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Molecular characterization of an outbreak-involved Bacillus anthracis strain confirms the spillover of anthrax from West Africa

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Infectious Diseases of Poverty 2024年第1期13卷 93-94页

作者： Shuchao Wang Roland Suluku Mohamed B.Jalloh Ahmed F.Samba Baogui Jiang Yubiao Xie Doris Harding Mengyao Zhang Foday Sahr Mahmud E.Sesay James S.Squire Mohamed A.Vandi moinina n.kallon Shoufeng Zhang Rongliang Hu Yuee Zhao Zhiqiang Mi Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Changchun China Department of Animal Sciences School of Agriculture and Food Sciences Njala University Njala Sierra Leone Department of Microbiology College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone Ministry of Agriculture and Food Sciences Freetown Sierra Leone Beijing Institute of Microbiology and Epidemiology Beijing China Ministry of Health and Sanitation Freetown Sierra Leone Beijing Institute of Biotechnology Beijing China

Background Anthrax,a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis,remains a major global public health concern,especially in countries with limited *** Leone,a West African country historically plagued by anthrax,has almost been out of report on this disease in recent *** this study,we described a large-scale anthrax outbreak affecting both animals and humans and attempted to characterize the *** The causative agent of the animal outbreak in Port Loko District,Sierra Leone,between March and May 2022 was identified using the nanopore sequencing technique.A nationwide active surveillance was implemented from May 2022 to June 2023 to monitor the occurrence of anthrax-specific symptoms in *** cases were subsequently verified using quantitative polymerase chain ***-genome sequencing was accomplished by combining long-read and short-read sequencing *** phylogenetic analysis was performed based on the full-chromosome single nucleotide *** The outbreak in Port Loko District,Sierra Leone,led to the death of 233 animals between March 26th and May 16th,*** ruled out the initial suspicion of Anaplasma species and successfully identified *** as the causative agent of the *** a result of the government's prompt response,out of the 49 suspected human cases identifed during the one-year active surveillance,only 6 human cases tested positive,all within the frst month after the official declaration of the *** phylogenetic analysis indicated that the BaSL2022 isolate responsible for the outbreak was positioned in the ***.153 clade within the TransEuroAsian group of *** We successfully identifed a large-scale anthrax outbreak in Sierra *** causative isolate of ***,BaSL2022,phylogenetically bridged other lineages in ***.153 clade and neighboring genetic groups,***.144 and ***.148,

关键词： Molecular identification Anthrax Bacillus anthracis Sierra Leone Phylogeny Single nucleotide polymorphism

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Astragalus polysaccharide enhances chickens immunity and inhibits H9n2 avian influenza virus in vitro and in vivo

Astragalus polysaccharide enhances chickens immunity and inh...

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全国动物生理生化第十二次学术交流会

作者： kallon Sanpha College of Animal Science South China Agricultural University

This study was carried out to determine the immunization potential of astragalus polysaccharide (APS) against H9n2 avian influenza *** effect of APS on H9n2 in Chick embryo fibroblast (CEF) was determined using MTT *** expression of MHCⅠ,MHCⅡ,IFn-γ,IL-2,IL-4 and

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Astragalus and ginseng polysaccharides are potential adjuvant in the formulation of a new avian influenza H5n1 vaccine

Astragalus and ginseng polysaccharides are potential adjuvan...

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全国动物生理生化第十二次学术交流会

作者： kallon Sanpha College of Animal Science South China Agricultural University

Astragalus and Ginseng polysaccharides were used in this study for the improvement of influenza vaccine(H5n1) in *** days old chickens were immunized with influenza vaccine alone (group 4) or combined with Astragalus(groups 1-3) or combined with Ginseng(groups 4-6)

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Astragalus polysaccharide enhances chickens immunity and inhibits H9n2 avian influenza virus in vitro and in vivo

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畜牧与兽医 2012年第S1期44卷 261-262页

作者： kallon Sanpha Xiaorong Li Qianyun Xi Qingyan Jiang Yongliang Zhang Qingmei Xie College of Animal Science South China Agricultural University

This study was carried out to determine the immunization potential of astragalus polysaccharide(APS)against H9n2 avian influenza *** effect of APS on H9n2 in Chick embryo fibroblast(CEF)was determined using MTT *** expression of MHCⅠ,MHCⅡ,IFn-γ,IL-2,IL-4 and IL-10 were analyzed by real-time PCR in *** results showed that viral inhibition rate was significantly high(Pne

关键词： avian immunity Astragalus astragalus cytokine vaccine embryo blank pathogen killed

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Astragalus polysaccharide enhances immunity and inhibits H9n2 avian influenza virus in vitro and in vivo

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Journal of Animal Science and Biotechnology 2013年第4期4卷 325-335页

作者： Sanpha kallon Xiaorong Li Jun Ji Cuiying Chen Qianyun Xi Shuang Chang Chunyi Xue Jingyun Ma Qingmei Xie Youngliang Zhang College of Animal Science South China Agricultural University US Department of Agriculture Agricultural Research Service Avian Disease and Oncology Laboratory State Key Laboratory of Biocontrol College of Life Sciences Sun Yat-Sen University

This study investigated the humoral immunization of Astragalus polysaccharide （APS） against Hgn2 avian influenza virus （H9n2 AIV） infection in chickens. The effects of APS treatment on H9n2 infection was evaluated by an Mqq- [3（4, 5-dimethylthiazol-2-yl）-2, 3-diphenyl tetrazolium bromide] assay and analysis of MFIC and cytokine mRnA expression. The effect on lymphocyte and serum antibody titers in vivo was also investigated. IL-4, IL-6, IL-10, LITAF, IL-12 and antibody titers to H9n2 AIV wet enhanced in the first week after APS treatment. The results indicated that APS treatment reduces H9n2 AIV replication and promotes early humoral immune responses in young *** study investigated the humoral immunization of Astragalus polysaccharide （APS） against Hgn2 avian influenza virus （H9n2 AIV） infection in chickens. The effects of APS treatment on Hgn2 infection was evaluated by an M]q- [3（4, 5-dimethylthiazol-2-yl）-2, 3-diphenyl tetrazolium bromide] assay and analysis of MHC and cytokine mRnA expression. The effect on lymphocyte and serum antibody titers in vivo was also investigated. IL-4, IL-6, IL-10, LITAF, IL-12 and antibody titers to PIgn2 AIV were enhanced in the first week after APS treatment. The results indicated that APS treatment reduces Hgn2 AIV replication and promotes early humoral immune responses in young chickens.

关键词： Astrogalus polysaccharide Hgn2 avian influenza virus Immune effect

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Astragalus and ginseng polysaccharides are potential adjuvant in the formulation of a new avian influenza H5n1 vaccine

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畜牧与兽医 2012年第S1期44卷 385-385页

作者： kallon Sanpha Qianyun Xi Yong Jiang Jiehua Xiong Ruisong Ye Qingyan Jiang Yongliang Zhang College of Animal Science South China Agricultural University

Astragalus and Ginseng polysaccharides were used in this study for the improvement of influenza vaccine(H5n1)in *** days old chickens were immunized with influenza vaccine alone(group 4)or combined with Astragalus(groups 1-3)or combined with Ginseng(groups 4-6)polysaccharide(100,200,and 400 mg/kg).Serum Ig antibody levels(by HI-test)as well as effects

关键词： vaccine avian Astragalus chicken adjuvant immunized formulation alone Serum concluded

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人参多糖和黄芪多糖对禽流感疫苗免疫的促进作用分析

人参多糖和黄芪多糖对禽流感疫苗免疫的促进作用分析

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中国畜牧兽医学会动物营养学分会第七届中国饲料营养学术研讨会

作者： Sanpha kallon 叶瑞松习欠云蒋勇江青艳张永亮华南农业大学动物科学学院

禽流感是一种威胁人类和动物健康的疾病,鸟类中主要为流感A菌株,如H5n1和H9n2菌株。疫苗接种是预防禽流感的主要措施,而疫苗免疫的效果是预防的关键。本研究主要目的是探索人参多糖(GPS)和黄芪多糖(APS)提高鸡流感疫苗的效果。主要内容... 详细信息

禽流感是一种威胁人类和动物健康的疾病,鸟类中主要为流感A菌株,如H5n1和H9n2菌株。疫苗接种是预防禽流感的主要措施,而疫苗免疫的效果是预防的关键。本研究主要目的是探索人参多糖(GPS)和黄芪多糖(APS)提高鸡流感疫苗的效果。主要内容如下:(1)采用MTT法确定在鸡胚胎成纤维细胞中,人参多糖对H9n2禽流感病毒(AIV)的效果。在鸡胚胎成纤维细胞中在感染H9n2的前后分别添加人参多糖后检测主要

关键词：人参复合多糖 H9n2 免疫

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