a monochrome focal-plane array or image sensor into a multispectral imaging device without any spectral filters or image recovery ***,the spectral responsivity of this diffractive multispectral imager is not sensitive to input polarization *** numerical simulations,we present different diffractive network designs that achieve snapshot multispectral imaging with 4,9 and 16 unique spectral bands within the visible spectrum,based on passive spatially-structured diffractive surfaces,with a compact design that axially spans ~72λ_(m),where λ_(m) is the mean wavelength of the spectral band of ***,we experimentally demonstrate a diffractive multispectral imager based on a 3D-printed diffractive network that creates at its output image plane a spatially repeating virtual spectral filter array with 2×2=4 unique bands at terahertz *** to their compact form factor and computation-free,power-efficient and polarization-insensitive forward operation,diffractive multispectral imagers can be transformative for various imaging and sensing applications and be used at different parts of the electromagnetic spectrum where high-density and wide-area multispectral pixel arrays are not widely available.

关键词： spectrum spectral spatially

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