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Impact of Cumulative Exposure to Circulating Ovarian Sex Hormones on Increasing the Risk of Hormone Receptor-Positive Breast Cancer

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生物组学研究杂志(英文) 2024年第1期07卷 36-43页

作者： mohanty swati sucharita mohanty Sumit Subhadarshi Panda Soumya Surath Sahoo Chita Ranjan mohanty Prafulla Kumar Padhy Rabindra Nath Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital Bhubaneswar Odisha India Regional Medical Research Centre Bhubaneswar Bhubaneswar Odisha India Khallikote Unitary University Brahmapur Odisha India

There were 2.3 million new cases of breast cancer registered in 2020, establishing it as the world’s leading cancer. The regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages. A literature review was performed by downloading research articles from PubMed Central, with keywords such as breast cancer, hormone exposure in breast cancer, estrogen/progesterone exposure in breast cancer, and breast cancer risk factors. Since breast cancer is a hormone-related disease, several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast cancer. Likewise, an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen exposure. All these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime. A healthy lifestyle, a more extended breastfeeding period, and regular physical activity may help lower one’s risk. This review summarizes the factors that increase the risk of estrogen/progesterone (hormone receptor) receptor-positive breast cancer due to overall cumulative estrogen exposure, with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

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Obesity as potential breast cancer risk factor for postmenopausal women

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Genes & Diseases 2021年第2期8卷 117-123页

作者： swati sucharita mohanty Prafulla Kumar mohanty Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswar751004OdishaIndia

Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during *** about 1.9 billion were overweight and over 650 million out of these were obese during *** is a significant relationship between breast cancer risk and *** menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk,because adipose tissue acts as the major reservoir for estrogen biosynthesis after *** estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal *** review explains body fat as a peripheral site for estrogen biosynthesis,estrogen exposure affecting body fat distribution,and the mechanism of estrogen production from body fats.

关键词： Adipocyte Aromatase Breast cancer Estrogen Obesity

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Role of hormone receptors and HER2 as prospective molecular markers for breast cancer:An update

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Genes & Diseases 2022年第3期9卷 648-658页

作者： swati sucharita mohanty Chita Ranjan Sahoo Rabindra Nath Padhy Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswarOdisha 751004India Central Research Laboratory Institute of Medical Sciences&SUM HospitalSiksha'O’Anusandhan Deemed to be UniversityBhubaneswarOdisha 751003India

This review provides an updated account on the current methods,principles and mechanism of action of therapies for the detection of molecular markers of therapeutic importance in the prognosis of breast cancer progression and recurrence,which includes estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor2(HER2).Indeed,hormone-receptors namely,ER,PR,proto-oncogene HER2 are the basic molecular markers that are recognized and established prognostic factors and predictors of response,for therapeutic *** markers can be detected by using immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH),which are established,faster and cost effective detection *** molecular markers along with clinicopathological prognostic parameters give the best prediction of the prognosis of cancer recurrence and ***,hormone receptors and HER2 as molecular markers are of prime therapeutic importance and have the capability to take part in future drug development techniques.

关键词： Breast cancer Molecular diagnostic Molecular markers Predictive markers Prognostic

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A Novel Approach for Mitigating Power Quality Issues in a PV Integrated Microgrid System Using an Improved Jelly Fish Algorithm

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Journal of Bionic Engineering 2023年第1期20卷 30-46页

作者： swati Suman Debashis Chatterjee Rupali mohanty Department of Electrical Engineering Jadavpur UniversityKolkataWest Bengal700032India

A two-step methodology was used to address and improve the power quality concerns for the PV-integrated microgrid system. First, partial shading was included to deal with the real-time issues. The Improved Jelly Fish Algorithm integrated Perturb and Obserb (IJFA-PO) has been proposed to track the Global Maximum Power Point (GMPP). Second, the main unit-powered via DC–AC converter is synchronised with the grid. To cope with the wide voltage variation and harmonic mitigation, an auxiliary unit undergoes a novel series compensation technique. Out of various switching approaches, IJFA-based Selective Harmonic Elimination (SHE) in 120° conduction gives the optimal solution. Three switching angles were obtained using IJFA, whose performance was equivalent to that of nine switching angles. Thus, the system is efficient with minimised higher-order harmonics and lower switching losses. The proposed system outperformed in terms of efficiency, metaheuristics, and convergence. The Total Harmonic Distortion (THD) obtained was 1.32%, which is within the IEEE 1547 and IEC tolerable limits. The model was developed in MATLAB/Simulink 2016b and verified with an experimental prototype of grid-synchronised PV capacity of 260 W tested under various loading conditions. The present model is reliable and features a simple controller that provides more convenient and adequate performance.

关键词： Harmonic mitigation Selective harmonic elimination pulse width modulation inverters Search-based optimization techniques Bionic algorithm Total harmonic distortion Modulation indices

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