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Bioactive compounds fractionated from endophyte Streptomyces SUK 08 with promising ex-vivo antimalarial activity

Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1062-1066页

作者： Noraziah Mohamad Zin Juwairiah Remali mohd nazir nasrom Shafariatul Akmar Ishak mohd Shukri Baba Juriyati Jalil School of Diagnostic Sciences and Applied Health Faculty of Health SciencesUniversiti Kebangsaan Malaysia50300 Kuala LumpurMalaysia Department of Biomedical Science Kulliyyah of Allied Health ScienceInternational Islamic University MalaysiaJalan Sultan Ahmad ShahBandar Indera Mahkota25200 KuantanPahangMalaysia Drug and Herbal Research Centre Faculty of PharmacyUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia

Objective: To determine ex vivo antimalarial activity and cytotoxicity of endophytic Streptomyces SUK 08 as well as the main core structure fractionated from its crude ***: The activities of SUK 08 crude extract were evaluated by using the Plasmodium lactate dehydrogenase assay and synchronization test against rodent malaria parasite Plasmodium berghei, instead of human malarial parasite Plasmodium falciparum. The cytotoxicity of the crude extract was determined by MTT assay. The crude extract was analyzed by thin-layer chromatography and gas chromatography–mass ***: The ethyl acetate crude extract showed very promising antimalarial activity with IC50 of 1.25 mg/m L. The synchronization tests showed that ethyl acetate extraction could inhibit all stages of the Plasmodium life cycle, but it was most effective at the Plasmodium ring stage. On the basis of a MTT assay on Chang Liver cells, ethyl acetate and ethanol demonstrated IC50 values of >1.0 mg/m L. The IC50 of parasitemia at 5% and30% for this extract was lower than chloroquine. Thin-layer chromatography, with 1: 9 ratio of ethyl acetate: hexane, was used to isolate several distinct compounds. Based on gas chromatography–mass spectrophotometry analysis, three core structures were identified as cyclohexane, butyl propyl ester, and 2,3-heptanedione. Structurally, these compounds were similar to currently available antimalarial ***: The results suggest that compounds isolated from Streptomyces SUK 08 are viable antimalarial drug candidates that require further investigations.

关键词： Butyl–propyl–ester Cyclohexane 2,3-Heptanedione Endophyte Streptomyces Antimalarial

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Traffic Priority-Aware Medical Data Dissemination Scheme for IoT Based WBASN Healthcare Applications

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Computers, Materials & Continua 2022年第6期71卷 4443-4456页

作者： Muhammad Anwar Farhan Masud Rizwan Aslam Butt Sevia Mahdaliza Idrus Mohammad nazir Ahmad mohd Yazid Bajuri Department of Computer Science NFC Institute of Engineering and Fertilizer ResearchFaisalabadPakistan Department of Statistics and Computer Science Faculty of Life Sciences Business ManagementUniversity of Veterinary and Animal SciencesLahorePakistan Department of Electronics Engineering NED University of Engineering and TechnologyKarachiPakistan School of Electrical Engineering Universiti Teknologi MalaysiaJohor BahruMalaysia Institute of IR4.0 Universiti Kebangsaan MalaysiaBangiSelangorMalaysia Department of Orthopedics and Traumatology Faculty of MedicineUniversiti Kebangsaan MalaysiaKuala LumpurMalaysia

Wireless Body Area Sensor Network(WBASN)is an automated system for remote health monitoring of *** under umbrella of Internet of Things(IoT)is comprised of small Biomedical Sensor Nodes(BSNs)that can communicate with each other without human *** BSNs can be placed on human body or inside the skin of the patients to regularly monitor their vital *** BSNs generate critical data as it is related to patient’s *** data traffic can be classified as Sensitive Data(SD)and Non-sensitive Data(ND)packets based on the value of vital *** data packets have different priority to *** ND packets may tolerate some delay or packet loss whereas,the SD packets required to be delivered on time with minimized packet loss otherwise it can be life threating to the *** this research,we propose a Traffic Priority-aware Medical Data Dissemination(TPMD2)scheme forWBASN to deliver the data packets according to their priority based on the sensitivity of the *** assessment of the proposed scheme is carried out in various *** simulation results of the TPMD2 scheme indicate a significant improvement in packets delivery,transmission delay and energy efficiency in comparison with the existing schemes.

关键词： WBANS wearable technology priority routing eHealth applications remote health monitoring

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An Exploration of Higher Vocational English Teachers’Professional Development on Students’Learning Ability in the Context of New Liberal Arts

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Journal of Contemporary Educational Research 2024年第2期8卷 203-207页

作者： Jing Xu mohd nazir Bin Zabit Faculty of Education Universiti Pendidikan Sultan Idris35900 Tanjong MalimPerakMalaysia Lanzhou Vocational Technical College Lanzhou 730070Gansu ProvinceChina

The concept of New Liberal Arts,a multidisciplinary combined integrator with Chinese values at its core,has brought new challenges to the teaching methods and professional development of higher-level English *** on the evolving professional development process of higher vocational English teachers in the context of the New Liberal Arts,this article analyzes how English teachers can integrate multidisciplinary knowledge and adopt advanced educational technology in the teaching *** this basis,it discusses the role of teachers’professional development in enhancing students’learning ability,such as through deepening disciplinary understanding,adopting innovative teaching strategies,and implementing personalized *** the end of the article,based on a variety of pedagogical theories,we put forward suggestions,including continuous professional training,interdisciplinary cooperation,and the application of innovative teaching techniques,which are mainly aimed at helping higher vocational English teachers get rid of the dilemma of the new situation,adapt to the needs of the new liberal arts education as soon as possible,and then effectively improve students’abilities.

关键词： New liberal arts Higher vocational education Professional development of English teachers Interdisciplinary teaching Personalized teaching

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Robust Grid Resource Broker Strategy for Economy Based Grid

Robust Grid Resource Broker Strategy for Economy Based Grid

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International Conference on Machine Learning and Computing（ICMLC 2009）

作者： Babar nazir mohd Fadzil Hassan Halabi Hasbullah Department of Computer and Information Sciences Universiti Teknologi PETRONAS

In this paper,we propose a robust grid resource broker in an economy-based *** proposed strategy is meant to ensure grid system will be able to accommodate more jobs and deal with user more *** proposed strategy if broker is unable to execute the user job within the user deadline and budget parameters,it gives the options in terms of tentative budget and deadline to the *** of giving discrete options of job accepted or not accepted to the user,broker is able to specify projected deadline and *** can choose the projected deadline and budget which its QoS *** proposed strategy can effectively increase the job submission rate by accepting more jobs that can be executed according to the user specified deadline and allotted ***,this helps in upholding trustworthiness of grid environment.

关键词： Economy Based Grid Grid Task Scheduling Grid Resource Management Distributed System

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