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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology Research 2024年第7期32卷 1231-1237页

作者： mohammad-taghi moradi DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

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In vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract of Quercus brantii *** and subsequent fractions

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Chinese Journal of Natural Medicines 2016年第3期14卷 196-202页

作者： mohammad-taghi moradi Ali Karimi Somayeh Alidadi Student's Research Committee Shahrekord University of Medical Science Medical Plants Research Center Shahrekord University of Medical Science Clinical Biochemistry Research Center Shahrekord University of Medical Science

Cancer cell resistance to widely used chemotherapeutic agents is gradually developed. Natural products, mainly isolated from medicinal plants, have been considered as valuable sources for herbal anticancer drugs. The present study aimed to evaluate in vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract and four fractions of Q. brantii acorn. Crude ethyle alcohole extract of Q. brantii acorn was prepared and subjected to fractionation with different polarity. Subsequently, the extract and the fractions wereevaluated for their in vitro antiproliferative activity in two cancerous(Hela and AGS) and one normal(HDFs) cell lines using MTT [3-(4, 5-dimethylthiazol-2ol) 2, 5 diphenyltetrazoliumbromide] assay. To determine whether the cytotoxicity of these compounds involved the induction of apoptosis, Hela cells were treated with IC_(50) concentrations of test compounds, stained with both propidium iodide(PI) and Annexin V-fluorescein isothiocyanate(FITC), and analyzed by flow cytometry. In vitro cytotoxicity assay showed that the cell viability was significantly reduced in a dose-dependent manner following treatment with crude ethyle alcohole extract and Cholophorm and n-Butanol fractions. Based on the probit regression model, antiproliferative activities of crude ethyle alcohole extract, Cholophorm fraction, and n-Butanol fraction on Hela and AGS cells and HDFs cells were significantly different(P < 0.001). The results of flow cytometric analysis showed that crude ethyle alcohole extract and two fractions of Q. brantii acorn induced early apoptotic cell death. These findings suggest that crude ethyle alcohole extract and Cholophorm and n-Butanol fractions of Q. brantii acorn suppress the proliferation of cancer cells through induction of early apoptosis.

关键词： Quercus brantii Lindl Cancer Proliferation Apoptosis

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Revealing connectivity in residential Architecture: An algorithmic approach to extracting adjacency matrices from floor plans

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Frontiers of Architectural Research 2024年第2期13卷 370-386页

作者： mohammad Amin moradi Omid mohammadrashidi Navid Niazkar Morteza Rahbar School of Architecture and Engineering University College of RouzbahanMazandaranIran School of Architecture Islamic Azad UniversitySafaDasht CampusTehranIran A.James Clark School of Engineering University of MarylandCollege ParkMDUSA School of Architecture and Environmental Design Iran University of Science and TechnologyTehranIran

In today's world, various approaches and parameters exist for designing a plan and determining its spatial, placement. Hence, various modes for identifying crucial locations can be explored when an architectural plan is designed in different dimensions. While designing all these modes takes considerable time, there are numerous potential applications for artificial intelligence (AI) in this domain. This study aims to compute and use an adjacency matrix to generate architectural residential plans. Additionally, it develops a plan generation algorithm in Rhinoceros software, utilizing the Grasshopper plugin to create a dataset of architectural plans. In the following step, the data was entered into a neural network to identify the architectural plan's type, furniture, icons, and use of spaces, which was achieved using YOLOv4, EfficientDet, YOLOv5, DetectoRS, and RetinaNet. The algorithm's execution, testing, and training were conducted using Darknet and PyTorch. The research dataset comprises 12,000 plans, with 70% employed in the training phase and 30% in the testing phase. The network was appropriately trained practically and precisely in relation to an average precision (AP) resulting of 91.50%. After detecting the types of space use, the main research algorithm has been designed and coded, which includes determining the adjacency matrix of architectural plan spaces in seven stages. All research processes were conducted in Python, including dataset preparation, network object detection, and adjacency matrix algorithm design. Finally, the adjacency matrix is given to the input of the proposed plan generator network, which consequently, based on the resulting adjacency, obtains different placement modes for spaces and furniture.

关键词： Algorithm design Adjacency matrix Generate floor plan Detection plan

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Synthesis of boron nitride nanorod and its performance as a metalfree catalyst for oxidative desulfurization of diesel fuel

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Chinese Journal of Chemical Engineering 2024年第4期68卷 120-132页

作者： Tanaz Ghanadi Gholamreza moradi Alimorad Rashidi Catalyst Research Center Faculty of Chemical and Petroleum EngineeringRazi UniversityKermanshahIran Nanotechnology Research Center Research Institute of Petroleum Industry(RIPI)TehranIran

In order to reduce the sulfur compounds in diesel fuel,boron nitride(BN)has been used as a novel metal-free catalyst in the present *** nanocatalyst was synthesized via template-free approach followed by heating treatment at 900℃ in nitrogen atmosphere that the characteristics of the sample were identified by the X-ray diffraction,Fourier-transform infrared spectroscopy,Raman spectroscopy,field emission scanning electron microscopy,transmission electron microscopy,atomic force microscopy,and N2 adsorption-desorption *** results of structural and morphological analysis represented that BN has been successfully *** efficacy of the main operating parameters on the process was studied by using response surface methodology based on the Box-Behnken design *** prepared catalyst showed high efficiency in oxidative desulfurization of diesel fuel with initial sulfur content of 8040 mg·kg^(-1)*** statistical analysis,a significant quadratic model was obtained to predict the sulfur removal as a function of efficient *** maximum efficiency of 72.4%was achieved under optimized conditions at oxidant/sulfur molar ratio of 10.2,temperature of 71℃,reaction time of 113 min,and catalyst dosage of 0.36 ***,the reusability of the BN was studied,and the result showed little reduction in activity of the catalyst after 10 times ***,a plausible mechanism was proposed for oxidation of sulfur compounds on the surface of the *** present study shows that BN materials can be selected as promising metal-free catalysts for desulfurization process.

关键词： Desulfurization Boron nitride(BN)nanostructure Experimental design BoxeBehnken

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Congenital Disseminated Pyogenic Granuloma: A Case With Numerous Mucocutaneous and Visceral Lesions

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母胎医学杂志(英文) 2024年第3期6卷 190-195页

作者： Ghaderi-Sohi Siavash moradi Behnaz Shirazi Mahboobeh Rahimi Rahil Ravanbakhsh Romina Kariminejad Ariana Feizabad Elham Kariminejad-Najmabadi Pathology & Genetics Center Tehran Iran Department of Radiology Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Sciences Tehran Iran Yas Complex Hospital Tehran University of Medical Sciences Tehran Iran Nikan Hospital Tehran Iran

Congenital disseminated pyogenic granuloma (CDPG) is characterized by eruptive disseminated or localized lesions, which may arise spontaneously or secondary to predisposing factors. Even rarer is the occurrence of CDPG with numerous lesions affecting variable organs, which develop during the fetal period. This report describes the case of a 32-week-old fetus presenting with severe hydrocephalus and vascular intracranial and right lung masses on magnetic resonance imaging. Preterm labor occurred at the 32nd week due to preterm premature rupture of membranes, and the newborn died due to cardiac dysfunction within 2 hours postpartum. The subsequent autopsy revealed multiple violaceous to dark red papules, nodules, pedunculated and un-pedunculated mucocutaneous masses, as well as two brain lesions, a lung lesion, a thoracic wall intramuscular mass, and a pyloric mass. Microscopic examination and immunohistochemical evaluation for glucose transporter 1 (GLUT1) confirmed the diagnosis of CDPG. CDPG represents a rare condition with an elusive etiology and limited reports in the literature. Differential diagnosis from multifocal infantile hemangioma, based on GLUT1 negativity of CDPG, is imperative due to differing clinical course and treatment modalities. This report underscores a severe case of CDPG characterized by preterm labor and demise shortly after delivery, notable for its extensive involvement across multiple organs, including the brain, lung, intestine, musculoskeletal system, mucosal, and numerous cutaneous sites.

关键词： Pyogenic Granuloma Congenital Hemangioma

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Molecular investigation of exoU and exoY virulence genes in Pseudomonas aeruginosa collected from hospitalized patients in North of Iran:A descriptive-analytical study

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Journal of Acute Disease 2024年第2期13卷 74-80页

作者： Ahmad Reza moradi Mehrdad Gholami Lotfollah Davoodi Negar Hajilou Hamid Reza Goli Sana Institute of Higher Education SariIran Department of Medical Microbiology and Virology Faculty of MedicineMazandaran University of Medical SciencesSariIran Antimicrobial Resistance Research Center Faculty of MedicineMazandaran University of Medical SciencesSariIran Molecular and Cell Biology Research Center Faculty of MedicineMazandaran University of Medical SciencesSariIran

Objective:To investigate the frequency of exoU and exoY genes in patients with Pseudomonas aeruginosa ***:In this study,100 clinical isolates of Pseudomonas aeruginosa were collected from patients hospitalized in educational-therapeutic hospitals and were identified using standard microbiological ***,the antibiotic resistance pattern of the isolates was determined by the disk agar diffusion *** bacterial DNAs were extracted by the alkaline lysis ***,the presence of exoU and exoY genes was evaluated by the PCR ***:In this study,47%,72%,29%,39%,40%,and 44%of the isolates were non-susceptible to piperacillin,aztreonam,ceftazidime,imipenem,tobramycin,and ciprofloxacin,*** addition,95%and 93%of the clinical isolates carried the exoU and exoY *** and fecal isolates had both virulence genes,while only one wound isolate had neither ***,all urinary isolates contained the exoY gene and only one isolate lacked the exoU ***,88 isolates simultaneously had both exoU and exoY ***:High prevalence of exoU and exoY genes in this region indicates a significant role of typeⅢsecretion system in pathogenesis of Pseudomonas *** typeⅢsecretion system may be a suitable target to reduce the pathogenicity of this bacterium.

关键词： Pseudomonas aeruginosa exoU exoY Virulence gene TypeⅢsecretion system PCR

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Molecular dynamic simulation of carbon dioxide,methane,and nitrogen adsorption on Faujasite zeolite

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Chinese Journal of Chemical Engineering 2022年第3期35卷 70-76页

作者： Hojatollah moradi Hedayat Azizpour Hossein Bahmanyar mohammad Emamian Surface Phenomenon and Liquid-Liquid Extraction Research Lab School of Chemical EngineeringCollege of EngineeringUniversity of TehranTehranIran Fouman Faculty of Engineering College of EngineeringUniversity of TehranIran

Removing impurities such as carbon dioxide and nitrogen from natural gas is a technical challenge and one of the major concerns in natural gas treatment *** this study,adsorption of CH_(4),N_(2),and CO_(2)on the Faujasite(FAU)zeolite has been studied using molecular dynamics simulation at temperatures of 293,308,and 323 K and pressures up to 1 *** force field was used to model the interactions between zeolite and guest *** and atom-based summation methods were used for the calculation of electrostatic and van der Waals forces,*** results were modeled using Langmuir,Freundlich,Toth,and Sips adsorption *** isotherm for CO_(2),and Toth isotherm for CH_(4)and N_(2)pure compounds showed the best *** of adsorption for CH_(4),CO_(2),and N_(2)were calculated to be-15.48,-24.1,and-13.31 kJ·mol^(-1),respectively.A comparative study showed that the simulation model was successful in predicting the overall trend of the adsorption with acceptable accuracy.

关键词： Adsorption Molecular simulation Isotherms Zeolite

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Topology optimization and seismic collapse assessment of shape memory alloy(SMA)-braced frames:Effectiveness of Fe-based SMAs

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Frontiers of Structural and Civil Engineering 2022年第3期16卷 281-301页

作者： Aydin HASSANZADEH Saber moradi Department of Civil Engineering Ryerson UniversityToronto M5B 2K3Canada

This paper presents a seismic topology optimization study of steel braced frames with shape memory alloy(SMA)*** SMA-braced frames(SMA-BFs)with either Fe-based SMA or NiTi braces are determined in a performance-based seismic design *** topology optimization is performed on 5-and 10-story SMA-BFs considering the placement,length,and cross-sectional area of SMA bracing ***,strength,and performance-based design constraints are considered in the *** seismic response and collapse safety of topologically optimal SMA-BFs are assessed according to the FEMA P695 methodology.A comparative study on the optimal SMA-BFs is also presented in terms of total relative cost,collapse capacity,and peak and residual story *** results demonstrate that Fe-based SMA-BFs exhibit higher collapse capacity and more uniform distribution of lateral displacement over the frame height while being more cost-effective than NiTi braced *** addition to a lower unit price compared to NiTi,Fe-based SMAs reduce SMA material *** frames with Fe-based SMA braces,the SMA usage is reduced by up to 80%.The results highlight the need for using SMAs with larger recoverable strains.

关键词： topology optimization shape memory alloy Fe-based SMA steel braced frames performance-based seismic design collapse assessment

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Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress,inflammation and apoptosis in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 242-249页

作者： Yosra Raziani Kimia Karami Hamid Reza mohammadi Hossein Mahmoudvand mohammad Nabi moradi Javad Ghasemian Yadegari Nursing Department Al-Mustaqbal University College51001 HillahBabylonIraq Razi Herbal Medicines Research Center Lorestan University of Medical SciencesKhorramabadIran Molecular and Cellular Laboratory School of Allied MedicineLorestan University of Medical SciencesKhorramabadIran

Objective:To assess the effect of oral treatment of methanolic extract of the aerial parts of Astragalus adscendens in streptozotocin-induced diabetic ***:In order to induce diabetes,rats intraperitoneally received streptozotocin at 65 mg/*** adult male Wistar rats were allocated into six groups(10 rats per each)including the healthy control group,the diabetic group as well as the diabetic group treated with Astragalus adscendens methanolic extract at 50,100,and 200 mg/kg per day or glibenclamide(0.6 mg/kg/day)for 28 *** effects of Astragalus adscendens methanolic extract on the levels of glucose,insulin,alanine aminotransferase,alkaline phosphatase,aspartate aminotransferase,bilirubin,creatinine,urea,uric acid,total protein,albumin,triglyceride,cholesterol,α-amylase,oxidant/antioxidant enzymes,and inflammatory cytokines were *** time-PCR was also used for measuring the gene expression of caspase-3,Bcl2,and ***:The levels of glucose,cholesterol,triglyceride,creatinine,urea,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,bilirubin,and malondialdehyde considerably declined(P<0.001)in diabetic rats after treatment with Astragalus adscendens methanolic extract especially at a dose of 200 mg/*** addition,treatment with Astragalus adscendens methanolic extract noticeably increased the level of insulin,total protein,and albumin as well as improved the activities of catalase,glutathione peroxidase,and superoxide dismutase,as well as the expression levels of TNF-α,IL-1β,caspase-3,Bcl2 and Bax(P<0.001)compared to the diabetic control *** extract also inhibitedα-amylase in a dose-dependent manner with an IC_(50)value of 19.6μg/***:Astragalus adscendens methanolic extract shows potent antidiabetic,anti-inflammatory,anti-apoptotic,and antioxidant effects in diabetic ***,more studies are needed to verify the underlying mechanism of the effect of this plant extract and test its effica

关键词： Herbal medicines Astragalus adscendens Diabetes Antioxidant Antidiabetes Streptozotocin Antiinflammation

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Proportional integral derivative controller design using Legendre orthogonal functions

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Journal of Central South University 2016年第10期23卷 2616-2629页

作者： Reza moradi mohammad Tabatabaei Department of Electrical Engineering Khomeinishahr Branch Islamic Azad University

The Legendre orthogonal functions are employed to design the family of PID controllers for a variety of plants. In the proposed method, the PID controller and the plant model are represented with their corresponding Legendre series. Matching the first three terms of the Legendre series of the loop gain with the desired one gives the PID controller parameters. The closed loop system stability conditions in terms of the Legendre basis function pole(λ) for a wide range of systems including the first order, second order, double integrator, first order plus dead time, and first order unstable plants are obtained. For first order and double integrator plants, the closed loop system stability is preserved for all values of λ and for the other plants, an appropriate range in terms of λ is obtained. The optimum value of λ to attain a minimum integral square error performance index in the presence of the control signal constraints is achieved. The numerical simulations demonstrate the benefits of the Legendre based PID controller.

关键词： PID controllers orthogonal functions legendre functions moment matching PI controller PD controller

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