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Isolated antibody to hepatitis B core antigen in patients with chronic hepatitis C virus infection

World Journal of Gastroenterology 2006年第27期12卷 4406-4410页

作者： Ahmed Helmy mohammed Ibrahim al-sebayel Department of Liver Transplantation Hepatobiliary and Pancreatic SurgeryKing Faisal Specialist Hospital & Research CenterRiyadhSaudi Arabiaand also affiliated to Faculty of MedicineAssiut University HospitalAssiutEgypt Department of Liver Transplantation Hepatobiliary and Pancreatic SurgeryKing Faisal Specialist Hospital & Research CenterRiyadhSaudi Arabia

AIM： To evaluate the prevalence of isolated anti-HBc in patients with chronic hepatitis C virus （HCV） infection, and its relation to disease severity. METHODS： We screened all patients with chronic HCV infection referred to King Faisal Specialist Hospital and Research Center for hepatitis B surface antigen （HBsAg）, antibody to hepatitis B surface antigen （anti- HBs）, and anti-HBc. One hundred and sixty nine patients who tested negative for both HBsAg and anti-HBs were included in this study. RESULTS： Pathologically, 59 had biopsy-proven cirrhosis and 110 had chronic active hepatitis （CAH）. Of these 169 patients, 85 （50.3%） tested positive for anti-HBc. Patients with CAH had significantly higher prevalence of isolated anti-HBc than patients with cirrhosis, 71 （6d.5%） and 14 （23.7%） respectively （P 〈 0.001）. Twenty-five patients were tested for HBV DNA by qualitative PCR. The test was positive in 3 of them （12%; occult HBV infection）. CONCLUSION： Isolated anti-HBc alone is common in Saudi patients with chronic HCV infection, and is significantly more common in those with CAH than those with cirrhosis. Therefore, a screening strategy that only tests for HBsAg and anti-HBs in these patients will miss a large number of individuals with isolated anti-HBc, who may be potentially infectious.

关键词： Cirrhosis Chronic hepatitis Dual infection Co-infection Hepatitis B screening Super-infection

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Liver transplantation in Wilson's disease: Single center experience from Saudi Arabia

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World Journal of Hepatology 2013年第3期5卷 127-132页

作者： Musthafa Chalikandy Peedikayil Hamad Ibrahim al Ashgar Abdullah al Mousa mohammed al sebayel Khalid al Kahtani Faisal Aba alkhail Department of Medicine King Faisal Specialist Hospital and Research Center Liver Transplantation and Hepatobiliary Surgery King Faisal Specialist Hospital and Research Center

AIM: To determine liver transplantation outcomes in Wilson's disease (WD) patients, focusing on neurological manifestations. METHODS: This retrospective study assessed data from 16 WD patients (nine males, 56%) who had liver transplants between 1991 and 2007. Survival, graft function, and neurological complications were assessed during a follow-up period of up to 15 years. In addition, each patient's medical record was reviewed in detail to find the type of Wilson's disease (hepatic or hepatic plus neurological WD), indication for liver transplantation, use of chelating agents prior to transplantation, immediate and long term complications following transplantation, the donor details, and the pathology of explanted liver. RESULTS: End-stage liver disease was the indication for transplantation in all 16 WD patients. Four patients displayed WD-related neurological symptoms in addition to liver disease. Living-related liver transplantation was done in three cases. One patient died on postoperative day 6 due to primary graft non-function. Oneyear post liver transplant survival was 94%. Neurological manifestations of all four patients disappeared during their follow-up. Four patients developed acute cellular rejection, but all responded to treatment. One patient developed chronic ductopenic rejection after 15 years post-transplantation and their graft failed; this patient is currently waiting for re-transplantation. Fourteen patients (88%) are still living. The long-term average survival is currently 10.5 years, with a current median survival of 8 years. Long-term graft survival is currently 81%. CONCLUSION: Shortand long-term survival in WD patient liver transplantation was excellent, and neurological and psychological WD manifestations disappeared during long-term follow-up.

关键词： Wilson’s disease Liver transplantation Neurological Psychiatric Penicillamine Saudi Arabia Transplantation

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Day-of-surgery rejection of donors in living donor liver transplantation

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World Journal of Hepatology 2012年第11期4卷 299-304页

作者： Bassem Hegab Mohamed Rabei Abdelfattah Ayman Azzam Hazem Mohamed Waleed al Hamoudi Faisal Aba alkhail Hamad al Bahili Hatem Khalaf mohammed al Sofayan mohammed al sebayel Department of Liver Trans-plantation and Hepatobiliary-Pancreatic Surgery King Faisal Specialist Hospital and Research Center Riyadh 11211 Saudi Arabia Department of Hepato-Biliary-Pancreatic Surgery and Liver Transplantation National Liver Institute University of Menoufiya Menoufiya 32714 Egypt Department of Hepato-Biliary and Pancreatic Surgery University of Alexan-dria Alexandria 21131 Egypt

AIM: To study diagnostic laparoscopy as a tool for excluding donors on the day of surgery in living donor liver transplantation (LDLT).METHODS: This study analyzed prospectively collected data from all potential donors for LDLT. all of the donors were subjected to a three-step donor evaluation protocol at our institution. Step one consisted of a clinical and social evaluation, including a liver profile, hepatitis markers, a renal profile, a complete blood count, and an abdominal ultrasound with Doppler. Step two involved tests to exclude liver diseases and to evaluate the donor’s serological status. This step also included a radiological evaluation of the biliary anatomy and liver vascular anatomy using magnetic resonance cholan-giopanc reatography and a computed tomography (CT) angiogram, respectively. A CT volumetric study was used to calculate the volume of the liver parenchyma. Step three included an ultrasound-guided liver biopsy. Between November 2002 and May 2009, sixty-nine potential living donors were assessed by open exploration prior to harvesting the planned part of the liver. Between the end of May 2009 and October 2010, 30 potential living donors were assessed laparoscopically to determine whether to proceed with the abdominal incision to harvest part of the liver for donation. RESULTS: Ninety-nine living donor liver transplants were attempted at our center between November 2002 and October 2010. Twelve of these procedures were aborted on the day of surgery (12.1%) due to donor findings, and eighty-seven were completed (87.9%). These 87 liver transplants were divided into the following groups: Group A, which included 65 transplants that were performed between November 2002 and May 2009, and Group B, which included 22 transplants that were performed between the end of May 2009 and October 2010. The demographic data for the two groups of donors were found to match; moreover, no significant difference was observed between the two groups of donors with res

关键词： Live donor Laparoscopic assessment Re-jected donors Day of surgery Fatty liver

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Liver transplantation for hepatitis B virus: Decreasing indication and changing trends

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World Journal of Gastroenterology 2015年第26期21卷 8140-8147页

作者： Waleed al-hamoudi Hussien Elsiesy Abdulrahman Bendahmash Nasser al-masri Safiyya ali Naglaa allam mohammed al Sofayan Hamad al Bahili mohammed al sebayel Dieter Broering Sammy Saab Faisal Abaalkhail Gastroenterology Unit Department of MedicineCollege of MedicineKing Saud University Department of Liver Transplantation and Hepatobiliary Surgery King Faisal Specialist Hospital and Research Center National Liver Institute Menoufeya University David Geffen School of Medicine UCLA

AIM: To evaluate the indication and outcome of hepatitis B virus(HBV)-related liver transplantation(LT) in the era of newer antiviral ***: We collected data on all patients who underwent transplantation at King Faisal Specialist Hospital and Research *** data included demographic,perioperative and long-term postoperative follow-up data including viral serological markers,HBV DNA,and repeated liver *** January 1990 and January 2012,133 patients(106 males and 27 females) underwent LT for HBV-related cirrhosis at our *** patients were followed up frequently during the first year following transplantation,according to our standard protocol; follow-up visits occurred every 3-6 mo *** infection was definedas re-emergence of HBV-DNA or hepatitis B surface antigen(HBs Ag) while on *** patients transplanted prior to 1992 did not receive immediate posttransplant anti-HBV prophylaxis; all other patients were treated with HBIG and at least one nucleos(t)ide ***: One hundred and thirty-three patients underwent LT for HBV and were followed for a median of 82 mo(range: 1-274).The rates of post-LT survival and HBV recurrence during the follow-up period were 89% and 11%,*** following factors were associated with disease recurrence: younger age(44.3 ± 16.2 years vs 51.4 ± 9.9 years,P = 0.02),positive pretransplant hepatitis B e antigen(HBe Ag)(60% vs 14%,P al of 64 transplants were performed,including 46(72%) for decompensated HBV cirrhosis,12(19%) for decompensated cirrhosis complicated by HCC and 6(10%) for compensated cirrhosis complicated by ***

关键词： Hepatitis B Hepatitis C Non-alcoholicsteatohepatitis Liver transplantation Hepatocellularcarcinoma

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