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Expanding the liver donor pool worldwide with hepatitis C infected livers, is it the time?

World Journal of Transplantation 2024年第2期14卷 13-27页

作者： Mai Hashem mohammed a medhat Doaa Abdeltawab Nahed A Makhlouf Fellow of Tropical Medicine and Gastroenterology Assiut University HospitalAssiut 71515Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Tropical Medicine and Gastroenterology Al-Rajhi Liver HospitalAssiut UniversityAssiut 71515Egypt

Liver transplantation(LT)provides a life-saving option for cirrhotic patients with complications and hepatocellular *** the increasing number of liver transplants performed each year,the number of LT candidates on the waitlist remains unchanged due to an imbalance between donor organ supply and the demand which increases the waitlist time and *** donor liver transplant had a great role in increasing the donor pool and shortened waitlist time for LT ***,further strategies can be implemented to increase the pool of potential donors in deceased donor LT,such as reducing the rate of organ *** hepatitis C virus(HCV)seropositive liver grafts is one of the expanded donor organ criteria.A yearly increase of hundreds of transplants is anticipated as a result of maximizing the utilization of HCV-positive organs for HCV-negative ***-acting antiviral therapy's efficacy has revolutionized the treatment of HCV infection and the use of HCV-seropositive donors in *** American Society of Transplantation advises against performing transplants from HCV-infected liver donors(D+)into HCV-negative recipient(R-)unless under Institutional Review Board-approved study rules and with full informed consent of the knowledge gaps associated with such *** selection of patients to be transplanted with HCV-infected grafts and confirming their access to direct-acting antivirals if needed is *** and international consensuses are needed to regulate this process to ensure the maximum benefit and the least adverse events.

关键词： Donor pool Hepatitis C-viremic organs Non-viremic organs Direct acting antivirals Hepatitis C virus treated Liver transplantation

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Histopathological,histochemical and biochemical postmortem changes in induced fatal hypothermia in rats

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Forensic Sciences Research 2022年第2期7卷 211-227页

作者： Mahrous Abdelbasset Ibrahim Sally Salem mohammed Hany Goda Tammam Rehab Ibrahim Abdel-Karim medhat mohammed Farag Forensic Medicine&Clinical Toxicology College of MedicineJouf UniversitySakakahSaudi Arabia Forensic Medicine&Clinical Toxicology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Histology and Cell Biology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Forensic Medicine and Clinical Toxicology Department Faculty of MedicineAl-Azhar UniversityCairoEgypt Medical biochemistry Department College of MedicineShaqra UniversityShaqraaSaudi Arabia Medical Biochemistry&Molecular Biology Department Faculty of MedicineBenha UniversityBenhaEgypt

Reaching a postmortem diagnosis of hypothermia is challenging in forensic ***,this study was conducted to detect the histopathological,histochemical and biochemical changes that occur in adult albino rats following exposure to induced fatal ***-four adult albino rats were divided into the negative control,moderate hypothermia,severe hypothermia and hypoxia *** in the control group were euthanized when those in the moderate hypothermic group *** samples were collected via heart puncture,and the cerebrum,heart,suprarenal gland,kidney,liver and skeletal muscle were removed to investigate the biochemical,histochemical and histopathological *** assessment depicted significant changes in lipid peroxidation,represented by increased malondialdehyde levels in the studied organs of the rats in hypothermic and hypoxia *** examination of the rats’organs revealed degeneration and necrosis in the hypothermia and hypoxia *** taken from the severe hypothermic rats revealed a loss of normal cardiac tissue architecture,necrotic changes in the pyramidal cells in the cerebral cortex,and massive necrosis,mainly in the tubules of the renal cortex and *** findings suggest that histological changes might be used as biochemical markers for postmortem diagnosing of fatal hypothermia,particularly in severe hypothermic conditions.

关键词： Forensic sciences forensic medicine legal medicine autopsy forensic pathology histochemical hypothermia

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Hepatic and gastrointestinal disturbances in Egyptian patients infected with coronavirus disease 2019: A multicentre cohort study

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World Journal of Gastroenterology 2021年第40期27卷 6951-6966页

作者： Hend Ibrahim Shousha Shimaa Afify Rabab Maher Noha Asem Eman Fouad Ehab F Mostafa mohammed a medhat Amr Abdalazeem Hazem Elmorsy Miriam M Aziz Rateba S mohammed Mohamed Ibrahem Hassan Elgarem Dalia Omran Mohamed Hassany Bassem Elsayed Ahmed Y Abdelaziz Mohamed El Kassas Endemic Medicine Faculty of MedicineCairo UniversityCairo 11562Egypt Gastroenterology Department National Hepatology&Tropical Medicine Research InstituteCairo 11563Egypt Hepatology Department Students HospitalCairo UniversityGiza 12566Egypt The Public Health Department Faculty of MedicineCairo UniversityCairo 11562Egypt Egyptian Ministry of Health and PopulationCairo 11567Egypt Department of Tropical Medicine and Gastroenterology Faculty of MedicineAssiut UniversityAssiut 15655Egypt Endemic Medicine Department Faculty of MedicineHelwan UniversityCairo 13544Egypt Internal Medicine 15 Mayo Smart HospitalMinistry of Health and PopulationCairo 13488Egypt Pediatrics Department Faculty of MedicineCairo UniversityCairo 11562Egypt Occupational and Environmental Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt Clinical Biochemistry Department Faculty of medicineCairo UniversityCairo 11562Egypt Endemic Medicine Department Faculty of MedicineCairo UniversityCairo 11562Egypt Urology Department Cairo UniversityCairo 11562Egypt

BACKGROUND Various liver and gastrointestinal involvements occur in patients with coronavirus disease 2019(COVID-19)at variable *** studies report mild liver function disturbances correlated with COVID-19 severity,though liver failure is *** To study liver and gastrointestinal dysfunctions in Egyptian patients with COVID-19 and their relation to disease outcomes METHODS This multicentre cohort study was conducted on 547 Egyptian patients from April 15,2020 to July 29,*** polymerase chain reaction-confirmed COVID-19 cases were included from four quarantine hospitals affiliated to the Egyptian ministry of *** information,laboratory characteristics,treatments,fibrosis-4(FIB-4)index,COVID-19 severity,and outcomes were recorded and compared according to the degree of liver enzyme elevation and the presence of gastrointestinal ***-ups were conducted until discharge or *** analyses were performed to determine the independent factors affecting *** This study included 547 patients,of whom 53(9.68%)died during hospitalization and 1 was discharged upon his ***’mean age was 45.04±17.61 years,and 21.98%had severe or critical *** aminotransferase(ALT)and aspartate aminotransferase(AST)were available for 430 and 428 patients,*** total,26%and 32%of patients had elevated ALT and AST,*** liver injury with ALT or AST elevation exceeding 3-fold was recorded in 21(4.91%)and 16(3.73%)patients,*** gender,smoking,hypertension,chronic hepatitis C,and lung involvement were associated with elevated AST or *** was elevated in 50%of patients over ***-4 was significantly higher in patients admitted to the intensive care unit(ICU),those with more severe COVID-19,and *** independent variables affecting outcome were supplementary vitamin C intake(1 g daily capsules)[odds ratio(OR):0.05,95%confidence interval(CI

关键词： COVID-19 Egypt Liver injury Gastrointestinal symptoms Fibrosis-4 Liver enzymes

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Efficient Image Captioning Based on Vision Transformer Models

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Computers, Materials & Continua 2022年第10期73卷 1483-1500页

作者： Samar Elbedwehy T.medhat Taher Hamza mohammed F.Alrahmawy Department of Data Science Faculty of Artificial IntelligenceKafrelsheikh UniversityEgypt Department of Electrical Engineering Faculty of EngineeringKafrelsheikh UniversityEgypt Department of Computer Science Faculty of Computer and Information ScienceMansouraEgypt

Image captioning is an emerging field in machine *** refers to the ability to automatically generate a syntactically and semantically meaningful sentence that describes the content of an *** captioning requires a complex machine learning process as it involves two sub models:a vision sub-model for extracting object features and a language sub-model that use the extracted features to generate meaningful ***-based vision transformers models have a great impact in vision field *** this paper,we studied the effect of using the vision transformers on the image captioning process by evaluating the use of four different vision transformer models for the vision sub-models of the image captioning The first vision transformers used is DINO(self-distillation with no labels).The second is PVT(Pyramid Vision Transformer)which is a vision transformer that is not using convolutional *** third is XCIT(cross-Covariance Image Transformer)which changes the operation in self-attention by focusing on feature dimension instead of token *** last one is SWIN(Shifted windows),it is a vision transformer which,unlike the other transformers,uses shifted-window in splitting the *** a deeper evaluation,the four mentioned vision transformers have been tested with their different versions and different configuration,we evaluate the use of DINO model with five different backbones,PVT with two versions:PVT_v1and PVT_v2,one model of XCIT,SWIN *** results show the high effectiveness of using SWIN-transformer within the proposed image captioning model with regard to the other models.

关键词： Image captioning sequence-to-sequence self-distillation transformer convolutional layer

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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Deflection behavior of a prestressed concrete beam reinforced with carbon fibers at elevated temperatures

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Frontiers of Structural and Civil Engineering 2019年第1期13卷 81-91页

作者： mohammed FARUQI mohammed Sheroz KHAN Department of Civil and Architectural Engineering Texas A&M University--KingsvilleTexasUSA

Fiber reinforced polymer(FRP) have unique advantages like high strength to weight ratio,excellent corrosion resistance,improving deformability and cost *** advantages have gained wide acceptance in civil engineering *** tendons for prestressing applications are emerging as one of the most promising technologies in the civil engineering ***,the behavior of such members under the influence of elevated temperatures is still *** knowledge and application of this could lead to a cost effective and practical considerations in fire safety ***,this study examines the deflection behavior of the carbon fiber reinforced polymer(CFRP) prestressed concrete beam at elevated *** this article,an analytical model is developed which integrates the temperature dependent changes of effective modulus of FRP in predicting the deflection behavior of CFRP prestressed concrete beams within the range of practical *** model is compared with a finite element mode (FEM) of a simply supported concrete beam prestressed with CFRP subjected to practical elevated *** addition,comparison is also made with an indirect reference to the real behavior of the *** results of the model correlated reasonably with the finite element model and the real ***,a practical application is provided.

关键词： FRP CFRP concrete elevated temperatures deflections prestress

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Predictors of graft function and survival in second kidney transplantation: A single center experience

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World Journal of Transplantation 2023年第6期13卷 331-343页

作者： Mahmoud Khalil Rabea Ahmed Gadelkareem medhat Ahmed Abdallah Mohamed Abdel-Basir Sayed FathyGaber Elanany Paolo Fornara Nasreldin mohammed Department of Urology Assiut Urology and Nephrology HospitalFaculty of MedicineAssiut UniversityAssiut 71515AssiutEgypt Department of Urology and Kidney Transplantation Martin Luther UniversityHalle(Saale)71515Germany

BACKGROUND The increasing kidney retransplantation rate has created a parallel field of research,including the risk factors and outcomes of this advanced form of renal replacement *** presentation of experiences from different kidney transplantation centers may help enrich the literature on kidney retransplantation,as a specific topic in the field of kidney *** To identify the risk factors affecting primary graft function and graft survival rates after second kidney transplantation(SKT).METHODS The records of SKT cases performed between January 1977 and December 2014 at a European tertiary-level kidney transplantation center were retrospectively reviewed and *** the descriptive characteristics,the survivals of patients and both the first and second grafts were described using Kaplan-Meier *** addition,Kaplan-Meier analyses were also used to estimate the survival probabilities at 1,3,5,and 10 post-operative years,as well as at the longest followup duration ***,bivariate associations between various predictors and the categorical outcomes were assessed,using the suitable biostatistical tests,according to the predictor *** Out of 1861 cases of kidney transplantation,only 48 cases with SKT were eligible for studying,including 33 men and 15 women with a mean age of 42.1±13 *** primary non-function(PNF)graft occurred in five patients(10.4%).In bivariate analyses,a high body mass index(P=0.009)and first graft loss due to acute rejection(P=0.025)were the only significant predictors of PNF *** second graft survival was reduced by delayed graft function in the first(P=0.008)and second(P<0.001)***,the effect of acute rejection within the first year after the first transplant did not reach the threshold of significance(P=0.053).The mean follow-up period was 59.8±48.6 *** graft/patient survival rates at 1,3,5 and 10 years were 90.5%/97.9%,79.9%/95.6%,73.7%/91.9%,and 51.6%/83.0%,respe

关键词： Graft failure Graft function Kidney Kidney retransplantation Primary non-function graft Second kidney transplantation

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MULTIDIMENSIONAL RELAXATION APPROXIMATIONS FOR HYPERBOLIC SYSTEMS OF CONSERVATION LAWS

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Journal of Computational Mathematics 2007年第4期25卷 440-457页

作者： mohammed Seaid UniversitSt Kaiserslautern Fachbereich Mathematik 67663 Kaiserslautern Germany

We construct and implement a non-oscillatory relaxation scheme for multidimensional hyperbolic systems of conservation laws. The method transforms the nonlinear hyperbolic system to a semilinear model with a relaxation source term and linear characteristics which can be solved numerically without using either Riemann solver or linear iterations. To discretize the relaxation system we consider a high-resolution reconstruction in space and a TVD Runge-Kutta time integration. Detailed formulation of the scheme is given for problems in three space dimensions and numerical experiments are implemented in both scalar and system cases to show the effectiveness of the method.

关键词： Multidimensional hyperbolic systems Relaxation methods Non-oscillatory reconstructions Asymptotic-preserving schemes.

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Recent advances on flexible electrodes for Na-ion batteries and Li–S batteries

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Journal of Energy Chemistry 2019年第5期28卷 15-44页

作者： mohammed-Ibrahim Jamesh Department of Physics and Materials Science City University of Hong Kong Applied and Plasma Physics School of Physics (A28) University of Sydney CSIR-Central Electrochemical Research Institute-Chennai Unit CSIR Madras Complex

Flexible energy storage devices are essential for emerging flexible electronics. The existing state-of-the-art Li-ion batteries are slowly reaching their limitation in terms of cost and energy density. Hence, flexible Na-ion batteries (SIBs) with abundanee Na resources and Li-S batteries with high energy density become the alternative for the Li-ion batteries in future. This review summarizes the recent advances in the development of flexible electrode materials for SIBs with metallic matrix and carb on aceous matrix such as carb on nano-tubes, carbon nano-fiber, graphene, carbon cloth, carbon fiber cloth, and cotton textiles. Then, the potential prototype flexible full SIBs are discussed. Further, the recent progress in the development of flexible electrode materials for Li-S batteries based on carb on nano-fiber, carb on nano-tubes, graphene, and cotton textiles is reviewed. Moreover, the design strategies of suitable interlayer, separator, electrolyte, and electrodes to prevent the dissolution and shuttle effect of polysulfides in flexible Li-S batteries are provided. Finally some prospective investigation trends towards future research of flexible SIBs and Li-S batteries are also proposed and discussed. The scientific and engineering knowledge gained on flexible SIBs and Li-S batteries provides conceivable development for practical application in near future.

关键词： Na-ion batteries Lithium-sulfur batteries Flexible Free-standing High performance energy storage Long cycle life

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Ingrowing Nail Correction by Advancing Composite Flap of the Nailbed and Periosteum—A Simple and Effective Technique

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Modern Plastic Surgery 2014年第2期4卷 26-31页

作者： Adil mohammed Hashish medhat Emil Habib Said Al-Busaidi Department of Plastic Reconstructive and Craniofacial Surgery Khoula Hospital Muscat Sultanate of Oman

Ingrowing toenails are common particularly in young adults. They usually result in a prolonged period of discomfort or pain that is sufficient to interfere with working and social activities. Apart from the toes, ingrowing nails can affect the fingers as well. Surgery is still the mainstay of treatment. A number of techniques have been described in the literature. But in all there is a high recurrence rate and sometimes the cosmetic result is not acceptable. In this article we describe our technique of surgical management of ingrowing nails of the toes and fingers. The technique involves excision of a part of the lateral nail fold and raising a composite flap consisting of the nail bed and the underlying periosteum which is then advanced. 105 cases were operated using this technique with very good postoperative results.

关键词： Ingrowing Toenail Fingernail Composite Flap Nailbed

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