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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M khan Zaw ali khan mohsin ali khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Ameet Kumar Jesrani Syed M Faiq Rahma Rashid Tariq ali Kalwar Rehan mohsin Tahir Aziz Nida Amin khan Muhammed Mubarak Department of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term *** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To compare the diagnostic performance of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and comparative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departments of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from August 2022 to February *** consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate(GFR)after three months of transplantation were enrolled in this *** and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic *** The mean age of all patients was 35.32±11.08 *** these,126(81.8%)were males and 28(18.2%)were *** mean serum creatinine in all patients was 2.86±1.68 mg/dL and the mean estimated GFR was 35.38±17.27 mL/min/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft damage were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

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Risk of infection with arboviruses in a healthy population in Pakistan based on seroprevalence

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Virologica Sinica 2024年第3期39卷 369-377页

作者： Shengyao Chen Muhammad Saqib Hafiz Sajid khan Yuan Bai Usman ali Ashfaq Muhammad Khalid Mansoor Abulimti Moming Jing Liu Min Zhou Saifullah khan Niazi Qiaoli Wu Awais-Ur-Rahman Sial Shuang Tang Muhammad Hassan Sarfraz Aneela Javed Sumreen Hayat mohsin Khurshid Iahtasham khan Muhammad Ammar Athar Zeeshan Taj Bo Zhang Fei Deng ali Zohaib Shu Shen Key Laboratory of Virology and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Faculty of Veterinary Science University of Agriculture FaisalabadFaisalabad 38040Pakistan The Children's Hospital Faisalabad 38000Pakistan Department of Bioinformatics and Biotechnology Government College University FaisalabadFaisalabad 38000Pakistan f Department of Microbiology Faculty of Veterinary and Animal SciencesThe Islamia University of BahawalpurBahawalpur 63100Pakistan Hubei Jiangxia Laboratory Wuhan 430200China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Armed Forces Institute of Pathology(AFIP) Rawalpindi 46000Pakistan Department of Clinical Studies Faculty of Veterinary&Animal SciencesPir Mehr Ali Shah Arid Agriculture UniversityRawalpindi 46300Pakistan Institute of Microbiology Government College University FaisalabadFaisalabad 38000Pakistan l Atta-ur-Rahman School of Applied Biosciences National University of Science and TechnologyIslamabad 44000Pakistan Department of Clinical Sciences University of Veterinary and Animal SciencesLahore Sub-campusJhang 35200Pakistan Department of Molecular Pathology National Medical Center DHA Phase 1Karachi 75500Pakistan

Infectious diseases caused by arboviruses are a public health concern in ***,studies on data prevalence and threats posed by arboviruses are *** study investigated the seroprevalence of arboviruses in a healthy population in Pakistan,including severe fever with thrombocytopenia syndrome virus(SFTSV),Crimean-Congo hemorrhagic fever virus(CCHFV),Tamdy virus(TAMV),and Karshi virus(KSIV)based on a newly established luciferase immunoprecipitation system(LIPS)assays,and Zika virus(ZIKV)by enzyme-linked immunosorbent assays(ELISA).Neutralizing activities against these arboviruses were further examined from the antibody positive *** results showed that the seroprevalence of SFTSV,CCHFV,TAMV,KSIV,and ZIKV was 17.37%,7.58%,4.41%,1.10%,and 6.48%,respectively,and neutralizing to SFTSV(1.79%),CCHFV(2.62%),and ZIKV(0.69%)were identified,as well as to the SFTSV-related Guertu virus(GTV,0.83%).Risk factors associated with the incidence of exposure and levels of antibody response were ***,co-exposure to different arboviruses was demonstrated,as thirty-seven individuals were having antibodies against multiple viruses and thirteen showed neutralizing ***,individuals aged40 years,and outdoor workers had a high risk of exposure to *** these results reveal the substantial risks of infection with arboviruses in Pakistan,and indicate the threat from co-exposure to multiple *** findings raise the need for further epidemiologic investigation in expanded regions and populations and the necessity to improve health surveillance in Pakistan.

关键词： Arbovirus Pakistan Seroprevalence Tick-borne virus Mosquito-borne virus

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Impact of dark current on pinned photo-diode capacitance of CMOS image sensor in low illumination regime

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Optoelectronics Letters 2024年第11期20卷 654-657页

作者： mohsin Suharwerdi Gausia Qazi Department of Electronics & Communication Engineering National Institute of Technology

Applications for quanta and space sensing both depend on efficient low-light imaging. To precisely optimize and design image sensor pixels for these applications, it is crucial to analyze the mechanisms behind dark cu... 详细信息

关键词： A

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用于储能应用的可生物降解的聚合物基电介质复合材料的制备

用于储能应用的可生物降解的聚合物基电介质复合材料的制备

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作者： mohsin ali KADHIM KADHIM 北京化工大学

学位级别：硕士

由于具有宽容量范围、高工作电压、轻质、性能可靠等优点,聚合物基的电介质薄膜电容器等在现代电子学中具有重要作用。通常所研究的介电聚合物和填料都是不可生物降解的,这是产生电子废物污染的原因之一。为了解决这个问题,本研究选择... 详细信息

由于具有宽容量范围、高工作电压、轻质、性能可靠等优点,聚合物基的电介质薄膜电容器等在现代电子学中具有重要作用。通常所研究的介电聚合物和填料都是不可生物降解的,这是产生电子废物污染的原因之一。为了解决这个问题,本研究选择了可生物降解的聚酯PBAT作为基体,将其分别与两种自制的生物质衍生填料复合,制备了可生物降解的聚合物基电介质复合材料。论文主要分为以下几个主要内容:首先,以香蕉皮废弃物（BP-W）为原料,通过热解的方法,分别制备了N掺杂和非掺杂的生物质炭,N掺杂技术解决了非掺杂生物炭性能上的一些缺陷,通过透射电子显微镜（TEM）、X射线衍射（XRD）、能量色散X射线分析（EDX）、X射线光电子能谱（XPS）、傅里叶变换红外光谱（FTIR）和热重分析（TGA）等手段对产物进行了系统表征,结果证实了氮的成功掺杂。并将它们作为含碳导电有机填料分别与PBAT复合制备了复合电介质材料,掺杂N生物炭可以改善聚合物复合材料的介电性能和热稳定性,而不会牺牲力学性能和生物降解性。具体而言,含有10 wt.%N掺杂生物炭的PBAT纳米复合材料的介电常数为10.64,比纯PBAT（介电常数为5.85）增加了83%。此外,复合材料介电损耗在1000 Hz时保持在0.071以下。其次,通过对生物质废料牛骨头的热解,制备了羟基磷灰石（HAp）并将其作为陶瓷无机填料,对其进行了系统的表征。随后,利用溶液共混和热压技术制备了包含HAp和PBAT的可生物降解介电复合材料,并进行了系统的表征。结果表明了单相结晶HAp的成功制备,具有良好定义的晶界,所得到的可生物降解复合材料表现出显著的介电性能,包括高介电常数、低介电损耗和良好的低填料含量下的击穿强度。介电常数随着填料含量的增加而增加,而介电损耗保持低水平,击穿强度随着填料含量的增加而略有降低。能量储存密度的理论研究表明,PBAT/HAp-3%复合材料具有较高的能量储存密度(Ust=3.56 J/cm3),比纯PBAT(Ust=2.48J/cm3)高出43.55%。HAp/PBAT复合材料的力学性能和热稳定性均得到了不同程度的提升。此外,对两个体系的复合材料生物降解性能进行了分析,评估了介电复合材料的生物降解行为,包括在不同时间段内浸泡在谷胱甘肽溶液中以模拟酶降解。评估参数包括重量损失率、力学性能和外观检查等。对完全可生物降解的PBAT/绿色填料复合材料的生物降解性能进行了全面的评价。

关键词：聚合物基复合材料介电性能生物降解生物炭生物来源羟基磷灰石

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新型PCV2衣壳融合蛋白在HEK293F细胞瞬时表达研究

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华东理工大学学报（自然科学版） 2024年第1期50卷 62-70页

作者：罗清平彭妍 ali mohsin 庄英萍郭美锦华东理工大学生物反应器工程国家重点实验室上海200237 上海国佳生化工程技术研究中心有限公司上海200237

猪圆环病毒2型(Porcine Circovirus type 2,PCV2)衣壳(Capsid)蛋白是制备抗猪圆环2型病毒亚单位疫苗的有效免疫抗原,能在大肠杆菌及杆状病毒/昆虫细胞表达系统中获得表达,然而在哺乳细胞中的表达研究仍然缺乏。瞬时表达条件考察结果显示... 详细信息

猪圆环病毒2型(Porcine Circovirus type 2,PCV2)衣壳(Capsid)蛋白是制备抗猪圆环2型病毒亚单位疫苗的有效免疫抗原,能在大肠杆菌及杆状病毒/昆虫细胞表达系统中获得表达,然而在哺乳细胞中的表达研究仍然缺乏。瞬时表达条件考察结果显示,采用宿主HEK293F细胞及PEI-40kDa转染试剂能获得35%病毒PCV2 Capsid基因细胞转染效率。转染试剂PEI(Polyethylenimine)与DNA比例差异会影响复合物形成大小及形态,复合物形成15~80 nm颗粒有利于转染效率的提高。实验以免疫逃逸型猪圆环病毒2b型NDSU41513病毒株,设计了新型PCV2 Capsid (△1-41aa)-Fc(pig) protein(PCFP)分子。在3 L反应器中成功实现了HEK293F细胞瞬时表达PCFP,表达水平达到3.8 mg/L。PCFP蛋白能够自主装形成约为41 nm类病毒颗粒,诱导小鼠机体内产生强烈的体液免疫反应,具有很高的应用潜力。

关键词：猪圆环病毒2型瞬时表达 HEK293F 类病毒颗粒疫苗

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Smart Breeding Platform:A web-based tool for high-throughput population genetics,phenomics,and genomic selection

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Molecular Plant 2024年第5期17卷 677-681页

作者： Huihui Li Xin Li Peng Zhang Yingwei Feng Junri Mi Shang Gao Lele Sheng mohsin ali Zikun Yang Liang Li Wei Fang Wensheng Wang Qian Qian Fei Gu Wenbin Zhou State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Nanfan Research Institute CAASSanyaHainan 572024China DAMO Academy Alibaba GroupHangzhou 310023China Hupan Lab Hangzhou 310023China Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhouZhejiang 310006China

Dear Editor,In the era of big data and artificial intelligence,"smart breeding"has become a broad conceptual framework encompassing the paradigm shift of crop breeding to relying on analysis of high-throughput population genetics and phenomics data to conduct genomic selection,allowing identification and optimal use of the genetic potential in crop species(Xiao et al.,2022;Xu et al.,2022;Wang et al.,2023).Most existing tools for analyzing high-throughput breeding data require extensive computational power,complex installation processes,and command-line expertise and are therefore challenging and inconvenient for the majority of researchers and breeders(Brandies and Hogg,2021).

关键词： breeding artificial breed

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Effect of Trimetazidine on Functional Capacity in Patient with Ischaemic Cardiomyopathy (TOFCAPI)

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International Journal of Clinical Medicine 2024年第2期15卷 55-67页

作者： mohsin Ahmed Golam Morshed Mahmood Hasan khan Md. Arifur Rahman Muhammed Aminur Razzaque Shariful Islam Sayeedur Rahman khan Chowdhury Md. Kudrat-E-Khuda Salahuddin Anis Shiblee Md. Habibur Rahman Department of Cardiology National Institute of Cardiovascular Diseases Dhaka Bangladesh Department of Cardiology Government Employee’s Hospital Dhaka Bangladesh Department of Cardiology Delta Hospital Ltd. Dhaka Bangladesh IPDI Foundation Dhaka Bangladesh

Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.

关键词： Bangladesh Heart Failure Exercise Capacity Trimetazidine Ischaemic Cardiomyopathy

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Recent progress in two-dimensional metallenes and their potential application as electrocatalyst

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Journal of Energy Chemistry 2024年第7期94卷 577-598页

作者： Umer Shahzad mohsin Saeed Muhammad Fazle Rabbee Hadi M.Marwani Jehan Y.Al-Humaidi Muhammad Altaf Raed H.Althomali Kwang-Hyun Baek Md.Rabiul Awual Mohammed M.Rahman Department of Chemistry Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Biotechnology Yeungnam UniversityGyeongsanSouth Korea Center of Excellence for Advanced Materials Research(CEAMR) King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityP.O.BOX 84428Riyadh 11671Saudi Arabia Department of Chemistry Center of Excellence for Innovation in Chemistry(PERCH-CIC)Center of Excellence in Materials Science and TechnologyFaculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Chemistry College of Art and SciencePrince Sattam Bin Abdulaziz UniversityWadi Al-Dawasir 11991Saudi Arabia Western Australian School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityGPO Box U 1987PerthWA 6845Australia

In this article,we looked at metallenes,a novel class of two-dimensional(2D)metals that are attracting interest in the energy and catalysis *** is one area where their exceptional physicochemical and electrical characteristics might be *** are unique because they include several metal atoms that are not in a coordinated *** makes them more active and improves their atomic uti-lization,which in turn increases their catalytic *** article delves into the potential of two-dimensional metals as electrocatalysts for carbon dioxide reduction,fuel oxidation,oxygen evolution,and oxygen reduction reactions in the context of sustainable energy *** to the exception-ally high surface-to-volume ratio,large surface area as well as their optimized atomic use efficiency,2D materials defined by atomic layers are crucial for surface-related sustainable energy *** to its exceptional properties,such as high conductivity and the ability to enhance the exposure of active metal sites,2D metallenes have recently attracted a lot of interest for use in catalysis,electronics,and energy-related *** their highly mobility,adjustable surface states,and electrical struc-tures that can be fine-tuned,2D metallenes are promising nanostructure materials for use in energy con-version with the sustainable applications.

关键词： Metallenes Electrocatalysts Electrochemical processes Atomically thin structure

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不同南瓜砧木对小果型西瓜生长和果实品质的影响

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中国瓜菜 2024年第8期37卷 82-91页

作者：李帅宋宇张春雨 KALEEM Muhammad mohsin 林昕原别之龙华中农业大学园艺林学学院武汉430070

近年来小果型西瓜的栽培面积增长迅速,为筛选出适宜小果型西瓜嫁接的南瓜砧木,以17个南瓜砧木和2个商业南瓜砧木(丰乐金甲、京欣砧4号)作为嫁接砧木,以小果型西瓜品种京美2K和武农8号作为接穗,研究不同南瓜砧木嫁接对西瓜嫁接苗成活率... 详细信息

近年来小果型西瓜的栽培面积增长迅速,为筛选出适宜小果型西瓜嫁接的南瓜砧木,以17个南瓜砧木和2个商业南瓜砧木(丰乐金甲、京欣砧4号)作为嫁接砧木,以小果型西瓜品种京美2K和武农8号作为接穗,研究不同南瓜砧木嫁接对西瓜嫁接苗成活率、定植成活率、植株田间长势、开花坐果节位、果实品质和产量的影响。结果表明,参试砧木均与小果型西瓜具有较高的亲和性;嫁接小果型西瓜的田间长势和产量优于自根栽培;除砧木S6和S26外,其他砧木嫁接不会显著改变西瓜果形指数;在内在品质指标中,春季以S12、S19、S5、S16、S13、S7和S17表现良好,秋季以S16、S19和S7表现最优。综合春秋两季的试验结果,S16、S19和S7这3个南瓜砧木优于2个商业砧木,适宜作为小果型西瓜的嫁接砧木。

关键词：小果型西瓜南瓜砧木生长品质产量

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