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Obstructive sleep apnea among commercial vehicle drivers in Malaysia: Issues and initiatives

Health 2013年第8期5卷 80-86页

作者： Ameer Batcha Wahida Othman Ilhamah Ahmad Mohamad Suffian mohd fahmi aimi Mohamed Norlen Shaw Voon Wong Director General Office Malaysian Institute of Road Safety Research Selangor Malaysia Vehicle Safety and Biomechanics Research Centre Malaysian Institute of Road Safety Research Selangor Malaysia

Obstructive Sleep Apnea (OSA) has been identified by many studies as one of the significant contributing factors for motor vehicle accidents. However, only a small number of studies have been conducted in Malaysia. Objective: This paper aims to highlight the prevalence of OSA among truck drivers and express bus drivers in Malaysia and efforts being undertaken to address issues related to OSA among commercial vehicle drivers. Methodology: Two separate studies were conducted: a cross sectional study among truck drivers and secondly among express bus drivers. The screening process for identifying the high risk group for OSA was done using Berlin questionnaire. Meanwhile, among express bus drivers, OSA was confirmed with sleep study using polysomnography test. Result: Screening of risk group of OSA among truck drivers revealed that 14.6% (19) of drivers were categorized as having high risk of OSA while 85.4% (111) having low risk of OSA. While, in another study, polysomnography test among express bus drivers showed that 83 (28.7%) had mild OSA, 26 (9.0%) had AHI moderate OSA, and 19 drivers (6.6%) severe OSA. Conclusion: This paper highlighted the issues of OSA among commercial vehicle drivers in Malaysia. With an alarming high prevalence, OSA should be a major road safety concern in this country. A special study focusing on sleep and fatigue related crashes may need to be conducted to complement the current studies and full implementation of existing efforts and initiatives to address OSA in road crashes should be realized by the relevant authorities.

关键词： OSA Obstructive Sleep Apnea Commercial Vehicle Drivers

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Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

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Journal of Renewable Materials 2024年第1期12卷 29-43页

作者： Thean Heng Tan Najihah mohd Hashim Wageeh Abdulhadi Yehya Dabdawb Mochamad Zakki fahmi Hwei Voon Lee Nanotechnology&Catalysis Research Center(NANOCAT) Universiti MalayaKuala Lumpur50603Malaysia Department of Pharmaceutical Chemistry Faculty of PharmacyUniversiti MalayaKuala Lumpur50603Malaysia Department of Chemistry Faculty of Science and TechnologyUniversitas AirlanggaCampus CMulyorejoSurabaya60115Indonesia

The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose(NCC)as a potential drug delivery system for targeting folate receptor-positive cancer *** FA-functionalized NCCs were synthesized through a series of chemical reactions,resulting in nanoparticles with favorable properties for biomedical *** microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor ***,these nanoparticles possessed a negative surface charge,enhancing their stability and repelling potential *** binding specificity of FA-functionalized NCCs to folate receptor-positive cancer cells was demonstrated through various *** free folic acid inhibition assay showed approximately 30%decrease in the binding of functionalized NCCs in the presence of just 5 mM free FA,confirming their selectivity for folate receptor-positive *** microscopy further validated this specificity,as only cancer cells displayed significant binding of functionalized ***,biocompatibility tests revealed that both NCCs and FA-functionalized NCCs had minimal effects on red blood cells,and they did not induce erythrocyte ***,cell viability assays demonstrated functionalized NCCs have selective cytotoxicity against colorectal cancer cells HT-29 and SW-620(68%–88%cell viability)while sparing noncancerous colon cells CCD-18Co(81%–97%cell viability).In summary,FA-functionalized NCCs exhibit promising characteristics for targeted drug delivery in cancer *** biocompatibility,stability,and selective cytotoxicity make them an attractive option for delivering therapeutic agents to folate receptor-positive cancer cells,potentially improving the effectiveness of cancer treatments while minimizing harm to healthy tissues.

关键词： Agricultural wastes sustainable nanocarrier blood biocompatibility folic acid receptor drug delivery system nanomedicine

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Low-energy X-ray attenuation characteristics of Rhizophora ***

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Nuclear Science and Techniques 2021年第3期32卷 11-29页

作者： Damilola Oluwafemi Samson Ahmad Shukri mohd Zubir Mat Jafri Rokiah Hashim mohd Zahri Abdul Aziz Sylvester Jande Gemanam mohd fahmi mohd Yusof School of Physics Universiti Sains Malaysia11800 GelugorPenangMalaysia School of Industrial Technology Universiti Sains Malaysia11800 GelugorPenangMalaysia Advanced Medical and Dental Institute Universiti Sains Malaysia13200 BertamPenangMalaysia School of Health Sciences Universiti Sains Malaysia16150 Kota BharuKelantanMalaysia

Photon absorption parameters such as mass attenuation coefficients(μ_m),molar extinction coefficients(ε),total molecular(σ_(t,m)),atomic(σ_(t,a))and electronic(σ_(t,el))cross sections,half-value layers(X_(1/2)),tenth-value layers(X_(1/10)),mean free paths(λ),effective atomic numbers(Z_(eff)),and effective electron densities(N_(el))were estimated for defatted soy flour(DSF),soy protein concentrate(SPC),and soy protein isolate(SPI)-based Rhizophora *** composites substituted with 10 wt%sodium hydroxide(NaOH)and 0,5,10,and 15 wt%itaconic acid polyamidoamine-epichlorohydrin(IA-PAE)*** composition was assessed using ultrahigh-resolution field emission scanning electron microscopy-energy dispersive X-ray spectrometry(UHR-FESEM-EDX).The interaction parameters were evaluated for K_(α1)photons at16.59,17.46,21.21,and 25.26 keV,employing a low-energy germanium(LEGe)detector system and an~(241)Amγ-ray source.X-ray diffraction characterization revealed an amorphous phase in the developed particleboard *** DSF15',SPC15',and SPI15'exhibited the highest values ofμ_m,ε,σ_(t,m),Zeff,and N_(el)among all of the studied particleboard samples,within the range of measured photon *** addition,all of the modified samples exhibited lower X_(1/2),X_(1/10),λ,σ_(t,a),andσ_(t,el)than the unmodified samples,with DSF-,SPC-,and SPI/NaOH/Rhizophora spp./IA-PAE(15 wt%),indicating insignificant *** current results of the particleboard samples'analysis can be useful for medical radiation applications and shielding research.

关键词： Photon interaction parameters Shielding DSF–SPC–SPI Particleboards NaOH/IA-PAE

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Experimental assessments of methanol-based foaming agent in latex modified foamed binders and warm asphalt mixtures

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Journal of Road Engineering 2022年第1期2卷 84-97页

作者： mohd Rosli mohd Hasan Tai Guo Hainian Wang Zul fahmi Mohamed Jaafar Zhanping You School of Civil Engineering Universiti Sains Malaysia(Engineering Campus)Nibong Tebal 14300Pulau PinangMalaysia School of Highway Chang'an UniversityXi'an 710064China Department of Civil and Environmental Engineering Michigan Technological UniversityHoughtonMI 49931USA

Latex is one of the natural rubbers that is used to enhance the performance of asphalt pavement for the last few *** presence of latex,which is categorized as an elastomer,helps to improve pavement performance and ***,higher viscosity of latex modified asphalt binder increases the production-temperatures of asphalt mixture,thus consuming higher energy during asphalt mixture’s production *** this study,the effectiveness of methanol as an energy-efficient foaming agent was assessed to reduce the viscosity and enhance the workability of the modified asphalt *** basic and rheological properties of the asphalt binders were determined through multiple laboratory tests including expansion ratio and half-life,rotational viscosity,softening point,torsional recovery,and dynamic shear *** properties of asphalt mixtures were assessed through the service characteristics,mechanical performance,and moisture resistance *** was found that the presence of latex results in an approximately twofold higher expansion ratio and a lower half-life of the asphalt binder at about the same *** the rotational viscosity test,the application of methanol into asphalt binder decreased the viscosity and led to better workability,despite the addition of latex as an asphalt *** application of methanol into asphalt binder improved the workability of mixture samples and lowered the compaction energy of the compaction process,which are the crucial criteria for a better mixing and compaction *** foamed asphalt mixtures with latex show much higher resistance to moisture damage and stiffness than control sample even though they were prepared at a lower temperature.

关键词： Foaming agent Foaming technique Latex Lower energy Methanol Natural rubber

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Antibiotic resistance and molecular typing of clinical Staphylococcus aureus isolates from Malaysian military hospital

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Asian Pacific Journal of Tropical Medicine 2023年第5期16卷 220-231页

作者： Nor Syaza Syahirah Amat Junaidi Nik Noorul Shakira Mohamed Shakrin Mohammad fahmi Daman Huri Ahmad Zakwan Kamarudin mohd Nasir mohd Desa Wan mohd Zin Wan Yunus Faculty of Medicine and Defence Health Universiti Pertahanan Nasional Malaysia(UPNM)Kem Sungai Besi57000 Sungai BesiKuala LumpurMalaysia Centre for Tropicalization(CENTROP) Universiti Pertahanan Nasional Malaysia(UPNM)Kem Sungai Besi57000 Sungai BesiKuala LumpurMalaysia Pathology Department Tuanku Mizan Armed Forces Hospital(TMAFH)53300 Kuala LumpurMalaysia Faculty of Medicine and Health Sciences Universiti Sains Islam Malaysia(USIM)Persiaran IlmuPutra Nilai71800 NilaiNegeri SembilanMalaysia Department of Biomedical Science Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Faculty of Defence Science and Technology Universiti Pertahanan Nasional Malaysia(UPNM)Kem Sungai Besi57000 Sungai BesiKuala LumpurMalaysia

Objective:To determine the antibiotic resistance profile(ARP)of Staphylococcus(S.)aureus isolates and molecular typing of the methicillin-resistant ***(MRSA)isolates from Tuanku Mizan Armed Forces Hospital(TMAFH),Kuala ***:The ARP and presence of the pvl gene were determined for 209 *** isolates from clinical *** these,123 were methicillin-susceptible ***(MSSA)isolates and 86 were MRSA *** MRSA isolates were characterized using SCCmec typing and spa *** analysis was performed to compare the demographic data with the phenotypic and genotypic variables of the *** ***:No vancomycin-intermediate and-resistant ***(VISA and VRSA,respectively)were detected among the study *** MSSA isolates showed low resistance rates to all tested antibiotics,were commonly invasive(28/42,66.7%),and mostly harboured pvl(35/42,83.3%).Meanwhile,MRSA isolates showed high resistance to penicillin(86/86,100%),ampicillin(86/86,100%),sulbactam/ampicillin(86/86,100%),cefuroxime(81/86,94.19%),cefoperazone(76/86,88.37%),azithromycin(56/86,65.12%),and erythromycin(54/86,62.79%).The majority of MRSA isolates were of SCCmec type IVh(65/86,75.58%),spa type t032(55/85,63.95%),and grouped into spaCC-t022(66/85,77.65%).The t032 type was found to be associated with resistance traits to azithromycin and erythromycin(P<0.05).We also found several spa types that are typically associated with hospital-,community-,and livestock-associated MRSA co-existing in our MRSA ***:This study reflected the consistent absence of VISA and VRSA and corroborated the clonal shifting of MRSA isolates in the Malaysian MRSA isolates.

关键词： Staphylococcus aureus Methicillin-resistant Staphylococcus aureus spa typing SCCmec typing Antibiotic resistance

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Antibiotic resistance profile and RAPD analysis of Campylobacter jejuni isolated from vegetables farms and retail markets

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Asian Pacific Journal of Tropical Biomedicine 2016年第1期6卷 71-75页

作者： John Yew Huat Tang mohd Ikhsan Khalid Syazana aimi Che Abdullah Abu-Bakar Son Radu Department of Food Industry Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin Tembila Campus Food Safety Research Centre Faculty of Food Science and Technology Universiti Putra Malaysia

Objective:To investigate antibiotic resistance profile and characterize Campylobacter jejuni(***) isolates using random amplified polymorphic DNA(RAPD) ***:Ninety eight *** isolates from farms and retail outlets were screened against 10 antibiotics commonly used clinically and agriculturally by using disk diffusion *** analysis was done to characterize 98 *** ***:Fifty-one percent of the isolates had multiple antibiotic resistance index 0.2 and *** indicated that the isolates in the vegetables were not from the high risk environment or extensive farming *** isolates found resistant towards penicillin G(93%),vancomycin(86%),ampicillin(35%),erythromycin(28%),gentamycin(4%),amikacin(3%),enrofloxacin(1%),norfloxacin(1%) and no resistance towards *** clustering analysis showed that the contamination of *** in vegetables was likely due to cross contamination at retail ***:*** contamination in vegetables at retail markets was due to cross *** finding proved that *** in small scale vegetables production was less expose towards antibiotic abuse.

关键词： Campylobacter jejuni Multiple antibiotic resistance index Antibiotic resistance RAPD analysis

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Reproductive aspects of the coastal trevally,Carangoides coeruleopinnatus in Terengganu Waters,Malaysia

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Aquaculture and Fisheries 2022年第5期7卷 500-506页

作者： Muhammad Hanif Fadzli Tun Nurul aimi Mat Jaafar mohd Sharol Ali Nuralif Fakhrullah mohd Nur Min Pau Tan Rumeaida Mat Piah Faculty of Fisheries and Food Science Universiti Malaysia TerengganuKuala NerusTerengganu21030Malaysia Institute of Marine Biotechnology Universiti Malaysia TerengganuKuala NerusTerengganu21030Malaysia

This study describes for the first time the reproductive biology of the coastal trevally(Carangoides coeruleopinnatus)(Ruppel,1830)caught from Terengganu waters,*** sample collection from April 2019 to March 2020 was done at Pulau Kambing fish landing port in Terengganu,Malaysia.A total of 687 individuals comprise of 362 males(52.69%)ranged from 6.3 cm to 26.6 cm(mean±SD:13.2±3.84 cm)and 325 females(47.31%)ranged from 9.0 cm to 26.4 cm(mean±SD:13.9±3.34 cm)were *** sex ratio significantly deviated in favor of males(1:0.90)(χ^(2)=1.99).However,there are significant differences between sexes over months in June(χ^(2)=10.89),July(χ^(2)=11.91),August(χ^(2)=6.10)and September(χ^(2)=4.41).The monthly variation of the gonadosomatic index(IG)peaked between February and April for males and females,indicating its spawning *** interpretation between condition factor(K)and hepatosomatic index(IH)showed that the energy mobilization from the body assists the gonad *** batch fecundity of 42 mature females ranged from 15.7 cm to 21.4 cm,and mass was 142.6 g-333.0 g giving 20,438 to 121,829 *** length at first maturity of males and females were 12.45 cm and 15.78 cm,*** male reached earlier maturity than the *** study increases the understanding of reproductive aspects of *** for future formulation of rules and regulations for suitable fishery management in Terengganu waters.

关键词： Carangoides coeruleopinnatus Fecundity Length at maturity(Lm) Reproduction Sex ratio Spawning period

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Effects of time-restricted eating with different eating duration on anthropometrics and cardiometabolic health:A systematic review and meta-analysis

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World Journal of Cardiology 2023年第7期15卷 354-374页

作者： Mazuin Kamarul Zaman Nur Islami mohd fahmi Teng Sazzli Shahlan Kasim Norsham Juliana Mohammed Abdullah Alshawsh Centre of Dietetics Studies Faculty of Health SciencesUniversiti Teknologi MARA Cawangan SelangorPuncak Alam 42300SelangorMalaysia Department of Cardiology Faculty of MedicineHospital Universiti Teknologi MARA(HUiTM)Puncak Alam 42300SelangorMalaysia Department of Physiology Faculty of Medicine and Health SciencesUniversiti Sains Islam MalaysiaNilai 71800Malaysia Department of Pharmacology Faculty of MedicineUniversiti MalayaKuala Lumpur 50603Malaysia School of Clinical Sciences Faculty of MedicineNursing and Health SciencesMonash UniversityClayton 3168VictoriaAustralia

BACKGROUND Time-restricted eating(TRE)is a dietary approach that limits eating to a set number of hours per *** studies on the effects of TRE intervention on cardiometabolic health have been *** in subjects and TRE interventions have led to inconsistency in ***,the impact of the duration of eating/fasting in the TRE approach has yet to be fully *** To analyze the existing literature on the effects of TRE with different eating durations on anthropometrics and cardiometabolic health markers in adults with excessive weight and obesity-related metabolic *** We reviewed a series of prominent scientific databases,including Medline,Scopus,Web of Science,Academic Search Complete,and Cochrane Library articles to identify published clinical trials on daily TRE in adults with excessive weight and obesity-related metabolic *** controlled trials were assessed for methodological rigor and risk of bias using version 2 of the Cochrane risk-of-bias tool for randomized trials(RoB-2).Outcomes of interest include body weight,waist circumference,fat mass,lean body mass,fasting glucose,insulin,HbA1c,homeostasis model assessment for insulin resistance(HOMA-IR),lipid profiles,C-reactive protein,blood pressure,and heart *** Fifteen studies were included in our systematic *** significantly reduces body weight,waist circumference,fat mass,lean body mass,blood glucose,insulin,and ***,no significant changes were observed in HbA1c,HOMA-IR,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,heart rate,systolic and diastolic blood ***,subgroup analyses based on the duration of the eating window revealed significant variation in the effects of TRE intervention depending on the length of the eating *** TRE is a promising chrononutrition-based dietary approach for improving anthropometric and cardiometabolic health.H

关键词： Cardiovascular disease Cardiometabolic health Time-restricted eating Chrononutrition Intermittent fasting Obesity

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Forensic profiling of non-volatile organic compounds in soil using ultra-performance liquid chromatography:a pilot study

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Forensic Sciences Research 2022年第4期7卷 761-773页

作者： Loong Chuen Lee Ab Aziz Ishak Ameeta A/P Nai Eyan Anas fahmi Zakaria Nurul Syahiera Kharudin Nor Azman mohd Noor Program of Forensic Sciences Centre for DiagnosticTherapeutic&Investigative StudiesFaculty of Health SciencesUniversiti Kebangsaan MalaysiaBangiMalaysia Institute of IR4.0 Universiti Kebangsaan MalaysiaBangiMalaysia Makmal Forensik Polis DiRaja Malaysia(PDRM) CherasMalaysia

Soil is of particular interest to the forensic community because it can be used as valuable associative evidence to link a suspect to a victim or a crime *** chromatography is a powerful analytical tool for organic compound ***,high-performance liquid chromatography(HPLC)has proven to be an efficient method for forensic soil analysis,especially in discriminating soils from proximity ***,ultra-performance liquid chromatography(UPLC),which is much more sensitive than HPLC,has never been explored in this *** study proposed a UPLC method for profiling non-volatile organic compounds in three Malaysian soils(red,brown and yellowish-brown soils).The three soils were analysed separately to assess the effects of individual chromatographic parameters:(a)elution programme(isocratic *** gradient programmes);(b)flow rate(0.1 vs.0.2 mL/min);(c)extraction solvent(acetonitrile ***)and(d)detection wavelength(230 vs.254 nm).The injection volume and total run time were set to 5μL and 35 min,***,each soil sample gave 24 different *** showed that the most desirable chromatographic parameters were(a)isocratic elution;(b)flow rate at 0.2 mL/min and(c)acetonitrile extraction *** proposed UPLC system is expected to be a feasible method for profiling non-volatile organic compounds in soil,and is more chemical-efficient than a comparable HPLC system.

关键词： Forensic sciences soil non-volatile organic compound liquid chromatography

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Distinctive Bullet Impact Holes by 9‑mm Caliber Projectile on Sheet Metal Surfaces

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Journal of Forensic Science and Medicine 2022年第3期8卷 97-103页

作者： Syamsul Anuar Abd Malik Farah Ad‑din Nordin Saiful Fazamil mohd Ali Ahmad fahmi Lim Abdullah Kah Haw Chang Forensic Science Programme School of Health SciencesHealth CampusUniversiti Sains MalaysiaKubang KerianKelantan Department of Chemistry Division of CriminalisticsForensic Science Analysis CentrePetaling JayaMalaysia

Introduction:A comprehensive scene reconstruction requires forensic investigators to examine the impact marks left on various surfaces to identify whether a projectile produces a specific ***,it is further necessary to determine whether a particular ammunition has caused the *** history,designs of ammunition have evolved with the intended effects,which could leave different impact marks on a target surface,especially by ammunition with a nonconventional *** examination on impact marks and determination of their specific characteristics on sheet metal of vehicle would provide crucialforensic ***:This study was aimed to physically characterize bullet impact holes made by 11 types of 9-mm caliber *** and Methods:Two automotive doors were shot with different ammunitionsfrom the same firearm,and the morphological features of bullet impact holes were observed and ***:Bullet impact holes produced by the various ammunitions could be differentiated through careful observation of bullet hole circumferences,presence of petalling effect,metallic ring and triangular peak at the edge,and deposition of residue at the peripheral area of bullet impact *** with nonconventional design such as Inceptor‑Polycase and GECO Hexagon showed observable morphological differences and discriminated them from bullet impact holes made by conventional ***:A thorough physical examination could aid in distinguishing bullet impact holes and predicting the possible types of ammunition that had made an impact hole on a surface.

关键词： Forensic science bullet hole physical examination Introduction projectile sheet metal

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