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Chinese expert consensus on the clinical application of drugcoated balloon(2^(nd) Edition)

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Journal of Geriatric Cardiology 2024年第2期21卷 135-152页

作者： The Expert Writing Committee of the Chinese Expert Consensus on Clinical Applications of Drug-Coated Balloon(2^(nd)Edition) Jun-Bo GE Yun-Dai CHEN 不详 Zhongshan Hospital Fudan University Chinese PLA General Hospital

Percutaneous coronary interventions have progressed through the era of plain balloon dilation, bare-metal stent insertion to drug-eluting stent treatment, which has significantly reduced the acute occlusion and restenosis rates of target vessels and improved patient prognosis, making drug-eluting stents the mainstream interventional treatment for coronary artery disease. In recent years, drug-coated balloons(DCBs) have become a new treatment strategy for coronary artery disease, and the drugs used in the coating and the coating technology have progressed in the past years. Without permanent implant, a DCB delivers antiproliferative drugs rapidly and uniformly into the vessel wall via the excipient during a single balloon dilation. Many evidence suggests that DCB angioplasty is an effective measure for dealing with in-stent restenosis and de novo lesions in small coronary *** more clinical studies are published, new evidence is emerging for the use of DCB angioplasty in a wide range of coronary diseases, and the indications are expanding internationally. Based on the latest research from China and elsewhere, the Expert Writing Committee of the Chinese Expert Consensus on Clinical Applications of Drug-Coated Balloon has updated the previous DCB consensus after evidence-based discussions and meetings in terms of adequate preparation of in-stent restenosis lesions, expansion of the indications for coronary de novo lesions, and precise guidance of DCB treatment by intravascular imaging and functional evaluation.

关键词： balloon drugs dealing

Progress of Lyman-alpha-based beam emission spectroscopy(Ly BES)diagnostic on the HL-2A tokamak

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Plasma Science and Technology 2024年第3期26卷 118-125页

作者：周艺轩余羿许敏柯锐聂林徐皓赵光义刘灏袁子豪肖晨雨李继全肖池阶 the HL-2A Team Southwestern Institute of Physics Chengdu 610041People's Republic of China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082People's Republic of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871People's Republic of China

An edge Lyman-alpha-based beam emission spectroscopy(LyBES)diagnostic,using a heating NBI(neutral beam injection)system,is currently under development on the HL-2A *** 20-channel edge LyBES,which is intended to measure the density fluctuation in plasma edge(from R=1960 mm to R=2026 mm)with an improved spatial resolution of 3.3 mm,is a complement to the existing conventional beam emission spectroscopy(BES)*** this article,we introduce the progress of LyBES diagnostic,including the collection optics,the monochromator,and the detector *** reflectance of the collection mirrors is measured to be~82%at 122 nm,and the aberration geometrical radius of the collection optics is tested to be~150μm in the aimed *** linear dispersion of the LyBES monochromator is designed to be~0.09 nm mm^(-1).The bandwidth of the detector system with the 5×10^(7)V A^(-1)preamplifier gain is measured to be~280 kHz,and the peak-to-peak noise of the detector system is tested to be~16 *** finalized design,components development and testing of the LyBES diagnostic have been completed at present,and an overall performance of the LyBES diagnostic is to be confirmed in the next HL-2A campaign.

关键词： density fluctuation Ly BES BES vacuum ultraviolet

Dissection of a rapidly evolving wheat resistance gene cluster by long-read genome sequencing accelerated the cloning of Pm69

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Plant Communications 2024年第1期5卷 69-83页

作者： Yinghui Li Zhen-Zhen Wei Hanan Sela Liubov Govta Valentyna Klymiuk Rajib Roychowdhury Harmeet Singh Chawla Jennifer Ens Krystalee Wiebe Valeria Bocharova Roi Ben-David Prerna B.Pawar Yuqi Zhang Samidha Jaiwar Istvan molnar Jaroslav Dolezel Gitta Coaker Curtis J.Pozniak Tzion Fahima Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel The Department of Evolutionary and Environmental Biology University of HaifaMt.CarmelHaifa 3498838Israel The Institute of Plant Protection Sichuan Academy of Agricultural SciencesChengdu 610066China Crop Development Centre and Department of Plant Sciences University of Saskatchewan51 Campus DriveSaskatoonSK S7N 5A8Canada Department of Vegetables and Field Crops Institute of Plant SciencesAgricultural Research Organization(ARO)–Volcani CenterRishon Lezion 7505101Israel Department of Crop Genomics and Bioinformatics China Agricultural UniversityBeijing 100094China Institute of Experimental Botany of the Czech Academy of Sciences Centre of the Region Hana´for Biotechnological and Agricultural ResearchSlechtitelu 3177900 OlomoucCzech Republic Plant Pathology Department University of CaliforniaDavisDavisCA 95616USA Present address:Department of Plant Science University of ManitobaWinnipegMB R3T 2N2Canada Present address:Agricultural Institute Centre for Agricultural ResearchELKHMartonvasar 2462Hungary

Gene cloning in repeat-rich polyploid genomes remains ***,we describe a strategy for overcoming major bottlenecks in cloning of the powdery mildew resistance gene(R-gene)Pm69 derived from tetraploid wild emmer wheat.A conventional positional cloning approach was not effective owing to suppressed *** sorting was compromised by insufficient purity.A Pm69 physical map,constructed by assembling Oxford Nanopore Technology(ONT)long-read genome sequences,revealed a rapidly evolving nucleotide-binding leucine-rich repeat(NLR)R-gene cluster with structural variations.A single candidate NLR was identified by anchoring RNA sequencing reads from susceptible mutants to ONT contigs and was validated by virus-induced gene ***69 is likely a newly evolved NLR and was discovered in only one location across the wild emmer wheat distribution range in ***69 was successfully introgressed into cultivated wheat,and a diagnostic molecular marker was used to accelerate its deployment and pyramiding with other R-genes.

关键词： cluster resistance Israel

The tri-band high spectral resolution spectrometer with gratings in tandem for the charge-exchange recombination spectroscopy diagnostic system on HL-2A tokamak

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Plasma Science and Technology 2024年第6期26卷 103-110页

作者：刘亮余德良马倩何小斐 Maarten DE BOCK Manfred von HELLERMANN Michael WALSH 陈文锦何小雪魏彦玲张能李栋魏会领 the HL-2A Team Southwestern Institute of Physics Chengdu 610041People’s Republic of China College of Physics and Optoelectronic Technology Baoji University of Arts and SciencesBaoji 721000People’s Republic of China ITER Organization Route de Vinon-sur-VerdonCS 90046St.Paul Lez Durance Cedex 13067France Fusion Spectroscopy Markgraf-Albrecht Str.14Berlin 10711Germany

Charge-exchange(CX) recombination spectroscopy is a powerful tool monitoring ion temperature and plasma rotation with good temporal and spatial resolutions. A compact, new design for a high-throughput, tri-band high spectral resolution spectrometer has been developed for the charge-exchange recombination spectroscopy measurement on the HL-2A tokamak. The simultaneous measurements of He II(468.57 nm), C VI(529.1 nm), and Dα(656.1 nm accompanied by beam emission spectra) with an acquisition frequency up to 400 Hz are achieved by vertically binning the spectrum from each fiber in experiments. Initial results indicate that the system can provide radial profiles of not only ion temperature and rotation velocity,but also concentration of carbon. For the case of helium, the measurements for the ion temperature and rotation velocity are straightforward but the apparent concentration associated with the observed CX intensity is obviously too high. Modeling of the active He II CX feature including plume contributions needs to be carried out to extract the true helium *** spectrometer could become a prototype for the ITER charge-exchange recombination spectroscopy diagnostic and the pilot experiments, as presented here, demonstrate the possibility of impurity concentrations measurements based on the combined measurement of local beam emission and charge-exchange recombination spectroscopy spectra.

关键词： CXRS ion temperature plasma rotation impurity concentration

钠-葡萄糖共转运蛋白2抑制剂联合胰岛素治疗2型糖尿病中国专家共识(2023版)

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中华糖尿病杂志 2024年第1期16卷 9-19页

作者：《钠-葡萄糖共转运蛋白2抑制剂联合胰岛素治疗2型糖尿病中国专家共识》编写委员会郭立新洪天配田勍张丽娜不详北京医院内分泌科国家老年医学中心北京100730 北京大学第三医院内分泌科北京100191 北京大学第三医院

口服降糖药(OAD)联合胰岛素治疗是2型糖尿病(T2DM)患者血糖控制达标的重要方法之一。新型OAD钠-葡萄糖共转运蛋白2抑制剂(SGLT2i)在有效降糖的同时还可发挥心肾保护作用。近年来,SGLT2i在T2DM患者中广泛使用,如何将这一类新型OAD与胰岛... 详细信息

口服降糖药(OAD)联合胰岛素治疗是2型糖尿病(T2DM)患者血糖控制达标的重要方法之一。新型OAD钠-葡萄糖共转运蛋白2抑制剂(SGLT2i)在有效降糖的同时还可发挥心肾保护作用。近年来,SGLT2i在T2DM患者中广泛使用,如何将这一类新型OAD与胰岛素安全、有效地联合应用,成为T2DM临床管理中需要关注的问题。本共识针对SGLT2i联合胰岛素的使用原则、患者人群选择、联合用药启动流程、治疗优势、联合治疗的安全性和注意事项等问题方面进行证据梳理,并结合我国的临床实际用药经验,提出13条推荐意见。旨在指导广大临床医师规范、合理用药,从而改善我国T2DM患者的临床结局。

关键词：糖尿病 2型钠-葡萄糖共转运蛋白2抑制剂胰岛素口服降糖药

《我的阿勒泰》的生活智慧:真正舒适的人生,是向内探求

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伴侣 2024年第6期 50-52页

作者： 37度2 不详

最近,《我的阿勒泰》迷你剧登录央视CCTV-1黄金档。辽阔山野,漫天星空,琐碎杂事,稀松日常,勾勒出无数人神往的美丽北疆生活。它的原著作者李娟曾说:“我写下的故事曾让无数读者向往,但其实最最向往的是我自己。”李娟对阿勒泰表达的深... 详细信息

最近,《我的阿勒泰》迷你剧登录央视CCTV-1黄金档。辽阔山野,漫天星空,琐碎杂事,稀松日常,勾勒出无数人神往的美丽北疆生活。它的原著作者李娟曾说:“我写下的故事曾让无数读者向往,但其实最最向往的是我自己。”李娟对阿勒泰表达的深深眷恋,总是让人恍惚。让人忘记阿勒泰壮美广阔的背后其实也有来自大自然的压迫感,它同时有并不算宜居的客观环境和躲不开的具体生活困难。可是李娟,不管境遇是糟心还是快活,她的文字始终雀跃,永远像草原上奔腾的小马。或许她无意中揭示了一种生活智慧:你永远可以在乏善可陈的日常里,寻找闪烁的微光。

关键词：生活智慧压迫感原著作者李娟乏善可陈阿勒泰壮美客观环境

HL-2A托卡马克上blob结构的喷气成像观测和定量研究

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核聚变与等离子体物理 2024年

作者：袁金榜袁博达许敏余羿聂林 HL-2A实验团队核工业西南物理研究院中山大学

在HL-2A装置上发展了一套用于边界和刮削层(SOL)中等离子体涨落测量的喷气成像诊断(GPI)系统，该诊断测量范围在弱场侧中平面附近，测量范围大小为160mm×160mm，极向-径向的空间分辨能力为2.5mm×2.5mm，时间分辨能力3～10μs。通过与... 详细信息

在HL-2A装置上发展了一套用于边界和刮削层(SOL)中等离子体涨落测量的喷气成像诊断(GPI)系统，该诊断测量范围在弱场侧中平面附近，测量范围大小为160mm×160mm，极向-径向的空间分辨能力为2.5mm×2.5mm，时间分辨能力3～10μs。通过与朗缪尔探针数据的对比，验证了GPI诊断可以得到高时空分辨率的等离子体密度扰动数据。在此基础上，发展了分析GPI实验数据的椭圆拟合算法，从而定量研究丝状结构(blob)运动，分别计算得到了blob位置、空间尺度(包括极向、径向特征长度)及运动速度等关键参数，blob空间尺度的演化验证了极向剪切流对大尺度湍流结构的拉伸及剪切分裂作用，且观察到极向运动由边界径向电场驱动的Er×B极向流主导。而blob径向速度向外，符合blob内部极向方向的电荷分离驱动了blob径向运动的分析。结果验证了椭圆拟合算法在GPI数据分析中的重要应用，为将来研究blob的演化过程提供了重要的测量分析方法和实验基础。

关键词：喷气成像诊断系统大尺度相干结构blob 椭圆拟合

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物理刺激响应型蠕虫状胶束研究进展

精细化工 2024年

作者： (2)捕集新原理与技术研究中心 (2)捕集新原理与技术研究中心 (2)捕集新原理与技术研究中心 (2)捕集新原理与技术研究中心天府永兴实验室CO

物理刺激响应型蠕虫状胶束是指在光、温度、磁场、超声等物理因子刺激下，微观结构发生明显改变的蠕虫状胶束体系，具有非侵入性、可远程操控、环境友好等诸多优点，契合当代绿色环保的发展理念。首先，综述了物理刺激响应型蠕虫状胶束... 详细信息

物理刺激响应型蠕虫状胶束是指在光、温度、磁场、超声等物理因子刺激下，微观结构发生明显改变的蠕虫状胶束体系，具有非侵入性、可远程操控、环境友好等诸多优点，契合当代绿色环保的发展理念。首先，综述了物理刺激响应型蠕虫状胶束〔光响应型、温度响应型、外力场（磁、电、超声）响应型、多重物理刺激响应型蠕虫状胶束〕的构筑策略、响应机制及流变性质。然后，阐述了物理刺激响应型蠕虫状胶束的应用进展及取得的成果。目前，物理刺激响应型蠕虫状胶束的研究主要侧重于体系构建和基础理论层面，构筑方式仍以低效率的试错法为主，而相关应用开发还处于实验室阶段。最后，指出未来物理刺激响应型蠕虫状胶束的开发应注重与大数据模拟、机器学习等人工智能技术的结合，探索出物理刺激响应型蠕虫状胶束的高效、低廉、规模化合成方法，并深入探究其在现场实施中的性能变化与响应特性，为其规模化生产与应用提供理论依据和技术支撑。

关键词：蠕虫状胶束黏弹性物理刺激响应表面活性剂流变特性

Exploring conservative management for cervical intraepithelial neoplasia grade 2 in organised cervical cancer screening programmes:a multicentre study in Italy

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Family Medicine and Community Health 2024年第S2期12卷 1-7页

作者： Silvia Gori Helena Frayle Alessio Pagan Marika Soldà Cesare Romagnolo Egle Insacco Licia Laurino Mario Matteucci Giuseppe Sordi Enrico Busato Manuel Zorzi Tiziano Maggino Annarosa Del Mistro CIN2 study Working Group Veneto Institute of Oncology IOV-IRCCS PadovaItaly Local Health Unit Marca Trevigiana TrevisoItaly Local Health Unit Serenissima VeneziaItaly Obstetrics and Gynecology Azienda Ospedale UniversitàPadovaItaly Local Health Unit Scaligera VeronaItaly Veneto Tumour Registry Azienda ZeroPadovaItaly 不详

Cervical intraepithelial neoplasia grade 2(CIN2)lesions may regress spontaneously,offering an alternative to immediate treatment,especially for women of childbearing age(15–45 years).We conducted a prospective multicentre study on conservative CIN2 management,with semiannual follow-up visits over 24 months,biomarkers’investigation and treatment for progression to CIN3+or CIN2 persistence for more than 12 ***,we assess women’s willingness to participate and adherence to the study *** study was set in population-based organised cervical cancer *** April 2019 to October 2021,640 CIN2 cases were diagnosed in women aged 25–64 participating in the screening *** to our predefined inclusion and exclusion criteria,228(35.6%)women were not eligible;93(22.6%)of the 412 eligible refused,and 319(77.4%)were *** for personal reasons(ie,desire to become pregnant,anxiety,difficulty in complying with the study protocol)and external barriers(ie,residence elsewhere and language problems)accounted for 71%and 17%,*** 9%expressed a preference for *** primary ineligibility factor was the upper age limit of 45 *** enrolment,12(4%)women without evidence of progression requested treatment,125(39%)were lost to follow-up(mostly after 6–12 months)and 182(57%)remained ***,40%of enrolees did not fully adhere to the protocol,whereas only 5%(20/412)of the eligible women desired *** study demonstrates a good acceptance of conservative management for CIN2 lesions by the women,supporting its implementation within cervical screening programmes.

关键词： cervical conservative centre