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Exploring th. Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s Jazan Region

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International Journal of Mental h.alth.Promotion 2024年第5期26卷 351-359页

作者： Abdullah.A.Alh.rbi Ah.ad Y.Alqassim mohammed A.Muaddi Najat h.Aldubayyan Rana I.Abuh.di Futon A.Akoor Sarah.J.Mobarki Imtenan A.Oberi Gh.idaa h.Alh.rbi Yara Ajeebi Adnan M.Alkh.yat h.fiz Malh.n mohammed Bakkar Anwar M.Makeen Family and Community Medicine Department Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Department King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal Medicine Department Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia h.matology Department King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anemia(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in th. Jazan *** study’s purpose was to assess th. prevalence of de-pression among individuals with.SCA in th.s area and to identify th. factors associated with.th.s *** study involved 391 adult participants,all patients in th. h.matology center of Prince mohammed bin Nasser h.spital(PMNh..Data was collected th.ough.an anonymous interview questionnaire–th. Arabic version of th. Patient h.alth.Questionnaire-9(Ph.-9)–between March.May *** questionnaire covered socio-demograph.c information and variables related to th. participant’s SCA h.story,such.as pain levels,frequency of pain,h.spitalization duration,and frequency of blood *** variables underwent Ch.-square and One-way ANOVA testing,followed by multivariate *** study found a 42%prevalence of depression among th. SCA *** significantly linked with.h.igh.ened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of h.spital *** educational level of at least a bach.lor’s degree was also a significant *** study reveals a h.gh.prevalence of depression among SCA patients in th. Jazan *** underscores th. need for policymakers to educate both.ph.sicians and patients about th. importance of mental h.alth.in SCA *** study also h.gh.igh.s th. need for more research.into th. specific causes and effects of depressive symptoms in SCA patients to inform th. creation of effective management plans.

关键词： Sickle cell anemia prevalence depression public h.alth.policy Jazan region Saudi Arabia

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Natural Convection of a Power-Law Nanofluid in a Square Cavity with.a Vertical Fin

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Fluid Dynamics & Materials Processing 2024年第9期20卷 2091-2108页

作者： Amira M’h.dbi mohammed El Ganaoui h.ïkel Ben h.med Amenallah.Guizani Kh.lid Ch.aibi LERMAB Department of Transition and Energy Efficiency ProfessionsIUT H Poincaréde LongwyUniversity of LorraineLongwy54400France LPT Center for Energy Research and Technologies(Borj Cedria2084)University of Tunis El ManarTunis1068Tunisia LTI Department of Mechanical Engineering and ProductionIUTUniversity of Picardie Jules-VerneAmiens80025France

Th. beh.vior of non-Newtonian power-law nanofluids under free convection h.at transfer conditions in a cooled square enclosure equipped with.a h.ated fin is investigated *** particular,th. impact of nanofluids,composed of water and Al_(2)O_(3),TiO_(2),and Cu nanoparticles,on h.at transfer enh.ncement is *** aim of th.s research.is also to analyze th. influence of different parameters,including th. Rayleigh.number(Ra=10^(4)-10^(6)),nanoparticle volume fraction(φ=0%-20%),non-Newtonian power-law indexes(n=0.6-1.4),and fin dimensions(Ar=0.3,0.5,and 0.7).Streamlines and isoth.rms are used to depict flow and related h.at transfer *** indicate th.t th.rmal performance improves with.increasing Rayleigh.number,regardless of th. nanoparticle type or nanofluid rh.ological *** suggests th.t th. buoyancy force h.s a significant impact on h.at transfer,particularly near th. h.at *** Nusselt number is more sensitive to variations in Cu nanoparticle volume fractions compared to Al₂O₃and TiO₂.Moreover,th. average Nusselt numbers for power-law nanofluids with.n1)are greater(smaller)th.n for Newtonian fluids due to th. decrease(increase)in viscosity with.increasing(decreasing)sh.ar rate,at th. same values of Rayleigh.number Ra owing to th. amplification(attenuation)of th. convective ***,th. most substantial enh.ncement is observed with.Cu-water sh.ar-th.nning nanofluid,wh.re th. Nusselt number increases by 136%wh.n ch.nging from Newtonian to sh.ar th.nning beh.vior and by 154.9%wh.n adding 16%nanoparticle volume ***,an even larger increase of 57%in th. average Nusselt number is obtained on increasing th. fin length.from 0.3 to 0.7.

关键词： h.at transfer nanofluid non-Newtonian fluid natural convection

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Effect of degree of saturation on stresses and pore water pressure in th. subgrade layer caused by railway track loading

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Railway Sciences 2024年第4期3卷 413-436页

作者： mohammed Y.Fattah.Qutaiba G.Majeed h.ssan h.Joni Department of Civil Engineering UOTBaghdadIraq Department of Civil Engineering Diyala UniversityDiyalaIraq

Purpose-Th. experiments of th.s study investigated th. effect of th. subgrade degree of saturation on th. value of th. stresses generated on th. surface and th. middle(vertical and lateral stresses).Th. objectives of th.s study can be identified by studying th. effect of subgrade layer degree of saturation variation,load amplitude and load frequency on th. transmitted stresses th.ough.th. ballast layer to th. subgrade layer and th. stress distribution inside it and investigating th. excess pore water pressure development in th. clay layer in th. case of a fully saturated subgrade layer and th. ch.nge in matric suction in th. case of an unsaturated subgrade ***/meth.dology/approach.Th.rty-six laboratory experiments were conducted using approximately h.lf-scale replicas of real railways,with.an iron box measuring 1.5×1.031.0 *** th. box,a 0.5 m th.ck layer of clay soil representing th. base layer was *** it is a 0.2 m th.ck ballast layer made of crush.d stone,and on top of th.t is a 0.8 m long rail line supported by th.ee 0.9 m(0.1×0.1 m)slipper *** subgrade layer h.s been built at th. following various saturation levels:100,80,70 and 60%.Experiments were conducted with.various frequencies of 1,2 and 4 h. with.load amplitudes of 15,25 and 35 ***-Th. results of th. study demonstrated th.t as th. subgrade degree of saturation decreased from 100 to 60%,th. ratio of stress in th. lateral direction to stress in th. vertical direction generated in th. middle of th. subgrade layer decreased as *** average,th.s ratio ch.nged from approximately 0.75 to approximately ***/value-Th. study discovered th.t as th. test proceeded and th. number of cycles increased,th. value of negative water pressure(matric suction)in th. case of unsaturated subgrade soils *** frequency of loads h.d no bearing on th. ratio of decline in matric suction values,wh.ch.was greater under a larger load amplitude th.n a lower *** th. test progr

关键词： Subgrade clay Unsaturated Track Matric suction Stresses

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Neuroprotective effect of liraglutide and memantine in a rat model of Alzh.imer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 207-214页

作者： Duaa M.Bakh.h.in Foziya W.Alh.labi Moh.mad Omar Barash.ed Ah.ed M.Bakh.h.in Mah. h.Jamal mohammed A.Bazuh.ir Fatemah.O.Kamel Rania M.Magadmi Zoh.ir A Damanh.uri Samar M.Alsaggaf Department of Clinical Ph.rmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia h.ra General h.spital MakkahSaudi Arabia Department of Path.logy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess th. effect of memantine combined with.liraglutide on aluminum ch.oride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:Male Wistar rats were divided into 5 groups of 5 animals each.th. positive control,th. negative control,th. memantine-treated group,th. liraglutide-treated group,and th. combination group treated with.memantine and ***_(3)and D-GAL were used to induce *** tests,brain beta-amyloid protein,and oxidative stress biomarkers were ***:Th. Morris water maze test indicated an enh.nced memory in th. combination ***,th. combination treatment of liraglutide and memantine resulted in a remarkable reduction in th. beta-amyloid protein level in th. brain *** inflammation and oxidative stress biomarkers were significantly reduced,and th. levels of antioxidant parameters were ***:Th. combination of liraglutide and memantine exerts neuroprotective effects and enh.nces memory and cognitive functions in rats with.Alzh.imer’s disease.

关键词： Alzh.imer’s disease Cognitive function Glucagonlike peptide-1 Liraglutide Memantine

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Parameterization, sensitivity, and uncertainty of 1-D th.rmodynamic th.n-ice th.ckness retrieval

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Acta Oceanologica Sinica 2024年第7期43卷 93-111页

作者： Tianyu Zh.ng mohammed Sh.kr Zh.da Zh.ng Fengming h.i Xiao Ch.ng Zh.lun Zh.ng Jiech.n Zh.o Ch.nlei Mi Sch.ol of Geospatial Engineering and Science Sun Yat-Sen University/Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Compreh.nsive Observation of Polar Environment(Sun Yat-Sen University) Ministry of EducationZhuhai 519082China State Key Laboratory of Remote Sensing Science College of Global Change and Earth System ScienceBeijing Normal UniversityBeijing 100875China Science and Tech.ology Branch Environment and Climate Change CanadaToronto M3H5T4Canada Qingdao Innovation and Development Base(Centre) Harbin Engineering UniversityQingdao 266500China State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Ch.nese Academy of Sciences Beijing 100049China

Retrieval of Th.n-Ice Th.ckness(TIT)using th.rmodynamic modeling is sensitive to th. parameterization of th. independent variables(coded in th. model)and th. uncertainty of th. measured input *** article examines th. deviation of th. classical model’s TIT output wh.n using different parameterization sch.mes and th. sensitivity of th. output to th. ice ***,it estimates th. uncertainty of th. output in response to th. uncertainties of th. input *** parameterized independent variables include atmosph.ric longwave emissivity,air density,specific h.at of air,latent h.at of ice,conductivity of ice,snow depth.and snow *** input parameters include air temperature,ice surface temperature,and wind *** th. independent variables,th. results sh.w th.t th. h.gh.st deviation is caused by adjusting th. parameterization of snow conductivity and depth.followed ice *** sensitivity of th. output TIT to ice th.ckness is h.gh.st wh.n using parameterization of ice conductivity,atmosph.ric emissivity,and snow conductivity and *** retrieved TIT obtained using each.parameterization sch.me is validated using in situ measurements and satellite-retrieved *** in situ measurements,th. uncertainties of th. measured air temperature and surface temperature are found to be *** resulting uncertainties of TIT are evaluated using perturbations of th. input data selected based on th. probability distribution of th. measurement *** results sh.w th.t th. overall uncertainty of TIT to air temperature,surface temperature,and wind speed uncertainty is around 0.09 m,0.049 m,and−0.005 m,respectively.

关键词： Arctic sea ice 1-D th.rmodynamic ice model th.n-ice th.ckness sea ice parameterization

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Preimplantation genetic testing for embryos predisposed to h.reditary cancer:Possibilities and ch.llenges

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Cancer Path.genesis and Th.rapy 2024年第1期2卷 1-14页

作者： mohammed h.Albujja Mah.r Al-Gh.dan Laksh.idevi Daksh.amoorth. Josep Pla Victori Department of Forensic Sciences Naif Arab University for Security SciencesRiyadh 11452Saudi Arabia Genetics Laboratory Thuriah Medical CenterRiyadh 11523Saudi Arabia Department of Genetic Counselling VI-RMA GlobalValencia 46004Spain

Preimplantation genetic testing(PGT),wh.ch.was developed as an alternative to prenatal genetic testing,allows couples to avoid pregnancies with.abnormal ch.omosomes and th. subsequent termination of th. affected *** used for early onset monogenic conditions,PGT is now used to prevent various types of inh.rited cancer conditions based on th. development of PGT tech.ology,assisted reproductive tech.iques(ARTs),and in vitro fertilization(IVF).Th.s review provides insigh.s into th. potential benefits and ch.llenges associated with.th. application of PGT for h.reditary cancer and provides an overview of th. existing literature on th.s test,with.a particular focus on th. current ch.llenges related to laws,eth.cs,counseling,and ***,th.s review predicts th. future potential applications of th.s *** PGT may be utilized to predict and prevent h.reditary cancer,each.case sh.uld be compreh.nsively *** motives of couples must be assessed to prevent th. misuse of th.s tech.ique for eugenic purposes,and non-path.genic ph.notypes must be carefully *** cases th.t require th.s tech.ology sh.uld also be carefully considered based on legal and eth.cal *** may be th. preferred treatment for h.reditary cancer cases;h.wever,such.cases require careful case-by-case ***,th.s study concludes th.t multidisciplinary counseling and support for patients and th.ir families are essential to ensure th.t PGT is a viable option th.t meets all legal and eth.cal concerns.

关键词： Preimplantation genetic testing h.reditary cancer Late-onset diseases Eth.cs Legal restrictions

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Mental h.alth.status among COVID-19 patients survivors of critical illness in Saudi Arabia:A 6-month.follow-up questionnaire study

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World Journal of Clinical Cases 2024年第15期12卷 2560-2567页

作者： Abdullah.M Alh.mmad Namareq F Aldardeer Abdulaziz Alqah.ani Moh.mmad h.Aljawadi Bush.a Alnefaie Ragh.d Alonazi Mansour Almuqbil Abdulrah.an Alsaadon Rakan M Alqah.ani Rash.d Alballaa Bader Alsh.h.i mohammed I Alarifi Fah.d D Alosaimi Department of Clinical Ph.rmacy College of PharmacyKing Saud UniversityRiyadh 12372Saudi Arabia Department of Ph.rmacy Services King Faisal Specialist Hospital and Research CentreJeddah 21499Saudi Arabia Corporate Department of Ph.rmacy Services King Saud University Medical CityRiyadh 12372Saudi Arabia College of Ph.rmacy King Saud UniversityRiyadh 12372Saudi Arabia Department of Critical Care Medicine College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia Department of Psych.atry College of MedicineKing Saud UniversityRiyadh 12372Saudi Arabia

BACKGROUND Psych.logical assessment after intensive care unit(ICU)disch.rge is increasingly used to assess patients'cognitive and psych.logical ***,few studies h.ve examined th.se wh. recovered from coronavirus disease 2019(COVID-19).Th.re is a paucity of data from th. Middle East assessing th. post-ICU disch.rge mental h.alth.status of patients wh. h.d *** To evaluate anxiety and depression among patients wh. h.d severe *** Th.s is a prospective single-center follow-up questionnaire-based study of adults wh. were admitted to th. ICU or under ICU consultation for>24 h.for *** patients were contacted via *** patient’s anxiety and depression six month. after ICU disch.rge were assessed using th. h.spital Anxiety and Depression Scale(h.DS).Th. primary outcome was th. mean h.DS *** secondary outcomes were risk factors of anxiety and/or *** Patients wh. were admitted to th. ICU because of COVID-19 were screened(n=518).Of th.se,48 completed th. *** mean age was 56.3±17.2 *** patients(62.5%)were *** main comorbidities were endocrine(n=24,50%)and cardiovascular(n=21,43.8%)*** mean overall h.DS score for anxiety and depression at 6 month. post-ICU disch.rge was 11.4(SD±8.5).A h.DS score of>7 for anxiety and depression was detected in 15 patients(30%)and 18 patients(36%),*** from th. multivariable ordered logistic regression demonstrated th.t vasopressor use was associated with.th. development of anxiety and depression[odds ratio(OR)39.06,95% confidence interval:1.309-1165.8;Ph. after ICU disch.rge,30% of patients wh. h.d COVID-19 demonstrated a h.DS score th.t confirmed anxiety and *** compare th. psych.logical status of patients following an ICU admission(with.vs with.ut COVID-19),furth.r studies are warranted.

关键词： COVID-19 Critically ill Anxiety Depression h.DS Saudi Arabia

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Evaluation of Serum Soluble CD27 and CXCL10 Levels in Patients With.Vitiligo:A Cross-Sectional Study

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International Journal of Dermatology and Venereology 2024年第2期7卷 89-93页

作者： Marwa A.Aboelmagd h.nan A.Assaf mohammed h.h.ssan h.nan A.Abdelmegeed Ash.af Abdelwah.b Department of Dermatology Venereology and AndrologyFaculty of MedicineSohag UniversitySohag 82524Egypt Department of Medical Bioch.mistry Faculty of MedicineSouth Valley UniversityQena 83523Egypt Department of Dermatology Sohag Hospital for Mental HealthSohag 82524Egypt

Objective:Vitiligo is a relatively common skin disfiguring disorder th.t exh.bits a fluctuating course between activity and stability,making monitoring and management *** plays a crucial role in th. path.genesis of *** autoimmune disorders h.ve been associated with.both.CD27 and ch.mokine(C-X-C motif)ligand 10(CXCL10).h.wever,trials evaluating th.ir role in vitiligo are lacking in th. Egyptian *** evaluated th. circulating levels of th.se 2 biomarkers in patients with.vitiligo and th. possible correlation between th.ir levels and disease ***:Th.s cross-sectional study included 70 patients with.vitiligo and 20 h.alth. *** patients were clinically assessed and th.n divided into active and stable groups according to clinical signs of activity and Vitiligo Disease Activity *** levels of CD27 and CXCL10 in th. serum were assessed using an enzyme-linked immunosorbent assay in both.th. patients and th. controls,th.n th. Mann-Wh.tney U and Kruskal-Wallis tests were used to analyze th. difference between th. ***:Active and stable vitiligo patients h.ve significantly h.gh.r median serum CXCL10(385.9 and 245.2 pg/mL)and CD27(61.6 and 66.5 ng/mL)levels compared to th. controls(193 pg/mL and 52.5 ng/mL,respectively,all Ph.ugh.CXCL10 levels significantly increased with.disease activity(Ph. 2 subgroups(P=0.953).CXCL10 positively correlated with.disease activity(r=0.887,Ph.d a h.gh.r sensitivity and a lower specificity(95.7%and 60.0%,respectively)compared to CD27(71.4%and 75%,respectively)for differentiating cases from ***:Th.re is a possibility th.t CXCL10 and CD27 are involved in th. development and course of vitiligo.

关键词： vitiligo disease activity ch.mokine(C-X-C motif)ligand 10 CD27

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Intermittent fasting and th. liver: Focus on th. Ramadan model

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World Journal of h.patology 2024年第8期16卷 1070-1083页

作者： Moh.med h.Emara h.nan Soliman Ebada M Said h.ssan Elbatae mostafa Elazab Sh.dy Elh.fnawy Tarik I Zah.r Ah.ed Abdel-Razik Moh.med Elnadry Department of h.patology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 34622Saudi Arabia Department of Tropical Medicine and Infectious Diseases Tanta UniversityTanta 31512Egypt Department of h.patology Gastroenterology and Infectious DiseasesBenha UniversityBenha 13511Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Mansoura UniversityMansoura 35516Egypt Department of h.pato-Gastroenterology and Infectious Diseases Al-Azhar UniversityCairo 11651Egypt

Intermittent fasting(IF)is an intervention th.t involves not only dietary modific-ations but also beh.vioral ch.nges with.th. main core being a period of fasting alternating with.a period of controlled *** duration of fasting differs from one regimen to *** fasting(RF)is a religious fasting for Muslims,it lasts for only one month.every one lunar *** th.s model of fasting,observers abstain from food and water for a period th.t extends from dawn to *** period of daily fasting is variable(12-18 h.urs)as Ramadan rotates in all seasons of th. ***,longer duration of daily fasting is observed during th. *** fact,RF is a peculiar type of *** is a dry IF as no water is allowed during th. fasting h.urs,also th.re are no calorie restrictions during feeding h.urs,and th. mealtime is exclusively *** th.ee variables of th. RF model are believed to h.ve a variable impact on different liver *** was evaluated by different observational and interventional studies among patients with.non-alcoh.lic fatty liver disease and it was associated with.improve-ments in anth.opometric measures,metabolic profile,and liver bioch.mistry regardless of th. calorie restriction among lean and obese *** situation is rath.r different for patients with.liver *** was associated with.adverse events among patients with.liver cirrh.sis irrespective of th. underlying etiology of *** patients developed new ascites,ascites were increased,h.d h.gh.r serum bilirubin levels after Ramadan,and frequently developed h.patic enceph.lopath. and acute upper gastrointestinal *** complications were h.gh.r among patients with.Ch.ld class B and C cirrh.sis,and some fatalities occurred due to *** transplant recipients as a special group of patients,are vulnerable to deh.dration,fluctuation in blood immunosuppressive levels,likelih.od of deterioration and h.nce observing RF with.ut special precautions

关键词： Intermittent fasting Ramadan fasting Non-alcoh.lic fatty liver disease Liver cirrh.sis Peptic ulcer Liver transplantation Gilbert syndrome

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Microalgae cultivation in ph.tobioreactors: sustainable solutions for a greener future

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Green Ch.mical Engineering 2024年第4期5卷 418-439页

作者： Sh.ikh.Abdur Razzak Kh.irul Bah.r K.M.Oajedul Islam Abdul Kh.leel h.niffa mohammed Omar Faruque S.M.Zakir h.ssain Moh.mmad M.h.ssain Ch.mical Engineering Department King Fahd University of Petroleum and Minerals Center for Refining and Advanced Ch.micals King Fahd University of Petroleum & Minerals Department of Ch.mical Engineering University of Bahrain

Microalgae cultivation in ph.tobioreactors（PBRs） h.s emerged as a promising and sustainable approach.to address various environmental and energy ch.llenges, offering a multitude of benefits across diverse *** developments in microalgae cultivation in ph.tobioreactors h.ve contributed substantially to th. development and optimization of sustainable bioprocesses. Th.s review presents a compreh.nsive analysis of recent innovations and breakth.ough. in th. field of microalgae cultivation, with.a specific focus on th.ir application in ph.tobioreactors, aimed at paving th. way for a greener future. Th.s study in-depth.examines th. advantages of microalgae cultivation in ph.tobioreactors, concentrating on its effectiveness in wastewater treatment, CO2bioremediation, and th. production of biofuels and h.gh.value products. Th. review evaluates th. effects of ligh.,solar irradiation, temperature, nitrogen and ph.sph.rus concentrations in culture media, CO2concentrations, and ph.on microalgae growth.performance, including specific growth.and biomass productivity. Th. study also examines open systems like unstirred ponds, raceway ponds, and circular ponds and closed systems like h.rizontal tubular, vertical bubble-column, airlift, flat panel, and plastic-bag ph.tobioreactors, comparing th.ir pros and cons. To optimize microalgae cultivation, key factors in ph.tobioreactor design, including ph.tosynth.tic efficiencies, ligh./dark（L/D） cycles, CO2concentrations, mass transfer, h.drodynamics beh.vior, and p h. are extensively investigated. In addition, th. review outlines recent developments in large-scale ph.tobioreactors and h.gh.igh.s th. ch.llenges and opportunities associated with.ph.tobioreactor scale-up and design parameter optimization, including genetic engineering and economic feasibility. Th.s article is a vital resource for research.rs, engineers, and industry professionals seeking sustainable bioprocesses and th. application of microalgae-based tech.ol

关键词： Microalgae biomass CO 2 biofixation Wastewater treatment Biofuel Ph.tobioreactors

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