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Surface-engineered liposomes for dual-drug delivery targeting strategy against methicillin-resistant Staphylococcus aureus(MRSA)

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Asian Journal of Pharmaceutical Sciences 2022年第1期17卷 102-119页

作者： Nur Najihah Izzati Mat Rani Xiang Yi Chen Zahraa M.Al-Zubaidi Hanisah Azhari Tzar mohd Nizam Khaitir Pei Yuen Ng Fhataheya Buang Geok Chin Tan Yin Ping Wong Mazlina mohd Said Adeel Masood Butt Azmy A.Hamid mohd cairul iqbal mohd amin Centre for Drug Delivery Technology Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Pharmacy and Health Sciences University Kuala Lumpur Royal College of Medicine Perak No.3Perak 30450Malaysia Department of Medical Microbiology&Immunology Faculty of MedicineUniversiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia Drug and Herbal Research Center Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Reading School of Pharmacy University of ReadingReading RG66ADUnited Kingdom Department of Pathology Faculty of MedicineUniversiti Kebangsaan MalaysiaKuala Lumpur 56000Malaysia Institute of Pharmaceutical Sciences University of Veterinary and Animal SciencesLahore 54000Pakistan XORIX Sdn Bhd Dungun Terengganu 23000Malaysia

This study focused on the encapsulation of vancomycin(VAN) into liposomes coated with a red blood cell membrane with a targeting ligand, daptomycin–polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine, formed by conjugation of DAPT and Nhydroxysuccinimidyl-polyethylene glycol-1,*** formulation is capable of providing controlled and targeted drug delivery to the bacterial cytoplasm. We performed MALDI-TOF, NMR and FTIR analyses to confirm the conjugation of the targeting ligand via the formation of amide bonds. Approximately 45% of VAN could be loaded into the aqueous cores, whereas 90% DAPT was detected using UV–vis spectrophotometry. In comparison to free drugs, the formulations controlled the release of drugs for > 72 h. Additionally, as demonstrated using CLSM and flow cytometry, the resulting formulation was capable of evading detection by macrophage cells. In comparison to free drugs, red blood cell membrane–DAPT–VAN liposomes, DAPT liposomes, and VAN liposomes reduced the MIC and significantly increased bacterial permeability, resulting in > 80% bacterial death within 4 h. Cytotoxicity tests were performed in vitro and in vivo on mammalian cells,in addition to hemolytic activity tests in human erythrocytes, wherein drugs loaded into the liposomes and RBCDVL exhibited low toxicity. Thus, the findings of this study provide insight about a dual antibiotic targeting strategy that utilizes liposomes and red blood cell membranes to deliver targeted drugs against MRSA.

关键词： Erythrocyte Dual drug delivery Liposome Methicillin-resistant staphylococcus aureus Vancomycin Daptomycin

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Metabolomics for quality assessment of poultry meat and eggs

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Food Quality and Safety 2024年第1期8卷 27-40页

作者： M.S.Yogeswari Jinap Selamat Nuzul Noorahya Jambari Alf Khatib mohd Hishammfariz mohd amin Suganya Murugesu Laboratory of Food Safety and Food Integrity Institute of Tropical Agriculture and Food SecurityUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of Food Science Faculty of Food Science and TechnologyUniversiti Putra MalaysiaSerdangSelangor Darul EhsanMalaysia Department of Pharmaceutical Chemistry Kulliyyah of PharmacyInternational Islamic University MalaysiaKuantanPahang Darul MakmurMalaysia Faculty of Pharmacy Airlangga UniversitySurabayaIndonesia Department of Veterinary Service Malaysia Federal Government Administration CentrePutrajayaMalaysia

The poultry industry is experiencing rapid growth *** accelerated growth has led to multiple food fraud incidents across the food supply chain,which consequently created a demand for precise determination of quality poultry *** increase in demand for precise poultry production quality has necessitated advanced *** has emerged as a viable solution by offering detailed differentiation of biochemical indicators throughout the poultry supply ***,this study provides a means to address risk factors affecting the poultry industry without compromising animal welfare,which is a critical *** review focuses on important issues related to poultry product quality *** adulteration has escalated in recent years as it is driven by the increasing focus on consuming high-quality and nutritious ***,there is no specifc guideline for such determinations,especially when appearance,texture,and taste can be manipulated by substituting for food *** can pave the way for a deeper understanding of existing and novel biochemical indicators responsible for determining the quality of poultry meat and *** approach holds the potential to enhance the overall quality of poultry meat and egg products while also preventing food fraud.

关键词： Poultry metabolomics welfare application authentication.

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Leveraging immunoliposomes as nanocarriers against SARS-CoV-2 and its emerging variants

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Asian Journal of Pharmaceutical Sciences 2023年第6期18卷 32-45页

作者： Nur Dini Fatini Mohammad Faizal Nurul Afina Ramli Nur Najihah Izzati Mat Rani Nur Adania Shaibie Aartid Pattaporn Poonsawas Sunil K.Sharma mohd cairul iqbal mohd amin Centre for Drug Delivery Technology and Vaccine(CENTRIC) Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty of Pharmacy University Royal College of Medicine Perak(UniKL RCMP)No.3Jalan GreentownIpoh 30450PerakMalaysia Faculty of Pharmacy Thammasat UniversityBangkok 10200Thailand Department of Chemistry University of DelhiDelhi 110007India

The global COVID-19 pandemic arising from SARS-CoV-2 has impacted many lives,gaining interest worldwide ever since it was first identified in December *** 2023,752 million cumulative cases and 6.8 million deaths were documented ***-19 has been rapidly evolving,affecting virus transmissibility and properties and contributing to increased disease *** Omicron is themost circulating variant of *** success in its treatment has indicated progress in tackling the virus,limitations in delivering the current antiviral agents in battling emerging variants remain *** the latest advancements in nanotechnology for controlling infectious diseases,liposomes have the potential to counteract SARS-CoV-2 because of their ability to employ different targeting strategies,incorporating monoclonal antibodies for the active and passive targeting of infected *** review will present a concise summary of the possible strategies for utilizing immunoliposomes to improve current treatment against the occurrence of SARSCoV-2 and its variants.

关键词： Coronavirus COVID-19 SARS-CoV-2 Liposomes Immunoliposomes

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Disease burden,antimicrobial resistance and molecular characterization of invasive group B Streptococcus among non-pregnant adults in Malaysia:A protocol study

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Asian Pacific Journal of Tropical Medicine 2023年第11期16卷 498-505页

作者： Abdulrahman Muthanna Nurul Hana Zainal Baharin mohd Nasir mohd Desa Nurul Diana Dzaraly Mohammad Noor Amal Azmai Syafinaz amin-Nordin Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Biology Faculty of ScienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Aquatic Animal Health and Therapeutics Laboratory Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Sultan Abdul Aziz Shah HospitalUniversiti Putra MalaysiaPersiaran MARDI-UPM43400SelangorMalaysia Laboratory of Vaccine and Biomolecules Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia

and pili genes are also ***:This multicentre,prospective,observational study is conducted in seven major tertiary hospitals in Malaysia among non-pregnant ***,a retrospective study is conducted in the selected hospitals with similar *** isolates are subjected to phenotyping,serotyping by multiplex PCR,antimicrobial susceptibility testing and PCR-detection of GBS virulence and pilus *** housekeeping genes are amplified and sequenced for multi-locus sequence ***:Findings from the study may contribute to the management of clinical practice to diagnose and prevent GBS related diseases in a timely *** use of antibiotics is encouraged by monitoring antimicrobial resistance.

关键词： Group B Streptococcus Incidence Serotype Antimicrobial resistance Virulence gene Multi-locus sequence typing

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A mixed acid methodology to produce thermally stable cellulose nanocrystal at high yield using phosphoric acid

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Journal of Bioresources and Bioproducts 2022年第2期7卷 17-26页

作者： Khairatun Najwa mohd amin Alireza Hosseinmardi Darren J.Martin Pratheep K.Annamalai Australian Institute for Bioengineering and Nanotechnology(AIBN) the University of QueenslandBrisbaneQLD 4072 Australia Faculty of Chemical and Process Engineering Technology College of Engineering TechnologyUniversiti Malaysia PahangLebuhraya Tun Razak26300 Gambang KuantanPahang D.M.Malaysia

Cellulose nanocrystal(CNC)with distinctive shape-morphology,enhanced thermal stability and dispersibility is essential for overcoming the challenges in processing polymer/CNC nanocom-posites through melt compounding at elevated *** study shows a mixed acid hy-drolysis method to produce CNC with improved thermal stability and high *** use of phosphoric acid(H_(3)PO_(4)),as a mild acid,in combination with a strong acid either sulphuric acid(H_(2)SO_(4))or hydrochloric acid(HCl)leads to reduced use of strong acids and low impact on our *** influences of acid combination and sequence of addition on the production yield were investigated by retaining the proportion of H_(3)PO_(4)to corrosive acid(H_(2)SO_(4)and HCl)4 to 1,and solid to liquid ratio 1꞉*** methodology has enabled to isolate CNC with higher thermal stability,dispersibility and productivity in terms of amount acid used 1 g of CNC,as compared with single acid *** CNC produced using the combination of H_(3)PO_(4)and HCl exhibits high thermal stability,dispersibility and rod-like shape morphology with length and width of(424±86)and(22±3)nm,***,this approach has reduced H_(3)PO_(4)consumption by 54%as compared with single acid hydrolysis method for the production of same amount of CNC.

关键词： Cellulose nanocrystal(CNC) Acid hydrolysis Thermal stability Mixed acid Crystallinity Production yield

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Vaccine development for leptospirosis:A systematic review

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Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 533-545页

作者： Yocyny Surendran Mahalingam Nandikha Syafinaz amin-Nordin Sandeep Kumar Dhanda Mohamad Ridhuan mohd Ali Narcisse MS Joseph Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400Malaysia Department of Biomedical Science Faculty of MedicineQuest International University30250Malaysia Department of Oncology St Jude Children’s Research Hospital Memphis38105USA Institute for Medical Research Ministry of HealthMalaysia

Objective:To assess the efficacy of various types of vaccines developed for ***:A comprehensive search was conducted in three databases:PubMed,Scopus,and Cochrane *** authors(YS and MN)selected the articles based on manual *** study eligibility criteria are all Leptospira species regardless of any cluster(pathogenic,intermediate and non-pathogenic).This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine *** studies on the effectiveness of outer membrane protein as vaccine candidates were also *** articles obtained in the databases were imported into the WPS spreadsheet,and duplicate documents were removed ***:A total of 24 studies were included in the review,which evaluated various types of leptospirosis *** vaccines were developed and tested;however,the heterogeneity of Leptospira species pose a *** an effective approach,an epitope based vaccine shows quite a promising ***,sufficient validation,testing and clinical trials are ***:Developing an effective vaccine for leptospirosis remains a global health *** significant progress has been made in recent years,there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations.

关键词： Leptospira Vaccine candidate Outer membrane protein

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Optimization of equitable irrigation water delivery for a large-scale rice irrigation scheme

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International Journal of Agricultural and Biological Engineering 2018年第5期11卷 160-166页

作者： Md Rowshon Kamal Muhammad iqbal Md Abdul Mojid mohd amin mohd Soom Lai Sai Hin Department of Biological and Agricultural Engineering Faculty of EngineeringUniversiti Putra Malaysia(UPM)UPM Serdang 43400Selangor DEMalaysia Department of Agricultural Engineering and Technology Faculty of Agricultural SciencesGhazi UniversityDera Ghazi KhanPakistan Department of Irrigation and Water Management Faculty of Agricultural Engineering and TechnologyBangladesh Agricultural UniversityMymensingh 2202Bangladesh Faculty of Sustainable Agriculture Universiti Malaysia Sabah(UMS)Jalan UMSKota Kinabalu 88400SabahMalaysia Department of Civil Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur 50603Malaysia

Equitable water allocation is essential in an irrigation scheme for obtaining potential crop yields from the entire scheme,especially when water supply is *** optimization model achieved this goal by coupling an optimal water allocation model with available water supply and irrigation water demand for a river-fed rice irrigation system in *** model consists of a paddy field water balance module and an optimization *** outputs from the module are daily irrigation demand and surface runoff,if there is *** optimization module consists of an objective function,which minimizes water shortage across the scheme area while maintaining equity in water *** model performs optimization subject to several system constraints,and the decision variable of the model is daily releases or supply to the tertiary *** of this model remained unaffected under different water supply conditions,and the optimization model reliably examined the effects of alternate water allocation and management rules with field *** improves efficiency and equity in water allocation with respect to crop growth stages and water shortages rather than simply cutting irrigation supply on a proportional basis to overcome water shortages.

关键词： irrigation optimization simulation equitable deliveries rice

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Influence of replacement of wheat flour by rice flour on rheo-structural changes, in vitro starch digestibility and consumer acceptability of low-gluten pretzels

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Food Production, Processing and Nutrition 2022年第1期4卷 95-106页

作者： Nusrat Jan H.R.Naik Gousia Gani Omar Bashir Tawheed amin Sajad mohd Wani Shakeel Ahmad Sofi Division of Food Science and Technology Sher-e-Kashmir University of Agricultural Sciences and Technology of KashmirSrinagarJammu and Kashmir190025India Department of Management Studies Central University of Kashmir(J&K)IndiaGreen CampusGanderbalIndia

This study aimed to access the influence of rice flour incorporation on various quality attributes of low-gluten wheat-based pretzels viz., functional, rheological, starch digestibility, color, textural and sensorial properties. Significant increase in swelling power (18.33 ± 0.51) and bulk density (0.58 ± 0.04) was observed in flour blend upon incorporation of rice flour, whereas, significant decrease in oil absorption capacity (0.62 ± 0.09), solubility index (6.72 ± 0.17), foaming capacity (9.67 ± 0.34), and foaming stability (3.39 ± 0.15) was recorded. Pasting properties of samples were studied using a Rapid Visco Analyser which indicated that all the pasting properties increased with an increase in rice flour incorporation. Fourier transform infrared spectroscopic studies revealed no difference in the basic functional groups of flour blend upon the incorporation of rice flour, however, it had a pronounced effect on elastic modulus (G′) of flour blend. In vitro starch digestion characteristics revealed 7.23% surge in slowly digestible starch and 13.36% reduction in rapidly digestible starch of developed low-gluten pretzels upon the incorporation of rice flour. Apparent amylose content (27.3 ± 1.45) and resistant starch content (6.12 ± 0.97) increased and starch digestibility index (69.87 ± 1.72) decreased in developed low-gluten pretzels. In conclusion, the developed low-gluten pretzels had significantly (p < 0.05) higher mineral profile and lightness (L*) and lower breaking strength in addition to having better overall acceptability. This study indicated that substituting wheat flour with rice flour up to a level of 35% affected the quality attributes of developed low-gluten pretzels.

关键词： Rice flour Wheat flour Low-gluten pretzels In vitro starch digestion Overall acceptability

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Liver Tumor Decision Support System on Human Magnetic Resonance Images:A Comparative Study

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Computer Systems Science & Engineering 2023年第8期46卷 1653-1671页

作者： Hiam Alquran Yazan Al-Issa Mohammed Alslatie Isam Abu-Qasmieh amin Alqudah Wan Azani Mustafa Yasmin mohd Yacob Department of Biomedical Systems and Informatics Engineering Yarmouk University 556Irbid21163Jordan Department of Biomedical Engineering Jordan University of Science and TechnologyIrbid22110Jordan Department of Computer Engineering Yarmouk University 556Irbid21163Jordan The of Biomedical Technology King Hussein Medical CenterRoyal Jordanian Medical ServiceAmman11855Jordan Faculty of Electrical Engineering&Technology Campus Pauh PutraUniversiti Malaysia PerlisArau02600PerlisMalaysia Faculty of Electronic Engineering&Technology Campus Pauh PutraUniversiti Malaysia PerlisArau02600PerlisMalaysia Advanced Computing Centre of Excellence(CoE)Universiti Malaysia PerlisArau02600PerlisMalaysia

Liver cancer is the second leading cause of cancer death *** tumor detection may help identify suitable treatment and increase the survival *** imaging is a non-invasive tool that can help uncover abnormalities in human *** Resonance Imaging(MRI),in particular,uses magnetic fields and radio waves to differentiate internal human organs ***,the interpretation of medical images requires the subjective expertise of a radiologist and ***,building an automated diagnosis computer-based system can help specialists reduce incorrect *** paper proposes a hybrid automated system to compare the performance of 3D features and 2D features in classifying magnetic resonance liver tumor *** paper proposed two models;the first one employed the 3D features while the second exploited the 2D *** first system uses 3D texture attributes,3D shape features,and 3D graphical deep descriptors beside an ensemble classifier to differentiate between four 3D tumor *** top of that,the proposed method is applied to 2D slices for comparison *** proposed approach attained 100%accuracy in discriminating between all types of tumors,100%Area Under the Curve(AUC),100%sensitivity,and 100%specificity and precision as well in 3D liver *** the other hand,the performance is lower in 2D *** maximum accuracy reached 96.4%for two classes and 92.1%for four *** top-class performance of the proposed system can be attributed to the exploitation of various types of feature selection methods besides utilizing the ReliefF features selection technique to choose the most relevant features associated with different *** novelty of this work appeared in building a highly accurate system under specific circumstances without any processing for the images and human input,besides comparing the performance between 2D and 3D *** the future,the presented work can be extended to be

关键词： Liver tumors ensemble classifier 3D shape features 3D cooccurrence matrix ResNet101

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A computing capability test for a switched system control design using the Haris-Rogers method

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第10期13卷 781-792页

作者： mohd amin AT-TASNEEM Sallehuddin Mohamed HARIS Zulkifli mohd NOPIAH Faculty of Mechanical Engineering University Malaysia Pahang Pekan 26600 Malaysia Department of Mechanical and Materials Engineering Faculty of Engineering and the Built Environment Universiti Kebangsaan Malaysia UKM Bangi 43600 Malaysia Unit of Fundamental Engineering Studies Faculty of Engineering and the Built Environment Universiti Kebangsaan Malaysia UKM Bangi 43600 Malaysia

The problem of finding stabilizing controllers for switched systems is an area of much research interest as conventional concepts from continuous time and discrete event dynamics do not hold true for these *** solutions have been proposed,most of which are based on finding the existence of a common Lyapunov function(CLF) or a multiple Lyapunov function(MLF) where the key is to formulate the problem into a set of linear matrix inequalities(LMIs).An alternative method for finding the existence of a CLF by solving two sets of linear inequalities(LIs) has previously been *** method is seen to be less computationally taxing compared to methods based on solving *** substantiate this,the computational ability of three numerical computational solvers,LMI solver,cvx,and Yalmip,as well as the symbolic computational program Maple were tested.A specific switched system comprising four second-order subsystems was used as a test *** the obtained solutions,the validity of the controllers and the corresponding CLF was *** was found that all tested solvers were able to correctly solve the *** issue of rounding-off error in numerical computation based software is discussed in *** test revealed that the guarantee of stability became uncertain when the rounding off was at a different decimal *** use of different external solvers led to the same conclusion in terms of the stability of switched *** a result,a shift from using a conventional numerical computation based program to using computer algebra is suggested.

关键词： Linear inequalities Hybrid systems Stability Common quadratic Lyapunov function Numerical computation Symbolic computation

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