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Generalized*-Lie Higher Derivable Mappings on*-Rings

Algebra Colloquium 2020年第3期27卷 415-432页

作者： Mohammad Ashraf mohd shuaib Akhtar Bilal Ahmad Wani Department of Mathematics Aligarh Muslim UniversityAligarh 202002India

Let R be a*-ring with the center Z(R)and N be the set of nonnegative *** this paper,it is shown that if R contains a nontrivial self-adjoint idempotent which admits a generalized Lie higher derivable mapping△={G_(n)}_(n∈N)associated with a*-Lie higher derivable mapping L={L_(n)}_(n∈N),then for any X,Y in R and for each n in N there exists an element Z_(X,Y)(depending on X and Y)in the center Z(R)such that G_(n)(X+Y)=G_(n)(X)+G_(n)(Y)+Z_(X,Y).

关键词： rings derivations *-Lie higher derivable mappings generalized*-Lie higher derivable mappings

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Rare earth element signatures of Paleoproterozoic Sallopat phosphorites of Aravalli Basin,India:implications for diagenetic effects and depositional environment

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Acta Geochimica 2023年第4期42卷 726-738页

作者： Samsuddin Khan Shamim A.Dar K.F.Khan mohd shuaib Department of Geology Aligarh Muslim UniversityAligarhUttar Pradesh 202002India Department of Geology Centre of Advanced StudyInstitute of ScienceBanaras Hindu UniversityVaranasi 221005India

As a repository of REE,the Paleoproterozoic phosphorite of the Aravalli Basin in India is explored time to *** phosphorite deposits of the Sallopat sub-basin Banswara district of the Aravalli Supergroup show moderate REE concentrations much lower than that of average marine *** ratios and PAAS-normalized REE distribution patterns reflect MREE enrichment over LREE and HREE in these *** enrichment confirmed by(Sm/Yb)Nversus(Sm/Pr)Nrelationship and attributed to the selective uptake by cyanobacteria and mixing of riverine inputs.Y/Ho,La/Ce and Er/Nd ratios confirm that the REE in Sallopat phosphorites might have been affected by the argillaceous terrigenous and plagioclase-rich sediments probably derived from Banded Gneissic *** modeling indicates that REE were concentrated during early diagenetic processes with limited weathering *** negative to low Ce anomaly depicts oxic to sub-oxic conditions of seawater due to oxidation of Ce^(3+)to Ce^(4+)whereas Eu^(3+)reduced to Eu^(2+)indicating positive Euanomaly and reducing conditions as well during the *** anomalies may be due to the stratified restricted marine environment of upwelling and mingling of organic-rich anoxic deep water with oxic upper seawater prior to the formation of phosphorite deposits in the *** of REE in Sallopat phosphorite relies on various physico-chemical *** phosphorites may have been formed in restricted marine water which was influenced by extra clastic sediment input carried out by fluvial systems.

关键词： Stromatolite Lower Aravalli Group Apatite-(CaF) Alkaline environment Diagenesis

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Bulbine frutescens phytochemicals as novel ABC-transporter inhibitor:a molecular docking and molecular dynamics simulation study

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 20-32页

作者： Prem Prakash Kushwaha Santosh Kumar Maurya Amit Singh Kumari Sunita Prajapati Atul Kumar Singh mohd shuaib Shashank Kumar Molecular Signaling&Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India Department of Computational Sciences Central University of PunjabBathinda 151401India.

Aim:The present in silico study aimed to evaluate the ATP-binding cassette(ABC)transporter inhibition potential of Bulbine frutescens(***)***:Several previous studies and databases were used to retrieve the ligands and target protein *** molecular docking study was performed using the Auto Dock Tools,and the GROMACS package was applied to accomplish molecular dynamics ***:Utilizing the molecular docking and simulation approach,~25 phytochemicals were screened against the ABC transporter *** score analysis revealed that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside exhibited strong binding on the ABC transporter protein with a minimum binding score-9.8 kcal/mol in comparison to the standard ABC transporter inhibitor diltiazem(-6.86 kcal/mol).Furthermore,molecular dynamics simulation for 4’-Demethylknipholone 2’-β-D-glucopyranoside showed an acceptable root mean square deviation,radius of gyration,root mean square fluctuation,and hydrogen bond,in addition to other lead ***:The in-silico study demonstrated that *** phytochemical 4’-Demethylknipholone 2’-β-D-glucopyranoside possesses anti-drug resistance properties and requires further testing in preclinical settings.

关键词： Cancer drug resistance ABC-transporter natural inhibitors Bulbine frutescens MM-GBSA

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Resistance to second generation antiandrogens in prostate cancer: pathways and mechanisms

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Cancer Drug Resistance 2020年第4期3卷 742-761页

作者： Shiv Verma Kumari Sunita Prajapati Prem Prakash Kushwaha mohd shuaib Atul Kumar Singh Shashank Kumar Sanjay Gupta Department of Urology Case Western Reserve UniversityClevelandOH 44106USA The Urology Institute University Hospitals Cleveland Medical CenterClevelandOH 44106USA School of Basic and Applied Sciences Department of Biochemistry and Microbial SciencesCentral University of PunjabBathinda 151001India Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOH 44106USA Department of Urology Louis Stokes Cleveland Veterans Affairs Medical CenterClevelandOH 44106USA

Androgen deprivation therapy targeting the androgens/androgen receptor(AR)signaling continues to be the mainstay treatment of advanced-stage prostate *** use of second-generation antiandrogens,such as abiraterone acetate and enzalutamide,has improved the survival of prostate cancer patients;however,a majority of these patients progress to castration-resistant prostate cancer(CRPC).The mechanisms of resistance to antiandrogen treatments are complex,including specific mutations,alternative splicing,and amplification of oncogenic proteins resulting in dysregulation of various signaling *** this review,we focus on the major mechanisms of acquired resistance to second generation antiandrogens,including AR-dependent and AR-independent resistance mechanisms as well as other resistance mechanisms leading to CRPC *** knowledge of resistance mechanisms to AR targeted treatments will lead to additional research on designing more effective therapies for advanced-stage prostate cancer.

关键词： Prostate cancer second-generation antiandrogens androgen receptor castration resistance prostate cancer

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Physicochemical properties of aqueous solutions of sodium glycinate in the non-precipitation regime from 298.15 to 343.15 K

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Chinese Journal of Chemical Engineering 2015年第3期23卷 536-540页

作者： Muhammad shuaib Shaikh Azmi mohd Shariff mohd Azmi Bustam Ghulam Murshid Research Center for CO_2 Capture(RCCO_2C) Department of Chemical EngineeringUniversiti Teknologi PETRONAS

The physicochemical properties,including the density,viscosity,and refractive index of aqueous solutions of sodium glycinate as a solvent for CO_2 absorption in the non-precipitation regime were measured under the wide temperature range of 298.15 to 343.15 *** concentration of the sodium glycinate in an aqueous form in the non-precipitation regime was identified up to 2.0 mol ? L^(-1).The coefficients of thermal expansion values were estimated from measured density *** was found that,the densities,viscosities and refractive indices of the aqueous sodium glycinate decrease with an increase in temperature,whereas with increasing sodium glycinate concentration in the solution,all three properties *** expansion coefficients slightly increase with rising temperature and *** measured values of density,viscosity and refractive index were correlated as a function of temperature by using the least squares *** predicted data obtained from correlation equations for all measured properties were in fairly good agreement with the experimental data.

关键词： Sodium glycinate Physicochemical property Density Viscosity Refractive index

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