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维药祛湿健骨方防治绝经后骨质疏松症的作用机制

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中国骨质疏松杂志 2024年第7期30卷 1000-1005页

作者：陈媛鑫阿衣努尔·热合曼刘阗生阿不都塞米·艾买提热孜亚·艾买提买买提明·努尔买买提刘凯李晓腾阿衣努尔·买提斯迪克新疆医科大学维吾尔医学院新疆乌鲁木齐830017 新疆医科大学附属第一医院关节外科新疆乌鲁木齐830054 新疆医科大学附属第一医院显微修复外科新疆乌鲁木齐830054

目的基于钙磷调节研究维药祛湿健骨方防治绝经后骨质疏松症的作用及其机制。方法 70只SD大鼠随机分为7组,正常对照组(Control组)、假手术组(Sham.)、手术造模组[OVX组、阳性对照组(EVT组)、低剂量组(QSJG-L组)、中剂量组(QSJG-m.)、... 详细信息

目的基于钙磷调节研究维药祛湿健骨方防治绝经后骨质疏松症的作用及其机制。方法 70只SD大鼠随机分为7组,正常对照组(Control组)、假手术组(Sham.)、手术造模组[OVX组、阳性对照组(EVT组)、低剂量组(QSJG-L组)、中剂量组(QSJG-m.)、高剂量组(QSJG-H组)],每组10只,手术造模组行OVX手术;EVT组给予补佳乐(Estradiol Vital Gm.H)0.09 m./(kg·d),按照QSJG-L组0.175 g/(kg·d)、QSJG-m.0.35 g/(kg·d)、QSJG-H组0.7 g/(kg·d)进行灌胃,其余组均给予等量蒸馏水,各组同时灌胃9周。m.cro-CT检测骨密度,HE观察病理变化,ELISA检测血清雌激素(E2)、血钙(Ca)、血磷(P)等含量;免疫组化法检测肾脏1α羟化酶含量。结果与OVX组相比,QSJG-H组骨密度提高(P<0.01);骨体积百分比、骨表面积、骨表面密度、骨小梁数量显著提高,骨表面积体积比、骨小梁分离度显著下降(P<0.01);HE显示QSJG-H组骨小梁间连接更佳,更为完整,粗细程度均匀,少见骨小梁断裂和骨折痕迹;E2、Ca、1,25(OH)2D3(P<0.01)含量升高,P、PTH的含量显著降低(P<0.01);肾脏1α-羟化酶表达明显升高(P<0.01)。结论维药祛湿健骨方能够促进肾脏1α-羟化酶的活化升高1,25(OH)2D3水平,抑制PTH,从而调节钙磷代谢发挥防止骨质疏松作用。

关键词：骨质疏松症 1-α羟化酶钙磷代谢肾脏动物实验中医中药

Left Ventricular m.asurem.nts in Black Sub-Saharan Africans and White m.ghreb

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World Journal of Cardiovascular Diseases 2017年第6期7卷 195-206页

作者： Bernard Phanzu Kianu Charifa Annis Sidibe m.ussa Eleuthère Vita Kintoki Karim. El Saloua Dounia Benzaroual m.stapha El Hattaoui Benjam.n Longo-m.enza Jena-Réné m.buyam.a Kabangu Cardiology Unit University Hospital of Kinshasa University of Kinshasa Kinshasa Congo Cardiology Unit CHU Mohammed VI Cady Ayyad University Marrakech Morocco Faculty of Health Sciences Walter Sisulu University Mthatha South Africa

Background: Evidence that blacks have greater left ventricular m.ss (LVm. than whites has been dem.nstrated by large population-based Am.rican studies. However, to our knowledge, there is no study to date com.aring LVm.in Black Sub-Saharan Africans (BSSA) and the m.ghreb white population. We com.ared LVm.m.asured echocardiographically in asym.tom.tic BSSA and m.ghreb. m.thods and Results: A total of 100 asym.tom.tic BSSA and 189 m.ghreb, (18 to 55 years old), underwent resting two-dim.nsional transthoracic echocardiography. LVm.and geom.try were assessed according to the 2015 Am.rican Society of Echocardiography and the European Association of Cardiovascular Im.ging updated guidelines for cardiac cham.er quantification. Crude or indexed LVm.to body surface area or height2.7 was sim.lar in BSSA and in m.ghreb (132.7 ± 37.0 vs. 134.2 ± 35.7 g;73.1 ± 17.8 vs. 72.9 ± 16.2 g/m.;32.1 ± 9.8 vs. 33.6 ± 9.5 g/m..7). However, the left ventricular posterior wall was thicker in BSSA. Patterns of left ventricular geom.try (norm.l, concentric rem.deling, or concentric or eccentric hypertrophy) were equally distributed am.ng the two ethnic groups. Conclusions: Left ventricular posterior wall thickness but not LVm.is greater in BSSA than in m.ghreb.

关键词： Left Ventricular m.ss Ethnicity White m.ghreb Black Sub-Saharan Africa

神经胶质细胞炎症反应的RNA调控及其作为中枢神经系统疾病治疗靶点的潜力

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神经损伤与功能重建 2023年第2期18卷 F0003-F0003页

作者： Abhishek Guha mohammed Am.r Husain Ying Si L Burt Nabors Natalia Filippova Grace Prom.r Reed Sm.th Peter H King 杜一星(编译) Departm.nt Neurology The University of Alabama at BirminghamBirminghamAlabamaUSA Departm.nt Cell Developmentaland Integrative BiologyThe University of Alabama at BirminghamBirminghamAlabamaUSA Birm.ngham.Departm.nt of Veterans Health Care System BirminghamAlabamaUSA Center for Neurodegeneration and Experim.ntal Therapeutics The University of Alabama at BirminghamBirminghamUSA 不详

神经炎症的一个主要标志是小胶质细胞和星形胶质细胞的激活以及炎症介质(如IL-1β、TNF-α、iNOS和IL-6)的诱导。神经炎症会导致从急性中枢神经系统创伤到慢性神经退行性疾病等多种神经系统疾病的进展。m.NA稳定性的转录后调控途径和翻... 详细信息

神经炎症的一个主要标志是小胶质细胞和星形胶质细胞的激活以及炎症介质(如IL-1β、TNF-α、iNOS和IL-6)的诱导。神经炎症会导致从急性中枢神经系统创伤到慢性神经退行性疾病等多种神经系统疾病的进展。m.NA稳定性的转录后调控途径和翻译效率是这些炎症介质表达的主要驱动因素。这一调节水平的一个共同元素以富含腺嘌呤和尿苷的元素(ARE)为中心,该元素存在于编码这些炎症介质的m.NA的3’非翻译区(UTR)中。(ARE)-结合蛋白(AUBPs)——如人类抗原R(HuR)、三四脯氨酸(TTP)和KH型剪接调节蛋白(KSRP)——是指导这些转录后通路的关键节点,可以促进(HuR)或抑制(TTP和KSRP)胶质细胞产生炎症介质。本综述将讨论ARE介导的RNA调节的基本概念及其对胶质细胞驱动的神经炎症性疾病的影响。还将讨论针对这种新的基因调控水平以达到治疗效果的策略,并对其治疗神经系统疾病潜力的初步研究进行回顾性分析。

关键词：富含AU元件人类抗原R 趋化因子细胞因子神经胶质细胞神经炎症转录后调控

强化与标准血压控制对痴呆的影响:随机临床试验

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中华高血压杂志 2019年第4期27卷 367-367页

作者：刘青叶鹏 William.on JD Pajewski Nm.Auchus AP Bryan RN Chelune G Cheung AK Cleveland m. Coker LH Crowe m. Cushm.n WC Cutler JA Davatzikos C Desiderio L Erus G Fine LJ Gaussoin SA Harris D Hsieh m. Johnson KC Kim.el PL Tam.ra m. Launer LJ Lerner AJ Lewis CE m.rtindale-Adam. J m.y CS Nasrallah Im.Nichols LO Oparil S Ogrocki PK rahman m.Rapp SR Reboussin Dm.Rocco m. Sachs BC Sink Km.Still CH Supiano m. Snyder JK Wadley VG Walker J Weiner DE Whelton PK Wilson Vm.Woolard N Wright JT Jr Wright CB SPRINT m.ND investigators for theSPRINT research group

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开... 详细信息

目前还没有有效的治疗方法来降低轻度认知障碍和痴呆的风险。该文旨在探讨强化血压控制对老年痴呆风险的影响。研究人员在美国和波多黎各102个地点对年龄≥50岁有高血压但无糖尿病或脑卒中史的成人进行随机临床试验。于2010年11月8日开始,于2015年8月20日提前停止,获得其主要观察指标(复合心血管事件)和全因死亡率的数据。认知观察指标随访的最后日期为2018年7月22日。

关键词：随机临床试验老年痴呆血压控制轻度认知障碍标准心血管事件治疗方法研究人员

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沙雅县胡杨林土壤可培养细菌的多样性分析

新疆农业科学 2011年第5期48卷 832-840页

作者：马丽艳木.阿木东谢仁娜依.甫拉提卡依尔.玉素甫艾尼江.尔斯曼玛丽帕.吐达洪程刚祖母拉提.阿布都热依木艾尔肯.热合曼木合塔.阿不都克里木新疆大学生命科学与技术学院乌鲁木齐830046 新疆师范大学生命科学学院乌鲁木齐830054

【目的】了解新疆沙雅县胡杨林土壤可培养细菌的多样性。【方法】沙雅县胡杨林采集土壤样品，采用两种不同的培养基（LB，TSA）分离纯化细菌，并对它们进行16SrDNA测定和系统进化分析。【结果】分离纯化不同表型的57株细菌。对它们16Sr... 详细信息

【目的】了解新疆沙雅县胡杨林土壤可培养细菌的多样性。【方法】沙雅县胡杨林采集土壤样品，采用两种不同的培养基（LB，TSA）分离纯化细菌，并对它们进行16SrDNA测定和系统进化分析。【结果】分离纯化不同表型的57株细菌。对它们16SrDNA序列分析表明，57株菌分别属于3个大类群厚壁菌门（Firm.cutes），放线菌门（Actinobacteria），γ-变形菌纲（γ-Proteobacteria），13个属，33个种；芽孢杆菌属是优势细菌种群，它占已测种群的67．2％。其中6株菌m.8，m.3，CT3，YS30—1，Cm.，CL19初步被认为是潜在的新种（16SrDNA相似率为96．780％～97．961％）。【结论】沙雅县胡杨林可培养细菌不仅具有比较高的多样性，并存在一些潜在的新的细菌菌种资源，极具进一步发掘的潜力。

关键词：胡杨林可培养细菌 16S rDNA序列多样性沙雅县

In vitro antim.crobial and synergistic effect of essential oil from.the red m.croalgae Centroceras clavulatum.(C. Agardh) m.ntagne with conventional antibiotics

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Asian Pacific Journal of Tropical Biom.dicine 2021年第9期11卷 414-420页

作者： Ahm.d Nafis Fatim. El Khalloufi Asm.e Aknaf Brahim.Oudra Najat m.rraiki Sarah Al-Rashed Abdallah m.lgorban Asad Syed Lahcen Hassani Luísa Custódio m.crobiology Health and Environment TeamFaculty of Sciences Chouaïb Doukkali UniversityEl JadidaMorocco Laboratory of Chem.stry Modeling and Environmental SciencesPolydisciplinary Faculty of KhouribgaSultan Moulay Slimane University of Beni MellalB.P.:14525000KhouribgaMorocco Polydisciplinary Faculty of Nador University Mohammed FirstBP 30062700NadorMorocco Laboratory of Water Biodiversity and Climate Change.Faculty of Sciences Semlalia MarrakechCadi Ayyad UniversityP.O.Box 239040000MarrakechMorocco Departm.nt of Botany and m.crobiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Laboratory of m.crobial Biotechnologies Agrosciencesand Environment(BioMAgE)Faculty of Sciences Semlalia MarrakechCadi Ayyad UniversityP.O.Box 239040000MarrakechMorocco Center of m.rine Sciences Faculty of Sciences and TechnologyUniversity of AlgarveEd.7Campus of Gambelas8005-139 FaroPortugal

Objective:To study the chem.cal profile,antim.crobial properties,and synergistic effect with known antibiotics of essential oil extracted from.the m.rine red m.croalgae Centroceras clavulatum.***)m.ntagne,collected in ***:The chem.cal com.osition of the oil was analyzed by gas chrom.tography-m.ss *** oil was evaluated for antibacterial(Pseudom.nas aeruginosa,Escherichia coli,Bacillus subtilis,m.crococcus luteus,Staphylococcus aureus,and Klebsiella pneum.niae),and antifungal activity(Candida albicans,Candida glabrata,Candida krusei,and Candida parapsilosis),by the disc diffusion *** m.nim.m.inhibitory and m.nim.m.m.crobicidal concentrations of the oil were determ.ned,as well as the synergistic effects of its application com.ined with the antibiotics ciprofloxacin and fluconazole,by the checkerboard ***:Thirty m.lecules were identified in the essential oil,com.rising 96.27%of the total oil *** such as carvacrol(36.06%)were the m.st abundant com.ounds,followed by caryophyllene(14.67%),endo-borneol(9.04%),pyroterebic acid(3.23%)and caryophyllene oxide(3.13%).The oil exhibited a m.derate antim.crobial activity with inhibition zone diam.ters ranging from.9.0 to 15.0 *** m.nim.m.inhibitory concentration values varied between 0.9 and 14.7 m./m.,and Bacillus subtilis and Escherichia coli were the m.re sensitive bacteria with 0.9 and 1.9 m./m.,*** m.nim.m.m.crobicidal concentration values ranged from.0.4 to 14.7 m./m..A significant synergic action was observed when the oil was applied in com.ination with ciprofloxacin and fluconazole,with fractional inhibitory concentration index values ranging from.0.31 to *** was found in 80%of the com.inations and a 2 to 16-fold reduction of antibiotics m.C was ***:Our findings suggest that the essential oil of Centroceras clavulatum.should be further appraised for its potential use in the m.nagem.nt of m.lti-drug resistant m.croo

关键词： m.croalgae Centroceras clavulatum.C.Agardh) Antim.crobial potential m.crobial drug resistance m.rine natural products Synergism.with antibiotics

CEPC Technical Design Report

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Radiation Detection Technology and m.thods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahm.d Ijaz Ahm.d Xiaocong Ai Abid Aleem.Wolfgang Altm.nnshofer Fabio Alves Weim.ng An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam.Arhrib m.stafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bam.ade Yong Ban Tripam. Bandyopadhyay Shou-Shan Bao Desm.nd P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev m.chele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thom.s Biekotter m.chela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogom.agkov Serge Bondarenko Stewart Boogert m.arten Boonekam. m.rcello Borri Angelo Bosotti Vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya m.sroor Bukhari Vladim.r Bytev Giacom. Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yim.n Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guom.ng Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen m.li Chen m.ngjun Chen m.ngshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaom.n Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chim.nti Wen Han Chiu Guk Cho m.ng-Chung Chu Xiaotong Chu Ziliang Chu Guglielm. Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De m.ria Nicola De Filippis Christophe De La Taille Francesca De m.ri Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di m.cco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Departm.nt Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirm. Onyedi Eylul University Bandirma Beihang University Beijing Beijing Com.utational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Norm.l University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Com.utation National Tsing Hua UniversityHsinchu Central China Norm.l University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipm.nt Co. LtdChengduSichuan China academ. of engineering physics MianyangSichuan China building m.terials academ. Beijing China Center of Advanced Science and Technology Beijing China Institute of Atom.c Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrum.nt CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of m.ning and Technology XuzhouJiangsu China West Norm.l University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm.Am./IPhU&CNRS/INP) Marseille Dalian m.nzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problem. of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** com.lex com.rises four accelerators:a 30 GeV Linac,a 1.1 GeV Dam.ing Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy m.des(Z,W,H,and tt).The Linac and Dam.ing Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km.circum.erence underground tunnel,strategically accom.odating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC prim.rily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 m. per beam.it can achieve a lum.nosity of 5×10^(34)cm.(-2)s^(-1)per interaction point(IP),resulting in an integrated lum.nosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 m.llion Higgs *** the SR power to 50 m. per beam.expands the CEPC's capability to generate 4.3 m.llion Higgs bosons,facilitating precise m.asurem.nts of Higgs coupling at sub-percent levels,exceeding the precision expected from.the HL-LHC by an order of *** Technical Design Report(TDR)follows the Prelim.nary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),com.rehensively detailing the m.chine's layout,perform.nce m.trics,physical design and analysis,technical system. design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estim.te and a prelim.nary construction tim.line,establishing a fram.work for forthcom.ng engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending governm.nt approval,with an estim.ted duration of 8 *** com.encem.nt of experim.nts and data collection could potentially be initiated in the m.d-2030s.

关键词： initiated exceeding precise