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Journal of Traffic and Transportation Engineering(English Edition) 2021年第5期8卷 638-680页

作者： mohit raj saxena Rakesh Kumar Maurya Prashant Mishra Department of Mechanical Engineering Indian Institute of Technology RoparRupnagar 140001India

The energy security concern and rapidly diminishing fossil fuel resources demand the development of renewable and economically attractive fuel for reciprocating *** is a promising renewable alternative *** studies have been carried out to explore the various aspects of the utilization of methanol in compression ignition(CI)*** review paper presents a detailed analysis of the effect of methanol on performance,combustion,and emission(NOx,CO,HC,and soot)characteristics of conventional CI-engine along with dual-fuel combustion *** study focuses on methanol utilization in dual-fuel mode,which is an advanced engine combustion ***,methanol production and solubility issues of methanol in diesel are briefly *** study discusses the soot and nano-particle emission from the methanol fueled CI-engine,which is one of the main concerns in the current emission *** was found that the utilization of methanol in CI-engine has the potential to improve the performance and simultaneously with a significant reduction in NOx,CO,soot,and nano-particle emissions in comparison to neat diesel ***,unburnt HC emission reduces for methanol-diesel blended fuel operation whereas HC emissions are higher for methanoldiesel dual-fuel operation.

关键词： Methanol Dual-fuel Combustion Diesel engine Particle emissions Thermal efficiency

Calcarea carbonica treatment rescues lipopolysaccharide-induced inflammatory response in human mononuclear cells via downregulation of inducible cyclooxygenase pathway

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Journal of Integrative Medicine 2020年第5期18卷 441-449页

作者： Swatantra Kumar Vimal KMaurya Debadatta Nayak Anil Khurana raj KManchanda Srinivasulu Gadugu Madan LBBhatt Shailendra K.saxena Centre for Advanced Research Faculy of MedicineKing George's Medical UniversityLucknow 226003India Central Council for Research in Homoeopathty.Ministry of Ayush.Janakpuri.New Delhi 10058 India Deparment of Medicine Jaisoorya and Potti Sreeramulu Government Medical Cllege.Hyderabad 500013India

Objective: Prolonged use of nonsteroidal anti-inflammatory drugs is associated with severe side effects and toxicity. Therefore, we studied the anti-inflammatory role of Calcarea carbonica which had minimal toxicity at the low ***: THP-1 human mononuclear cells were treated with C. carbonica to evaluate the 50% cytotoxicity concentration(CC_(50)) and 50% effective concentration(EC_(50)). Cell survival was evaluated in lipopolysaccharide-stimulated C. carbonica-treated cells. Nitric oxide(NO) and tumor necrosis factor-a(TNF-a) were measured to evaluate the anti-inflammatory activity of C. carbonica. Cyclooxygenase-2(COX-2) protein expression was determined by Western blotting analysis, and the interaction of C. carbonica with the COX-2 protein was evaluated using molecular docking ***: The CC_(50) and EC_(50) of C. carbonica were found to be 43.26 and 11.99 mg/mL, respectively. The cell survival assay showed a 1.192-fold(P = 0.0129), 1.443-fold(P = 0.0009) and 1.605-fold(P = 0.0004)increase in cell survival at 24, 48 and 72 h after initiating C. carbonica treatment, respectively. C. carbonica-treated cells showed a reduction in NO levels by 2.355 folds(P = 0.0001), 2.181 folds(P = 0.0001) and 2.071 folds(P = 0.0001) at 24, 48 and 72 h, respectively. The treated cells also showed a reduction in TNFa levels by 1.395 folds(P = 0.0013), 1.541 folds(P = 0.0005) and 1.550 folds(P = 0.0005) at 24, 48 and72 h, respectively. In addition, a 1.193-fold reduction(P = 0.0126) in COX-2 protein expression was found in C. carbonica-treated cells. The molecular docking showed interaction of C. carbonica with the phenylalanine 367 residue present in active site of ***: C. carbonica exhibited anti-inflammatory properties in lipopolysaccharide-stimulated cells by significantly reducing NO production and TNF-a level through downregulation of the COX-2 protein. This effect is probably mediated through interaction of C. carbonica with the phenylalanine

关键词： Inflammation Calcarea carbonica Cyclooxygenase-2 Nitric oxide Tumor necrosis factor-a Anti-inflammatory

Titers of Anti-Brucella Antibodies by Enzyme Linked Immunosorbant Assay in Vaccinated and Unvaccinated Brucellosis Infected Cattle

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Open Journal of Veterinary Medicine 2017年第10期7卷 131-137页

作者： Sugandha raj Hari Mohan saxena Sikh Tejinder Singh Department of Veterinary Microbiology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India Department of Animal Genetics and Breeding Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India

Brucellosis is an important re-emerging zoonotic disease caused by Brucella organisms. In the absence of a Differentiation of Infected from Vaccinated Animal (DIVA) assay for bovine Brucellosis, it becomes difficult to assess whether the anti-Brucella antibody response in an animal is due to vaccination or infection. We compared the anti-Brucella antibody titers of naturally Brucellosis affected unvaccinated cows, previously vaccinated infected cows, normal healthy vaccinated cows and healthy unvaccinated calves. The titers of anti-Brucella antibodies were estimated by indirect ELISA. The mean titer (log10) was found to be 1.518 ± 0.005 in case of naturally Brucellosis affected cattle which had been vaccinated during calf hood. The mean titer in case of naturally infected cattle which had never been vaccinated was 1.5441 ± 0.005. The mean titer in healthy unaffected cattle vaccinated during calf hood was 1.504 ± 0.002 and that of unvaccinated healthy calves was 0.560 ± 0.016. It was interesting to find that the antibody titers in naturally affected cattle which had never been vaccinated were very significantly (p < 0.01) higher than those of Brucellosis affected cows which had been vaccinated during calf hood. The titer in vaccinated infected cattle was very significantly (p < 0.01) higher than that of uninfected vaccinated cows.

关键词： Antibody Titer Brucella Brucellosis Bovine ELISA

Variations in Solar Cycles 22, 23 &24 and Their Effect on Earth’s Climate

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International Journal of Astronomy and Astrophysics 2016年第1期6卷 8-13页

作者： Prithvi raj Singh Chandra Mani Tiwari Ajay Kumar saxena Department of Physics Awadhesh Pratap Singh University Rewa India

In the present work, the study of influence of solar activity, cosmic ray intensity and geomagnetic activity on Earth’s climate during solar cycles 22, 23 and 24 has been done. The change in Earth’s climate, specifically the change in the global mean temperature has been associated with the variation of some solar activity indices, cosmic ray intensity and geomagnetic activity indices in the period of 1986-2014 (Till Dec.). The important solar indices that are total solar irradiance (TSI), Sunspot Number (SSN), F10.7 index, Cosmic Ray Intensity (CRI) Kiel (NM), geomagnetic activity indices Auroral Electrojet Index (AE) and aa index, have been presented. The study of the Earth’s climate in relationship with solar activity, cosmic ray intensity and geomagnetic activity has been analysed with variations and correlations. The variations of SSN with CRI are in anti-phase;SSN with F10.7, SSN with TSI, SSN with AE, SSN with aa are in same phase. The correlation of SSN with CRI is strongly negatively correlated;SSN with F10.7, SSN with TSI is strongly positively and SSN with AE, SSN with aa positively correlated to averaging solar cycles 22, 23 and 24. The Earth’s climate will be affected by the solar activity, cosmic ray intensity and geomagnetic activity.

关键词： Solar Activity Geomagnetic Activity Cosmic Ray Intensity

Effect of Coronal Mass Ejection on Earth’s Magnetic Field during Ascending Phase of Solar Cycles 23-24

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International Journal of Astronomy and Astrophysics 2017年第3期7卷 213-220页

作者： Bharti Nigam Prithvi raj Singh Pramod Kumar Chamadia Ajay Kumar saxena Chandra Mani Tiwari Govt. Autonamous P. G. Science College Satna India Department of Physics Awadhesh Pratap Singh University Rewa India

We have studied the width and speed of coronal mass ejections (CMEs) and geomagnetic disturbance storm time (Dst) Index during ascending phase of solar cycles 23 and 24. We have classified total CMEs according to angular width and speed for the ascending period 1996-2002 and 2008-2014. We have found that the width of 62% CMEs is narrow, and 3% are Halo for the solar cycle 23 and 73% CMEs are narrow, and 2% CMEs are Halo for the solar cycle 24. The speed distribution of 65% CMEs has speed ≤ 500 km/sec and 4% CMEs has speed > 1000 km/sec for solar cycle 23 and 84% CMEs has speed ≤ 500 km/sec and 1% CMEs has speed > 1000 km/sec in cycle 24. The relationship between width and speed is more pronounced for fast ejecta (>1000 km/sec.), while slower ejecta shows more astronomically immense scatter. We have reported that the correlation between Dst and CMEs for ascending phase of solar cycle 24 is less than as compare to ascending phase of solar cycle 23.

关键词： CME Dst SSN

Cosmic Ray Associated with Coronal Index and Solar Flare Index during Solar Cycle 22 - 23

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International Journal of Astronomy and Astrophysics 2017年第3期7卷 162-173页

作者： Prithvi raj Singh Shabir Ahmad A. C. Pandey Ajay Kumar saxena Chandra Mani Tiwari A. P. Mishra Department of Physics A.P.S. University Rewa M.P. India

We study the relation between monthly average counting rates of the cosmic ray intensity (CRI) observed at Moscow Neutron Monitoring Station, solar flare index (SFI) and coronal index during the solar cycles 22 and 23, for the period 1986-2008. The long-term behaviour of various solar activity parameters: sunspot numbers (SSN), solar flare index (Hα flare index), coronal index (CI) in relation to the duration of solar cycles 22 and 23 is examined. We find that the correlation coefficient of CRI with the coronal index as well as Hα flare index is relatively large anti-correlation during solar cycle 22. However, the monthly mean values of sunspot number, Hα flare index, and coronal index are well positively correlated with each other. We have analyzed the statistical analysis of the above parameters using of linear model and second order polynomial fits model.

关键词： Solar Activity Sunspot Number Coronal Index Solar Flare Index Cosmic Ray Intensity

Synthesis and cytotoxic evaluation of substituted 3-(3'-indolyl-/3'-pyridyl)-isoxazolidines and bis-indoles

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Acta Pharmaceutica Sinica B 2012年第1期2卷 32-41页

作者： Vishal Sharma Raman Kalia Tilak raj Vivek K.Gupta Nitasha Suri Ajit K.saxena Deepak Sharma Surinderjit S.Bhella Gurpinder Singh Mohan Paul S.Ishar Bio-Organic and Photochemistry Laboratory Department of Pharmaceutical SciencesGuru Nanak Dev UniversityAmritsar 143005India Pharmacology Division Indian Institute of Integrative MedicineJammu 180001India Post-Graduate Department of Physics University of JammuJammu Tawi 180006India

Regio-and stereoselective 1,3-dipolar cycloadditions of C-(3-indolyl)-N-phenylnitrone(10)were carried out with different mono-substituted,disubstituted and cyclic dipolarophiles under mono-mode microwave irradiation to obtain substituted 3-(indol-30-yl)-N-phenyl-isoxazolidines(16–22).Reactions of nitrone(10)with allenic esters under similar conditions afforded,via a domino process,bis-indole derivatives(23a–c)along with compounds 24 and ***,reactions of C-(3-pyridyl)-N-phenylnitrone(26)with mono-substituted,disubstituted and cyclic dipolarophiles were carried out in refluxing dry toluene to obtain substituted 3-(30-pyridyl)-Nphenylisoxazolidines(27–34).Some of the compounds(16f,18b,23a,23c,27c and 29f)display significant cytotoxicity against a number of human cancer cell lines.

关键词： 3-Indolylisoxazolidines 3-Pyridylisoxazolidines Bis-indoles 1,3-Dipolar cycloadditions Modified nucleosides Cytotoxic activity

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三轴感应电阻率测井新技术

国外测井技术 2009年第5期24卷 57-70页

作者： Barbara Anderson Tom Barber Rob Leveridge Rabi Bastia Kamlesh raj saxena Anti Kumar Tyag Jean-Baptiste Clavaud Brian Coffin Madhumita Das Ron Hayden Theodore Klimentos Chanh Cao Mirth Stephen Williams 美国马萨诸塞州堪布里奇美国得克萨新州Sugar Land 信实工业公司印度盂买雪弗龙能源技术公司得克萨斯州休斯敦 HighMount勘探与生产公司得克萨斯州休斯敦 Utkal大学印度奥里萨邦布巴内斯瓦尔得克萨新州休斯敦印度孟买安哥拉罗安达挪威国家石油公司挪威斯塔万格

一种新型感应电阻率测井仪器能够提供远离井筒地层的三维信息，提高斜井和倾斜地层的电阻率测量精度，而且不需要接触井壁就能够直接测量地层倾角大小和方位。采用这种高精度三轴电阻率测井仪器可以减少漏掉油气层的机会，加强对储层的... 详细信息

一种新型感应电阻率测井仪器能够提供远离井筒地层的三维信息，提高斜井和倾斜地层的电阻率测量精度，而且不需要接触井壁就能够直接测量地层倾角大小和方位。采用这种高精度三轴电阻率测井仪器可以减少漏掉油气层的机会，加强对储层的认识。

关键词：电阻率测井感应电阻率三轴技术测井仪器倾斜地层三维信息测量精度