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Prevalence and risk factors associated with metabolic dysfunctionassociated steatohepatitis in patients with Helicobacter pylori infection: A population-based study

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World Journal of Hepatology 2024年第10期16卷 1169-1176页

作者： rashid Abdel-Razeq Lynn Bitar Elio R Bitar Chidera Onwuzo Mohamad-Noor abu-Hammour Barish Eren Islam Mohamed Adejoke Johnson Antoine Boustany Somtochukwu Onwuzo Imad Asaad Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44111United States Faculty of Medicine Saint Joseph University of BeirutBeirut 11042020Lebanon Faculty of Medicine American University of BeirutBeirut 11072020Lebanon Department of Medicine&Surgery General Hospital Lagos IslandLagos Island 101223LagosNigeria Department of Internal Medicine Jacobi Medical Center/North Central Bronx HospitalBronxNY 10461United States Division of Gastroenterology Department of Internal MedicineUniversity of Florida College of MedicineJacksonvilleFL 32209United States Department of Gastroenterology Allegheny General HospitalPittsburghPA 15212United States Department of Gastroenterology Firelands HealthSanduskyOH 44870United States

BACKGROUND Helicobacter pylori(***)is associated with the development of gastrointestinal disorders ranging from gastritis to gastric *** evidence of the association between metabolic dysfunction-associated steatohepatitis(MASH)and *** infection in the literature is ***,we aim to evaluate the risk of developing MASH in patients who have had a diagnosis of *** infection independently of any confounding *** To evaluate the risk of developing MASH in patients who have had a diagnosis of *** *** This study used a validated multicenter research database of over 360 hospitals across 26 healthcare systems across the United States from 1999 to *** regression analysis assessed the risk of developing MASH,adjusting for confounders including *** infection,obesity,type 2 diabetes,hypertension,dyslipidemia,and male gender.A two-sided P value<0.05 was considered as statistically significant,and all statistical analyses were performed using R version 4.0.2(R Foundation for Statistical Computing,Vienna,Austria,2008).RESULTS A total of 79476132 individuals were screened in the database and 69232620 were selected in the final analysis after accounting for inclusion and exclusion ***(14.30%),patients with hyperlipidemia(70.35%),hypertension(73.86%),diabetes mellitus type 2(56.46%),and obese patients(58.15%)were more common in patients with MASH compared to *** a multivariate regression analysis,the risk of MASH was increased in diabetics[odds ratio(OR):3.55;95%CI:3.48-3.62],obese(OR:5.93;95%CI:5.81-6.04),males(OR:1.49;95%CI:1.46-1.52),individuals with hyperlipidemia(OR:2.43;95%CI:2.38-2.49)and *** infection(OR:2.51;95%CI:2.31-2.73).CONCLUSION This is the largest population-based study in the United States illustrating an increased prevalence and odds of developing MASH in patients with *** infection after adjusting for risk factors.

关键词： Metabolic dysfunction-associated steatohepatitis Metabolic dysfunction-associated steatotic liver disease Helicobacter Pylori Cirrhosis Liver

Enhanced Steganalysis for Color Images Using Curvelet Features and Support Vector Machine

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Computers, Materials & Continua 2024年第1期78卷 1311-1328页

作者： Arslan Akram Imran Khan Javed rashid Mubbashar Saddique Muhammad Idrees Yazeed Yasin Ghadi Abdulmohsen Algarni Faculty of Computer Science and Information Technology Department of Computer ScienceSuperior UniversityLahore54000Pakistan Machine Learning Code(MLC)Lab Meharban HouseHouse Number 209Zafar ColonyOkara56300Pakistan Information Technology Services University of OkaraOkara56310Pakistan Department of Computer Science&Engineering University of Engineering&Technology LahoreNarowal CampusNarowal51601Pakistan Department of Computer Science and Software Engineering Al Ain UniversityAl Ain11671Abu Dhabi Department of Computer Science King Khalid UniversityAbha61421Saudi Arabia

Algorithms for steganography are methods of hiding data transfers in media *** machine learning architectures have been presented recently to improve stego image identification performance by using spatial information,and these methods have made it feasible to handle a wide range of problems associated with image *** with little information or low payload are used by information embedding methods,but the goal of all contemporary research is to employ high-payload images for *** address the need for both low-and high-payload images,this work provides a machine-learning approach to steganography image classification that uses Curvelet transformation to efficiently extract characteristics from both type of *** Vector Machine(SVM),a commonplace classification technique,has been employed to determine whether the image is a stego or *** Wavelet Obtained Weights(WOW),Spatial Universal Wavelet Relative Distortion(S-UNIWARD),Highly Undetectable Steganography(HUGO),and Minimizing the Power of Optimal Detector(MiPOD)steganography techniques are used in a variety of experimental scenarios to evaluate the performance of the *** WOW at several payloads,the proposed approach proves its classification accuracy of 98.60%.It exhibits its superiority over SOTA methods.

关键词： Curvelets fast fourier transformation support vector machine high pass filters steganography

Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.abu Ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur rashid Md.Khalid Juhani Rafi Tanvir Ahmed Siddiqui Md.Muzahid Ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran rashid Sohail rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

Spatial and seasonal distribution of intertidal macrobenthos with their biomass and functional feeding guilds in the Naf River estuary, Bangladesh

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Journal of Oceanology and Limnology 2019年第3期37卷 1010-1023页

作者： Md. abu NOMAN MAMUNUR rashid M SHAHANUL Islam M. Belal HOSSAIN College of Marine & Environmental Science Tianjin University of Science and TechnologyTianjin 300072China Department of Fisheries and Marine Science Noakhali Science and Technology UniversityBangladesh Faculty of Food Engineering and Biotechnology Tianjin University of Science and TechnologyTianjin 300457China

The Naf River estuary is one of the most productive ecological ecosystems in Bangladesh providing an important feeding area for fishes and other aquatic ***,detailed information on macrobenthic communities is rarely available in this *** study focused on the seasonal and spatial variability of macrobenthic community structure with their biomass and functional *** total,fortyseven taxa were identified under nine major groups and seven functional feeding *** macrobenthic taxa,Polychaeta was dominant in both seasons and all over the estuary contributing 60%of total *** mean abundance of macrobenthos was higher during the pre-monsoon(2 972±1 994 inds./m^2)than the monsoon(1 572±361 inds./m^2)being maximum at mid-estuary region and minimum at upper and lower estuary *** the diversity indices,density(P=0.01,P=0.003),the number of taxa(P=0.000 3,P=0.000 9)and Margalef′s Index(P=0.000 4,P=0.001)of macrobenthos were significantly different among stations and ***-Weiner index(P=0.009,P=0.12)and Pielou’s evenness index(P=0.03,P=0.14)had significant differences among stations but not among *** analysis suggested that distribution of macrofauna is strongly influenced by *** the feeding types,carnivorous were found to be dominant at the upper and mid-estuarine regions,and herbivorous were at lower estuarine *** species were dominant in both *** have shown to be the most abundant feeding type in terms of biomass though herbivores were highest during monsoon.

关键词： macrobenthos seasonal variation spatial variation feeding guilds biomass Naf River estuary

Secure Watermarking Scheme for Color DICOM Images in Telemedicine Applications

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Computers, Materials & Continua 2022年第2期70卷 2525-2542页

作者： Kamred Udham Singh Hatem Salem abu-Hamatta Abhishek Kumar Achintya Singhal Mamoon rashid A.K.Bashir Department of Computer Science and Information Engineering National Cheng Kung UniversityTainanTaiwan Department of Applied Sciences Aqaba University CollegeAl Balqa Applied UniversityAqabaJordan School of Computer Science&IT JAIN(to be Deemed University)BangaloreIndia Department of Computer Science Banaras Hindu UniversityVaranasiIndia Department of Computer Engineering Faculty of Science and TechnologyVishwakarma UniversityPune411048India Department of Computing and Mathematics ManchesterMetropolitan UniversityUK

Teleradiology plays a vital role in the medical field,which permits transmitting medical and imaging data over a communication *** ensures data reliability and provides convenient communication for clinical interpretation and diagnostic *** transmission of this medical data over a network raises the problems of legal,ethical issues,privacy,and copyright *** copyright protection of medical images is a significant issue in the medical *** schemes are used to address these issues.A gray-level or binary image is used as a watermark frequently in color image watermarking *** this paper,the authors propose a novel non-blind medical image watermarking scheme based on 2-D LiftingWavelet Transform(LWT),Multiresolution Singular Value Decomposition(MSVD),and LU factorization to improve the robustness and authenticity of medical *** this scheme,multiple color watermarks are embedded into the colored DICOM(Digital Imaging and Communications inMedicine)images obtained from Color Doppler images(DICOM format),and the average results achieved by our proposed scheme is 46.84 db for Peak Signal-to-Noise Ratio(PSNR),37.46 db for Signal-to-Noise Ratio(SNR),0.99 for Quality of Image and 0.998 for Normalized Correlation for various image processing *** results make our watermarking technique an ideal candidate for medical image watermarking.

关键词： Digital imaging medicine multiresolution medical image watermarking

Hemoglobin Subunit Beta Gene Polymorphism rs33949930 T>C and Risk of Sickle Cell Disease—A Case Control Study from Tabuk (Northwestern Part of Saudi Arabia)

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International Journal of Clinical Medicine 2016年第1期7卷 25-31页

作者： rashid Mir Fawzia Sharaf abu-Duhier FM Prince Fahd Bin Sultan Research Chair Division of Cancer Molecular Genetics Faculty of Applied Medical Sciences University of Tabuk Tabuk Kingdom of Saudi Arabia King Khaled Hospital Ministry of Health Tabuk Kingdom of Saudi Arabia

Background: Sickle cell disease and sickle cell trait are common erythrocyte disorders that are most often caused by a point mutation (rs334, designated HbS) in the hemoglobin beta gene (HBB);however of this fact, there is extreme variability in occurrence and clinical presentation of sickle cell disease which may be explained by some other genetic changes associated with the gene. In the present study we examined the association between HBB gene polymorphism rs33949930 T>C in the occurrence of sickle cell disease in Saudi Arabia population. Materials and Methods: A case control study of 100 sickle cell disease patients and 100 healthy controls from Tabuk, Saudi Arabia. HBB gene rs33949930 T>C polymorphism was analyzed using Allele specific polymerase chain reaction technique. Results: It was observed that the genotype percentages TT, TC and CC among the patients with sickle cell disease were 63.0%, 35.0% and 2.0% and healthy controls were 68.0%, 27.0% and 5.0% respectively. Allele frequency for T allele was observed to be fT = 0.20 and fT = 0.19, where as for C allele was fC = 0.80 and fC = 0.81 among cases and controls respectively (p = 0.29). Compared to the TT genotype, the odds ratio of 1.4 (95% CI 0.76 - 2.57), risk ratio of 1.2 (95% CI 0.86 - 1.65) and risk difference of 8.4 (-6.66 - 23.38) for heterozygous genotype of HBB rs33949930 T>C was observed in relation to sickle cell disease. In addition, some difference in the laboratory values was observed among sickle cell disease patients with the different variants of HBB gene rs33949930 T>C polymorphism, especially the carriers of heterozygous TC genotype;however, the difference doesn’t reach to statically significant number. Conclusion: Present study suggested that there was not any significant association between HBB gene rs33949930 T>C polymorphism and occurrence of sickle cell disease. However, the heterozygous TC genotype of the polymorphism showed some higher ratios among cases as compared to healthy con

关键词： Hemoglobin Subunit Beta (HBB) Sickle Cell Disease (SCD) Tabuk-Northwestern Part of Saudi Arabia

Heat transfer effectiveness characteristics maps for additively manufactured TPMS compact heat exchangers

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Energy Storage and Saving 2022年第3期1卷 153-161页

作者： Moza Alteneiji Mohamed I.Hassan Ali Kamran A.Khan rashid K.abu Al-Rub Advanced Digital&Additive Manufacturing Center United Arab Emirates Department of Mechanical Engineering Khalifa UniversityAbu DhabiUnited Arab Emirates Aerospace Engineering Department Khalifa UniversityAbu DhabiUnited Arab Emirates Mechanical Power Engineering Department Helwan UniversityCairoEgypt(on leave)

Increased power density in modern miniaturized electronics caused difficulty in keeping electronic performance *** challenge leads to the search for high-performance compact heat exchanger as one of the thermal management *** manufactured heat exchangers had limitations that thwart the develop-ment of geometrically complex heat exchangers which are capable of exploiting topological aspects to enhance thermal ***,additive manufacturing(AM)is proposed as a powerful fabrication tech-nique for compact heat exchanger based on the mathematically known triply periodic minimal surfaces(TPMS).In this work,we present 3D compact crossflow heat exchanger computational fluid dynamics(CFD)modelling of geometrically complex structures based on TPMS using STARCCM+CFD ***,CFD modelling is used to obtain new characteristics maps that relate heat transfer effectiveness(Ɛ)and number of transfer units for the proposed heat *** convection heat transfer coefficient,pressure drop,and inlet and outlet fluid temperature are all examined.

关键词： Compact crossflow heat exchanger(CCHE) Additive manufacturing(AM) Triply periodic minimal surface(TPMS) Effectiveness(Ɛ) Number of transfer units(NTU)

Frequency of Null Phenotypes of Glutathione S-Transferase M1 and T1 among the Populations of Tabuk (Northwestern Part of Saudi Arabia)

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Open Journal of Genetics 2016年第1期6卷 9-18页

作者： rashid Mir Abdullah Yahya Hamadi abu-Duhier F.M. Prince Fahd Bin Sultan Research Chair Division of Cancer Molecular Genetics Department of Medical Lab Technology Faculty of Applied Medical Sciences University of Tabuk Kingdom of Saudi Arabia

Background: The variability in the distribution of the null phenotypes of GSTM1 and GSTT1, due to total or partial gene deletion resulting in the lack of the active enzyme, has been reported in different populations, especially in ethnically well-defined groups but not in Tabuk. This study investigated the variability in the distribution of the null phenotypes of GSTM1 and GSTT1 in the population of Tabuk (northwestern part of Saudi Arabia). Method: This study was conducted on 200 subjects of Tabuk—northwestern part of Saudi Arabia among which 100 were chronic smokers and 100 were nonsmokers. The subjects were reporting to hospital for routine checkup. All were without past history of any chronic disease and no significant abnormality. GST genotyping was done by multiplex PCR-based methods. The smoker and control groups were compared using a chi-square test with P GSTM1 deletion homozygosity of 14% and 1% was reported among non smokers and smokers, respectively whereas GSTT1 deletion homozygosity of 28% and 6% was reported among non smokers and smokers, respectively. Our results indicate that there are major differences in allelic distribution of GSTM1 and GSTT1 genes between the two groups investigated. Combined analysis of both genes revealed that 15% of smokers and non smokers harbor the deleted genotype of GSTM1 and 34% of smokers and non smokers harbor the deleted genotype of GSTT1 with significant differences. Conclusion: This study enables selecting subgroups among the general population who are more susceptible to DNA damage and will help genetic studies on the association of GST polymorphisms with disease risks and drug effects in Arab population. Studies with a larger sample size are needed to evaluate and confirm the validity of our results.

关键词： GSTT1-Mu Glutathione S-Transferase GSTT1-Theta Glutathione S-Transferase Null Phenotypes of GST Tabuk—A Northwestern Part of Saudi Arabia