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Induction of innate immunity and its perturbation by influenza viruses

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Protein & Cell 2015年第10期6卷 712-721页

作者： mohsan ullah Goraya Song Wang Muhammad Munir Ji-Long Chen College of Animal Science Fujian Agriculture and Forestry University Fuzhou 350002 China The Pirbright Institute Ash Road Pirbright Woking GU24 0NF UK CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China

Influenza A viruses （IAV） are highly contagious patho- gens causing dreadful losses to human and animal, around the globe. IAVs first interact with the host through epithelial cells, and the viral RNA containing a 5＇-triphosphate group is thought to be the critical trigger for activation of effective innate immunity via pattern recognition receptors-dependent signaling pathways. These induced immune responses establish the antiviral state of the host for effective suppression of viral replication and enhancing viral clearance. However, IAVs have evolved a variety of mechanisms by which they can invade host cells, circumvent the host immune responses, and use the machineries of host cells to synthesize and transport their own components, which help them to establish a successful infection and repli- cation. In this review, we will highlight the molecular mechanisms of how IAV infection stimulates the host innate immune system and strategies by which IAV evades host responses.

关键词： influenza A virus innate immunity immuneescape

STARLIKENESS ASSOCIATED WITH THE SINE HYPERBOLIC FUNCTION

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Acta Mathematica Scientia 2024年第4期44卷 1244-1270页

作者： mohsan RAZA Hadiqa ZAHID Jinlin LIU Department of Mathematics Government College University FaisalabadFaisalabad 38000Pakistan Department of Information Science Yangzhou UniversityYangzhou 225002China

Let q_(λ)(z)=1+λsinh(ζ),0<λ<1/sinh(1)be a non-vanishing analytic function in the open unit *** introduce a subclass S^(*)(q_(λ))of starlike functions which contains the functions f such that zf'/f is subordinated by q_(λ).We establish inclusion and radii results for the class S^(*)(q_(λ))for several known classes of starlike ***,we obtain sharp coefficient bounds and sharp Hankel determinants of order two for the class S^(*)(q_(λ)).We also find a sharp bound for the third Hankel determinant for the caseλ=1/2.

关键词： starlike functions sine hyperbolic functions radii problems coefficient bounds Hankel determinants

Highly selective adsorption of rhenium by amyloid-like protein material

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Science China(Technological Sciences) 2024年第5期67卷 1417-1430页

作者： MUHAMMAD Arif YANG QingMin KANWAL Aisha ZHAO Jian NAWAZ mohsan REN Hao YANG Peng Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Xi’an Key Laboratory of Polymeric Soft Matter International Joint Research Center on Functional Fiber and Soft Smart TextileSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an710119China School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an710072China

Rhenium separation from molybdenum in molybdenite minerals and waste leachate has become an emerging *** this challenge,we prepared a set of protein-based alkylamine/alkylammonium salts complexes as extractants for selective uptake of rhenium from molybdenum,where the protein component turned into the insoluble amyloid-like structure when its internal disulfide bonds were reduced,namely phase-transition *** them,the phase-transited lysozyme and methyletrioctyleammonium chloride complex(PTL-N263)exhibited the most efficient adsorption at the alkaline condition for the electrostatic interaction between negatively charged metal ions with positively charged center(R_(4)N^(+))in N263,where negatively charged protein residues hindered the ion exchange of Cl^(-)in N263 for larger size Mo species(Mo_(7)O_(24)^(6-))than smaller size Re species(ReO^(4-)).The adsorption follows the Freundlich model and pseudo-second-order kinetics,which exhibits toplevel adsorption performance with a maximum adsorption capacity of 124 mg/g and a separation factor(β_(Re/Mo))of 2.78×10^(3)for *** adsorption capacity per unit area(57.2 mg/(g m^(2)))is 1.6–41 times higher than previously reported adsorbents,and the cost for adsorbing 1 g of Re(VII)is$1.07,indicating its industrial *** adsorption strategy can be applied to separating Re from Mo in binary solutions and industrial wastewater with other competing ions.

关键词： amyloid phase-transited lysozyme selective adsorption rhenium waste leachate solution

EFFECT OF THE COMPOSITION OF m-CRESOL/H_2O SOLVENT ON HYDRODYNAMIC PROPERTIES OF NYLON 6

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Chinese Journal of Polymer Science 2006年第4期24卷 369-377页

作者： Musa Kaleem Baloch mohsan Nawaz Department of Chemistry

The intrinsic viscosity [η], Huggins constant （Ku）, [η]0, α^3 and flow activation energy values of nylon 6 have been measured in wateηm-cresol （0/100-20/80） systems at different temperatures （20-60℃）. It has been found that the intrinsic viscosity, [η]0 and α^3 increase with the increase in water contents in m-cresol up to 15% and then decrease. They increase with the increase in temperature irrespective of solvent composition. It has been noted that the percent increase of α^3 is the highest at 60℃ and the lowest at 20℃ for a particular solvent system. The intrinsic viscosity data obey Arrhenius equation over the considered conditions. The activation energy and the KH values decrease very sharply with the addition of water, giving a minimum value at 15% of water and then increase slowly. The variation of all the parameters has been explained in terms of variation in thermodynamic quality of solvent with the addition of water to m-cresol and change in temperature, resulting in the change of conformational and orientational properties of polymer molecules. This change of solvent quality also results in variation of selective sorption of solvent over the polymer, such as hydrogen bonding, etc.

关键词： Intrinsic viscosity Huggins constant Thermodynamic quality of solvent Activation energy Hydrogen bonding Conformation Selective sorption.

Thermomechanical response of aluminum alloys under the combined action of tensile loading and laser irradiations

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Chinese Physics B 2018年第3期27卷 469-480页

作者： mohsan Jelani Zewen Li Zhonghua Shen Maryam Sardar School of Science Nanjing University of Science and Technology Nanjing 210094 China Advanced Launching Co-Innovation Centre Nanjing University of Science and Technology Nanjing 210094 China

This study reports the investigation of the thermomechanical behavior of aluminum alloys （AI-1060, A1-6061, and A1-7075） under the combined action of tensile loading and laser irradiations. The continuous wave ytterbium fiber laser （wavelength 1080 nm） was employed as the irradiation source, while tensile loading was provided by the tensile testing machine. The effects of various pre-loading and laser power densities on the failure time, temperature distribution, and the deformation behavior of aluminum alloys are analyzed. The experimental results represent the significant reduction in failure time for higher laser power densities and for high preloading values, which implies that preloading may contribute a significant role in the failure of the material at elevated temperature. Fracture on a microscopic scale was predominantly ductile comprising micro-void nucleation, growth, and coalescence. The AI-1060 specimens behaved plastically to some extent, while A1-6061 and A1-7075 specimens experienced catastrophic failure. The reason and characterization of ma- terial failure by tensile and laser loading are explored in detail. A comparative behavior of under-tested materials is also investigated. This work suggests that studies considering only combined loading are not enough to fully understand the mechanical behavior of under-tested materials. For complete characterization, one should consider the effect of heating as well as loading rate and the corresponding involved processes with the help of thermomechanical coupling and the thermal elastic-plastic theory.

关键词： aluminum alloys fiber laser tensile loading thermomechanical effects failure evolution

Numerical Simulation of Reiner–Rivlin Nanofluid Flow under the Influence of Thermal Radiation and Activation Energy over a Rotating Disk

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Computer Modeling in Engineering & Sciences 2022年第6期131卷 1669-1692页

作者： Arfan Shahzad Muhammad Imran Muhammad Nawaz Naeem mohsan Raza Department of Mathematics Government College University FaisalabadFaisalabad38000Pakistan Department of Sciences&Humanities National University of Computer and Emerging SciencesChiniot-Faisalabad CampusFaisalabad38000Pakistan

In current study,the numerical computations of Reiner–Rivlin nanofluid flow through a rotational disk under the influence of thermal radiation and Arrhenius activation energy is *** innovative physical situations,the motile microorganisms are incorporated *** multiple slip effects are considered in the boundary *** bioconvection of motile microorganism is utilized alongside nanofluids to provide stability to enhanced thermal *** Bioconvection pattern in various nanoparticles accredits novel applications of biotechnology like the synthesis of biological polymers,biosensors,fuel cells,petroleum engineering,and the natural *** deploying some suitable similarity transformation functions,the governing partial differential equations(PDEs)of the flow problem are rehabilitated into dimensionless *** accomplished ordinary differential equations(ODEs)are solved numerically through the bvp4c scheme via a built-in function in computational MATLAB *** upshots of some prominent physical and bioconvection parameters including wall slip parameters,thermophoresis parameter,Brownian motion parameter,Reiner–Revlin nanofluid parameter,Prandtl number,Peclet number,Lewis number,bioconvection Lewis number,and the mixed convection parameter against velocity,temperature,nanoparticles concentration,and density of motile microorganism profiles are dichotomized and pondered through graphs and *** presented computations show that the velocity profiles are de-escalated by the wall slip parameters while the thermal and solutal fields are upgraded with augmentation in thermophoresis number and wall slip *** presence of thermal radiation enhances the temperature profile of *** concentration profile of nanoparticles is boosted by intensification in activation ***,the increasing values of bioconvection Lewis number and Peclet number decay the motile microorganisms’field.

关键词： Reiner-Rivlin nanofluid bioconvection motile swimming microorganisms rotational disk multiple slip conditions bvp4c

Bioconvection Cross Diffusion Effects on MHD Flow of Nanofluids over Three Different Geometries with Melting

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Computer Modeling in Engineering & Sciences 2022年第5期131卷 1023-1039页

作者： Tahir Kamran Muhammad Imran Muhammad N.Naeem mohsan Raza Department of Mathematics Government College University FaisalabadFaisalabad38000Pakistan

Currently,nanofluid is a hot area of interest for *** nanofluid with bioconvection phenomenon attracted the researchers owing to its numerous applications in the field of nanotechnology,microbiology,nuclear science,heat storage devices,biosensors,biotechnology,hydrogen bomb,engine of motors,cancer treatment,the atomic reactor,cooling of devices,and in many *** article presents the bioconvection cross-diffusion effects on the magnetohydrodynamic flow of nanofluids on three different geometries(cone,wedge,and plate)with mixed *** temperature-dependent thermal conductivity,thermal diffusivity,and Arrhenius activation energy applications are considered on the fluid flow with melting *** flow is analyzed under thermal and solutal Robin’s *** problem is formulated in the mathematical formulation of partial differential equations(PDEs).The similarity transformations are applied to diminish the governing nonlinear coupled boundary value problems into higher-order non-linear ordinary differential equations(ODEs).The resulting expressions/equation numerically tackled utilizing the famous bvp4c package by MATLAB for various interesting *** results were physically and numerically calculated through graphics and tables for the velocity field,energy distribution,nanoparticles concentration,and microorganisms profile for numerous *** the obtained results,we discern that the transfer of heat and mass coefficient is high over a plate and cone in the flow,*** velocity profile is reduced via a larger magnetic *** thermal conductivity enhances the thermal *** thermophoresis enhanced the concentration of *** microorganisms’Biot number boosts the microorganism’s profile.

关键词： MHD nano-fluids bioconvection heat flux MATLAB

Edge-Computing with Graph Computation:A Novel Mechanism to Handle Network Intrusion and Address Spoofing in SDN

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Computers, Materials & Continua 2020年第12期65卷 1869-1890页

作者： Rashid Amin Mudassar Hussain Mohammed Alhameed Syed mohsan Raza Fathe Jeribi Ali Tahir University of Engineering and Technology TaxilaPakistan University of Wah Wah CanttPakistan Jazan University JazanSaudi Arabia Abasyn University Islamabad IslamabadPakistan

Software Defined Networking(SDN)being an emerging network control model is widely recognized as a control and management *** model provides efficient techniques to control and manage the enterprise *** emerging paradigm is edge computing in which data processing is performed at the edges of the network instead of a central *** data processing at the edge nodes reduces the latency and bandwidth *** SDN,the controller is a single point of *** security issues related to the traditional network can be solved by using SDN central management and *** Spoofing and Network Intrusion are the most common *** attacks severely degrade performance and *** propose an edge computing-based mechanism that automatically detects and mitigates those *** this mechanism,an edge system gets the network topology from the controller and the Address Resolution Protocol(ARP)traffic is directed to it for further *** such,the controller is saved from unnecessary processing related to addressing *** propose a graph computation based method to identify the location of an attacker or intruder by implementing a graph difference *** using the correct location information,the exact attacker or intruder is blocked,while the legitimate users get access to the network *** proposed mechanism is evaluated in a Mininet simulator and a POX *** results show that it improves system performance in terms of attack mitigation time,attack detection time,and bandwidth requirements.

关键词： Software Defined Networking(SDN) edge computing Address Resolution Protocol(ARP) ARP inspection security graph difference

Update on management of gastric varices

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World Journal of Hepatology 2019年第3期11卷 250-260页

作者： Louisa J Vine mohsan Subhani Juan G Acevedo South West Liver Unit University Hospitals Plymouth NHS Trust

Gastric varices(GV) have different physiology and clinical characteristics compared to oesophageal varices(OV). There is little information about the management of GV. Most part of the recommendations is extrapolated from studies where the majority of participants had OV. Thus, most recommendations lack of strong evidence. This is a comprehensive review on all aspects of management of GV, i.e., primary, secondary prophylaxis and management of acute bleeding. The papers on which international societies' recommendations are based are scrutinised in this review and areas of research are identified.

关键词： Gastric varices Oesophageal varices Portal hypertension Cirrhosis