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Donkey whey proteins ameliorate dextran sulfate sodium-induced ulcerative colitis in mice by downregulating the S100A8-TRAF6-NF-κB axis-mediated inflammatory response

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Food Science and Human Wellness 2023年第5期12卷 1809-1819页

作者： mohan li Qilong li Rayhnigul Abdlla Jiali Chen Xiqing Yue Siew Young Quek College of Food Science Shenyang Agricultural UniversityShenyang 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyang 110866China Food Science School of Chemical SciencesThe University of AucklandAuckland 1010New Zealand Riddet Institute Centre for Research Excellence in Food ResearchPalmerston North 4474New Zealand

Donkey milk has a variety of physiological functions, including antibacterial and anti-inflammatory. Donkey whey proteins(DWPs), as the main functional component in donkey milk, its inhibitory effect on colitis is still unclear. In this study, the inhibitory effect and potential mechanism of DWPs on dextran sulfate sodium(DSS)-induced colitis were investigated. Firstly, the DWPs and bovine milk whey proteins(BWPs)were characterized using proteomics. Then, we administered DWPs and BWPs to mice with colitis via oral gavage. The results of immunohistochemistry and flow cytometry indicated that DWPs increased T regulatory cell accumulation and increased the abundance of the cluster of differentiation 205+(CD205+)macrophages compared to those with BWPs and in model groups. In addition, DWPs exhibited a more remarkable ability to inhibit pro-inflammatory proteins(S100A8, TRAF6, and NF-κB)expression and inflammatory secretion than BWPs. In addition, DWPs significantly decreased NF-κB and CD86 levels more than BWPs or the negative control in both LPS-stimulated human peripheral blood mononuclear cells or cell lines. These findings indicate that DWPs comprise a promising anti-colitis functional food, and this work has established a foundation for future research on these compounds.

关键词： Donkey milk Proteomics Whey proteins NF-κB

A Coarse Alignment Based on the Sliding Fixed-Interval Least Squares Denoising Method

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Computers, Materials & Continua 2019年第9期61卷 1305-1321页

作者： Yongyun Zhu Tao Zhang mohan li Di Wang Shaoen Wu School of Instrumental Science and Engineering Southeast UniversityNanjing210096China China Shipbuilding Industry System Engineering Research Institute Beijing100036China Department of Computer Science Ball State UniversityMuncieUSA

The observation vectors in traditional coarse alignment contain random noise caused by the errors of inertial instruments,which will slow down the convergence *** solve the above problem,a real-time noise reduction method,sliding fixed-interval least squares(SFI-LS),is devised to depress the noise in the observation *** this paper,the least square method,improved by a sliding fixed-interval approach,is applied for the real-time noise *** order to achieve a better-performed coarse alignment,the proposed method is utilized to de-noise the random noise in observation ***,the principles of proposed SFI-LS algorithm and coarse alignment are devised.A simulation test and turntable experiment were executed to demonstrate the availability of the designed *** is indicated that,from the results of the simulation and turntable tests,the designed algorithm can effectively reduce the random noise in observation ***,the proposed method can enhance the performance of coarse alignment availably.

关键词： Coarse alignment observation vectors real-time noise reduction sliding fixed-interval least squares

Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach

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Food Science and Human Wellness 2023年第4期12卷 1224-1231页

作者： mohan li Qilong li Haikun Yu Xiumin Zhang Dehao li Wanying Song Yan Zheng Xiqing Yue College of Food Science Shenyang Agricultural UniversityShenyang 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyang 110866China Beijing Academy of Food Sciences Beijing 100068China The Fourth Affiliated Hospital of China Medical University Shenyang 110866China

This study aimed to analyze and compare the differentially expressed whey proteins(DEWPs)of donkey and bovine colostrum using high-performance liquid chromatography with tandem mass spectrometry-based proteomics.A total of 620 and 696 whey proteins were characterized in the donkey and bovine colostrum,respectively,including 383 common whey *** these common proteins,80 were identified as DEWPs,including 21 upregulated and 59 downregulated DEWPs in donkey colostrum compared to bovine *** Ontology analysis revealed that these DEWPs were mainly related to cellular components,such as extracellular exosome,plasma membrane,and mitochondrion;biological processes,such as oxidation-reduction process,cell-cell adhesion,and small guanosine triphosphate(GTP)ase-mediated signal transduction;and molecular functions,such as GTP binding,GTPase activity,and soluble N-ethylmaleimide-sensitive factor(NSF)attachment protein receptor *** pathway analysis suggested that the majority of the DEWPs were associated with soluble NSF factor attachment protein receptor interactions in vesicular transport,fatty acid biosynthesis,and estrogen signaling *** results provide a vital insight into the differences between donkey and bovine colostrum,along with important information on the significant components as nutritional and functional factors to be included in infant formula based on multiple milk sources.

关键词： Bovine colostrum Donkey colostrum Proteomics Whey protein Gene Ontology Kyoto Encyclopedia of Genes and Genomes

DPIF:A Framework for Distinguishing Unintentional Quality Problems From Potential Shilling Attacks

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Computers, Materials & Continua 2019年第4期59卷 331-344页

作者： mohan li Yanbin Sun Shen Su Zhihong Tian Yuhang Wang Xianzhi Wang Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China School of Software University of Technology SydneySydneyAustralia

Maliciously manufactured user profiles are often generated in batch for shilling *** profiles may bring in a lot of quality problems but not worthy to be *** repairing data always be expensive,we need to scrutinize the data and pick out the data that really deserves to be *** this paper,we focus on how to distinguish the unintentional data quality problems from the batch generated fake users for shilling attacks.A two-steps framework named DPIF is proposed for the *** on the framework,the metrics of homology and suspicious degree are *** homology can be used to represent both the similarities of text and the data quality problems contained by different *** suspicious degree can be used to identify potential *** experiments on real-life data verified that the proposed framework and the corresponding metrics are effective.

关键词： Data quality shilling attacks functional dependency suspicious degree homology

Long Short Term Memory Networks Based Anomaly Detection for KPIs

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Computers, Materials & Continua 2019年第8期61卷 829-847页

作者： Haiqi Zhu Fanzhi Meng Seungmin Rho mohan li Jianyu Wang Shaohui liu Feng Jiang School of Computer Science and Technology Harbin Institute of TechnologyHarbin150000China Institute of Computer Application China Academy of Engineer PhysicsMianyang621900China Department of Software Sejong UniversitySeoulKorea Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China

In real-world many internet-based service companies need to closely monitor large amounts of data in order to ensure stable operation of their ***,anomaly detection for these data with various patterns and data quality has been a great challenge,especially without *** this paper,we adopt an anomaly detection algorithm based on Long Short-Term Memory(LSTM)Network in terms of reconstructing KPIs and predicting *** use the reconstruction error and prediction error respectively as the criteria for judging anomalies,and we test our method with real data from a company in the insurance industry and achieved good performance.

关键词： LSTM anomaly detection KPIs

Location Privacy in Device-Dependent Location-Based Services:Challenges and Solution

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Computers, Materials & Continua 2019年第6期59卷 983-993页

作者： Yuhang Wang Yanbin Sun Shen Su Zhihong Tian mohan li Jing Qiu Xianzhi Wang Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China School of Software University of Technology SydneySydney NSW 2007Australia

With the evolution of location-based services(LBS),a new type of LBS has already gain a lot of attention and implementation,we name this kind of LBS as the Device-Dependent LBS(DLBS).In DLBS,the service provider(SP)will not only send the information according to the user’s location,more significant,he also provides a service device which will be carried by the *** has been successfully practised in some of the large cities around the world,for example,the shared bicycle in Beijing and *** this paper,we,for the first time,blow the whistle of the new location privacy challenges caused by DLBS,since the service device is enabled to perform the localization without the permission of the *** conquer these threats,we design a service architecture along with a credit system between DLBS provider and the *** credit system tie together the DLBS device usability with the curious behaviour upon user’s location privacy,DLBS provider has to sacrifice their revenue in order to gain extra location information of their *** make the simulation of our proposed scheme and the result convince its effectiveness.

关键词： Location privacy device-dependent location-based service location-based service credit system location privacy preserving mechanism shared bicycle

Identifying Honeypots from ICS Devices Using lightweight Fuzzy Testing

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Computers, Materials & Continua 2020年第11期65卷 1723-1737页

作者： Yanbin Sun Xiaojun Pan Chao Xu Penggang Sun Quanlong Guan mohan li Men Han Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China Guangzhou Information Technology Security Evaluation Center Guangzhou510006China Jinan University Guangzhou510006China Kennesaw State University 1100 South Marietta Pkwy MariettaGeorgia30060USA

The security issues of industrial control systems(ICSs)have become increasingly *** an important part of ICS security,honeypots and anti-honeypots have become the focus of offensive and defensive ***,research on ICS honeypots still lacks breakthroughs,and it is difficult to simulate real ICS devices *** this paper,we studied ICS honeypots to identify and address their ***,an intelligent honeypot identification framework is proposed,based on which feature data type requirements and feature data acquisition for honeypot identification is *** by vulnerability mining,we propose a feature acquisition approach based on lightweight fuzz testing,which utilizes the differences in error handling between the ICS device and the ICS *** combining the proposed method with common feature acquisition approaches,the integrated feature data can be *** experimental results show that the feature data acquired is effective for honeypot identification.

关键词： ICS device honeypot identification

Evaluating the Topology Coverage of BGP Monitors

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Computers, Materials & Continua 2020年第3期62卷 1397-1412页

作者： Shen Su Zhihong Tian Jing Qiu Yu Jiang Yanbin Sun mohan li Dunqiu Fan Haining Yu Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhou510006China NSFOCUS Inc. Beijing100089China The Department of Computer Science City University of Hong KongKowloon TongHong Kong

BGP monitors are currently the main data resource of AS-level topology measurement,and the integrity of measurement result is limited to the location of such BGP ***,there is currently no work to conduct a comprehensive study of the range of measurement results for a single BGP *** this paper,we take the first step to describe the observed topology of each BGP *** that end,we first investigate the construction and theoretical up-limit of the measured topology of a BGP monitor based on the valley-free model,then we evaluate the individual parts of the measured topology by comparing such theoretical results with the actually observed *** find that:1)for more than 90%of the monitors,the actually observed peer-peer links merely takes a small part of all theoretical visible links;2)increasing the BGP monitors in the same AS may improve the measurement result,but with limited improvement;and 3)deploying multiple BGP monitors in different ASs can significantly improve the measurement results,but non-local BGP monitors can hardly replace the local AS BGP *** also propose a metric for monitor selection optimization,and prove its effectiveness with experiment evaluation.

关键词： Autonomous System(AS) border gateway protocol AS-level topology visible links

Adversarial Attacks on Content-Based Filtering Journal Recommender Systems

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Computers, Materials & Continua 2020年第9期64卷 1755-1770页

作者： Zhaoquan Gu Yinyin Cai Sheng Wang mohan li Jing Qiu Shen Su Xiaojiang Du Zhihong Tian Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhouChina Department of Computer and Information Sciences Temple UniversityPhiladelphiaUSA

Recommender systems are very useful for people to explore what they really *** papers are important achievements for researchers and they often have a great deal of choice to submit their *** order to improve the efficiency of selecting the most suitable journals for publishing their works,journal recommender systems(JRS)can automatically provide a small number of candidate journals based on key information such as the title and the ***,users or journal owners may attack the system for their own *** this paper,we discuss about the adversarial attacks against content-based filtering *** propose both targeted attack method that makes some target journals appear more often in the system and non-targeted attack method that makes the system provide incorrect *** also conduct extensive experiments to validate the proposed *** hope this paper could help improve JRS by realizing the existence of such adversarial attacks.

关键词： Journal recommender system adversarial attacks Rocchio algorithm k-nearest-neighbor algorithm